JP4489945B2 - ミクロ流体製品およびその製造方法 - Google Patents
ミクロ流体製品およびその製造方法 Download PDFInfo
- Publication number
- JP4489945B2 JP4489945B2 JP2000554525A JP2000554525A JP4489945B2 JP 4489945 B2 JP4489945 B2 JP 4489945B2 JP 2000554525 A JP2000554525 A JP 2000554525A JP 2000554525 A JP2000554525 A JP 2000554525A JP 4489945 B2 JP4489945 B2 JP 4489945B2
- Authority
- JP
- Japan
- Prior art keywords
- substrate
- microfluidic
- product
- mold
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 12
- 238000000034 method Methods 0.000 claims description 47
- 239000000463 material Substances 0.000 claims description 30
- 238000000465 moulding Methods 0.000 claims description 29
- 239000012530 fluid Substances 0.000 claims description 25
- 239000000758 substrate Substances 0.000 description 117
- 239000000047 product Substances 0.000 description 85
- 238000012545 processing Methods 0.000 description 66
- 229920000307 polymer substrate Polymers 0.000 description 45
- 238000004377 microelectronic Methods 0.000 description 30
- 239000011347 resin Substances 0.000 description 28
- 229920005989 resin Polymers 0.000 description 28
- 239000011342 resin composition Substances 0.000 description 26
- 239000000523 sample Substances 0.000 description 19
- 238000004049 embossing Methods 0.000 description 17
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 16
- 230000009969 flowable effect Effects 0.000 description 14
- 239000000203 mixture Substances 0.000 description 12
- 229920000642 polymer Polymers 0.000 description 12
- 229920000515 polycarbonate Polymers 0.000 description 11
- 238000013461 design Methods 0.000 description 10
- 238000001125 extrusion Methods 0.000 description 10
- 239000004417 polycarbonate Substances 0.000 description 10
- 239000004926 polymethyl methacrylate Substances 0.000 description 9
- 239000000853 adhesive Substances 0.000 description 8
- 230000001070 adhesive effect Effects 0.000 description 8
- 229910052759 nickel Inorganic materials 0.000 description 8
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 8
- 230000005855 radiation Effects 0.000 description 8
- 238000000926 separation method Methods 0.000 description 8
- 238000000576 coating method Methods 0.000 description 7
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 6
- 239000012491 analyte Substances 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 6
- 239000000872 buffer Substances 0.000 description 6
- 229910052802 copper Inorganic materials 0.000 description 6
- 239000010949 copper Substances 0.000 description 6
- 238000011144 upstream manufacturing Methods 0.000 description 6
- 239000004642 Polyimide Substances 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 239000011248 coating agent Substances 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 229920005570 flexible polymer Polymers 0.000 description 5
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 229920001721 polyimide Polymers 0.000 description 5
- 239000004020 conductor Substances 0.000 description 4
- 238000001962 electrophoresis Methods 0.000 description 4
- 239000010408 film Substances 0.000 description 4
- 238000010030 laminating Methods 0.000 description 4
- 239000002699 waste material Substances 0.000 description 4
- WGLPBDUCMAPZCE-UHFFFAOYSA-N Trioxochromium Chemical compound O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 description 3
- -1 benzoin ethers Chemical class 0.000 description 3
- 229910000423 chromium oxide Inorganic materials 0.000 description 3
- 238000010924 continuous production Methods 0.000 description 3
- 238000001723 curing Methods 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- MPTQRFCYZCXJFQ-UHFFFAOYSA-L copper(II) chloride dihydrate Chemical compound O.O.[Cl-].[Cl-].[Cu+2] MPTQRFCYZCXJFQ-UHFFFAOYSA-L 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 238000010894 electron beam technology Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 150000007523 nucleic acids Chemical group 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 150000002923 oximes Chemical class 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 238000007747 plating Methods 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000012744 reinforcing agent Substances 0.000 description 2
- 230000010076 replication Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 229920005992 thermoplastic resin Polymers 0.000 description 2
- 229920001187 thermosetting polymer Polymers 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- MSAHTMIQULFMRG-UHFFFAOYSA-N 1,2-diphenyl-2-propan-2-yloxyethanone Chemical compound C=1C=CC=CC=1C(OC(C)C)C(=O)C1=CC=CC=C1 MSAHTMIQULFMRG-UHFFFAOYSA-N 0.000 description 1
- FRASJONUBLZVQX-UHFFFAOYSA-N 1,4-naphthoquinone Chemical compound C1=CC=C2C(=O)C=CC(=O)C2=C1 FRASJONUBLZVQX-UHFFFAOYSA-N 0.000 description 1
- PIZHFBODNLEQBL-UHFFFAOYSA-N 2,2-diethoxy-1-phenylethanone Chemical compound CCOC(OCC)C(=O)C1=CC=CC=C1 PIZHFBODNLEQBL-UHFFFAOYSA-N 0.000 description 1
- FHFVUEXQSQXWSP-UHFFFAOYSA-N 2-hydroxy-2,2-dimethoxy-1-phenylethanone Chemical compound COC(O)(OC)C(=O)C1=CC=CC=C1 FHFVUEXQSQXWSP-UHFFFAOYSA-N 0.000 description 1
- XMLYCEVDHLAQEL-UHFFFAOYSA-N 2-hydroxy-2-methyl-1-phenylpropan-1-one Chemical compound CC(C)(O)C(=O)C1=CC=CC=C1 XMLYCEVDHLAQEL-UHFFFAOYSA-N 0.000 description 1
- BQZJOQXSCSZQPS-UHFFFAOYSA-N 2-methoxy-1,2-diphenylethanone Chemical compound C=1C=CC=CC=1C(OC)C(=O)C1=CC=CC=C1 BQZJOQXSCSZQPS-UHFFFAOYSA-N 0.000 description 1
- RZVINYQDSSQUKO-UHFFFAOYSA-N 2-phenoxyethyl prop-2-enoate Chemical compound C=CC(=O)OCCOC1=CC=CC=C1 RZVINYQDSSQUKO-UHFFFAOYSA-N 0.000 description 1
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Natural products CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- 239000004831 Hot glue Substances 0.000 description 1
- 229920002633 Kraton (polymer) Polymers 0.000 description 1
- 229920004142 LEXAN™ Polymers 0.000 description 1
- 239000004418 Lexan Substances 0.000 description 1
- 239000004425 Makrolon Substances 0.000 description 1
- 244000141359 Malus pumila Species 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 229920005372 Plexiglas® Polymers 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 244000028419 Styrax benzoin Species 0.000 description 1
- 235000000126 Styrax benzoin Nutrition 0.000 description 1
- 235000008411 Sumatra benzointree Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000008062 acetophenones Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000002313 adhesive film Substances 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 125000005250 alkyl acrylate group Chemical group 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000021016 apples Nutrition 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 229960002130 benzoin Drugs 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- DEGAKNSWVGKMLS-UHFFFAOYSA-N calcein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC(CN(CC(O)=O)CC(O)=O)=C(O)C=C1OC1=C2C=C(CN(CC(O)=O)CC(=O)O)C(O)=C1 DEGAKNSWVGKMLS-UHFFFAOYSA-N 0.000 description 1
- 238000005251 capillar electrophoresis Methods 0.000 description 1
- 238000000533 capillary isoelectric focusing Methods 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000005229 chemical vapour deposition Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000012875 competitive assay Methods 0.000 description 1
- 238000002967 competitive immunoassay Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000009749 continuous casting Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- ISAOCJYIOMOJEB-UHFFFAOYSA-N desyl alcohol Natural products C=1C=CC=CC=1C(O)C(=O)C1=CC=CC=C1 ISAOCJYIOMOJEB-UHFFFAOYSA-N 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 125000004386 diacrylate group Chemical group 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 238000005370 electroosmosis Methods 0.000 description 1
- 238000009713 electroplating Methods 0.000 description 1
- 238000001952 enzyme assay Methods 0.000 description 1
- 229920006332 epoxy adhesive Polymers 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000003269 fluorescent indicator Substances 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 235000019382 gum benzoic Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 239000012784 inorganic fiber Substances 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 239000004611 light stabiliser Substances 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000006224 matting agent Substances 0.000 description 1
- 238000003701 mechanical milling Methods 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 238000001465 metallisation Methods 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- OPECTNGATDYLSS-UHFFFAOYSA-N naphthalene-2-sulfonyl chloride Chemical compound C1=CC=CC2=CC(S(=O)(=O)Cl)=CC=C21 OPECTNGATDYLSS-UHFFFAOYSA-N 0.000 description 1
- 238000007826 nucleic acid assay Methods 0.000 description 1
- 238000007899 nucleic acid hybridization Methods 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 238000010943 off-gassing Methods 0.000 description 1
- 229960002378 oftasceine Drugs 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 238000000059 patterning Methods 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 238000000016 photochemical curing Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920003055 poly(ester-imide) Polymers 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 239000003128 rodenticide Substances 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 238000004557 single molecule detection Methods 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229920000468 styrene butadiene styrene block copolymer Polymers 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000005382 thermal cycling Methods 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004634 thermosetting polymer Substances 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 239000013008 thixotropic agent Substances 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
- B29C59/02—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing
- B29C59/04—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing using rollers or endless belts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C39/00—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
- B29C39/14—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of indefinite length
- B29C39/148—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of indefinite length characterised by the shape of the surface
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
- B29C43/22—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of indefinite length
- B29C43/222—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of indefinite length characterised by the shape of the surface
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
- B29C59/02—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing
- B29C59/022—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing characterised by the disposition or the configuration, e.g. dimensions, of the embossments or the shaping tools therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00009—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with a sample supporting tape, e.g. with absorbent zones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S428/00—Stock material or miscellaneous articles
- Y10S428/906—Roll or coil
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
- Y10T428/24479—Structurally defined web or sheet [e.g., overall dimension, etc.] including variation in thickness
- Y10T428/24562—Interlaminar spaces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
- Y10T428/24479—Structurally defined web or sheet [e.g., overall dimension, etc.] including variation in thickness
- Y10T428/2457—Parallel ribs and/or grooves
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
- Y10T428/24479—Structurally defined web or sheet [e.g., overall dimension, etc.] including variation in thickness
- Y10T428/24612—Composite web or sheet
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
- Y10T428/24744—Longitudinal or transverse tubular cavity or cell
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31678—Of metal
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Micromachines (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Shaping Of Tube Ends By Bending Or Straightening (AREA)
- Casting Or Compression Moulding Of Plastics Or The Like (AREA)
- Exposure Of Semiconductors, Excluding Electron Or Ion Beam Exposure (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/099,562 | 1998-06-18 | ||
| US09/099,562 US6375871B1 (en) | 1998-06-18 | 1998-06-18 | Methods of manufacturing microfluidic articles |
| PCT/US1999/011024 WO1999065664A1 (en) | 1998-06-18 | 1999-05-18 | Microfluidic articles and method of manufacturing same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010023193A Division JP2010111129A (ja) | 1998-06-18 | 2010-02-04 | ミクロ流体製品およびその製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002518202A JP2002518202A (ja) | 2002-06-25 |
| JP2002518202A5 JP2002518202A5 (enExample) | 2009-06-18 |
| JP4489945B2 true JP4489945B2 (ja) | 2010-06-23 |
Family
ID=22275608
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000554525A Expired - Lifetime JP4489945B2 (ja) | 1998-06-18 | 1999-05-18 | ミクロ流体製品およびその製造方法 |
| JP2010023193A Pending JP2010111129A (ja) | 1998-06-18 | 2010-02-04 | ミクロ流体製品およびその製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010023193A Pending JP2010111129A (ja) | 1998-06-18 | 2010-02-04 | ミクロ流体製品およびその製造方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6375871B1 (enExample) |
| EP (1) | EP1087864B1 (enExample) |
| JP (2) | JP4489945B2 (enExample) |
| KR (1) | KR100618013B1 (enExample) |
| CN (1) | CN100374283C (enExample) |
| AU (1) | AU742931B2 (enExample) |
| DE (1) | DE69930254T2 (enExample) |
| WO (1) | WO1999065664A1 (enExample) |
Families Citing this family (231)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5885470A (en) * | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
| US6375871B1 (en) | 1998-06-18 | 2002-04-23 | 3M Innovative Properties Company | Methods of manufacturing microfluidic articles |
| US6420622B1 (en) * | 1997-08-01 | 2002-07-16 | 3M Innovative Properties Company | Medical article having fluid control film |
| US6833242B2 (en) * | 1997-09-23 | 2004-12-21 | California Institute Of Technology | Methods for detecting and sorting polynucleotides based on size |
| CA2306126A1 (en) | 1997-10-15 | 1999-04-22 | Aclara Biosciences, Inc. | Laminate microstructure device and method for making same |
| GB9808836D0 (en) * | 1998-04-27 | 1998-06-24 | Amersham Pharm Biotech Uk Ltd | Microfabricated apparatus for cell based assays |
| US7223364B1 (en) | 1999-07-07 | 2007-05-29 | 3M Innovative Properties Company | Detection article having fluid control film |
| AU7101000A (en) * | 1999-09-10 | 2001-04-10 | Caliper Technologies Corporation | Microfabrication methods and devices |
| SE0000300D0 (sv) * | 2000-01-30 | 2000-01-30 | Amersham Pharm Biotech Ab | Microfluidic assembly, covering method for the manufacture of the assembly and the use of the assembly |
| US6749813B1 (en) | 2000-03-05 | 2004-06-15 | 3M Innovative Properties Company | Fluid handling devices with diamond-like films |
| US7485454B1 (en) | 2000-03-10 | 2009-02-03 | Bioprocessors Corp. | Microreactor |
| US20040132174A1 (en) * | 2000-03-28 | 2004-07-08 | Smith Allan Joseph Hilling | Perfusion incubator |
| US6741523B1 (en) | 2000-05-15 | 2004-05-25 | 3M Innovative Properties Company | Microstructured time dependent indicators |
| AU2001273057A1 (en) * | 2000-06-27 | 2002-01-08 | Fluidigm Corporation | A microfluidic design automation method and system |
| US6627159B1 (en) * | 2000-06-28 | 2003-09-30 | 3M Innovative Properties Company | Centrifugal filling of sample processing devices |
| US7294503B2 (en) * | 2000-09-15 | 2007-11-13 | California Institute Of Technology | Microfabricated crossflow devices and methods |
| US6939451B2 (en) * | 2000-09-19 | 2005-09-06 | Aclara Biosciences, Inc. | Microfluidic chip having integrated electrodes |
| WO2002030486A2 (en) * | 2000-10-13 | 2002-04-18 | Fluidigm Corporation | Microfluidic device based sample injection system for analytical devices |
| WO2002065005A1 (en) * | 2000-11-06 | 2002-08-22 | California Institute Of Technology | Electrostatic valves for microfluidic devices |
| US8097471B2 (en) * | 2000-11-10 | 2012-01-17 | 3M Innovative Properties Company | Sample processing devices |
| JP2002214241A (ja) * | 2000-11-20 | 2002-07-31 | Minolta Co Ltd | マイクロチップ |
| US20020108860A1 (en) * | 2001-01-15 | 2002-08-15 | Staats Sau Lan Tang | Fabrication of polymeric microfluidic devices |
| US6531206B2 (en) | 2001-02-07 | 2003-03-11 | 3M Innovative Properties Company | Microstructured surface film assembly for liquid acquisition and transport |
| US6802342B2 (en) | 2001-04-06 | 2004-10-12 | Fluidigm Corporation | Microfabricated fluidic circuit elements and applications |
| AU2002307152A1 (en) * | 2001-04-06 | 2002-10-21 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
| US6814938B2 (en) | 2001-05-23 | 2004-11-09 | Nanostream, Inc. | Non-planar microfluidic devices and methods for their manufacture |
| US7785098B1 (en) | 2001-06-05 | 2010-08-31 | Mikro Systems, Inc. | Systems for large area micro mechanical systems |
| US7141812B2 (en) * | 2002-06-05 | 2006-11-28 | Mikro Systems, Inc. | Devices, methods, and systems involving castings |
| CA2448736C (en) * | 2001-06-05 | 2010-08-10 | Mikro Systems, Inc. | Methods for manufacturing three-dimensional devices and devices created thereby |
| US7128876B2 (en) * | 2001-07-17 | 2006-10-31 | Agilent Technologies, Inc. | Microdevice and method for component separation in a fluid |
| US7075162B2 (en) * | 2001-08-30 | 2006-07-11 | Fluidigm Corporation | Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes |
| US7192629B2 (en) | 2001-10-11 | 2007-03-20 | California Institute Of Technology | Devices utilizing self-assembled gel and method of manufacture |
| US8440093B1 (en) | 2001-10-26 | 2013-05-14 | Fuidigm Corporation | Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels |
| GB0128350D0 (en) * | 2001-11-27 | 2002-01-16 | Lab901 Ltd | Non-rigid apparatus for microfluidic applications |
| US7691333B2 (en) * | 2001-11-30 | 2010-04-06 | Fluidigm Corporation | Microfluidic device and methods of using same |
| ES2403560T3 (es) * | 2001-11-30 | 2013-05-20 | Fluidigm Corporation | Dispositivo microfluídico y procedimientos de utilización del mismo |
| CN100496446C (zh) * | 2001-12-11 | 2009-06-10 | 宝洁公司 | 制造预成形物品的方法 |
| US7140495B2 (en) | 2001-12-14 | 2006-11-28 | 3M Innovative Properties Company | Layered sheet construction for wastewater treatment |
| AU2002360822A1 (en) * | 2001-12-17 | 2003-06-30 | Aclara Biosicences, Inc. | Microfluidic analytical apparatus |
| DE10201640A1 (de) * | 2002-01-17 | 2003-08-07 | Fraunhofer Ges Forschung | Verfahren zur Herstellung einer Folie mit Oberflächenstrukturen im Mikro- und Nanometerbereich sowie eine diesbezügliche Folie |
| CA2480728A1 (en) | 2002-04-01 | 2003-10-16 | Fluidigm Corporation | Microfluidic particle-analysis systems |
| US7312085B2 (en) * | 2002-04-01 | 2007-12-25 | Fluidigm Corporation | Microfluidic particle-analysis systems |
| DE60328089D1 (de) | 2002-04-03 | 2009-08-06 | 3M Innovative Properties Co | Produkte zur anzeige der zeit oder zeit-temperatur |
| US6803090B2 (en) | 2002-05-13 | 2004-10-12 | 3M Innovative Properties Company | Fluid transport assemblies with flame retardant properties |
| US8206666B2 (en) * | 2002-05-21 | 2012-06-26 | Battelle Memorial Institute | Reactors having varying cross-section, methods of making same, and methods of conducting reactions with varying local contact time |
| US20060134157A1 (en) * | 2002-06-06 | 2006-06-22 | Rutgers, The State University | Co-continuous phase composite polymer blends for in-vivo and in-vitro biomedical applications |
| WO2004000721A2 (en) * | 2002-06-24 | 2003-12-31 | Fluidigm Corporation | Recirculating fluidic network and methods for using the same |
| US7201881B2 (en) * | 2002-07-26 | 2007-04-10 | Applera Corporation | Actuator for deformable valves in a microfluidic device, and method |
| US7135147B2 (en) | 2002-07-26 | 2006-11-14 | Applera Corporation | Closing blade for deformable valve in a microfluidic device and method |
| US20060234042A1 (en) * | 2002-09-05 | 2006-10-19 | Rui Yang | Etched dielectric film in microfluidic devices |
| US6911132B2 (en) | 2002-09-24 | 2005-06-28 | Duke University | Apparatus for manipulating droplets by electrowetting-based techniques |
| US7329545B2 (en) | 2002-09-24 | 2008-02-12 | Duke University | Methods for sampling a liquid flow |
| WO2004028955A2 (en) | 2002-09-25 | 2004-04-08 | California Institute Of Technology | Microfluidic large scale integration |
| EP1546412B1 (en) | 2002-10-02 | 2014-05-21 | California Institute Of Technology | Microfluidic nucleic acid analysis |
| US6913931B2 (en) | 2002-10-03 | 2005-07-05 | 3M Innovative Properties Company | Devices, methods and systems for low volume microarray processing |
| JP4009684B2 (ja) * | 2002-10-28 | 2007-11-21 | アークレイ株式会社 | 分析用具における液成分の温調方法、および分析用具 |
| JP3866183B2 (ja) * | 2002-11-01 | 2007-01-10 | Asti株式会社 | バイオチップ |
| US6963007B2 (en) | 2002-12-19 | 2005-11-08 | 3M Innovative Properties Company | Diacetylenic materials for sensing applications |
| US20040126897A1 (en) * | 2002-12-19 | 2004-07-01 | 3M Innovative Properties Company | Colorimetric sensors constructed of diacetylene materials |
| JP3856763B2 (ja) * | 2003-03-11 | 2006-12-13 | 財団法人川村理化学研究所 | マイクロ流体素子の製造方法 |
| CA2521171C (en) * | 2003-04-03 | 2013-05-28 | Fluidigm Corp. | Microfluidic devices and methods of using same |
| US7476363B2 (en) * | 2003-04-03 | 2009-01-13 | Fluidigm Corporation | Microfluidic devices and methods of using same |
| US8828663B2 (en) * | 2005-03-18 | 2014-09-09 | Fluidigm Corporation | Thermal reaction device and method for using the same |
| US20050145496A1 (en) | 2003-04-03 | 2005-07-07 | Federico Goodsaid | Thermal reaction device and method for using the same |
| US7604965B2 (en) * | 2003-04-03 | 2009-10-20 | Fluidigm Corporation | Thermal reaction device and method for using the same |
| US6986428B2 (en) | 2003-05-14 | 2006-01-17 | 3M Innovative Properties Company | Fluid separation membrane module |
| CA2526368A1 (en) | 2003-05-20 | 2004-12-02 | Fluidigm Corporation | Method and system for microfluidic device and imaging thereof |
| US7413712B2 (en) * | 2003-08-11 | 2008-08-19 | California Institute Of Technology | Microfluidic rotary flow reactor matrix |
| US20050047967A1 (en) * | 2003-09-03 | 2005-03-03 | Industrial Technology Research Institute | Microfluidic component providing multi-directional fluid movement |
| US7378451B2 (en) * | 2003-10-17 | 2008-05-27 | 3M Innovative Properties Co | Surfactant composition having stable hydrophilic character |
| US20050106360A1 (en) | 2003-11-13 | 2005-05-19 | Johnston Raymond P. | Microstructured surface building assemblies for fluid disposition |
| US7279215B2 (en) | 2003-12-03 | 2007-10-09 | 3M Innovative Properties Company | Membrane modules and integrated membrane cassettes |
| KR100572207B1 (ko) * | 2003-12-18 | 2006-04-19 | 주식회사 디지탈바이오테크놀러지 | 플라스틱 마이크로 칩의 접합 방법 |
| SE0400007D0 (sv) * | 2004-01-02 | 2004-01-02 | Gyros Ab | Large scale surface modifiv´cation of microfluidic devices |
| JP2007524849A (ja) * | 2004-01-06 | 2007-08-30 | ユィロス・パテント・アクチボラグ | 接触加熱アレンジメント |
| ES2439225T3 (es) | 2004-01-26 | 2014-01-22 | President And Fellows Of Harvard College | Sistema y método para el suministro de fluidos |
| US8030057B2 (en) * | 2004-01-26 | 2011-10-04 | President And Fellows Of Harvard College | Fluid delivery system and method |
| SE0400181D0 (sv) * | 2004-01-29 | 2004-01-29 | Gyros Ab | Segmented porous and preloaded microscale devices |
| US20050210996A1 (en) * | 2004-03-12 | 2005-09-29 | Quinn John G | Flow channel structure and method |
| WO2007001274A2 (en) * | 2004-06-21 | 2007-01-04 | 3M Innovative Properties Company | Patterning and aligning semiconducting nanoparticles |
| DE602005024418D1 (de) * | 2004-08-26 | 2010-12-09 | Life Technologies Corp | Elektrobenetzende abgabevorrichtungen und dazugehörige verfahren |
| EP1786789B1 (en) * | 2004-09-08 | 2010-11-17 | Pacific Scientific Energetic Materials Company | Process for preparing substituted tetrazoles from aminotetrazole |
| US8796583B2 (en) * | 2004-09-17 | 2014-08-05 | Eastman Kodak Company | Method of forming a structured surface using ablatable radiation sensitive material |
| KR20070083967A (ko) | 2004-10-06 | 2007-08-24 | 더 스테이트 오브 오레곤 액팅 바이 앤드 쓰루 더 스테이트 보드 오브 하이어 에쥬케이션 온 비해프 오브 오레곤 스테이트 유니버시티 | Mecs 투석기 |
| US7955504B1 (en) | 2004-10-06 | 2011-06-07 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use |
| DE102004050062A1 (de) * | 2004-10-13 | 2006-04-27 | Boehringer Ingelheim Microparts Gmbh | Vorrichtung, Meßgerät und Verfahren zur Aufnahme und Untersuchung oder Manipulation von Probenflüssigkeiten in einer mikrofluidischen Plattform |
| JP2008524603A (ja) * | 2004-12-17 | 2008-07-10 | スリーエム イノベイティブ プロパティズ カンパニー | ジアセチレン物質で構成される比色分析センサー |
| EP1838443B1 (en) * | 2005-01-20 | 2012-05-16 | 3M Innovative Properties Company | Structured polymer films and methods for forming the same |
| US20060157381A1 (en) * | 2005-01-20 | 2006-07-20 | Adams James T | Component carrier and method for making |
| DK1859330T3 (da) | 2005-01-28 | 2012-10-15 | Univ Duke | Apparater og fremgangsmåder til håndtering af små dråber på et trykt kredsløbskort |
| US7454988B2 (en) * | 2005-02-10 | 2008-11-25 | Applera Corporation | Method for fluid sampling using electrically controlled droplets |
| US20060245933A1 (en) * | 2005-05-02 | 2006-11-02 | General Electric Company | Valve and pump for microfluidic systems and methods for fabrication |
| US20090029065A1 (en) * | 2005-06-25 | 2009-01-29 | Nobuto Terada | Conductive circuit manufacturing method |
| JP4679992B2 (ja) * | 2005-07-27 | 2011-05-11 | 大日本印刷株式会社 | エンボス加工装置およびエンボス加工方法 |
| US20070134739A1 (en) * | 2005-12-12 | 2007-06-14 | Gyros Patent Ab | Microfluidic assays and microfluidic devices |
| CA2634027A1 (en) * | 2005-12-16 | 2007-07-05 | James A. Glazier | Sub-micron surface plasmon resonance sensor systems |
| US8355136B2 (en) | 2005-12-16 | 2013-01-15 | Indiana University Research And Technology Corporation | Sub-micron surface plasmon resonance sensor systems |
| JP5016611B2 (ja) * | 2006-01-24 | 2012-09-05 | マイクロラボ ピーティーワイ エルティーディー | スタンピング方法 |
| FR2897858B1 (fr) * | 2006-02-27 | 2008-06-20 | Commissariat Energie Atomique | Procede de fabrication d'un reseau de capillaires d'une puce |
| EP1996704A2 (en) * | 2006-03-08 | 2008-12-03 | Barry Beroth | Thin sheet for retaining biomolecules |
| JP4977198B2 (ja) * | 2006-03-20 | 2012-07-18 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 電子マイクロ流体素子のシステム・イン・パッケージプラットフォーム |
| US20140193807A1 (en) | 2006-04-18 | 2014-07-10 | Advanced Liquid Logic, Inc. | Bead manipulation techniques |
| US8637317B2 (en) * | 2006-04-18 | 2014-01-28 | Advanced Liquid Logic, Inc. | Method of washing beads |
| US8613889B2 (en) * | 2006-04-13 | 2013-12-24 | Advanced Liquid Logic, Inc. | Droplet-based washing |
| US8492168B2 (en) * | 2006-04-18 | 2013-07-23 | Advanced Liquid Logic Inc. | Droplet-based affinity assays |
| US9476856B2 (en) | 2006-04-13 | 2016-10-25 | Advanced Liquid Logic, Inc. | Droplet-based affinity assays |
| US7851184B2 (en) * | 2006-04-18 | 2010-12-14 | Advanced Liquid Logic, Inc. | Droplet-based nucleic acid amplification method and apparatus |
| US8716015B2 (en) | 2006-04-18 | 2014-05-06 | Advanced Liquid Logic, Inc. | Manipulation of cells on a droplet actuator |
| US7816121B2 (en) * | 2006-04-18 | 2010-10-19 | Advanced Liquid Logic, Inc. | Droplet actuation system and method |
| US7815871B2 (en) * | 2006-04-18 | 2010-10-19 | Advanced Liquid Logic, Inc. | Droplet microactuator system |
| US8980198B2 (en) | 2006-04-18 | 2015-03-17 | Advanced Liquid Logic, Inc. | Filler fluids for droplet operations |
| US8637324B2 (en) | 2006-04-18 | 2014-01-28 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
| US8809068B2 (en) | 2006-04-18 | 2014-08-19 | Advanced Liquid Logic, Inc. | Manipulation of beads in droplets and methods for manipulating droplets |
| US7901947B2 (en) | 2006-04-18 | 2011-03-08 | Advanced Liquid Logic, Inc. | Droplet-based particle sorting |
| US10078078B2 (en) | 2006-04-18 | 2018-09-18 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
| US8658111B2 (en) | 2006-04-18 | 2014-02-25 | Advanced Liquid Logic, Inc. | Droplet actuators, modified fluids and methods |
| US8470606B2 (en) * | 2006-04-18 | 2013-06-25 | Duke University | Manipulation of beads in droplets and methods for splitting droplets |
| US7763471B2 (en) * | 2006-04-18 | 2010-07-27 | Advanced Liquid Logic, Inc. | Method of electrowetting droplet operations for protein crystallization |
| US7439014B2 (en) | 2006-04-18 | 2008-10-21 | Advanced Liquid Logic, Inc. | Droplet-based surface modification and washing |
| WO2007123908A2 (en) * | 2006-04-18 | 2007-11-01 | Advanced Liquid Logic, Inc. | Droplet-based multiwell operations |
| US8041463B2 (en) * | 2006-05-09 | 2011-10-18 | Advanced Liquid Logic, Inc. | Modular droplet actuator drive |
| US7822510B2 (en) * | 2006-05-09 | 2010-10-26 | Advanced Liquid Logic, Inc. | Systems, methods, and products for graphically illustrating and controlling a droplet actuator |
| US7939021B2 (en) * | 2007-05-09 | 2011-05-10 | Advanced Liquid Logic, Inc. | Droplet actuator analyzer with cartridge |
| US20080108122A1 (en) * | 2006-09-01 | 2008-05-08 | State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon | Microchemical nanofactories |
| CN101578520B (zh) | 2006-10-18 | 2015-09-16 | 哈佛学院院长等 | 基于形成图案的多孔介质的横向流动和穿过生物测定装置、及其制备方法和使用方法 |
| US20080138248A1 (en) * | 2006-12-11 | 2008-06-12 | Institut Curie | Method for improving the bonding properties of microstructured substrates, and devices prepared with this method |
| GB2445738A (en) * | 2007-01-16 | 2008-07-23 | Lab901 Ltd | Microfluidic device |
| GB2445739A (en) | 2007-01-16 | 2008-07-23 | Lab901 Ltd | Polymeric laminates containing heat seals |
| ES2687620T3 (es) | 2007-05-04 | 2018-10-26 | Opko Diagnostics, Llc | Dispositivo y método para análisis en sistemas microfluídicos |
| DE102007021544A1 (de) * | 2007-05-08 | 2008-11-13 | Siemens Ag | Messeinheit und Verfahren zur optischen Untersuchung einer Flüssigkeit auf eine Analytkonzentration |
| JP2008284626A (ja) * | 2007-05-16 | 2008-11-27 | Miraial Kk | マイクロ流路デバイス |
| US8920879B2 (en) * | 2007-06-08 | 2014-12-30 | Board Of Trustees Of The University Of Illinois | Self-healing materials with microfluidic networks |
| EP2179261B1 (en) * | 2007-07-23 | 2021-09-15 | Sartorius BioAnalytical Instruments, Inc | Fluidic configuration for flow injection analysis system |
| US8268246B2 (en) | 2007-08-09 | 2012-09-18 | Advanced Liquid Logic Inc | PCB droplet actuator fabrication |
| WO2009051901A2 (en) * | 2007-08-30 | 2009-04-23 | Pepex Biomedical, Llc | Electrochemical sensor and method for manufacturing |
| WO2009032760A2 (en) | 2007-08-30 | 2009-03-12 | Pepex Biomedical Llc | Electrochmical sensor and method for manufacturing |
| US20090130746A1 (en) * | 2007-10-25 | 2009-05-21 | Canon U.S. Life Sciences, Inc. | Microchannel surface coating |
| CN101918842A (zh) * | 2007-11-20 | 2010-12-15 | 3M创新有限公司 | 利用含二乙炔的聚合物传感器分析细菌样品的方法 |
| US20090211977A1 (en) * | 2008-02-27 | 2009-08-27 | Oregon State University | Through-plate microchannel transfer devices |
| US8431671B2 (en) * | 2008-03-26 | 2013-04-30 | 3M Innovative Properties Company | Structured polydiorganosiloxane polyamide containing devices and methods |
| KR20100128340A (ko) * | 2008-03-27 | 2010-12-07 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 종이 기반 마이크로유체 시스템 |
| CA2719322C (en) * | 2008-03-27 | 2018-11-27 | President And Fellows Of Harvard College | Cotton thread as a low-cost multi-assay diagnostic platform |
| CN102016595B (zh) | 2008-03-27 | 2014-08-06 | 哈佛学院院长等 | 三维微流体装置 |
| CN101978272B (zh) * | 2008-03-27 | 2015-02-04 | 哈佛学院院长等 | 基于纸的细胞阵列 |
| WO2009131677A1 (en) | 2008-04-25 | 2009-10-29 | Claros Diagnostics, Inc. | Flow control in microfluidic systems |
| WO2010002679A2 (en) * | 2008-06-30 | 2010-01-07 | 3M Innovative Properties Company | Method of forming a microstructure |
| JP5319769B2 (ja) * | 2008-06-30 | 2013-10-16 | スリーエム イノベイティブ プロパティズ カンパニー | パターン形成された基板の形成方法 |
| US9315663B2 (en) * | 2008-09-26 | 2016-04-19 | Mikro Systems, Inc. | Systems, devices, and/or methods for manufacturing castings |
| US20110174435A1 (en) * | 2008-10-02 | 2011-07-21 | Bruce Malcolm Peterson | Microwell Sampling Tape Sealing Apparatus and Methods |
| WO2010056876A2 (en) * | 2008-11-14 | 2010-05-20 | Pepex Biomedical, Llc | Manufacturing electrochemical sensor module |
| WO2010056878A2 (en) | 2008-11-14 | 2010-05-20 | Pepex Biomedical, Llc | Electrochemical sensor module |
| US8951377B2 (en) | 2008-11-14 | 2015-02-10 | Pepex Biomedical, Inc. | Manufacturing electrochemical sensor module |
| EP2376226B1 (en) | 2008-12-18 | 2018-09-12 | Opko Diagnostics, LLC | Improved reagent storage in microfluidic systems and related articles and methods |
| DK2391451T3 (en) | 2009-02-02 | 2018-10-15 | Opko Diagnostics Llc | STRUCTURES FOR MANAGING LIGHT INTERACTION WITH MICROFLUIDIC DEVICES |
| PL2403645T3 (pl) | 2009-03-06 | 2017-05-31 | President And Fellows Of Harvard College | Mikroprzepływowe, elektrochemiczne urządzenia |
| EP2244489A1 (de) * | 2009-04-24 | 2010-10-27 | Bayer MaterialScience AG | Verfahren zur Herstellung eines elektromechanischen Wandlers |
| US20100326914A1 (en) * | 2009-06-24 | 2010-12-30 | State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon | Microfluidic devices |
| US8801922B2 (en) * | 2009-06-24 | 2014-08-12 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Dialysis system |
| KR101735133B1 (ko) * | 2009-10-21 | 2017-05-12 | 아사히 가라스 가부시키가이샤 | 임프린트용 몰드, 그 제조 방법, 임프린트 장치 및 임프린트 방법 |
| US20130004967A1 (en) * | 2009-11-23 | 2013-01-03 | Halverson Kurt J | Microwell array articles and methods of use |
| ES2859481T3 (es) | 2009-11-24 | 2021-10-04 | Opko Diagnostics Llc | Mezcla y suministro de fluidos en sistemas microfluídicos |
| US20110189048A1 (en) * | 2009-12-05 | 2011-08-04 | Curtis James R | Modular dialysis system |
| US8753515B2 (en) | 2009-12-05 | 2014-06-17 | Home Dialysis Plus, Ltd. | Dialysis system with ultrafiltration control |
| EP2526397B1 (en) * | 2010-01-20 | 2020-11-25 | Nexcelom Bioscience LLC | Cell counting and sample chamber and methods of fabrication |
| CN102821861B (zh) | 2010-02-03 | 2015-03-25 | 哈佛大学校长及研究员协会 | 用于多重测定的装置和方法 |
| JP5585138B2 (ja) * | 2010-03-17 | 2014-09-10 | オムロン株式会社 | 流路チップ及び治具 |
| CA2795215C (en) | 2010-04-16 | 2018-11-06 | Opko Diagnostics, Llc | Systems and devices for analysis of samples |
| US8580161B2 (en) | 2010-05-04 | 2013-11-12 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Fluidic devices comprising photocontrollable units |
| USD645971S1 (en) | 2010-05-11 | 2011-09-27 | Claros Diagnostics, Inc. | Sample cassette |
| US8501009B2 (en) | 2010-06-07 | 2013-08-06 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Fluid purification system |
| CN102069564B (zh) * | 2010-11-12 | 2013-12-04 | 中南大学 | 用于微流控芯片制造的旋转多工位注射成型模具 |
| WO2012162151A2 (en) | 2011-05-20 | 2012-11-29 | Pepex Biomedical, Inc. | Manufacturing electrochemical sensor modules |
| US9513253B2 (en) | 2011-07-11 | 2016-12-06 | Advanced Liquid Logic, Inc. | Droplet actuators and techniques for droplet-based enzymatic assays |
| US20130090633A1 (en) * | 2011-10-07 | 2013-04-11 | University Of Southern California | Osmotic patch pump |
| JP2014533133A (ja) | 2011-10-07 | 2014-12-11 | ホーム・ダイアリシス・プラス・リミテッドHome DialysisPlus, Ltd. | 透析システムのための熱交換流体の精製 |
| CN104169378B (zh) | 2011-11-02 | 2018-04-13 | 3M创新有限公司 | 亲水流体输送装置 |
| US11092977B1 (en) | 2017-10-30 | 2021-08-17 | Zane Coleman | Fluid transfer component comprising a film with fluid channels |
| US8813824B2 (en) | 2011-12-06 | 2014-08-26 | Mikro Systems, Inc. | Systems, devices, and/or methods for producing holes |
| SG11201406213WA (en) | 2012-03-05 | 2014-11-27 | Arctic Partners Ab Oy | Methods and apparatuses for predicting risk of prostate cancer and prostate gland volume |
| JP2013224188A (ja) * | 2012-04-20 | 2013-10-31 | Nippon Electric Glass Co Ltd | ベルトコンベア |
| WO2014031523A2 (en) * | 2012-08-19 | 2014-02-27 | University Of Rochester | Method for preparing microfluidic device with reduced channel height |
| EP2925229A4 (en) | 2012-12-03 | 2017-01-25 | Pepex Biomedical, Inc. | Sensor module and method of using a sensor module |
| US10040018B2 (en) | 2013-01-09 | 2018-08-07 | Imagine Tf, Llc | Fluid filters and methods of use |
| EP2948435B1 (en) | 2013-01-22 | 2017-08-30 | Pacific Scientific Energetic Materials Company | Facile method for preparation of 5-nitrotetrazolates using a flow system |
| CA2900708C (en) | 2013-03-13 | 2021-06-15 | Opko Diagnostics, Llc | Mixing of fluids in fluidic systems |
| WO2015003722A1 (en) * | 2013-07-10 | 2015-01-15 | Delta Dansk Elektronik, Lys & Akustik | Single-use device with a reaction chamber and a method for controlling the temperature in the device and uses thereof |
| JP6611734B2 (ja) | 2014-04-24 | 2019-11-27 | スリーエム イノベイティブ プロパティズ カンパニー | 親水性表面を有する流体制御フィルム、その作製方法、及び構造化表面を洗浄する方法 |
| US20150310392A1 (en) | 2014-04-24 | 2015-10-29 | Linkedin Corporation | Job recommendation engine using a browsing history |
| EP3838308A1 (en) | 2014-04-29 | 2021-06-23 | Outset Medical, Inc. | Dialysis system and methods |
| US9861920B1 (en) | 2015-05-01 | 2018-01-09 | Imagine Tf, Llc | Three dimensional nanometer filters and methods of use |
| WO2015187959A1 (en) | 2014-06-04 | 2015-12-10 | Pepex Biomedical, Inc. | Electrochemical sensors and methods for making electrochemical sensors using advanced printing technology |
| US9598380B2 (en) | 2014-06-12 | 2017-03-21 | Sri International | Facile method for preparation of 5-nitrotetrazolates using a batch system |
| US9686540B2 (en) | 2014-06-23 | 2017-06-20 | Xerox Corporation | Robust colorimetric processing method for paper based sensors |
| US9266105B2 (en) * | 2014-06-23 | 2016-02-23 | Xerox Corporation | System and method for forming bonded substrates |
| KR102238956B1 (ko) * | 2014-06-24 | 2021-04-13 | 삼성전자주식회사 | 유체 분석 시트, 이를 포함하는 유체 분석 카트리지 및 유체 분석 카트리지의 제조방법 |
| US10730047B2 (en) | 2014-06-24 | 2020-08-04 | Imagine Tf, Llc | Micro-channel fluid filters and methods of use |
| US10124275B2 (en) | 2014-09-05 | 2018-11-13 | Imagine Tf, Llc | Microstructure separation filters |
| US10330095B2 (en) * | 2014-10-31 | 2019-06-25 | Encite Llc | Microelectromechanical systems fabricated with roll to roll processing |
| KR102587637B1 (ko) | 2014-12-12 | 2023-10-10 | 옵코 다이어그노스틱스, 엘엘씨 | 성형에 의해 제조되는 유체 시스템을 비롯한, 항온 처리 채널을 포함하는 유체 시스템 |
| WO2016115564A1 (en) | 2015-01-16 | 2016-07-21 | Pacific Scientific Energetic Materials Company | Facile method for preparation of sodium 5-nitrotetrazolate using a flow system |
| US10758849B2 (en) | 2015-02-18 | 2020-09-01 | Imagine Tf, Llc | Three dimensional filter devices and apparatuses |
| US10118842B2 (en) | 2015-07-09 | 2018-11-06 | Imagine Tf, Llc | Deionizing fluid filter devices and methods of use |
| USD804682S1 (en) | 2015-08-10 | 2017-12-05 | Opko Diagnostics, Llc | Multi-layered sample cassette |
| US10479046B2 (en) | 2015-08-19 | 2019-11-19 | Imagine Tf, Llc | Absorbent microstructure arrays and methods of use |
| WO2017074464A1 (en) * | 2015-10-30 | 2017-05-04 | Hewlett-Packard Development Company, L.P. | Microfluidic channel filter |
| WO2017100457A1 (en) | 2015-12-11 | 2017-06-15 | Opko Diagnostics, Llc | Fluidic systems involving incubation samples and/or reagents |
| WO2017126200A1 (ja) * | 2016-01-18 | 2017-07-27 | 東レ株式会社 | 表面構造フィルムの製造方法および製造装置 |
| US11534537B2 (en) | 2016-08-19 | 2022-12-27 | Outset Medical, Inc. | Peritoneal dialysis system and methods |
| WO2018093447A2 (en) | 2016-09-07 | 2018-05-24 | Pacific Scientific Energetic Materials Company | Purification of flow sodium 5- nitrotetrazolate solutions with copper modified cation exchange resin |
| US10121645B2 (en) * | 2016-12-05 | 2018-11-06 | National Institutes of Health (NIH) U.S. Department of Health and Human Services (DHHS), U.S. Government NIH Division of Extramural Inventions and Technology Resources (DEITR) | Sheathless interface for capillary electrophoresis/electrospray ionization-mass spectrometry |
| CN110036249B (zh) | 2016-12-05 | 2021-03-30 | 3M创新有限公司 | 冷凝物管理系统 |
| JP6983253B2 (ja) | 2016-12-20 | 2021-12-17 | スリーエム イノベイティブ プロパティズ カンパニー | 結露管理マニホールド及びシステム |
| US10807092B2 (en) * | 2017-03-15 | 2020-10-20 | Electronics And Telecommunications Research Institute | Microfluidic control system and microfluidic control method using the same |
| KR102564002B1 (ko) * | 2017-03-15 | 2023-08-08 | 한국전자통신연구원 | 미세유체 제어 시스템 및 이를 이용한 미세유체 제어 방법 |
| KR20190136041A (ko) * | 2017-04-03 | 2019-12-09 | 더 거벌먼트 오브 디 유나이티드 스테이츠 오브 아메리카 애즈 리프레젠티드 바이 더 디파트먼트 오브 베테랑스 어페어스 | 미세 유체 확산 장치 및 시스템, 그리고 그 제조 및 사용 방법 |
| WO2018236593A1 (en) | 2017-06-23 | 2018-12-27 | 3M Innovative Properties Company | Films with a primer layer containing composite particles that include an organic polymer portion and a siliceous portion |
| EP3642272B1 (en) | 2017-06-23 | 2024-11-13 | 3M Innovative Properties Company | Films with a primer layer containing silica nanoparticles modified by an organic silane |
| CN109551754B (zh) * | 2017-09-25 | 2024-11-19 | 长春工业大学 | 一种超声辅助辊对辊热纳米压印装置及方法 |
| US11578922B2 (en) | 2017-12-29 | 2023-02-14 | 3M Innovative Properties Company | Managing condensation with fluid control film apparatus |
| EP3732424A4 (en) | 2017-12-29 | 2021-09-29 | 3M Innovative Properties Company | MANAGEMENT OF CONDENSATION WITH LIQUID CONTROL FILM DEVICE |
| USD878622S1 (en) * | 2018-04-07 | 2020-03-17 | Precision Nanosystems Inc. | Microfluidic chip |
| US20210190410A1 (en) | 2018-08-10 | 2021-06-24 | 3M Innovative Properties Company | Condensation management apparatus with gutter assembly |
| EP3840798B1 (en) | 2018-08-23 | 2025-05-14 | Outset Medical, Inc. | Dialysis system and methods |
| AU2020266584B2 (en) | 2019-04-30 | 2025-10-23 | Outset Medical, Inc. | Dialysis system and methods |
| DE102019119571A1 (de) * | 2019-07-18 | 2021-01-21 | Uwe Beier | Verfahren und Vorrichtung zur Herstellung eines Substratverbundes |
| US20220250077A1 (en) | 2019-07-24 | 2022-08-11 | Hewlett-Packard Development Company, L.P. | Digital microfluidics device with droplet processing components |
| CN114126833A (zh) * | 2019-07-26 | 2022-03-01 | 通用电气公司 | 用于增材制造中将热塑性打印珠形成为净形结构的方法 |
| CN114651041B (zh) | 2019-11-21 | 2024-08-30 | 3M创新有限公司 | 包含聚环氧烷嵌段共聚物的微结构化膜、组合物和方法 |
| DE102020114621A1 (de) | 2020-06-02 | 2021-12-02 | Joanneum Research Forschungsgesellschaft Mbh | Bauteil mit Mikrofluidikstrukturen, Herstellungsverfahren und Verwendung |
| EP4288289A1 (en) * | 2021-02-04 | 2023-12-13 | Universiteit Maastricht | A method for manufacturing a structure with at least one microchannel for fluid |
| EP4046715A1 (de) * | 2021-02-18 | 2022-08-24 | Joanneum Research Forschungsgesellschaft mbH | Mikrofluidisches system aus einer gefalteten folie und herstellungsverfahren |
Family Cites Families (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3442686A (en) | 1964-03-13 | 1969-05-06 | Du Pont | Low permeability transparent packaging films |
| SE325370B (enExample) | 1967-03-06 | 1970-06-29 | Gambro Ab | |
| US3520300A (en) | 1967-03-15 | 1970-07-14 | Amp Inc | Surgical sponge and suction device |
| BE754658A (fr) | 1969-08-12 | 1971-02-10 | Merck Patent Gmbh | Lamelle indicatrice, se composant d'une matiere capillaire impregnee, absorbante et gainee de feuilles |
| CA941280A (en) | 1969-11-17 | 1974-02-05 | Franklin R. Elevitch | Method and apparatus for forming electrophoresis apparatus and the like |
| GB1354502A (en) | 1970-08-28 | 1974-06-05 | Ici Ltd | Heat exchangers |
| BE794510A (fr) | 1972-01-28 | 1973-05-16 | World Inventions Ltd | Perfectionnements apportes aux aspirateurs |
| US3812972A (en) | 1972-05-02 | 1974-05-28 | J Rosenblum | Liquid filter and method for fabricating same |
| US3993566A (en) | 1975-01-08 | 1976-11-23 | Amerace Corporation | Reverse osmosis apparatus |
| US4668558A (en) | 1978-07-20 | 1987-05-26 | Minnesota Mining And Manufacturing Company | Shaped plastic articles having replicated microstructure surfaces |
| US4233029A (en) | 1978-10-25 | 1980-11-11 | Eastman Kodak Company | Liquid transport device and method |
| US4200681A (en) | 1978-11-13 | 1980-04-29 | General Electric Company | Glass coated polycarbonate articles |
| US4392362A (en) | 1979-03-23 | 1983-07-12 | The Board Of Trustees Of The Leland Stanford Junior University | Micro miniature refrigerators |
| US4277966A (en) | 1979-06-04 | 1981-07-14 | Raytheon Company | Method of manufacturing a foraminous plate |
| US4271119A (en) | 1979-07-23 | 1981-06-02 | Eastman Kodak Company | Capillary transport device having connected transport zones |
| US4413407A (en) | 1980-03-10 | 1983-11-08 | Eastman Kodak Company | Method for forming an electrode-containing device with capillary transport between electrodes |
| FR2481790A1 (fr) | 1980-04-30 | 1981-11-06 | Ecopol | Element modulaire moule, et application de cet element modulaire aux echangeurs a plaques et aux procedes de separation a membrane |
| DE3212295A1 (de) | 1982-04-02 | 1983-10-06 | Friedrich Von Amelen | Verfahren zum verbinden zweier flaechen von platten |
| US4601861A (en) | 1982-09-30 | 1986-07-22 | Amerace Corporation | Methods and apparatus for embossing a precision optical pattern in a resinous sheet or laminate |
| US4533352A (en) | 1983-03-07 | 1985-08-06 | Pmt Inc. | Microsurgical flexible suction mat |
| US4579555A (en) | 1983-12-05 | 1986-04-01 | Sil-Fab Corporation | Surgical gravity drain having aligned longitudinally extending capillary drainage channels |
| US4552791A (en) | 1983-12-09 | 1985-11-12 | Cosden Technology, Inc. | Plastic container with decreased gas permeability |
| DE3435661A1 (de) | 1984-09-28 | 1986-04-03 | Wilhelm 6000 Frankfurt Schuster | Saugerduese |
| US4740468A (en) | 1985-02-14 | 1988-04-26 | Syntex (U.S.A.) Inc. | Concentrating immunochemical test device and method |
| FR2579025B1 (fr) | 1985-03-15 | 1987-04-10 | Occidental Chem Co | Pile a combustible a separation amelioree |
| US4986496A (en) | 1985-05-31 | 1991-01-22 | Minnesota Mining And Manufacturing | Drag reduction article |
| US5133516A (en) | 1985-05-31 | 1992-07-28 | Minnesota Mining And Manufacturing Co. | Drag reduction article |
| US4639748A (en) | 1985-09-30 | 1987-01-27 | Xerox Corporation | Ink jet printhead with integral ink filter |
| AT396998B (de) | 1985-12-09 | 1994-01-25 | Ottosensors Corp | Messeinrichtungen und rohranschluss sowie verfahren zur herstellung einer messeinrichtung und verfahren zur verbindung von rohren mit einer messeinrichtung bzw. zur herstellung von rohranschlüssen |
| US4906439A (en) | 1986-03-25 | 1990-03-06 | Pb Diagnostic Systems, Inc. | Biological diagnostic device and method of use |
| JP2582066B2 (ja) | 1987-03-19 | 1997-02-19 | 株式会社日立製作所 | 光機能性デバイス |
| US5249359A (en) | 1987-03-20 | 1993-10-05 | Kernforschungszentrum Karlsruhe Gmbh | Process for manufacturing finely structured bodies such as heat exchangers |
| DE3709278A1 (de) | 1987-03-20 | 1988-09-29 | Kernforschungsz Karlsruhe | Verfahren zur herstellung von feinstrukturkoerpern |
| US5078925A (en) | 1987-07-01 | 1992-01-07 | Minnesota Mining And Manufacturing Company | Preparing polypropylene articles |
| US4950549A (en) | 1987-07-01 | 1990-08-21 | Minnesota Mining And Manufacturing Company | Polypropylene articles and method for preparing same |
| US4867876A (en) | 1987-10-02 | 1989-09-19 | Kopf Henry B | Filter plate, filter plate element, and filter comprising same |
| US4913858A (en) | 1987-10-26 | 1990-04-03 | Dennison Manufacturing Company | Method of embossing a coated sheet with a diffraction or holographic pattern |
| SE460013B (sv) | 1987-11-20 | 1989-09-04 | Adolf Gunnar Gustafson | Anordning foer att medelst undertryck avlaegsna partiklar, vaetskor etc.fraan ett underlag |
| US4871623A (en) | 1988-02-19 | 1989-10-03 | Minnesota Mining And Manufacturing Company | Sheet-member containing a plurality of elongated enclosed electrodeposited channels and method |
| US5158557A (en) | 1988-04-04 | 1992-10-27 | Minnesota Mining And Manufacturing Company | Refastenable adhesive tape closure |
| GB8809608D0 (en) * | 1988-04-22 | 1988-05-25 | Alcan Int Ltd | Sol-gel method of making ceramics |
| US4908112A (en) | 1988-06-16 | 1990-03-13 | E. I. Du Pont De Nemours & Co. | Silicon semiconductor wafer for analyzing micronic biological samples |
| US5132012A (en) | 1988-06-24 | 1992-07-21 | Hitachi, Ltd. | Liquid chromatograph |
| US5175030A (en) | 1989-02-10 | 1992-12-29 | Minnesota Mining And Manufacturing Company | Microstructure-bearing composite plastic articles and method of making |
| US5411858A (en) | 1989-05-17 | 1995-05-02 | Actimed Laboratories, Inc. | Manufacturing process for sample initiated assay device |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| JPH03132705A (ja) | 1989-10-19 | 1991-06-06 | Brother Ind Ltd | 光導波路アレイ及びその製造方法 |
| US5014389A (en) | 1989-11-15 | 1991-05-14 | Concept Inc. | Foot manipulated suction head and method for employing same |
| US5136678A (en) | 1990-02-19 | 1992-08-04 | Brother Kogyo Kabushiki Kaisha | Optical wave guide array |
| ES2077844T5 (es) | 1990-02-20 | 2001-02-01 | Procter & Gamble | Estructuras de canales capilares abiertos, procedimiento mejorado para producir estructuras de canales capilares, y boquilla de extrusion para uso en el mismo. |
| US5126022A (en) | 1990-02-28 | 1992-06-30 | Soane Tecnologies, Inc. | Method and device for moving molecules by the application of a plurality of electrical fields |
| US5750015A (en) | 1990-02-28 | 1998-05-12 | Soane Biosciences | Method and device for moving molecules by the application of a plurality of electrical fields |
| US5534576A (en) | 1990-04-17 | 1996-07-09 | E. I. Du Pont De Nemours And Company | Sealant for electrochemical cells |
| SE470347B (sv) | 1990-05-10 | 1994-01-31 | Pharmacia Lkb Biotech | Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system |
| AU9064391A (en) | 1990-11-16 | 1992-06-11 | Abbott Laboratories | Improved agglutination reaction device having geometrically modified chambers |
| US5698299A (en) | 1991-02-28 | 1997-12-16 | Dyconex Patente Ag | Thin laminated microstructure with precisely aligned openings |
| US5474796A (en) | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| US5605662A (en) | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
| EP0544969B1 (de) | 1991-12-06 | 1997-03-05 | Ciba-Geigy Ag | Elektrophoretische Trennvorrichtung und elektrophoretisches Trennverfahren |
| WO1993011727A1 (en) | 1991-12-18 | 1993-06-24 | Minnesota Mining And Manufacturing Company | Liquid management member for absorbent articles |
| US5514120A (en) | 1991-12-18 | 1996-05-07 | Minnesota Mining And Manufacturing Company | Liquid management member for absorbent articles |
| US5227008A (en) | 1992-01-23 | 1993-07-13 | Minnesota Mining And Manufacturing Company | Method for making flexible circuits |
| DE4210072A1 (de) | 1992-03-27 | 1993-03-25 | Daimler Benz Ag | Vorrichtung zum auftragen zaeher klebermassen auf starre anklebeflaechen |
| US5176667A (en) | 1992-04-27 | 1993-01-05 | Debring Donald L | Liquid collection apparatus |
| US5637469A (en) | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems |
| US5726026A (en) | 1992-05-01 | 1998-03-10 | Trustees Of The University Of Pennsylvania | Mesoscale sample preparation device and systems for determination and processing of analytes |
| US5296375A (en) | 1992-05-01 | 1994-03-22 | Trustees Of The University Of Pennsylvania | Mesoscale sperm handling devices |
| US5304487A (en) | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices |
| US5498392A (en) | 1992-05-01 | 1996-03-12 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
| US5265184A (en) | 1992-05-28 | 1993-11-23 | Motorola, Inc. | Molded waveguide and method for making same |
| US5440332A (en) | 1992-07-06 | 1995-08-08 | Compa Computer Corporation | Apparatus for page wide ink jet printing |
| JPH0724643B2 (ja) | 1992-10-26 | 1995-03-22 | 東京コスモス電機株式会社 | 還流式掃除機及び吸引式掃除機 |
| US5583211A (en) | 1992-10-29 | 1996-12-10 | Beckman Instruments, Inc. | Surface activated organic polymers useful for location - specific attachment of nucleic acids, peptides, proteins and oligosaccharides |
| US5651888A (en) | 1992-12-16 | 1997-07-29 | Kubota Corporation | Filtration membrane cartridge |
| US5399486A (en) | 1993-02-18 | 1995-03-21 | Biocircuits Corporation | Disposable unit in diagnostic assays |
| US5401913A (en) | 1993-06-08 | 1995-03-28 | Minnesota Mining And Manufacturing Company | Electrical interconnections between adjacent circuit board layers of a multi-layer circuit board |
| DE4328001C2 (de) | 1993-08-20 | 1997-03-20 | Dia Nielsen Gmbh | Tintenbehälter |
| US5728446A (en) | 1993-08-22 | 1998-03-17 | Johnston; Raymond P. | Liquid management film for absorbent articles |
| US5437651A (en) | 1993-09-01 | 1995-08-01 | Research Medical, Inc. | Medical suction apparatus |
| US5691846A (en) | 1993-10-20 | 1997-11-25 | Minnesota Mining And Manufacturing Company | Ultra-flexible retroreflective cube corner composite sheetings and methods of manufacture |
| US5450235A (en) | 1993-10-20 | 1995-09-12 | Minnesota Mining And Manufacturing Company | Flexible cube-corner retroreflective sheeting |
| US5429807A (en) | 1993-10-28 | 1995-07-04 | Beckman Instruments, Inc. | Method and apparatus for creating biopolymer arrays on a solid support surface |
| US6287517B1 (en) * | 1993-11-01 | 2001-09-11 | Nanogen, Inc. | Laminated assembly for active bioelectronic devices |
| US5737457A (en) | 1994-02-25 | 1998-04-07 | Fci - Fiberchem, Inc. | Chip level waveguide sensor |
| US6001229A (en) | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
| US5510155A (en) | 1994-09-06 | 1996-04-23 | Becton, Dickinson And Company | Method to reduce gas transmission |
| US5707799A (en) | 1994-09-30 | 1998-01-13 | Abbott Laboratories | Devices and methods utilizing arrays of structures for analyte capture |
| US5641400A (en) | 1994-10-19 | 1997-06-24 | Hewlett-Packard Company | Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems |
| US5658413A (en) | 1994-10-19 | 1997-08-19 | Hewlett-Packard Company | Miniaturized planar columns in novel support media for liquid phase analysis |
| US5500071A (en) | 1994-10-19 | 1996-03-19 | Hewlett-Packard Company | Miniaturized planar columns in novel support media for liquid phase analysis |
| US5571410A (en) | 1994-10-19 | 1996-11-05 | Hewlett Packard Company | Fully integrated miniaturized planar liquid sample handling and analysis device |
| US5645702A (en) | 1995-06-07 | 1997-07-08 | Hewlett-Packard Company | Low voltage miniaturized column analytical apparatus and method |
| US5585069A (en) | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
| DE19501017C2 (de) | 1995-01-14 | 2002-10-24 | Michael Volkmer | Chirurgisches Absauginstrument |
| US5757482A (en) | 1995-04-20 | 1998-05-26 | Perseptive Biosystems, Inc. | Module for optical detection in microscale fluidic analyses |
| US5692263A (en) | 1995-06-02 | 1997-12-02 | Sorenson; R. Wayne | Delicate dusting vacuum tool |
| US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| US5658802A (en) | 1995-09-07 | 1997-08-19 | Microfab Technologies, Inc. | Method and apparatus for making miniaturized diagnostic arrays |
| EP0854781A1 (en) | 1995-10-12 | 1998-07-29 | Minnesota Mining And Manufacturing Company | Microstructured polymeric substrate |
| US5716825A (en) | 1995-11-01 | 1998-02-10 | Hewlett Packard Company | Integrated nucleic acid analysis system for MALDI-TOF MS |
| US5705813A (en) | 1995-11-01 | 1998-01-06 | Hewlett-Packard Company | Integrated planar liquid handling system for maldi-TOF MS |
| US5628735A (en) | 1996-01-11 | 1997-05-13 | Skow; Joseph I. | Surgical device for wicking and removing fluid |
| US5721435A (en) | 1996-04-09 | 1998-02-24 | Hewlett Packard Company | Methods and apparatus for measuring optical properties of biological and chemical substances |
| US5885470A (en) | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
| NZ333346A (en) | 1996-06-28 | 2000-03-27 | Caliper Techn Corp | High-throughput screening assay systems in microscale fluidic devices |
| US5932315A (en) | 1997-04-30 | 1999-08-03 | Hewlett-Packard Company | Microfluidic structure assembly with mating microfeatures |
| US6375871B1 (en) | 1998-06-18 | 2002-04-23 | 3M Innovative Properties Company | Methods of manufacturing microfluidic articles |
| US5842787A (en) | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
| US6167910B1 (en) * | 1998-01-20 | 2001-01-02 | Caliper Technologies Corp. | Multi-layer microfluidic devices |
-
1998
- 1998-06-18 US US09/099,562 patent/US6375871B1/en not_active Expired - Lifetime
-
1999
- 1999-05-18 AU AU40032/99A patent/AU742931B2/en not_active Ceased
- 1999-05-18 EP EP19990923208 patent/EP1087864B1/en not_active Expired - Lifetime
- 1999-05-18 KR KR1020007014303A patent/KR100618013B1/ko not_active Expired - Fee Related
- 1999-05-18 DE DE1999630254 patent/DE69930254T2/de not_active Expired - Lifetime
- 1999-05-18 CN CNB998073776A patent/CN100374283C/zh not_active Expired - Lifetime
- 1999-05-18 WO PCT/US1999/011024 patent/WO1999065664A1/en not_active Ceased
- 1999-05-18 JP JP2000554525A patent/JP4489945B2/ja not_active Expired - Lifetime
-
2002
- 2002-03-27 US US10/108,069 patent/US6761962B2/en not_active Expired - Lifetime
-
2010
- 2010-02-04 JP JP2010023193A patent/JP2010111129A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69930254D1 (de) | 2006-05-04 |
| AU4003299A (en) | 2000-01-05 |
| EP1087864B1 (en) | 2006-03-08 |
| KR100618013B1 (ko) | 2006-08-31 |
| US6761962B2 (en) | 2004-07-13 |
| CN1305410A (zh) | 2001-07-25 |
| US6375871B1 (en) | 2002-04-23 |
| WO1999065664A1 (en) | 1999-12-23 |
| EP1087864A1 (en) | 2001-04-04 |
| US20020098124A1 (en) | 2002-07-25 |
| JP2010111129A (ja) | 2010-05-20 |
| CN100374283C (zh) | 2008-03-12 |
| JP2002518202A (ja) | 2002-06-25 |
| AU742931B2 (en) | 2002-01-17 |
| KR20010052934A (ko) | 2001-06-25 |
| DE69930254T2 (de) | 2006-12-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4489945B2 (ja) | ミクロ流体製品およびその製造方法 | |
| Gale et al. | Fabrication and packaging: Low-cost MEMS technologies | |
| US20050067286A1 (en) | Microfabricated structures and processes for manufacturing same | |
| Haraldsson et al. | 3D polymeric microfluidic device fabrication via contact liquid photolithographic polymerization (CLiPP) | |
| CA2599238A1 (en) | 3-d interconnected multi-layer microstructure of thermoplastic materials | |
| EP1431018B1 (en) | Method of producing resin molded product | |
| Sudarsan et al. | Printed circuit technology for fabrication of plastic-based microfluidic devices | |
| Sethu et al. | Cast epoxy-based microfluidic systems and their application in biotechnology | |
| JP2004325153A (ja) | マイクロチップ及びその製造方法 | |
| JP2003084001A (ja) | 微小バルブ機構を有するマイクロ流体デバイス、マイクロ流体デバイスの微小バルブ機構駆動装置、及び流量調節方法 | |
| US7682541B2 (en) | Manufacturing method of a microchemical chip made of a resin | |
| US20030232450A1 (en) | Microfluidic device and method for producing the same | |
| US20240084368A1 (en) | Microfluidic system consisting of a folded foil, and production method | |
| Rhoads et al. | Using microfluidic channel networks to generate gradients for studying cell migration | |
| JP4307771B2 (ja) | マイクロ流体デバイスの製造方法 | |
| JP2000093816A (ja) | 小型実験プレートの製造方法及びインライン型小型実験プレートの製造装置 | |
| Charlot et al. | A low cost and hybrid technology for integrating silicon sensors or actuators in polymer microfluidic systems | |
| WO2001044875A2 (en) | Micromolds fabricated using mems technology and methods of use therefor | |
| TRICHUR | Development of polymer MEMS structures for lab-on-a-chips using UV-LIGA and injection molding techniques | |
| JP2004286449A (ja) | マイクロ分析チップ、その製造法及びこれを用いた分析装置 | |
| Worgull et al. | Hot embossing | |
| Gale et al. | 1.12 a0005 Low-Cost MEMS Technologies | |
| JP2025082642A (ja) | 微細構造体デバイス製造システム及び微細構造体デバイス製造方法 | |
| CN120481143A (zh) | 一种三维结构微流道柔性触觉传感器模具及其制作方法 | |
| Klank | Polymer micromachining |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060426 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060426 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20081226 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090120 |
|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20090420 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090804 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20091102 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20091110 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100204 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20100302 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20100401 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130409 Year of fee payment: 3 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130409 Year of fee payment: 3 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20140409 Year of fee payment: 4 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |