JP4436130B2 - インビトロ直鎖化によるポリヌクレオチドのランダム組込 - Google Patents

インビトロ直鎖化によるポリヌクレオチドのランダム組込 Download PDF

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Publication number
JP4436130B2
JP4436130B2 JP2003529956A JP2003529956A JP4436130B2 JP 4436130 B2 JP4436130 B2 JP 4436130B2 JP 2003529956 A JP2003529956 A JP 2003529956A JP 2003529956 A JP2003529956 A JP 2003529956A JP 4436130 B2 JP4436130 B2 JP 4436130B2
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host cell
vector
polynucleotide
endonuclease
dna
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JP2005503161A5 (enExample
JP2005503161A (ja
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シューリカ，アンドレ
ジョリー，ジャン−ステファヌ
テルメ，ビオレット
リストラトーレ，フィロメナ
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Cellectis SA
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Cellectis SA
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Husbandry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2003529956A 2001-09-14 2002-09-12 インビトロ直鎖化によるポリヌクレオチドのランダム組込 Expired - Lifetime JP4436130B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31881801P 2001-09-14 2001-09-14
US33063901P 2001-10-26 2001-10-26
PCT/EP2002/010224 WO2003025183A2 (en) 2001-09-14 2002-09-12 Random integration of a polynucleotide after in vivo linearization

Publications (3)

Publication Number Publication Date
JP2005503161A JP2005503161A (ja) 2005-02-03
JP2005503161A5 JP2005503161A5 (enExample) 2006-01-05
JP4436130B2 true JP4436130B2 (ja) 2010-03-24

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JP2003529956A Expired - Lifetime JP4436130B2 (ja) 2001-09-14 2002-09-12 インビトロ直鎖化によるポリヌクレオチドのランダム組込

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US (1) US7098031B2 (enExample)
EP (1) EP1427828B1 (enExample)
JP (1) JP4436130B2 (enExample)
AT (1) ATE466088T1 (enExample)
AU (1) AU2002333832B2 (enExample)
DE (1) DE60236182D1 (enExample)
DK (1) DK1427828T3 (enExample)
ES (1) ES2342159T3 (enExample)
WO (1) WO2003025183A2 (enExample)

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ATE401410T1 (de) * 1997-11-18 2008-08-15 Pioneer Hi Bred Int Zusammensetzungen und verfahren für die genetische modifizierung von pflanzen
US7102055B1 (en) * 1997-11-18 2006-09-05 Pioneer Hi-Bred International, Inc. Compositions and methods for the targeted insertion of a nucleotide sequence of interest into the genome of a plant
CA2360878A1 (en) * 1999-02-03 2000-08-10 The Children's Medical Center Corporation Gene repair involving excision of targeting dna
WO2003038049A2 (en) 2001-10-29 2003-05-08 Renovis, Inc. Method for isolating cell-type specific mrnas
FR2879622B1 (fr) * 2004-12-17 2008-02-01 Agronomique Inst Nat Rech Procede in vitro de production d'ovocytes ou d'oeufs presentant une modification genomique ciblee
WO2006074956A1 (en) * 2005-01-14 2006-07-20 Bayer Bioscience N.V. Improved plant transformation methods
CA2615797C (en) 2005-07-18 2014-04-29 Pioneer Hi-Bred International, Inc. Modified frt recombination sites and methods of use
US7663019B2 (en) 2006-05-24 2010-02-16 North Carolina State University Transgenic snakes and methods of making
EP2602323B1 (en) 2007-06-01 2018-02-28 Open Monoclonal Technology, Inc. Compositions and methods for inhibiting endogenous immunoglobin genes and producing transgenic human idiotype antibodies
WO2009006297A2 (en) 2007-06-29 2009-01-08 Pioneer Hi-Bred International, Inc. Methods for altering the genome of a monocot plant cell
WO2009114321A2 (en) 2008-03-11 2009-09-17 Precision Biosciencs, Inc. Rationally-designed meganucleases for maize genome engineering
WO2009114185A2 (en) 2008-03-12 2009-09-17 The Rockefeller University Methods and compositions for translational profiling and molecular phenotyping
JP2011519558A (ja) * 2008-04-28 2011-07-14 プレシジョン バイオサイエンシズ，インク． 合理的に設計されたｄｎａ結合タンパク質とエフェクタードメインとの融合分子
CN103025866A (zh) 2010-03-22 2013-04-03 菲利普莫里斯生产公司 修饰植物中酶的活性
AR085302A1 (es) 2011-02-24 2013-09-18 Sanofi Sa Metodo de produccion de anticuerpos sialilados
CA2865097A1 (en) * 2012-02-20 2013-08-29 Advanced Tactical Ordnance LLC Chimeric dna identifier
AU2013274542B2 (en) 2012-06-12 2017-03-30 Syngenta Crop Protection Ag Methods and compositions for determination of vector backbone in a nucleic acid sample
WO2014083379A1 (en) 2012-11-30 2014-06-05 Institut Pasteur Use of anti-fcyri and/or anti-fcyriia antibodies for treating arthritis, inflammation, thrombocytopenia and allergic shock
WO2016097420A1 (en) 2014-12-19 2016-06-23 Universite De Nantes Anti il-34 antibodies
USD765215S1 (en) 2015-01-22 2016-08-30 United Tactical Systems, Llc Non-lethal projectile
US9766049B2 (en) 2015-01-27 2017-09-19 United Tactical Systems, Llc Aerodynamic projectile
EP3427055A1 (en) 2016-03-07 2019-01-16 Pierre Fabre Medicament A new universal method to capture and analyze adcs for characterization of drug distribution and the drug-to-antibody ratio in biological samples
SG10202109874VA (en) 2017-01-19 2021-10-28 Open Monoclonal Tech Inc Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci
CN107372348A (zh) * 2017-08-31 2017-11-24 广西沙田仙人滩农业投资有限公司 一种绿壳蛋鸡育虫生态养殖方法
PL3720879T3 (pl) 2017-12-05 2022-09-12 Progastrine Et Cancers S.À R.L. Terapia skojarzona przeciwciałami przeciwko progastynie i immunoterapią w leczeniu nowotworu
KR102699073B1 (ko) 2018-02-27 2024-08-26 이씨에스-프로가스트린 에스에이 면역치료요법용 생체표지자로서 프로가스트린
CN118994395A (zh) 2018-07-20 2024-11-22 皮埃尔法布雷医药公司 Vista受体
US20210277421A1 (en) * 2018-08-06 2021-09-09 NemaMetrix, Inc Homologous Recombination Reporter Construct and Uses Thereof
EP3856229A1 (en) 2018-09-28 2021-08-04 Pierre Fabre Medicament New immunocytokines for the treatment of cancer
MX2022002672A (es) 2019-09-04 2022-06-16 Y Biologics Inc Anticuerpo anti-vsig4 o fragmento de union a antigeno y usos del mismo.
EP4073117A1 (en) 2019-12-10 2022-10-19 Institut Pasteur New antibody blocking human fcgriiia and fcgriiib
EP3889183A1 (en) 2020-04-01 2021-10-06 Pierre Fabre Medicament A protein complex comprising an immunocytokine
KR20230156727A (ko) 2021-03-03 2023-11-14 피에르 파브르 메디카먼트 항-vsig4 항체 또는 이의 항원 결합 단편 및 용도
CA3218086A1 (en) 2021-04-30 2022-11-03 Pierre Fabre Medicament New stable anti-vista antibody
WO2023213814A1 (en) 2022-05-02 2023-11-09 Pierre Fabre Medicament New formulation of anti vista antibody
WO2024121380A1 (en) 2022-12-08 2024-06-13 Pierre Fabre Medicament Vaccinal composition and adjuvant
WO2024209089A1 (en) 2023-04-07 2024-10-10 Commissariat A L'energie Atomique Et Aux Energies Alternatives Use of antibody against the endothelin receptor b for diagnostic and therapeutic applications

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US5474896A (en) * 1992-05-05 1995-12-12 Institut Pasteur Nucleotide sequence encoding the enzyme I-SceI and the uses thereof
US5792632A (en) * 1992-05-05 1998-08-11 Institut Pasteur Nucleotide sequence encoding the enzyme I-SceI and the uses thereof

Also Published As

Publication number Publication date
ATE466088T1 (de) 2010-05-15
AU2002333832B2 (en) 2007-07-26
US7098031B2 (en) 2006-08-29
EP1427828A2 (en) 2004-06-16
DK1427828T3 (da) 2010-07-19
DE60236182D1 (de) 2010-06-10
US20030106077A1 (en) 2003-06-05
EP1427828B1 (en) 2010-04-28
WO2003025183A3 (en) 2003-08-28
AU2002333832B9 (en) 2003-04-01
JP2005503161A (ja) 2005-02-03
WO2003025183A2 (en) 2003-03-27
ES2342159T3 (es) 2010-07-02

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