JP2005503161A5 - - Google Patents
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- Publication number
- JP2005503161A5 JP2005503161A5 JP2003529956A JP2003529956A JP2005503161A5 JP 2005503161 A5 JP2005503161 A5 JP 2005503161A5 JP 2003529956 A JP2003529956 A JP 2003529956A JP 2003529956 A JP2003529956 A JP 2003529956A JP 2005503161 A5 JP2005503161 A5 JP 2005503161A5
- Authority
- JP
- Japan
- Prior art keywords
- host cell
- polynucleotide
- composition
- vector
- endonuclease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 34
- 210000004027 cell Anatomy 0.000 claims 30
- 238000003776 cleavage reaction Methods 0.000 claims 14
- 108091033319 polynucleotide Proteins 0.000 claims 14
- 102000040430 polynucleotide Human genes 0.000 claims 14
- 239000002157 polynucleotide Substances 0.000 claims 14
- 230000007017 scission Effects 0.000 claims 14
- 102000004533 Endonucleases Human genes 0.000 claims 10
- 108010042407 Endonucleases Proteins 0.000 claims 10
- 230000009261 transgenic effect Effects 0.000 claims 9
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 241001465754 Metazoa Species 0.000 claims 7
- 235000013601 eggs Nutrition 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 241000196324 Embryophyta Species 0.000 claims 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims 2
- 230000006801 homologous recombination Effects 0.000 claims 2
- 238000002744 homologous recombination Methods 0.000 claims 2
- 230000010354 integration Effects 0.000 claims 2
- 210000001161 mammalian embryo Anatomy 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 239000013612 plasmid Substances 0.000 claims 2
- 230000035935 pregnancy Effects 0.000 claims 2
- 210000001082 somatic cell Anatomy 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 241000251468 Actinopterygii Species 0.000 claims 1
- 241000252492 Astyanax Species 0.000 claims 1
- 241000283690 Bos taurus Species 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- 241000252212 Danio rerio Species 0.000 claims 1
- 241000195955 Equisetum hyemale Species 0.000 claims 1
- 241000287828 Gallus gallus Species 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 241000270322 Lepidosauria Species 0.000 claims 1
- 241000699666 Mus <mouse, genus> Species 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 241000276569 Oryzias latipes Species 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 108700019146 Transgenes Proteins 0.000 claims 1
- 241000269370 Xenopus <genus> Species 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 239000012620 biological material Substances 0.000 claims 1
- 210000001109 blastomere Anatomy 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000004602 germ cell Anatomy 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31881801P | 2001-09-14 | 2001-09-14 | |
| US33063901P | 2001-10-26 | 2001-10-26 | |
| PCT/EP2002/010224 WO2003025183A2 (en) | 2001-09-14 | 2002-09-12 | Random integration of a polynucleotide after in vivo linearization |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005503161A JP2005503161A (ja) | 2005-02-03 |
| JP2005503161A5 true JP2005503161A5 (enExample) | 2006-01-05 |
| JP4436130B2 JP4436130B2 (ja) | 2010-03-24 |
Family
ID=26981685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003529956A Expired - Lifetime JP4436130B2 (ja) | 2001-09-14 | 2002-09-12 | インビトロ直鎖化によるポリヌクレオチドのランダム組込 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7098031B2 (enExample) |
| EP (1) | EP1427828B1 (enExample) |
| JP (1) | JP4436130B2 (enExample) |
| AT (1) | ATE466088T1 (enExample) |
| AU (1) | AU2002333832B2 (enExample) |
| DE (1) | DE60236182D1 (enExample) |
| DK (1) | DK1427828T3 (enExample) |
| ES (1) | ES2342159T3 (enExample) |
| WO (1) | WO2003025183A2 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE401410T1 (de) * | 1997-11-18 | 2008-08-15 | Pioneer Hi Bred Int | Zusammensetzungen und verfahren für die genetische modifizierung von pflanzen |
| US7102055B1 (en) * | 1997-11-18 | 2006-09-05 | Pioneer Hi-Bred International, Inc. | Compositions and methods for the targeted insertion of a nucleotide sequence of interest into the genome of a plant |
| CA2360878A1 (en) * | 1999-02-03 | 2000-08-10 | The Children's Medical Center Corporation | Gene repair involving excision of targeting dna |
| WO2003038049A2 (en) | 2001-10-29 | 2003-05-08 | Renovis, Inc. | Method for isolating cell-type specific mrnas |
| FR2879622B1 (fr) * | 2004-12-17 | 2008-02-01 | Agronomique Inst Nat Rech | Procede in vitro de production d'ovocytes ou d'oeufs presentant une modification genomique ciblee |
| WO2006074956A1 (en) * | 2005-01-14 | 2006-07-20 | Bayer Bioscience N.V. | Improved plant transformation methods |
| CA2615797C (en) | 2005-07-18 | 2014-04-29 | Pioneer Hi-Bred International, Inc. | Modified frt recombination sites and methods of use |
| US7663019B2 (en) | 2006-05-24 | 2010-02-16 | North Carolina State University | Transgenic snakes and methods of making |
| EP2602323B1 (en) | 2007-06-01 | 2018-02-28 | Open Monoclonal Technology, Inc. | Compositions and methods for inhibiting endogenous immunoglobin genes and producing transgenic human idiotype antibodies |
| WO2009006297A2 (en) | 2007-06-29 | 2009-01-08 | Pioneer Hi-Bred International, Inc. | Methods for altering the genome of a monocot plant cell |
| WO2009114321A2 (en) | 2008-03-11 | 2009-09-17 | Precision Biosciencs, Inc. | Rationally-designed meganucleases for maize genome engineering |
| WO2009114185A2 (en) | 2008-03-12 | 2009-09-17 | The Rockefeller University | Methods and compositions for translational profiling and molecular phenotyping |
| JP2011519558A (ja) * | 2008-04-28 | 2011-07-14 | プレシジョン バイオサイエンシズ，インク． | 合理的に設計されたｄｎａ結合タンパク質とエフェクタードメインとの融合分子 |
| CN103025866A (zh) | 2010-03-22 | 2013-04-03 | 菲利普莫里斯生产公司 | 修饰植物中酶的活性 |
| AR085302A1 (es) | 2011-02-24 | 2013-09-18 | Sanofi Sa | Metodo de produccion de anticuerpos sialilados |
| CA2865097A1 (en) * | 2012-02-20 | 2013-08-29 | Advanced Tactical Ordnance LLC | Chimeric dna identifier |
| AU2013274542B2 (en) | 2012-06-12 | 2017-03-30 | Syngenta Crop Protection Ag | Methods and compositions for determination of vector backbone in a nucleic acid sample |
| WO2014083379A1 (en) | 2012-11-30 | 2014-06-05 | Institut Pasteur | Use of anti-fcyri and/or anti-fcyriia antibodies for treating arthritis, inflammation, thrombocytopenia and allergic shock |
| WO2016097420A1 (en) | 2014-12-19 | 2016-06-23 | Universite De Nantes | Anti il-34 antibodies |
| USD765215S1 (en) | 2015-01-22 | 2016-08-30 | United Tactical Systems, Llc | Non-lethal projectile |
| US9766049B2 (en) | 2015-01-27 | 2017-09-19 | United Tactical Systems, Llc | Aerodynamic projectile |
| EP3427055A1 (en) | 2016-03-07 | 2019-01-16 | Pierre Fabre Medicament | A new universal method to capture and analyze adcs for characterization of drug distribution and the drug-to-antibody ratio in biological samples |
| SG10202109874VA (en) | 2017-01-19 | 2021-10-28 | Open Monoclonal Tech Inc | Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci |
| CN107372348A (zh) * | 2017-08-31 | 2017-11-24 | 广西沙田仙人滩农业投资有限公司 | 一种绿壳蛋鸡育虫生态养殖方法 |
| PL3720879T3 (pl) | 2017-12-05 | 2022-09-12 | Progastrine Et Cancers S.À R.L. | Terapia skojarzona przeciwciałami przeciwko progastynie i immunoterapią w leczeniu nowotworu |
| KR102699073B1 (ko) | 2018-02-27 | 2024-08-26 | 이씨에스-프로가스트린 에스에이 | 면역치료요법용 생체표지자로서 프로가스트린 |
| CN118994395A (zh) | 2018-07-20 | 2024-11-22 | 皮埃尔法布雷医药公司 | Vista受体 |
| US20210277421A1 (en) * | 2018-08-06 | 2021-09-09 | NemaMetrix, Inc | Homologous Recombination Reporter Construct and Uses Thereof |
| EP3856229A1 (en) | 2018-09-28 | 2021-08-04 | Pierre Fabre Medicament | New immunocytokines for the treatment of cancer |
| MX2022002672A (es) | 2019-09-04 | 2022-06-16 | Y Biologics Inc | Anticuerpo anti-vsig4 o fragmento de union a antigeno y usos del mismo. |
| EP4073117A1 (en) | 2019-12-10 | 2022-10-19 | Institut Pasteur | New antibody blocking human fcgriiia and fcgriiib |
| EP3889183A1 (en) | 2020-04-01 | 2021-10-06 | Pierre Fabre Medicament | A protein complex comprising an immunocytokine |
| KR20230156727A (ko) | 2021-03-03 | 2023-11-14 | 피에르 파브르 메디카먼트 | 항-vsig4 항체 또는 이의 항원 결합 단편 및 용도 |
| CA3218086A1 (en) | 2021-04-30 | 2022-11-03 | Pierre Fabre Medicament | New stable anti-vista antibody |
| WO2023213814A1 (en) | 2022-05-02 | 2023-11-09 | Pierre Fabre Medicament | New formulation of anti vista antibody |
| WO2024121380A1 (en) | 2022-12-08 | 2024-06-13 | Pierre Fabre Medicament | Vaccinal composition and adjuvant |
| WO2024209089A1 (en) | 2023-04-07 | 2024-10-10 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Use of antibody against the endothelin receptor b for diagnostic and therapeutic applications |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5474896A (en) * | 1992-05-05 | 1995-12-12 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
| US5792632A (en) * | 1992-05-05 | 1998-08-11 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
-
2002
- 2002-09-12 DK DK02798716.3T patent/DK1427828T3/da active
- 2002-09-12 AT AT02798716T patent/ATE466088T1/de active
- 2002-09-12 DE DE60236182T patent/DE60236182D1/de not_active Expired - Lifetime
- 2002-09-12 ES ES02798716T patent/ES2342159T3/es not_active Expired - Lifetime
- 2002-09-12 AU AU2002333832A patent/AU2002333832B2/en not_active Expired
- 2002-09-12 WO PCT/EP2002/010224 patent/WO2003025183A2/en not_active Ceased
- 2002-09-12 JP JP2003529956A patent/JP4436130B2/ja not_active Expired - Lifetime
- 2002-09-12 EP EP02798716A patent/EP1427828B1/en not_active Expired - Lifetime
- 2002-09-13 US US10/242,664 patent/US7098031B2/en not_active Expired - Lifetime
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