JP4392240B2 - プローブの完全性を検証するための方法、装置、およびコンピュータプログラム - Google Patents

プローブの完全性を検証するための方法、装置、およびコンピュータプログラム Download PDF

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JP4392240B2
JP4392240B2 JP2003514378A JP2003514378A JP4392240B2 JP 4392240 B2 JP4392240 B2 JP 4392240B2 JP 2003514378 A JP2003514378 A JP 2003514378A JP 2003514378 A JP2003514378 A JP 2003514378A JP 4392240 B2 JP4392240 B2 JP 4392240B2
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probe
temperature
fluorescence
signal
self
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JP2005515404A (ja
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スタンレー エイチ． サカイ
ウィリアム マクミラン
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/20—Polymerase chain reaction [PCR]; Primer or probe design; Probe optimisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

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  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
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  • Molecular Biology (AREA)
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  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
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  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Tests Of Electronic Circuits (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
JP2003514378A 2001-07-16 2002-07-16 プローブの完全性を検証するための方法、装置、およびコンピュータプログラム Expired - Lifetime JP4392240B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/906,897 US7226732B2 (en) 2001-07-16 2001-07-16 Methods, apparatus, and computer programs for verifying the integrity of a probe
PCT/US2002/022728 WO2003009100A2 (en) 2001-07-16 2002-07-16 Methods, apparatuses, and computer programs for verifying the integrity of a probe

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009040061A Division JP5328412B2 (ja) 2001-07-16 2009-02-24 プローブの完全性を検証するための方法、装置、およびコンピュータプログラム

Publications (3)

Publication Number Publication Date
JP2005515404A JP2005515404A (ja) 2005-05-26
JP2005515404A5 JP2005515404A5 (enExample) 2006-01-12
JP4392240B2 true JP4392240B2 (ja) 2009-12-24

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JP2003514378A Expired - Lifetime JP4392240B2 (ja) 2001-07-16 2002-07-16 プローブの完全性を検証するための方法、装置、およびコンピュータプログラム
JP2009040061A Expired - Lifetime JP5328412B2 (ja) 2001-07-16 2009-02-24 プローブの完全性を検証するための方法、装置、およびコンピュータプログラム
JP2013120613A Expired - Lifetime JP5955274B2 (ja) 2001-07-16 2013-06-07 プローブの完全性を検証するための方法、装置、およびコンピュータプログラム
JP2016061354A Expired - Lifetime JP6434930B2 (ja) 2001-07-16 2016-03-25 プローブの完全性を検証するための方法、装置、およびコンピュータプログラム

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JP2009040061A Expired - Lifetime JP5328412B2 (ja) 2001-07-16 2009-02-24 プローブの完全性を検証するための方法、装置、およびコンピュータプログラム
JP2013120613A Expired - Lifetime JP5955274B2 (ja) 2001-07-16 2013-06-07 プローブの完全性を検証するための方法、装置、およびコンピュータプログラム
JP2016061354A Expired - Lifetime JP6434930B2 (ja) 2001-07-16 2016-03-25 プローブの完全性を検証するための方法、装置、およびコンピュータプログラム

Country Status (9)

Country Link
US (3) US7226732B2 (enExample)
EP (1) EP1415152B1 (enExample)
JP (4) JP4392240B2 (enExample)
AT (1) ATE508360T1 (enExample)
AU (1) AU2002355109B2 (enExample)
CA (1) CA2453366C (enExample)
DE (1) DE60239940D1 (enExample)
ES (1) ES2365699T3 (enExample)
WO (1) WO2003009100A2 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7226732B2 (en) 2001-07-16 2007-06-05 Cepheid Methods, apparatus, and computer programs for verifying the integrity of a probe
US20080193961A1 (en) * 2004-09-29 2008-08-14 Easley Christopher J Localized Control of Thermal Properties on Microdevices and Applications Thereof
US8056881B2 (en) 2004-10-13 2011-11-15 University Of Virginia Patent Foundation Electrostatic actuation for management of flow in micro-total analysis systems (μ-TAS) and related method thereof
US8084260B2 (en) * 2004-11-24 2011-12-27 Applied Biosystems, Llc Spectral calibration method and system for multiple instruments
JP4922185B2 (ja) * 2004-12-22 2012-04-25 ユニバーシティ・オブ・ヴァージニア・パテント・ファウンデーション マイクロデバイスまたはナノスケールデバイスにおける熱用途または非熱用途のためのマイクロ波の使用
WO2007030240A2 (en) * 2005-08-01 2007-03-15 University Of Virginia Patent Foundation Microdevices for chemical sensing and chemical actuation
AU2006283177B2 (en) * 2005-08-23 2011-11-17 University Of Virginia Patent Foundation Passive components for micro-fluidic flow profile shaping and related method thereof
CA2624914A1 (en) * 2005-10-04 2007-04-12 University Of Virginia Patent Foundation Microchip-based acoustic trapping or capture of cells for forensic analysis and related method thereof
US8916375B2 (en) * 2005-10-12 2014-12-23 University Of Virginia Patent Foundation Integrated microfluidic analysis systems
US20070207490A1 (en) * 2006-03-06 2007-09-06 Applera Corporation Method and system for generating sample plate layout for validation
WO2007114338A1 (ja) 2006-03-31 2007-10-11 Takeda Pharmaceutical Company Limited 酸分泌抑制薬
JP2008180677A (ja) * 2007-01-26 2008-08-07 Konica Minolta Medical & Graphic Inc マイクロチップ検査システム、マイクロチップ検査装置及びプログラム
FR2922897B1 (fr) * 2007-10-25 2009-11-27 Bio Rad Pasteur Mesure d'une population d'acides nucleiques,en particulier par pcr en temps reel.
US20120100548A1 (en) * 2010-10-26 2012-04-26 Verinata Health, Inc. Method for determining copy number variations
EP2848704B1 (en) 2010-01-19 2018-08-29 Verinata Health, Inc Sequencing methods for prenatal diagnoses
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
EP2513341B1 (en) * 2010-01-19 2017-04-12 Verinata Health, Inc Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing
CA2786565C (en) 2010-01-19 2017-04-25 Verinata Health, Inc. Partition defined detection methods
US9323888B2 (en) 2010-01-19 2016-04-26 Verinata Health, Inc. Detecting and classifying copy number variation
WO2011090556A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Methods for determining fraction of fetal nucleic acid in maternal samples
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
US9822397B2 (en) 2010-06-30 2017-11-21 Gen-Probe Incorporated Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals
RS57837B1 (sr) 2011-04-12 2018-12-31 Verinata Health Inc Razrešavanje genomskih frakcija upotrebom broja kopija polimorfizama
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
WO2014093360A1 (en) 2012-12-10 2014-06-19 Landers James P Frequency-based filtering of mechanical actuation using fluidic device
GB201403076D0 (en) * 2014-02-21 2014-04-09 ALERE TECHNOLOGIES GmbH Methods for detecting multiple nucleic acids in a sample
ES2896198T3 (es) * 2014-10-10 2022-02-24 Univ Rutgers Cebadores y sondas de reacción en cadena de polimerasa para Mycobacterium tuberculosis
US20190093155A1 (en) * 2017-05-25 2019-03-28 Roche Molecular Systems, Inc. Multiplex Nucleic Acid Amplification Assay
JP7219473B2 (ja) * 2017-08-28 2023-02-08 静岡県公立大学法人 コリバクチンおよびコリバクチン産生菌の検出方法および検出プローブ

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
WO1991012342A1 (en) * 1990-02-16 1991-08-22 F. Hoffmann-La Roche Ag Improvements in the specificity and convenience of the polymerase chain reaction
US5627032A (en) * 1990-12-24 1997-05-06 Ulanovsky; Levy Composite primers for nucleic acids
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
DE69739357D1 (de) * 1996-06-04 2009-05-28 Univ Utah Res Found Überwachung der hybridisierung während pcr
ES2215230T3 (es) 1996-06-04 2004-10-01 University Of Utah Research Foundation Sistema y metodo para llevar a cabo y supervisar reacciones de cadena de polimerasa.
US5736333A (en) 1996-06-04 1998-04-07 The Perkin-Elmer Corporation Passive internal references for the detection of nucleic acid amplification products
US5866336A (en) * 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US5863736A (en) * 1997-05-23 1999-01-26 Becton, Dickinson And Company Method, apparatus and computer program products for determining quantities of nucleic acid sequences in samples
US5952202A (en) 1998-03-26 1999-09-14 The Perkin Elmer Corporation Methods using exogenous, internal controls and analogue blocks during nucleic acid amplification
US6312929B1 (en) 2000-12-22 2001-11-06 Cepheid Compositions and methods enabling a totally internally controlled amplification reaction
US7226732B2 (en) * 2001-07-16 2007-06-05 Cepheid Methods, apparatus, and computer programs for verifying the integrity of a probe

Also Published As

Publication number Publication date
US20070259362A1 (en) 2007-11-08
JP6434930B2 (ja) 2018-12-05
JP2005515404A (ja) 2005-05-26
US20030064368A1 (en) 2003-04-03
EP1415152A2 (en) 2004-05-06
ES2365699T3 (es) 2011-10-10
JP5328412B2 (ja) 2013-10-30
US7226732B2 (en) 2007-06-05
ATE508360T1 (de) 2011-05-15
WO2003009100A2 (en) 2003-01-30
JP5955274B2 (ja) 2016-07-20
US9464317B2 (en) 2016-10-11
JP2009165475A (ja) 2009-07-30
WO2003009100A3 (en) 2003-11-27
EP1415152B1 (en) 2011-05-04
US9206470B2 (en) 2015-12-08
DE60239940D1 (de) 2011-06-16
EP1415152A4 (en) 2005-03-23
CA2453366A1 (en) 2003-01-30
JP2016154550A (ja) 2016-09-01
JP2013188228A (ja) 2013-09-26
US20080227090A1 (en) 2008-09-18
CA2453366C (en) 2013-04-16
AU2002355109B2 (en) 2007-05-31

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