DE60236182D1 - Zufällige integration von polynukleotide nach in vivo linearisierung - Google Patents
Zufällige integration von polynukleotide nach in vivo linearisierungInfo
- Publication number
- DE60236182D1 DE60236182D1 DE60236182T DE60236182T DE60236182D1 DE 60236182 D1 DE60236182 D1 DE 60236182D1 DE 60236182 T DE60236182 T DE 60236182T DE 60236182 T DE60236182 T DE 60236182T DE 60236182 D1 DE60236182 D1 DE 60236182D1
- Authority
- DE
- Germany
- Prior art keywords
- polynucleotide
- present
- vector
- host cell
- cleavage site
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000040430 polynucleotide Human genes 0.000 title abstract 4
- 108091033319 polynucleotide Proteins 0.000 title abstract 4
- 239000002157 polynucleotide Substances 0.000 title abstract 4
- 230000010354 integration Effects 0.000 title 1
- 238000003776 cleavage reaction Methods 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000007017 scission Effects 0.000 abstract 2
- 230000009261 transgenic effect Effects 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000012620 biological material Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Environmental Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Husbandry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31881801P | 2001-09-14 | 2001-09-14 | |
| US33063901P | 2001-10-26 | 2001-10-26 | |
| PCT/EP2002/010224 WO2003025183A2 (en) | 2001-09-14 | 2002-09-12 | Random integration of a polynucleotide after in vivo linearization |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60236182D1 true DE60236182D1 (de) | 2010-06-10 |
Family
ID=26981685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60236182T Expired - Lifetime DE60236182D1 (de) | 2001-09-14 | 2002-09-12 | Zufällige integration von polynukleotide nach in vivo linearisierung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7098031B2 (enExample) |
| EP (1) | EP1427828B1 (enExample) |
| JP (1) | JP4436130B2 (enExample) |
| AT (1) | ATE466088T1 (enExample) |
| AU (1) | AU2002333832B2 (enExample) |
| DE (1) | DE60236182D1 (enExample) |
| DK (1) | DK1427828T3 (enExample) |
| ES (1) | ES2342159T3 (enExample) |
| WO (1) | WO2003025183A2 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE401410T1 (de) * | 1997-11-18 | 2008-08-15 | Pioneer Hi Bred Int | Zusammensetzungen und verfahren für die genetische modifizierung von pflanzen |
| US7102055B1 (en) * | 1997-11-18 | 2006-09-05 | Pioneer Hi-Bred International, Inc. | Compositions and methods for the targeted insertion of a nucleotide sequence of interest into the genome of a plant |
| CA2360878A1 (en) * | 1999-02-03 | 2000-08-10 | The Children's Medical Center Corporation | Gene repair involving excision of targeting dna |
| WO2003038049A2 (en) | 2001-10-29 | 2003-05-08 | Renovis, Inc. | Method for isolating cell-type specific mrnas |
| FR2879622B1 (fr) * | 2004-12-17 | 2008-02-01 | Agronomique Inst Nat Rech | Procede in vitro de production d'ovocytes ou d'oeufs presentant une modification genomique ciblee |
| WO2006074956A1 (en) * | 2005-01-14 | 2006-07-20 | Bayer Bioscience N.V. | Improved plant transformation methods |
| CA2615797C (en) | 2005-07-18 | 2014-04-29 | Pioneer Hi-Bred International, Inc. | Modified frt recombination sites and methods of use |
| US7663019B2 (en) | 2006-05-24 | 2010-02-16 | North Carolina State University | Transgenic snakes and methods of making |
| EP2602323B1 (en) | 2007-06-01 | 2018-02-28 | Open Monoclonal Technology, Inc. | Compositions and methods for inhibiting endogenous immunoglobin genes and producing transgenic human idiotype antibodies |
| WO2009006297A2 (en) | 2007-06-29 | 2009-01-08 | Pioneer Hi-Bred International, Inc. | Methods for altering the genome of a monocot plant cell |
| WO2009114321A2 (en) | 2008-03-11 | 2009-09-17 | Precision Biosciencs, Inc. | Rationally-designed meganucleases for maize genome engineering |
| WO2009114185A2 (en) | 2008-03-12 | 2009-09-17 | The Rockefeller University | Methods and compositions for translational profiling and molecular phenotyping |
| JP2011519558A (ja) * | 2008-04-28 | 2011-07-14 | プレシジョン バイオサイエンシズ，インク． | 合理的に設計されたｄｎａ結合タンパク質とエフェクタードメインとの融合分子 |
| CN103025866A (zh) | 2010-03-22 | 2013-04-03 | 菲利普莫里斯生产公司 | 修饰植物中酶的活性 |
| AR085302A1 (es) | 2011-02-24 | 2013-09-18 | Sanofi Sa | Metodo de produccion de anticuerpos sialilados |
| CA2865097A1 (en) * | 2012-02-20 | 2013-08-29 | Advanced Tactical Ordnance LLC | Chimeric dna identifier |
| AU2013274542B2 (en) | 2012-06-12 | 2017-03-30 | Syngenta Crop Protection Ag | Methods and compositions for determination of vector backbone in a nucleic acid sample |
| WO2014083379A1 (en) | 2012-11-30 | 2014-06-05 | Institut Pasteur | Use of anti-fcyri and/or anti-fcyriia antibodies for treating arthritis, inflammation, thrombocytopenia and allergic shock |
| WO2016097420A1 (en) | 2014-12-19 | 2016-06-23 | Universite De Nantes | Anti il-34 antibodies |
| USD765215S1 (en) | 2015-01-22 | 2016-08-30 | United Tactical Systems, Llc | Non-lethal projectile |
| US9766049B2 (en) | 2015-01-27 | 2017-09-19 | United Tactical Systems, Llc | Aerodynamic projectile |
| EP3427055A1 (en) | 2016-03-07 | 2019-01-16 | Pierre Fabre Medicament | A new universal method to capture and analyze adcs for characterization of drug distribution and the drug-to-antibody ratio in biological samples |
| SG10202109874VA (en) | 2017-01-19 | 2021-10-28 | Open Monoclonal Tech Inc | Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci |
| CN107372348A (zh) * | 2017-08-31 | 2017-11-24 | 广西沙田仙人滩农业投资有限公司 | 一种绿壳蛋鸡育虫生态养殖方法 |
| PL3720879T3 (pl) | 2017-12-05 | 2022-09-12 | Progastrine Et Cancers S.À R.L. | Terapia skojarzona przeciwciałami przeciwko progastynie i immunoterapią w leczeniu nowotworu |
| KR102699073B1 (ko) | 2018-02-27 | 2024-08-26 | 이씨에스-프로가스트린 에스에이 | 면역치료요법용 생체표지자로서 프로가스트린 |
| CN118994395A (zh) | 2018-07-20 | 2024-11-22 | 皮埃尔法布雷医药公司 | Vista受体 |
| US20210277421A1 (en) * | 2018-08-06 | 2021-09-09 | NemaMetrix, Inc | Homologous Recombination Reporter Construct and Uses Thereof |
| EP3856229A1 (en) | 2018-09-28 | 2021-08-04 | Pierre Fabre Medicament | New immunocytokines for the treatment of cancer |
| MX2022002672A (es) | 2019-09-04 | 2022-06-16 | Y Biologics Inc | Anticuerpo anti-vsig4 o fragmento de union a antigeno y usos del mismo. |
| EP4073117A1 (en) | 2019-12-10 | 2022-10-19 | Institut Pasteur | New antibody blocking human fcgriiia and fcgriiib |
| EP3889183A1 (en) | 2020-04-01 | 2021-10-06 | Pierre Fabre Medicament | A protein complex comprising an immunocytokine |
| KR20230156727A (ko) | 2021-03-03 | 2023-11-14 | 피에르 파브르 메디카먼트 | 항-vsig4 항체 또는 이의 항원 결합 단편 및 용도 |
| CA3218086A1 (en) | 2021-04-30 | 2022-11-03 | Pierre Fabre Medicament | New stable anti-vista antibody |
| WO2023213814A1 (en) | 2022-05-02 | 2023-11-09 | Pierre Fabre Medicament | New formulation of anti vista antibody |
| WO2024121380A1 (en) | 2022-12-08 | 2024-06-13 | Pierre Fabre Medicament | Vaccinal composition and adjuvant |
| WO2024209089A1 (en) | 2023-04-07 | 2024-10-10 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Use of antibody against the endothelin receptor b for diagnostic and therapeutic applications |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5474896A (en) * | 1992-05-05 | 1995-12-12 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
| US5792632A (en) * | 1992-05-05 | 1998-08-11 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
-
2002
- 2002-09-12 DK DK02798716.3T patent/DK1427828T3/da active
- 2002-09-12 AT AT02798716T patent/ATE466088T1/de active
- 2002-09-12 DE DE60236182T patent/DE60236182D1/de not_active Expired - Lifetime
- 2002-09-12 ES ES02798716T patent/ES2342159T3/es not_active Expired - Lifetime
- 2002-09-12 AU AU2002333832A patent/AU2002333832B2/en not_active Expired
- 2002-09-12 WO PCT/EP2002/010224 patent/WO2003025183A2/en not_active Ceased
- 2002-09-12 JP JP2003529956A patent/JP4436130B2/ja not_active Expired - Lifetime
- 2002-09-12 EP EP02798716A patent/EP1427828B1/en not_active Expired - Lifetime
- 2002-09-13 US US10/242,664 patent/US7098031B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE466088T1 (de) | 2010-05-15 |
| AU2002333832B2 (en) | 2007-07-26 |
| US7098031B2 (en) | 2006-08-29 |
| EP1427828A2 (en) | 2004-06-16 |
| DK1427828T3 (da) | 2010-07-19 |
| US20030106077A1 (en) | 2003-06-05 |
| EP1427828B1 (en) | 2010-04-28 |
| WO2003025183A3 (en) | 2003-08-28 |
| AU2002333832B9 (en) | 2003-04-01 |
| JP4436130B2 (ja) | 2010-03-24 |
| JP2005503161A (ja) | 2005-02-03 |
| WO2003025183A2 (en) | 2003-03-27 |
| ES2342159T3 (es) | 2010-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |