JP4486256B2 - 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体 - Google Patents
副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体 Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10553098P | 1998-10-22 | 1998-10-22 | |
| US60/105,530 | 1998-10-22 | ||
| PCT/US1999/024481 WO2000023594A1 (fr) | 1998-10-22 | 1999-10-20 | PEPTIDES ET DERIVES PEPTIDIQUES BIOACTIFS DE L'HORMONE PARATHYROIDE (PTH) ET DE LA PROTEINE LIEE A L'HORMONE PARATHYROIDE (PTHrP) |
Publications (3)
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|---|---|
| JP2002528060A JP2002528060A (ja) | 2002-09-03 |
| JP2002528060A5 JP2002528060A5 (fr) | 2006-12-07 |
| JP4486256B2 true JP4486256B2 (ja) | 2010-06-23 |
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| US (3) | US6495662B1 (fr) |
| EP (1) | EP1123401A1 (fr) |
| JP (1) | JP4486256B2 (fr) |
| AU (1) | AU1447600A (fr) |
| WO (1) | WO2000023594A1 (fr) |
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| JP4486256B2 (ja) | 1998-10-22 | 2010-06-23 | ザ・ジェネラル・ホスピタル・コーポレイション | 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体 |
| JP2003533167A (ja) * | 1998-11-25 | 2003-11-11 | ザ ゼネラル ホスピタル コーポレーション | アミノ末端改変副甲状腺ホルモン（ｐｔｈ）アナログ |
| DE69942035D1 (de) * | 1998-11-25 | 2010-04-01 | Gen Hospital Corp | Menschliches parathyroidhormon, modifikationen, herstellung und verwendung |
| WO2000032771A1 (fr) * | 1998-11-30 | 2000-06-08 | The General Hospital Corporation | Recepteurs de pth1r et de pth3r, procedes s'y rapportant et utilisation |
| AU2486800A (en) * | 1998-12-31 | 2000-07-31 | General Hospital Corporation, The | Pth functional domain conjugate peptides, derivatives thereof and novel tetheredligand-receptor molecules |
| US7057012B1 (en) * | 1998-12-31 | 2006-06-06 | The General Hospital Corporation | PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules |
| WO2000040698A1 (fr) * | 1998-12-31 | 2000-07-13 | The General Hospital Corporation | Recepteur pth et test de criblage l'utilisant |
| US6872519B1 (en) * | 1999-04-27 | 2005-03-29 | Mirus Bio Corporation | In vitro process for selecting phage resistant to blood inactivation |
| WO2001023521A2 (fr) | 1999-09-29 | 2001-04-05 | The General Hospital Corporation | Derives polypeptidiques de l'hormone parathyroidienne (pth) |
| US6756480B2 (en) | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| KR100491737B1 (ko) * | 2001-07-20 | 2005-05-27 | 주식회사 한국아이템개발 | 공기 정화 기능의 모기 퇴치기 |
| WO2003009804A2 (fr) | 2001-07-23 | 2003-02-06 | The General Hospital Corporation | Analogues d'hormone parathyroide (pth) a contrainte conformationnelle |
| EP1531855A4 (fr) * | 2002-01-10 | 2009-07-22 | Osteotrophin Llc | Traitement des affections osseuses avec des medicaments anabolisants du squelette |
| AU2003239869A1 (en) | 2002-05-23 | 2003-12-12 | Michael Holick | Use of a parathyroid hormone peptide analogs for the treatment of vaginal atrophy |
| EP1511857B1 (fr) * | 2002-05-31 | 2007-12-12 | McGill University | Prediction et diagnostic de maladies osseuses basees sur pthrp |
| AU2002951372A0 (en) * | 2002-09-13 | 2002-09-26 | St Vincent's Institute Of Medical Research | Parathyroid hormone-like polypeptides |
| US7378495B2 (en) * | 2002-10-21 | 2008-05-27 | Pevion Biotech, Ltd. | PTH-rP related peptide cancer therapeutics |
| AU2003217243A1 (en) * | 2003-01-24 | 2004-08-23 | Thomas J. Gardella | Conformationally constrained parathyroid hormone (pth) analogs with lactam bridges |
| WO2004093902A1 (fr) | 2003-03-19 | 2004-11-04 | The General Hospital Corporation | Hormones parathyroidiennes contraintes de maniere conformationnelle avec des stabilisateurs en helice $g(a) |
| US20040220094A1 (en) * | 2003-05-01 | 2004-11-04 | Skinner Keith K. | Inverse agonist and agonist peptides that stimulate/inhibit hair growth |
| WO2005009358A2 (fr) * | 2003-07-17 | 2005-02-03 | The General Hospital Corporation | Analogues d'hormone parathyroide (pth) a conformation contrainte |
| WO2005116056A1 (fr) * | 2004-05-26 | 2005-12-08 | Green Peptide Co., Ltd. | Peptide à liaison hla-a24 ou hla-a2 de protéine lié à la parathormone |
| WO2007059470A2 (fr) * | 2005-11-10 | 2007-05-24 | Board Of Control Of Michigan Technological University | Parathormone de l'ours noir et procedes d'utilisation de la parathormone de l'ours noir |
| WO2008019062A2 (fr) | 2006-08-04 | 2008-02-14 | The General Hospital Corporation | Dérivés polypeptidiques de l'hormone parathyroïdienne (pth) |
| EP1961765A1 (fr) * | 2006-12-08 | 2008-08-27 | Zealand Pharma A/S | Peptides PTH tronqués à formation cyclique |
| US8568737B2 (en) | 2007-08-01 | 2013-10-29 | The General Hospital Corporation | Screening methods using G-protein coupled receptors and related compositions |
| US8999935B2 (en) * | 2009-02-11 | 2015-04-07 | New York University | Treatment of osteoporosis in peri- and post-menopausal women with hepcidin |
| US8563513B2 (en) | 2009-03-27 | 2013-10-22 | Van Andel Research Institute | Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use |
| CA2757874C (fr) | 2009-04-24 | 2016-02-16 | Cadila Healthcare Limited | Peptides a chaine courte comme agoniste du recepteur de l'hormone parathyroidienne (pth) |
| JP2013512688A (ja) | 2009-12-07 | 2013-04-18 | ミシガン テクノロジカル ユニバーシティ | クロクマの副甲状腺ホルモン及びクロクマの副甲状腺ホルモンを使用する方法 |
| JP5941040B2 (ja) | 2010-05-13 | 2016-06-29 | ザ ジェネラル ホスピタル コーポレイション | 副甲状腺ホルモン類似体およびその使用 |
| WO2012120532A2 (fr) | 2011-02-02 | 2012-09-13 | Cadila Healthcare Limited | Peptides cycliques à chaîne courte |
| JP7148493B2 (ja) | 2016-08-01 | 2022-10-05 | ゾーマ （ユーエス） リミテッド ライアビリティ カンパニー | 副甲状腺ホルモン受容体１（ｐｔｈ１ｒ）抗体およびその使用 |
| WO2019178462A1 (fr) | 2018-03-16 | 2019-09-19 | The General Hospital Corporation | Conjugués polypeptes-hormone parathyroïde et leurs procédés d'utilisation |
| CN109541239B (zh) * | 2018-12-21 | 2021-09-24 | 云南农业大学 | 一种基于甲状旁腺素血液生化标记选育武定鸡的方法 |
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| US3364768A (en) * | 1965-05-03 | 1968-01-23 | Chrysler Corp | Multiple speed power transmission mechanism |
| US4086196A (en) * | 1975-03-28 | 1978-04-25 | Armour Pharmaceutical Company | Parathyroid hormone |
| US4849338A (en) * | 1982-07-16 | 1989-07-18 | Syntex (U.S.A.) Inc. | Simultaneous calibration heterogeneous immunoassay |
| US4843000A (en) * | 1979-12-26 | 1989-06-27 | Syntex (U.S.A.) Inc. | Simultaneous calibration heterogeneous immunoassay |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4675189A (en) * | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
| US4423037A (en) * | 1982-05-13 | 1983-12-27 | The General Hospital Corporation | Inhibitors of peptide hormone action |
| US4512922A (en) * | 1982-12-22 | 1985-04-23 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4620948A (en) * | 1982-12-22 | 1986-11-04 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4518526A (en) * | 1982-12-22 | 1985-05-21 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4511502A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4736866A (en) * | 1984-06-22 | 1988-04-12 | President And Fellows Of Harvard College | Transgenic non-human mammals |
| IL78342A (en) | 1985-04-04 | 1991-06-10 | Gen Hospital Corp | Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof |
| US4761406A (en) | 1985-06-06 | 1988-08-02 | The Procter & Gamble Company | Regimen for treating osteoporosis |
| US5010010A (en) * | 1986-10-22 | 1991-04-23 | Selmer-Sande, A.S. | Production of human parathyroid hormone from microorganisms |
| US5527772A (en) | 1987-10-20 | 1996-06-18 | Holick; Michael F. | Regulation of cell proliferation and differentiation using peptides |
| US5605815A (en) * | 1988-03-14 | 1997-02-25 | Yale University | Nucleic acids encoding and expression of parathyroid hormone-like peptide |
| EP0341962B1 (fr) | 1988-05-09 | 1995-03-15 | Merck & Co. Inc. | Antagonistes du facteur humoral hypercalcémique |
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| WO1990009441A1 (fr) * | 1989-02-01 | 1990-08-23 | The General Hospital Corporation | Vecteur d'expression du virus d'herpes simplex, type i |
| WO1991005050A1 (fr) | 1989-09-29 | 1991-04-18 | Her Majesty In Right Of Canada As Represented By The National Research Council Of Canada | Synthese de l'hormone parathyroïde humaine mature |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| DE69032809T2 (de) * | 1989-11-06 | 1999-07-08 | Cell Genesys Inc | Herstellung von Proteinen mittels homologer Rekombination |
| IT1238348B (it) * | 1989-11-16 | 1993-07-13 | Processo per la preparazione di costrutti genetici per l'espressione del fattore di crescita nervoso in cellule eucariote. | |
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-
1999
- 1999-10-20 JP JP2000577302A patent/JP4486256B2/ja not_active Expired - Fee Related
- 1999-10-20 WO PCT/US1999/024481 patent/WO2000023594A1/fr active Application Filing
- 1999-10-20 US US09/421,379 patent/US6495662B1/en not_active Expired - Lifetime
- 1999-10-20 EP EP99970686A patent/EP1123401A1/fr not_active Withdrawn
- 1999-10-20 AU AU14476/00A patent/AU1447600A/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| US7153951B2 (en) | 2006-12-26 |
| JP2002528060A (ja) | 2002-09-03 |
| EP1123401A1 (fr) | 2001-08-16 |
| WO2000023594A1 (fr) | 2000-04-27 |
| US7985835B2 (en) | 2011-07-26 |
| WO2000023594A9 (fr) | 2000-10-12 |
| US20070111946A1 (en) | 2007-05-17 |
| US6495662B1 (en) | 2002-12-17 |
| AU1447600A (en) | 2000-05-08 |
| US20030166838A1 (en) | 2003-09-04 |
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