JP4409097B2 - 複数の共刺激分子を発現する組換えベクターおよびその利用 - Google Patents

複数の共刺激分子を発現する組換えベクターおよびその利用 Download PDF

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JP4409097B2
JP4409097B2 JP2000586927A JP2000586927A JP4409097B2 JP 4409097 B2 JP4409097 B2 JP 4409097B2 JP 2000586927 A JP2000586927 A JP 2000586927A JP 2000586927 A JP2000586927 A JP 2000586927A JP 4409097 B2 JP4409097 B2 JP 4409097B2
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recombinant
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gene
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JP2002531133A (ja
JP2002531133A5 (enExample
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シュロム，ジェフリー
ホッジ，ジェームズ
パニカリ，デニス
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JP2000586927A 1998-12-09 1999-11-12 複数の共刺激分子を発現する組換えベクターおよびその利用 Expired - Lifetime JP4409097B2 (ja)

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US11158298P 1998-12-09 1998-12-09
US60/111,582 1998-12-09
PCT/US1999/026866 WO2000034494A1 (en) 1998-12-09 1999-11-12 A recombinant vector expressing multiple costimulatory molecules and uses thereof

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JP2002531133A JP2002531133A (ja) 2002-09-24
JP2002531133A5 JP2002531133A5 (enExample) 2005-12-22
JP4409097B2 true JP4409097B2 (ja) 2010-02-03

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JP2000586927A Expired - Lifetime JP4409097B2 (ja) 1998-12-09 1999-11-12 複数の共刺激分子を発現する組換えベクターおよびその利用
JP2009187330A Expired - Lifetime JP5254153B2 (ja) 1998-12-09 2009-08-12 複数の共刺激分子を発現する組換えベクターおよびその利用

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EP (1) EP1137792B9 (enExample)
JP (2) JP4409097B2 (enExample)
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CA (2) CA2678259C (enExample)
CY (1) CY1107698T1 (enExample)
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Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756038B1 (en) * 1997-10-10 2004-06-29 The United States Of America As Represented By The Department Of Health And Human Services Agonist and antagonist peptides of carcinoembryonic antigen (CEA)
WO2002010379A2 (en) * 2000-07-31 2002-02-07 Aventis Pasteur Limited Modified cea and uses thereof
WO2001024832A2 (de) * 1999-09-27 2001-04-12 Gabriele Pecher Pharmazeutische zusammensetzung zur behandlung und prophylaxe von humanen tumoren, die das tumorantigen muzin und/oder das carcinoembryonale antigen (cea) exprimieren und ihre verwendung
CA2388301C (en) * 1999-10-22 2011-01-04 Aventis Pasteur Limited Modified gp100 and uses thereof
US7179462B2 (en) 2000-06-02 2007-02-20 University Of Connecticut Health Center α (2) macroglobulin receptor as a heat shock protein receptor and uses thereof
US7186515B1 (en) 2000-06-02 2007-03-06 University Of Connecticut Health Center Alpha(2) macroglobulin receptor as a heat shock protein receptor and uses thereof
US7449557B2 (en) 2000-06-02 2008-11-11 University Of Connecticut Health Center Complexes of alpha (2) macroglobulin and antigenic molecules for immunotherapy
US7025968B2 (en) 2000-08-30 2006-04-11 Chemocentryx, Inc. CMV vaccines
WO2002027007A2 (en) 2000-09-25 2002-04-04 Regents Of The University Of Michigan Production of viral vectors
CA2437201C (en) 2001-02-02 2008-11-18 Chemocentryx, Inc. Methods and compositions useful for stimulating an immune response
WO2003008537A2 (en) * 2001-04-06 2003-01-30 Mannkind Corporation Epitope sequences
US7414032B2 (en) 2001-06-25 2008-08-19 Immunofrontier, Inc. Vaccine comprising a polynucleotide encoding an antigen recognized by a CD4+ helper T-cell and a polynucleotide encoding a tumor specific or associated antigen recognized by a CD8+ CTL
WO2005035773A2 (en) * 2003-10-08 2005-04-21 Sanofi Pasteur, Inc. Modified cea /b7 vector
JP4914990B2 (ja) 2002-12-16 2012-04-11 グローブイミューン，インコーポレイテッド 動物を癌から守るための治療用組成物
AU2004273034A1 (en) * 2003-09-05 2005-03-24 Sanofi Pasteur Limited Multi-antigen vectors for melanoma
WO2005046622A2 (en) 2003-11-12 2005-05-26 Therion Biologics Corporation Custom vectors for treating and preventing pancreatic cancer
ES2476990T3 (es) * 2003-11-12 2014-07-15 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Sistema para tratar y prevenir cáncer de mama
US20090156519A1 (en) * 2003-12-23 2009-06-18 Aventis Pasteur, Inc. Modified KSA and Uses Thereof
CN1976946A (zh) * 2004-07-03 2007-06-06 财团法人牧岩生命工学研究所 诱导抗hcv有效ctl应答的超型表位、其编码寡核苷酸及其应用
US7785875B2 (en) 2004-07-03 2010-08-31 Mogam Biotechnology Research Institute Polynucleotide encoding HCV epitopes which can bind to various HLA supertypes, immunogenic composition comprising same and method of inducing an HCV-specific immune response using same
ES2313807B1 (es) * 2005-07-30 2009-12-23 Consejo Superior De Investigaciones Cientificas Vectores recombinantes basados en el virus vaccinia modificado de ankara (mva) como vacunas contra la leishmaniasis.
EP1792996A1 (en) * 2005-12-01 2007-06-06 Consejo Superior de Investigaciones Cientificas Nucleic acid sequences encoding vaccines against Porcine reproductive and respiratory syndrome virus (PRRSV)
US8389282B2 (en) * 2007-03-30 2013-03-05 Memorial Sloan-Kettering Cancer Center Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
ES2725450T3 (es) 2007-07-02 2019-09-24 Etubics Corp Métodos y composiciones para la producción de un vector adenoviral para su uso en vacunaciones múltiples
ES2608604T3 (es) * 2007-10-18 2017-04-12 Bavarian Nordic A/S Uso de MVA para tratar el cáncer de próstata
WO2010042433A1 (en) 2008-10-06 2010-04-15 Bristol-Myers Squibb Company Combination of cd137 antibody and ctla-4 antibody for the treatment of proliferative diseases
JP5588990B2 (ja) * 2008-10-31 2014-09-10 トレムアールエックス， インコーポレイテッド 機械的表皮破壊を介したポックスウイルスベクターによるワクチン接種
US8691502B2 (en) 2008-10-31 2014-04-08 Tremrx, Inc. T-cell vaccination with viral vectors via mechanical epidermal disruption
ES2660597T3 (es) 2009-04-17 2018-03-23 Globeimmune, Inc. Composiciones inmunoterápicas de combinación contra el cáncer y métodos
CN109010809A (zh) 2011-08-17 2018-12-18 全球免疫股份有限公司 酵母-muc1免疫治疗组合物及其用途
US9605276B2 (en) 2012-08-24 2017-03-28 Etubics Corporation Replication defective adenovirus vector in vaccination
SG11201510064WA (en) 2013-06-14 2016-01-28 Psioxus Theraupeutics Ltd A dosing regime and formulations for type b adenoviruses
KR102272932B1 (ko) 2013-10-25 2021-07-05 싸이오서스 테라퓨틱스 엘티디. 이종 유전자로 무장된 종양살상 아데노바이러스
ES2895977T3 (es) * 2013-11-28 2022-02-23 Bavarian Nordic As Composiciones y métodos de inducción de una respuesta inmunitaria mejorada usando vectores de poxvirus
JP5917626B2 (ja) * 2014-07-28 2016-05-18 トレムアールエックス， インコーポレイテッド 機械的表皮破壊を介したポックスウイルスベクターによるワクチン接種
AU2016205215B2 (en) 2015-01-09 2021-03-11 Etubics Corporation Methods and compositions for combination immunotherapy
US10695417B2 (en) 2015-01-09 2020-06-30 Etubics Corporation Human adenovirus serotype 5 vectors containing E1 and E2B deletions encoding the ebola virus glycoprotein
US11149087B2 (en) 2015-04-20 2021-10-19 Etubics Corporation Methods and compositions for combination immunotherapy
DK3288573T3 (da) 2015-04-30 2020-03-16 Psioxus Therapeutics Ltd Onkolytisk adenovirus, der koder for et b7-protein
US11155622B2 (en) 2015-12-17 2021-10-26 Psioxus Therapeutics Limited Virus encoding an anti-TCR-complex antibody or fragment
AU2017233072B2 (en) * 2016-03-18 2020-12-24 Nantcell, Inc. Multimodal vector for dendritic cell infection
EP3735984A1 (en) * 2016-05-27 2020-11-11 Etubics Corporation Neoepitope vaccine compositions and methods of use thereof
KR102491752B1 (ko) 2016-08-29 2023-01-26 싸이오서스 테라퓨틱스 엘티디. 이중특이성 T 세포 세포 관여자(BiTE)가 보강된 아데노바이러스
GB201713765D0 (en) 2017-08-28 2017-10-11 Psioxus Therapeutics Ltd Modified adenovirus
CA3092860A1 (en) * 2018-03-06 2019-09-12 Pepvax, Inc. Nucleic acid molecules and methods of using the same
US20210290708A1 (en) 2018-09-21 2021-09-23 Nantcell, Inc. Methods and compositions for modulating myeloid-derived suppressor cells
GB202010095D0 (en) * 2020-07-01 2020-08-12 Tcer Ab Immunotherapy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960701988A (ko) * 1993-04-20 1996-03-28 윌리엄 에스. 로빈슨 세포내 감염원에 감염된 개체의 치료방법 및 치료물질(methods and materials for treatment of individuals infected with intracellular in-fectious agents)
ATE197765T1 (de) * 1994-10-03 2000-12-15 Us Gov Health & Human Serv Zusammensetzung enthaltend ein antigen exprimierendes rekombinantes virus und ein immunstimulierendes molekül exprimierendes rekombinantes virus
EP0954593A1 (en) * 1996-07-25 1999-11-10 Therion Biologics Corporation Recombinant pox virus for immunization against tumor-associated antigens

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CA2354024A1 (en) 2000-06-15
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AU774076B2 (en) 2004-06-17
CA2678259C (en) 2016-10-18
JP5254153B2 (ja) 2013-08-07
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