JP4365586B2 - 血管形成阻害活性を有するフタラジン誘導体 - Google Patents
血管形成阻害活性を有するフタラジン誘導体 Download PDFInfo
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- JP4365586B2 JP4365586B2 JP2002587426A JP2002587426A JP4365586B2 JP 4365586 B2 JP4365586 B2 JP 4365586B2 JP 2002587426 A JP2002587426 A JP 2002587426A JP 2002587426 A JP2002587426 A JP 2002587426A JP 4365586 B2 JP4365586 B2 JP 4365586B2
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- LFSXCDWNBUNEEM-UHFFFAOYSA-N phthalazine Chemical class C1=NN=CC2=CC=CC=C21 LFSXCDWNBUNEEM-UHFFFAOYSA-N 0.000 title abstract description 22
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- SANWDQJIWZEKOD-UHFFFAOYSA-N tributyl(furan-2-yl)stannane Chemical compound CCCC[Sn](CCCC)(CCCC)C1=CC=CO1 SANWDQJIWZEKOD-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0111078.2A GB0111078D0 (en) | 2001-05-04 | 2001-05-04 | Organic compounds |
| PCT/EP2002/004892 WO2002090346A1 (en) | 2001-05-04 | 2002-05-03 | Phthalazine derivatives with angiogenesis inhibiting activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004532241A JP2004532241A (ja) | 2004-10-21 |
| JP2004532241A5 JP2004532241A5 (https=) | 2006-01-05 |
| JP4365586B2 true JP4365586B2 (ja) | 2009-11-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2002587426A Expired - Fee Related JP4365586B2 (ja) | 2001-05-04 | 2002-05-03 | 血管形成阻害活性を有するフタラジン誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7399761B2 (https=) |
| EP (1) | EP1387836B1 (https=) |
| JP (1) | JP4365586B2 (https=) |
| CN (1) | CN1314681C (https=) |
| AT (1) | ATE393152T1 (https=) |
| BR (1) | BR0209332A (https=) |
| CA (1) | CA2446051A1 (https=) |
| DE (1) | DE60226225T2 (https=) |
| ES (1) | ES2301648T3 (https=) |
| GB (1) | GB0111078D0 (https=) |
| PT (1) | PT1387836E (https=) |
| WO (1) | WO2002090346A1 (https=) |
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| EP1712234B1 (en) * | 2001-09-12 | 2009-01-28 | Novartis AG | Use of 4-Pyridylmethylphthalazines for Renal Cancer Treatment |
| WO2004002485A1 (en) * | 2002-06-28 | 2004-01-08 | Novartis Ag | Combination comprising a vasculostatic compound and an alkylating agent for the treatmemt of a tumor |
| EP1738752A1 (en) * | 2002-12-27 | 2007-01-03 | Schering Aktiengesellschaft | Pharmaceutical combinations comprising cis-retine acid |
| UA89035C2 (ru) | 2003-12-03 | 2009-12-25 | Лео Фарма А/С | Эфиры гидроксамовых кислот и их фармацевтическое применение |
| EP1919906B1 (en) * | 2005-08-29 | 2011-10-12 | Vertex Pharmaceuticals Incorporated | 3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases |
| RU2522444C2 (ru) | 2008-08-27 | 2014-07-10 | Лео Фарма А/С | Производные пиридина в качестве ингибиторов рецепторов фактора роста эндотелия сосудов 2 подтипа (vegfr-2) и протеинтирозинкиназы |
| JP6088063B2 (ja) * | 2012-11-16 | 2017-03-01 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ブルトン型チロシンキナーゼの阻害剤 |
| JP6282721B2 (ja) | 2013-03-14 | 2018-02-21 | ダート・ニューロサイエンス・（ケイマン）・リミテッド | Ｐｄｅ４阻害剤としての置換ピリジン及びピラジン化合物 |
| JP2024505256A (ja) * | 2021-01-28 | 2024-02-05 | ユニバーシティ オブ フロリダ リサーチファウンデーション インコーポレイティッド | 神経変性、変性及び代謝性障害の処置のための化合物並びにその使用 |
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| BE567431A (https=) | 1957-05-07 | |||
| GB1293565A (en) * | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
| US4665181A (en) * | 1984-05-17 | 1987-05-12 | Pennwalt Corporation | Anti-inflammatory phthalazinones |
| JPH03106875A (ja) | 1989-09-20 | 1991-05-07 | Morishita Pharmaceut Co Ltd | １―（３―ピリジルメチル）フタラジン誘導体 |
| EP0600831A1 (de) | 1992-11-27 | 1994-06-08 | Ciba-Geigy Ag | Phthalazinonderivate |
| DE69533057T2 (de) | 1994-08-09 | 2005-06-16 | Eisai Co., Ltd. | Kondensierte pyridazinverbindungen |
| MY117098A (en) | 1996-01-15 | 2004-05-31 | Janssen Pharmaceutica Nv | Angiogenesis inhibiting pyridazinamines |
| CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| CN1660840A (zh) * | 1999-03-30 | 2005-08-31 | 诺瓦提斯公司 | 治疗炎性疾病的酞嗪衍生物 |
| AR025068A1 (es) | 1999-08-10 | 2002-11-06 | Bayer Corp | Pirazinas sustituidas y piridazinas fusionadas, composicion farmaceutica que las comprenden, uso de dichos compuestos para la manufactura de un medicamentocon actividad inhibidora de angiogenesis |
-
2001
- 2001-05-04 GB GBGB0111078.2A patent/GB0111078D0/en not_active Ceased
-
2002
- 2002-05-03 PT PT02738031T patent/PT1387836E/pt unknown
- 2002-05-03 JP JP2002587426A patent/JP4365586B2/ja not_active Expired - Fee Related
- 2002-05-03 WO PCT/EP2002/004892 patent/WO2002090346A1/en not_active Ceased
- 2002-05-03 ES ES02738031T patent/ES2301648T3/es not_active Expired - Lifetime
- 2002-05-03 EP EP02738031A patent/EP1387836B1/en not_active Expired - Lifetime
- 2002-05-03 US US10/475,419 patent/US7399761B2/en not_active Expired - Fee Related
- 2002-05-03 AT AT02738031T patent/ATE393152T1/de active
- 2002-05-03 BR BR0209332-4A patent/BR0209332A/pt not_active IP Right Cessation
- 2002-05-03 CN CNB028092937A patent/CN1314681C/zh not_active Expired - Fee Related
- 2002-05-03 DE DE60226225T patent/DE60226225T2/de not_active Expired - Lifetime
- 2002-05-03 CA CA002446051A patent/CA2446051A1/en not_active Abandoned
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2008
- 2008-06-18 US US12/141,179 patent/US20090076003A1/en not_active Abandoned
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2010
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Also Published As
| Publication number | Publication date |
|---|---|
| US8034814B2 (en) | 2011-10-11 |
| GB0111078D0 (en) | 2001-06-27 |
| WO2002090346A1 (en) | 2002-11-14 |
| US20110130399A1 (en) | 2011-06-02 |
| ATE393152T1 (de) | 2008-05-15 |
| EP1387836A1 (en) | 2004-02-11 |
| ES2301648T3 (es) | 2008-07-01 |
| US7399761B2 (en) | 2008-07-15 |
| JP2004532241A (ja) | 2004-10-21 |
| DE60226225D1 (de) | 2008-06-05 |
| PT1387836E (pt) | 2008-06-27 |
| BR0209332A (pt) | 2004-07-20 |
| EP1387836B1 (en) | 2008-04-23 |
| DE60226225T2 (de) | 2009-09-10 |
| US20090076003A1 (en) | 2009-03-19 |
| CN1507444A (zh) | 2004-06-23 |
| US20040180899A1 (en) | 2004-09-16 |
| CN1314681C (zh) | 2007-05-09 |
| CA2446051A1 (en) | 2002-11-14 |
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