ATE466088T1 - Zufällige integration von polynukleotide nach in vivo linearisierung - Google Patents

Zufällige integration von polynukleotide nach in vivo linearisierung

Info

Publication number
ATE466088T1
ATE466088T1 AT02798716T AT02798716T ATE466088T1 AT E466088 T1 ATE466088 T1 AT E466088T1 AT 02798716 T AT02798716 T AT 02798716T AT 02798716 T AT02798716 T AT 02798716T AT E466088 T1 ATE466088 T1 AT E466088T1
Authority
AT
Austria
Prior art keywords
present
polynucleotides
random integration
vector
polynucleotide
Prior art date
Application number
AT02798716T
Other languages
German (de)
English (en)
Inventor
Andre Choulika
Jean-Stephane Joly
Violette Thermes
Filomena Ristoratore
Original Assignee
Cellectis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellectis filed Critical Cellectis
Application granted granted Critical
Publication of ATE466088T1 publication Critical patent/ATE466088T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Husbandry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT02798716T 2001-09-14 2002-09-12 Zufällige integration von polynukleotide nach in vivo linearisierung ATE466088T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31881801P 2001-09-14 2001-09-14
US33063901P 2001-10-26 2001-10-26
PCT/EP2002/010224 WO2003025183A2 (en) 2001-09-14 2002-09-12 Random integration of a polynucleotide after in vivo linearization

Publications (1)

Publication Number Publication Date
ATE466088T1 true ATE466088T1 (de) 2010-05-15

Family

ID=26981685

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02798716T ATE466088T1 (de) 2001-09-14 2002-09-12 Zufällige integration von polynukleotide nach in vivo linearisierung

Country Status (9)

Country Link
US (1) US7098031B2 (enExample)
EP (1) EP1427828B1 (enExample)
JP (1) JP4436130B2 (enExample)
AT (1) ATE466088T1 (enExample)
AU (1) AU2002333832B2 (enExample)
DE (1) DE60236182D1 (enExample)
DK (1) DK1427828T3 (enExample)
ES (1) ES2342159T3 (enExample)
WO (1) WO2003025183A2 (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE401410T1 (de) * 1997-11-18 2008-08-15 Pioneer Hi Bred Int Zusammensetzungen und verfahren für die genetische modifizierung von pflanzen
US7102055B1 (en) * 1997-11-18 2006-09-05 Pioneer Hi-Bred International, Inc. Compositions and methods for the targeted insertion of a nucleotide sequence of interest into the genome of a plant
CA2360878A1 (en) * 1999-02-03 2000-08-10 The Children's Medical Center Corporation Gene repair involving excision of targeting dna
WO2003038049A2 (en) 2001-10-29 2003-05-08 Renovis, Inc. Method for isolating cell-type specific mrnas
FR2879622B1 (fr) * 2004-12-17 2008-02-01 Agronomique Inst Nat Rech Procede in vitro de production d'ovocytes ou d'oeufs presentant une modification genomique ciblee
WO2006074956A1 (en) * 2005-01-14 2006-07-20 Bayer Bioscience N.V. Improved plant transformation methods
CA2615797C (en) 2005-07-18 2014-04-29 Pioneer Hi-Bred International, Inc. Modified frt recombination sites and methods of use
US7663019B2 (en) 2006-05-24 2010-02-16 North Carolina State University Transgenic snakes and methods of making
EP2602323B1 (en) 2007-06-01 2018-02-28 Open Monoclonal Technology, Inc. Compositions and methods for inhibiting endogenous immunoglobin genes and producing transgenic human idiotype antibodies
WO2009006297A2 (en) 2007-06-29 2009-01-08 Pioneer Hi-Bred International, Inc. Methods for altering the genome of a monocot plant cell
WO2009114321A2 (en) 2008-03-11 2009-09-17 Precision Biosciencs, Inc. Rationally-designed meganucleases for maize genome engineering
WO2009114185A2 (en) 2008-03-12 2009-09-17 The Rockefeller University Methods and compositions for translational profiling and molecular phenotyping
JP2011519558A (ja) * 2008-04-28 2011-07-14 プレシジョン バイオサイエンシズ，インク． 合理的に設計されたｄｎａ結合タンパク質とエフェクタードメインとの融合分子
CN103025866A (zh) 2010-03-22 2013-04-03 菲利普莫里斯生产公司 修饰植物中酶的活性
AR085302A1 (es) 2011-02-24 2013-09-18 Sanofi Sa Metodo de produccion de anticuerpos sialilados
CA2865097A1 (en) * 2012-02-20 2013-08-29 Advanced Tactical Ordnance LLC Chimeric dna identifier
AU2013274542B2 (en) 2012-06-12 2017-03-30 Syngenta Crop Protection Ag Methods and compositions for determination of vector backbone in a nucleic acid sample
WO2014083379A1 (en) 2012-11-30 2014-06-05 Institut Pasteur Use of anti-fcyri and/or anti-fcyriia antibodies for treating arthritis, inflammation, thrombocytopenia and allergic shock
WO2016097420A1 (en) 2014-12-19 2016-06-23 Universite De Nantes Anti il-34 antibodies
USD765215S1 (en) 2015-01-22 2016-08-30 United Tactical Systems, Llc Non-lethal projectile
US9766049B2 (en) 2015-01-27 2017-09-19 United Tactical Systems, Llc Aerodynamic projectile
EP3427055A1 (en) 2016-03-07 2019-01-16 Pierre Fabre Medicament A new universal method to capture and analyze adcs for characterization of drug distribution and the drug-to-antibody ratio in biological samples
SG10202109874VA (en) 2017-01-19 2021-10-28 Open Monoclonal Tech Inc Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci
CN107372348A (zh) * 2017-08-31 2017-11-24 广西沙田仙人滩农业投资有限公司 一种绿壳蛋鸡育虫生态养殖方法
PL3720879T3 (pl) 2017-12-05 2022-09-12 Progastrine Et Cancers S.À R.L. Terapia skojarzona przeciwciałami przeciwko progastynie i immunoterapią w leczeniu nowotworu
KR102699073B1 (ko) 2018-02-27 2024-08-26 이씨에스-프로가스트린 에스에이 면역치료요법용 생체표지자로서 프로가스트린
CN118994395A (zh) 2018-07-20 2024-11-22 皮埃尔法布雷医药公司 Vista受体
US20210277421A1 (en) * 2018-08-06 2021-09-09 NemaMetrix, Inc Homologous Recombination Reporter Construct and Uses Thereof
EP3856229A1 (en) 2018-09-28 2021-08-04 Pierre Fabre Medicament New immunocytokines for the treatment of cancer
MX2022002672A (es) 2019-09-04 2022-06-16 Y Biologics Inc Anticuerpo anti-vsig4 o fragmento de union a antigeno y usos del mismo.
EP4073117A1 (en) 2019-12-10 2022-10-19 Institut Pasteur New antibody blocking human fcgriiia and fcgriiib
EP3889183A1 (en) 2020-04-01 2021-10-06 Pierre Fabre Medicament A protein complex comprising an immunocytokine
KR20230156727A (ko) 2021-03-03 2023-11-14 피에르 파브르 메디카먼트 항-vsig4 항체 또는 이의 항원 결합 단편 및 용도
CA3218086A1 (en) 2021-04-30 2022-11-03 Pierre Fabre Medicament New stable anti-vista antibody
WO2023213814A1 (en) 2022-05-02 2023-11-09 Pierre Fabre Medicament New formulation of anti vista antibody
WO2024121380A1 (en) 2022-12-08 2024-06-13 Pierre Fabre Medicament Vaccinal composition and adjuvant
WO2024209089A1 (en) 2023-04-07 2024-10-10 Commissariat A L'energie Atomique Et Aux Energies Alternatives Use of antibody against the endothelin receptor b for diagnostic and therapeutic applications

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474896A (en) * 1992-05-05 1995-12-12 Institut Pasteur Nucleotide sequence encoding the enzyme I-SceI and the uses thereof
US5792632A (en) * 1992-05-05 1998-08-11 Institut Pasteur Nucleotide sequence encoding the enzyme I-SceI and the uses thereof

Also Published As

Publication number Publication date
AU2002333832B2 (en) 2007-07-26
US7098031B2 (en) 2006-08-29
EP1427828A2 (en) 2004-06-16
DK1427828T3 (da) 2010-07-19
DE60236182D1 (de) 2010-06-10
US20030106077A1 (en) 2003-06-05
EP1427828B1 (en) 2010-04-28
WO2003025183A3 (en) 2003-08-28
AU2002333832B9 (en) 2003-04-01
JP4436130B2 (ja) 2010-03-24
JP2005503161A (ja) 2005-02-03
WO2003025183A2 (en) 2003-03-27
ES2342159T3 (es) 2010-07-02

Similar Documents

Publication Publication Date Title
ATE466088T1 (de) Zufällige integration von polynukleotide nach in vivo linearisierung
WO2019103442A3 (ko) CRISPR/Cpf1 시스템을 이용한 유전체 편집용 조성물 및 이의 용도
BR0011499A (pt) Moléculas de ácido nucléico oriundas de plantas e células de,planta transgênicas de trigo e o seu uso para a produção de amido modificado
DE602005027621D1 (de) Verwendung einer Nukleinsäure zur Herstellung einer transgenen Pflanze mit verbesserter Toleranz gegenüber Trockenheit
DE69834908D1 (de) Verfahren zur erhöhung der expression von endogenen oder exogenen genprodukten in pflanzen
AR014155A1 (es) Proteina aislada involucrada en la resistencia a nematodos, secuencia de adn aislada, vector de transformacion, planta, semillas y metodo para aumentarla resistencia a nematodos en una planta
WO2004009761A3 (en) Methods for using artificial polynucleotides and compositions thereof to reduce transgene silencing
EP2169069A3 (en) Phosphatase stress-related proteins and methods of use in plants
ES2246227T8 (es) Moléculas de ácido nucleico que codifican alternansacarasa
DE69636288D1 (de) Samenstrenung resistenz
BR0209745A (pt) Cromossomas artificiais de plantas, usos e dos mesmos e método para preparação de cromossomas artificiais de plantas
BR0009471A (pt) Composições e processos para modificação de transcrição de gene
ATE526818T1 (de) Gentechnisch hergestellte wasserlinse
ATE408698T1 (de) Kommerzielle herstellung von aprotinin in pflanzen
ATE471378T1 (de) Dna-konstrukte und verfahren zur verbesserung der produktion kommerziell realisierbarer transgener pflanzen
NO20020949L (no) Fettsyredesaturasegen fra planter
WO2001081600A3 (en) Transgenic plants
DE60043470D1 (de) Pflanzliche Defensine
AR024934A1 (es) Genes quimericos
AP9901469A0 (en) Protein kinases and uses thereof.
WO2002083867A3 (en) Ires enabled gene trapping in plants
DE10346611A1 (de) Promotor zur epidermisspezifischen Transgenexpression in Pflanzen
AR047590A1 (es) Alteracion de la estructura de la raiz durante el desarrollo de la planta
DE69919186D1 (de) Transgene geminivirus-resistente pflanzen
WO2001064890A3 (en) Novel defense induced genes and uses thereof

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1427828

Country of ref document: EP