DK1427828T3 - Tilfældig integration af et polynucleotid efter in vivo-linearisering - Google Patents

Tilfældig integration af et polynucleotid efter in vivo-linearisering

Info

Publication number
DK1427828T3
DK1427828T3 DK02798716.3T DK02798716T DK1427828T3 DK 1427828 T3 DK1427828 T3 DK 1427828T3 DK 02798716 T DK02798716 T DK 02798716T DK 1427828 T3 DK1427828 T3 DK 1427828T3
Authority
DK
Denmark
Prior art keywords
polynucleotide
present
random integration
vector
host cell
Prior art date
Application number
DK02798716.3T
Other languages
English (en)
Inventor
Andre Choulika
Jean-Stephane Joly
Violette Thermes
Filomena Ristoratore
Original Assignee
Cellectis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellectis filed Critical Cellectis
Application granted granted Critical
Publication of DK1427828T3 publication Critical patent/DK1427828T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
DK02798716.3T 2001-09-14 2002-09-12 Tilfældig integration af et polynucleotid efter in vivo-linearisering DK1427828T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31881801P 2001-09-14 2001-09-14
US33063901P 2001-10-26 2001-10-26
PCT/EP2002/010224 WO2003025183A2 (en) 2001-09-14 2002-09-12 Random integration of a polynucleotide after in vivo linearization

Publications (1)

Publication Number Publication Date
DK1427828T3 true DK1427828T3 (da) 2010-07-19

Family

ID=26981685

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02798716.3T DK1427828T3 (da) 2001-09-14 2002-09-12 Tilfældig integration af et polynucleotid efter in vivo-linearisering

Country Status (9)

Country Link
US (1) US7098031B2 (da)
EP (1) EP1427828B1 (da)
JP (1) JP4436130B2 (da)
AT (1) ATE466088T1 (da)
AU (1) AU2002333832B2 (da)
DE (1) DE60236182D1 (da)
DK (1) DK1427828T3 (da)
ES (1) ES2342159T3 (da)
WO (1) WO2003025183A2 (da)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999025821A1 (en) * 1997-11-18 1999-05-27 Pioneer Hi-Bred International, Inc. Compositions and methods for genetic modification of plants
US7102055B1 (en) * 1997-11-18 2006-09-05 Pioneer Hi-Bred International, Inc. Compositions and methods for the targeted insertion of a nucleotide sequence of interest into the genome of a plant
CA2360878A1 (en) * 1999-02-03 2000-08-10 The Children's Medical Center Corporation Gene repair involving excision of targeting dna
AU2002350039A1 (en) * 2001-10-29 2003-05-12 Renovis, Inc. Method for isolating cell-type specific mrnas
FR2879622B1 (fr) * 2004-12-17 2008-02-01 Agronomique Inst Nat Rech Procede in vitro de production d'ovocytes ou d'oeufs presentant une modification genomique ciblee
WO2006074956A1 (en) * 2005-01-14 2006-07-20 Bayer Bioscience N.V. Improved plant transformation methods
US7736897B2 (en) * 2005-07-18 2010-06-15 Pioneer Hi-Bred International, Inc. FRT recombination sites and methods of use
US7663019B2 (en) 2006-05-24 2010-02-16 North Carolina State University Transgenic snakes and methods of making
KR101661357B1 (ko) 2007-06-01 2016-09-29 오픈 모노클로날 테크놀로지, 인코포레이티드 내생적 면역글로불린 유전자를 억제하고 트랜스제닉 인간 이디오타입 항체를 생산하기 위한 방법 및 조성물
CA2691440A1 (en) 2007-06-29 2009-01-08 Pioneer Hi-Bred International, Inc. Methods for altering the genome of a monocot plant cell
WO2009114321A2 (en) 2008-03-11 2009-09-17 Precision Biosciencs, Inc. Rationally-designed meganucleases for maize genome engineering
US20110071049A1 (en) * 2008-03-12 2011-03-24 Nathaniel Heintz Methods and compositions for translational profiling and molecular phenotyping
JP2011519558A (ja) * 2008-04-28 2011-07-14 プレシジョン バイオサイエンシズ，インク． 合理的に設計されたｄｎａ結合タンパク質とエフェクタードメインとの融合分子
US20130198897A1 (en) 2010-03-22 2013-08-01 Philip Morris Products S.A. Modifying enzyme activity in plants
AR085302A1 (es) 2011-02-24 2013-09-18 Sanofi Sa Metodo de produccion de anticuerpos sialilados
WO2013126412A1 (en) * 2012-02-20 2013-08-29 Advanced Tactical Ordnance LLC Chimeric dna identifier
AU2013274542B2 (en) 2012-06-12 2017-03-30 Syngenta Participations Ag Methods and compositions for determination of vector backbone in a nucleic acid sample
EP2925779A1 (en) 2012-11-30 2015-10-07 Institut Pasteur Use of anti-fcyri and/or anti-fcyriia antibodies for treating arthritis, inflammation, thrombocytopenia and allergic shock
ES2870983T3 (es) 2014-12-19 2021-10-28 Univ Nantes Anticuerpos anti-IL-34
USD765215S1 (en) 2015-01-22 2016-08-30 United Tactical Systems, Llc Non-lethal projectile
US9766049B2 (en) 2015-01-27 2017-09-19 United Tactical Systems, Llc Aerodynamic projectile
US11340233B2 (en) 2016-03-07 2022-05-24 Pierre Fabre Medicament Universal method to capture and analyze ADCs for characterization of drug distribution and the drug-to-antibody ratio in biological samples
CN107372348A (zh) * 2017-08-31 2017-11-24 广西沙田仙人滩农业投资有限公司 一种绿壳蛋鸡育虫生态养殖方法
CA3084687C (en) 2017-12-05 2024-01-02 Progastrine Et Cancers S.A R.L. Combination therapy between anti-progastrin antibody and immunotherapy to treat cancer
KR20200144541A (ko) 2018-02-27 2020-12-29 이씨에스-프로가스트린 에스에이 면역치료요법용 생체표지자로서 프로가스트린
EP3824287A1 (en) 2018-07-20 2021-05-26 Pierre Fabre Médicament Receptor for vista
US20210277421A1 (en) * 2018-08-06 2021-09-09 NemaMetrix, Inc Homologous Recombination Reporter Construct and Uses Thereof
BR112021005665A2 (pt) 2018-09-28 2021-06-22 Pierre Fabre Medicament novas imunocitocinas para o tratamento de câncer
EP4025606A1 (en) 2019-09-04 2022-07-13 Y-Biologics Inc. Anti-vsig4 antibody or antigen binding fragment and uses thereof
US20230227559A1 (en) 2019-12-10 2023-07-20 Institut Pasteur New antibody blocking human fcgriiia and fcgriiib
EP3889183A1 (en) 2020-04-01 2021-10-06 Pierre Fabre Medicament A protein complex comprising an immunocytokine
WO2022184853A1 (en) 2021-03-03 2022-09-09 Pierre Fabre Medicament Anti-vsig4 antibody or antigen binding fragment and uses thereof
TW202309088A (zh) 2021-04-30 2023-03-01 法商皮爾法伯製藥公司 新的穩定抗ｖｉｓｔａ抗體
WO2023213814A1 (en) 2022-05-02 2023-11-09 Pierre Fabre Medicament New formulation of anti vista antibody

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474896A (en) * 1992-05-05 1995-12-12 Institut Pasteur Nucleotide sequence encoding the enzyme I-SceI and the uses thereof
US5792632A (en) * 1992-05-05 1998-08-11 Institut Pasteur Nucleotide sequence encoding the enzyme I-SceI and the uses thereof

Also Published As

Publication number Publication date
ATE466088T1 (de) 2010-05-15
JP4436130B2 (ja) 2010-03-24
EP1427828B1 (en) 2010-04-28
WO2003025183A2 (en) 2003-03-27
AU2002333832B9 (en) 2003-04-01
AU2002333832B2 (en) 2007-07-26
EP1427828A2 (en) 2004-06-16
US20030106077A1 (en) 2003-06-05
ES2342159T3 (es) 2010-07-02
WO2003025183A3 (en) 2003-08-28
JP2005503161A (ja) 2005-02-03
US7098031B2 (en) 2006-08-29
DE60236182D1 (de) 2010-06-10

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