DE60019228D1 - Struktur und Verfahren zur kapillaren Hämatokritabtrennung - Google Patents

Struktur und Verfahren zur kapillaren Hämatokritabtrennung

Info

Publication number
DE60019228D1
DE60019228D1 DE60019228T DE60019228T DE60019228D1 DE 60019228 D1 DE60019228 D1 DE 60019228D1 DE 60019228 T DE60019228 T DE 60019228T DE 60019228 T DE60019228 T DE 60019228T DE 60019228 D1 DE60019228 D1 DE 60019228D1
Authority
DE
Germany
Prior art keywords
capillary
reaction region
obstructions
inlet port
capillary pathway
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60019228T
Other languages
English (en)
Other versions
DE60019228T2 (de
Inventor
Raghbir S Bhullar
Christopher D Wilsey
Jeffrey N Shelton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics Corp
Original Assignee
Roche Diagnostics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Corp filed Critical Roche Diagnostics Corp
Publication of DE60019228D1 publication Critical patent/DE60019228D1/de
Application granted granted Critical
Publication of DE60019228T2 publication Critical patent/DE60019228T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • External Artificial Organs (AREA)
DE60019228T 1999-10-28 2000-10-24 Struktur und Verfahren zur kapillaren Hämatokritabtrennung Expired - Lifetime DE60019228T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US428691 1995-04-25
US09/428,691 US6319719B1 (en) 1999-10-28 1999-10-28 Capillary hematocrit separation structure and method

Publications (2)

Publication Number Publication Date
DE60019228D1 true DE60019228D1 (de) 2005-05-12
DE60019228T2 DE60019228T2 (de) 2006-05-11

Family

ID=23699972

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60019228T Expired - Lifetime DE60019228T2 (de) 1999-10-28 2000-10-24 Struktur und Verfahren zur kapillaren Hämatokritabtrennung

Country Status (6)

Country Link
US (1) US6319719B1 (de)
EP (1) EP1096254B1 (de)
JP (1) JP4520620B2 (de)
AT (1) ATE292799T1 (de)
CA (1) CA2324131C (de)
DE (1) DE60019228T2 (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6749814B1 (en) 1999-03-03 2004-06-15 Symyx Technologies, Inc. Chemical processing microsystems comprising parallel flow microreactors and methods for using same
US6406672B1 (en) * 2000-01-28 2002-06-18 Roche Diagnostics Plasma retention structure providing internal flow
US6555387B1 (en) * 2000-09-27 2003-04-29 Becton, Dickinson And Company Method for producing thin liquid samples for microscopic analysis
US6814843B1 (en) * 2000-11-01 2004-11-09 Roche Diagnostics Corporation Biosensor
SE0201738D0 (sv) * 2002-06-07 2002-06-07 Aamic Ab Micro-fluid structures
US20040019300A1 (en) * 2002-07-26 2004-01-29 Leonard Leslie Anne Microfluidic blood sample separations
EP1546710A4 (de) 2002-09-10 2011-05-25 Placor Inc Verfahren und vorrichtung für die berwachung der thrombozytenfunktion
JP4075765B2 (ja) * 2002-10-30 2008-04-16 日本電気株式会社 分離装置およびその製造方法、ならびに分析システム
JP2004354364A (ja) * 2002-12-02 2004-12-16 Nec Corp 微粒子操作ユニット、それを搭載したチップと検出装置、ならびにタンパク質の分離、捕獲、および検出方法
DE10305050A1 (de) * 2003-02-07 2004-08-19 Roche Diagnostics Gmbh Analytisches Testelement und Verfahren für Blutuntersuchungen
WO2004097393A1 (ja) * 2003-04-28 2004-11-11 Matsushita Electric Industrial Co., Ltd. フィルタとそれを備えたバイオセンサ
US8679853B2 (en) 2003-06-20 2014-03-25 Roche Diagnostics Operations, Inc. Biosensor with laser-sealed capillary space and method of making
US8071030B2 (en) * 2003-06-20 2011-12-06 Roche Diagnostics Operations, Inc. Test strip with flared sample receiving chamber
WO2004113901A1 (en) * 2003-06-20 2004-12-29 Roche Diagnostics Gmbh Test strip with slot vent opening
KR100845163B1 (ko) * 2003-06-20 2008-07-09 에프. 호프만-라 로슈 아게 전기화학 바이오센서에 관한 장치 및 방법
DE10352535A1 (de) * 2003-11-07 2005-06-16 Steag Microparts Gmbh Mikrostrukturierte Trennvorrichtung und Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Partikel enthaltenden Flüssigkeit
GB0329220D0 (en) * 2003-12-17 2004-01-21 Inverness Medical Switzerland System
DE102004027422A1 (de) * 2004-06-04 2005-12-29 Boehringer Ingelheim Microparts Gmbh Vorrichtung zur Aufnahme von Blut und Abtrennung von Blutbestandteilen
EP1787129A1 (de) * 2004-08-21 2007-05-23 LG Life Sciences, Ltd. Mikrofluidvorrichtung sowie diagnose- und analysegerät unter verwendung davon
WO2006031095A1 (en) * 2004-09-13 2006-03-23 Leja Holding B.V. Capillary-loading slide and method of microscopic research with correction of the serge silberberg effect
EP1875232A2 (de) * 2005-04-25 2008-01-09 PlaCor, Inc. Verfahren und vorrichtungen zur überwachung der blutplättchenfunktion
DE102005048236A1 (de) * 2005-10-07 2007-04-12 Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg Vorrichtung und Verfahren zur Bestimmung der Volumenanteile der Phasen in einer Suspension
JP2007309741A (ja) * 2006-05-17 2007-11-29 Olympus Corp 血液分離方法および血液分離装置
DE102006025477B4 (de) * 2006-05-30 2009-01-15 Ekf - Diagnostic Gmbh Küvette und Verfahren zu ihrer Herstellung
US20100099130A1 (en) * 2006-10-25 2010-04-22 Placor Inc. Methods and devices for monitoring platelet function
KR100897524B1 (ko) 2006-12-04 2009-05-15 한국전자통신연구원 혈장 분리용 마이크로 필터 소자
JP5309312B2 (ja) * 2007-11-01 2013-10-09 Ｊｆｅテクノス株式会社 マイクロチップ、マイクロチップデバイス及びマイクロチップを用いた蒸発操作方法
US8470259B2 (en) 2008-03-07 2013-06-25 Advanced Microdevices Pvt Ltd Method and device for particle removal and droplet preparation for qualitative and quantitative bioanalysis
JP5438351B2 (ja) * 2009-03-30 2014-03-12 Ｊｆｅテクノス株式会社 マイクロチップを用いたｐｅｔ用標識化合物の調剤方法及び装置
SG184592A1 (en) * 2011-03-18 2012-10-30 Univ Singapore Isolating target cells from a biological fluid
JP5490492B2 (ja) * 2009-10-30 2014-05-14 学校法人立命館 血漿分離器及び血液分析装置
EP2375249B1 (de) 2010-04-09 2019-12-25 F. Hoffmann-La Roche AG Vorrichtungen und Verfahren zum Trennen von Plasma aus einer Blutprobe
CN102947701B (zh) * 2010-04-15 2015-01-28 西托根有限公司 微流体装置及利用其的标靶的分离方法
US20110301049A1 (en) * 2010-06-04 2011-12-08 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Fluid Flow Contour Control Using Flow Resistance
TWI439689B (zh) 2010-09-23 2014-06-01 Bionime Corp Electrochemical test specimen
RU2477645C1 (ru) * 2011-08-24 2013-03-20 Российская Федерация, от имени которой выступает Министерство промышленности и торговли Российской Федерации (Минпромторг России) Устройство для отделения частиц от жидкости
EP2587248A1 (de) * 2011-10-25 2013-05-01 Koninklijke Philips Electronics N.V. Filtern von Partikeln aus Blut oder anderen Medien
AU2012327218C1 (en) 2011-11-30 2015-12-24 Wellstat Diagnostics, Llc. Filtration Module
JP6073072B2 (ja) * 2012-04-27 2017-02-01 株式会社キコーコーポレーション ナノファイバー不織布を用いたろ過装置
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9075042B2 (en) 2012-05-15 2015-07-07 Wellstat Diagnostics, Llc Diagnostic systems and cartridges
BR112015002561A2 (pt) * 2012-08-08 2018-05-22 Koninklijke Philips Nv sistema para separação de um analito heterogêneo, e método para separação de um analito heterogêneo.
USD962471S1 (en) 2013-03-13 2022-08-30 Abbott Laboratories Reagent container
USD978375S1 (en) 2013-03-13 2023-02-14 Abbott Laboratories Reagent container
US9535082B2 (en) 2013-03-13 2017-01-03 Abbott Laboratories Methods and apparatus to agitate a liquid
US10058866B2 (en) 2013-03-13 2018-08-28 Abbott Laboratories Methods and apparatus to mitigate bubble formation in a liquid
JP6352954B2 (ja) 2013-03-15 2018-07-04 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 電気化学的な分析物測定において回復パルスからの情報を使用する方法およびデバイス、装置とそれらを組み込むシステム
WO2014140172A1 (en) 2013-03-15 2014-09-18 Roche Diagnostics Gmbh Methods of failsafing electrochemical measurements of an analyte as well as devices, apparatuses and systems incorporating the same
WO2014140170A1 (en) 2013-03-15 2014-09-18 Roche Diagnostics Gmbh Methods of scaling data used to construct biosensor algorithms as well as devices, apparatuses and systems incorporating the same
CA2900572C (en) 2013-03-15 2018-02-13 F. Hoffmann-La Roche Ag Methods of detecting high antioxidant levels during electrochemical measurements and failsafing an analyte concentration therefrom as well as devices, apparatuses and systems incorporting the same
MX370653B (es) 2013-04-15 2019-12-18 Becton Dickinson Co Dispositivo de transferencia de muestras de sangre.
JP6193474B2 (ja) 2013-04-15 2017-09-06 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 生体液採取移送装置ならびに生体液分離および検査システム
JP6339663B2 (ja) 2013-04-15 2018-06-06 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 生体液採集装置、および、生体液採集検査システム
US10238325B2 (en) 2013-04-15 2019-03-26 Becton, Dickinson And Company Medical device for collection of a biological sample
CA2909367C (en) 2013-04-15 2019-01-08 Becton, Dickinson And Company Biological fluid separation device and biological fluid separation and testing system
EP2986381B1 (de) 2013-04-15 2018-08-01 Becton, Dickinson and Company Entnahmevorrichtung für biologische flüssigkeit sowie trennungs- und testsystem für biologischen flüssigkeiten
CA2909263C (en) 2013-04-15 2020-01-28 Becton, Dickinson And Company Biological fluid sampling transfer device and biological fluid separation and testing system
EP3513727B1 (de) 2013-04-15 2020-09-09 Becton, Dickinson and Company Vorrichtung zur entnahme biologischer flüssigkeitsproben
US9833182B2 (en) 2013-04-15 2017-12-05 Becton, Dickinson And Company Biological fluid separation device and biological fluid separation and testing system
US10194851B2 (en) 2013-04-15 2019-02-05 Becton, Dickinson And Company Blood sampling transfer device and blood separation and testing system
BR112015026139B1 (pt) 2013-04-15 2022-12-06 Becton, Dickinson And Company Dispositivo de coleta de fluido biológico, dispositivo de separação de fluido biológico e sistema de separação e teste de fluido biológico
US10080516B2 (en) 2013-04-15 2018-09-25 Becton, Dickinson And Company Biological fluid collection device and biological fluid separation and testing system
JP6267319B2 (ja) * 2013-04-15 2018-01-24 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 生物学的流体移送デバイスおよび生物学的流体サンプリングシステム
CA3005826C (en) 2013-04-15 2021-11-23 Becton, Dickinson And Company Biological fluid collection device and biological fluid separation and testing system
WO2016156376A1 (en) 2015-03-31 2016-10-06 Roche Diagnostics Gmbh Plasma separation card
EP3936047B1 (de) 2015-08-06 2023-02-15 Becton, Dickinson and Company Vorrichtung zum sammeln eines biologischen fluids
CN109804240A (zh) 2016-10-05 2019-05-24 豪夫迈·罗氏有限公司 用于多分析物诊断测试元件的检测试剂和电极布置以及其使用方法
KR101872780B1 (ko) * 2017-01-24 2018-06-29 광주과학기술원 헤링본 타입 유체유도유닛 및 이를 이용한 세포 농축 장치

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5113428B1 (de) * 1970-05-09 1976-04-28
DE2757384A1 (de) * 1976-12-29 1978-07-06 Rosemount Inc Nach dem prinzip der wirbelabloesung arbeitender durchflussmesser
US4233029A (en) 1978-10-25 1980-11-11 Eastman Kodak Company Liquid transport device and method
US4271119A (en) 1979-07-23 1981-06-02 Eastman Kodak Company Capillary transport device having connected transport zones
US4310399A (en) 1979-07-23 1982-01-12 Eastman Kodak Company Liquid transport device containing means for delaying capillary flow
US4302313A (en) 1979-07-23 1981-11-24 Eastman Kodak Company Electrode-containing device with capillary transport between electrodes
US4426451A (en) 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
US4473457A (en) 1982-03-29 1984-09-25 Eastman Kodak Company Liquid transport device providing diversion of capillary flow into a non-vented second zone
US4439526A (en) 1982-07-26 1984-03-27 Eastman Kodak Company Clustered ingress apertures for capillary transport devices and method of use
US4549952A (en) 1982-11-22 1985-10-29 Eastman Kodak Company Capillary transport device having means for increasing the viscosity of the transported liquid
US4618476A (en) 1984-02-10 1986-10-21 Eastman Kodak Company Capillary transport device having speed and meniscus control means
US5144139A (en) 1985-08-05 1992-09-01 Biotrack, Inc. Capillary flow device
US5164598A (en) 1985-08-05 1992-11-17 Biotrack Capillary flow device
US4756884A (en) 1985-08-05 1988-07-12 Biotrack, Inc. Capillary flow device
US5204525A (en) 1985-08-05 1993-04-20 Biotrack Capillary flow device
US5140161A (en) 1985-08-05 1992-08-18 Biotrack Capillary flow device
US4948961A (en) 1985-08-05 1990-08-14 Biotrack, Inc. Capillary flow device
US5004923A (en) 1985-08-05 1991-04-02 Biotrack, Inc. Capillary flow device
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
US4753776A (en) 1986-10-29 1988-06-28 Biotrack, Inc. Blood separation device comprising a filter and a capillary flow pathway exiting the filter
US5135719A (en) 1986-10-29 1992-08-04 Biotrack, Inc. Blood separation device comprising a filter and a capillary flow pathway exiting the filter
US4849340A (en) 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
US4983038A (en) * 1987-04-08 1991-01-08 Hitachi, Ltd. Sheath flow type flow-cell device
GB8709882D0 (en) 1987-04-27 1987-06-03 Genetics Int Inc Membrane configurations
US5051237A (en) * 1988-06-23 1991-09-24 P B Diagnostic Systems, Inc. Liquid transport system
US5208147A (en) * 1988-07-21 1993-05-04 Radiometer A/S Means for measuring a characteristic in a sample fluid
US4957582A (en) 1989-03-16 1990-09-18 Eastman Kodak Company Capillary transport zone coated with adhesive
EP0388782A1 (de) 1989-03-20 1990-09-26 Quantai Biotronics Inc. Verfahren zum Nachweis von Analyten
US5039617A (en) 1989-04-20 1991-08-13 Biotrack, Inc. Capillary flow device and method for measuring activated partial thromboplastin time
US5135716A (en) 1989-07-12 1992-08-04 Kingston Diagnostics, L.P. Direct measurement of HDL cholesterol via dry chemistry strips
CA2019865A1 (en) 1989-07-12 1991-01-12 Yatin B. Thakore Device and method for separation of fluid components for component testing
CA2020029A1 (en) 1989-07-12 1991-01-13 Yatin B. Thakore Device and method for separation of plasma from blood and determination of blood analytes
US5620863A (en) 1989-08-28 1997-04-15 Lifescan, Inc. Blood glucose strip having reduced side reactions
AU640162B2 (en) 1989-08-28 1993-08-19 Lifescan, Inc. Blood separation and analyte detection techniques
US5230866A (en) 1991-03-01 1993-07-27 Biotrack, Inc. Capillary stop-flow junction having improved stability against accidental fluid flow
US5540888A (en) 1991-11-11 1996-07-30 British Technology Group Limited Liquid transfer assay devices
DE69303898T3 (de) * 1992-05-01 2007-01-18 Trustees Of The University Of Pennsylvania Fluessigkeitsbehandlung in mikrofabrizierten analytischen vorrichtungen
US5885527A (en) 1992-05-21 1999-03-23 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membrances
US6156270A (en) * 1992-05-21 2000-12-05 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US5458852A (en) * 1992-05-21 1995-10-17 Biosite Diagnostics, Inc. Diagnostic devices for the controlled movement of reagents without membranes
GB9309797D0 (en) 1993-05-12 1993-06-23 Medisense Inc Electrochemical sensors
US6113855A (en) * 1996-11-15 2000-09-05 Biosite Diagnostics, Inc. Devices comprising multiple capillarity inducing surfaces
US5976336A (en) 1997-04-25 1999-11-02 Caliper Technologies Corp. Microfluidic devices incorporating improved channel geometries
US5798031A (en) 1997-05-12 1998-08-25 Bayer Corporation Electrochemical biosensor
DE19753849A1 (de) 1997-12-04 1999-06-10 Roche Diagnostics Gmbh Analytisches Testelement mit sich verjüngendem Kapillarkanal
GB9907665D0 (en) 1999-04-01 1999-05-26 Cambridge Molecular Tech Fluidic devices

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EP1096254A3 (de) 2001-06-13
US6319719B1 (en) 2001-11-20
EP1096254B1 (de) 2005-04-06
ATE292799T1 (de) 2005-04-15
JP4520620B2 (ja) 2010-08-11
JP2001183363A (ja) 2001-07-06
EP1096254A2 (de) 2001-05-02
CA2324131A1 (en) 2001-04-28
DE60019228T2 (de) 2006-05-11
CA2324131C (en) 2007-07-31

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