JP4328021B2 - デスフォルモテロール及びその製造方法 - Google Patents
デスフォルモテロール及びその製造方法 Download PDFInfo
- Publication number
- JP4328021B2 JP4328021B2 JP2000555854A JP2000555854A JP4328021B2 JP 4328021 B2 JP4328021 B2 JP 4328021B2 JP 2000555854 A JP2000555854 A JP 2000555854A JP 2000555854 A JP2000555854 A JP 2000555854A JP 4328021 B2 JP4328021 B2 JP 4328021B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- rui
- pharmaceutically
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- NGNDCBMDEZQKNY-UHFFFAOYSA-N CC(CCCCCN(CCCCCc(cc1)ccc1OC)Cc1ccccc1)(CC=C1OCc2ccccc2)C=C1[N+]([O-])=O Chemical compound CC(CCCCCN(CCCCCc(cc1)ccc1OC)Cc1ccccc1)(CC=C1OCc2ccccc2)C=C1[N+]([O-])=O NGNDCBMDEZQKNY-UHFFFAOYSA-N 0.000 description 1
- 0 Cc1cc(C2(CNC3(Cc4ccc(*)cc4)CC3)CC2)ccc1O Chemical compound Cc1cc(C2(CNC3(Cc4ccc(*)cc4)CC3)CC2)ccc1O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/04—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reaction of ammonia or amines with olefin oxides or halohydrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/103,212 | 1998-06-23 | ||
| US09/103,212 US5965622A (en) | 1998-06-23 | 1998-06-23 | Desformoterol and process for its preparation |
| PCT/US1999/014082 WO1999067198A1 (en) | 1998-06-23 | 1999-06-22 | Desformoterol and process for its preparation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002518468A JP2002518468A (ja) | 2002-06-25 |
| JP2002518468A5 JP2002518468A5 (https=) | 2006-07-13 |
| JP4328021B2 true JP4328021B2 (ja) | 2009-09-09 |
Family
ID=22293976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000555854A Expired - Lifetime JP4328021B2 (ja) | 1998-06-23 | 1999-06-22 | デスフォルモテロール及びその製造方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5965622A (https=) |
| EP (1) | EP1093450B1 (https=) |
| JP (1) | JP4328021B2 (https=) |
| AT (1) | ATE238271T1 (https=) |
| AU (1) | AU747329B2 (https=) |
| CA (1) | CA2335154C (https=) |
| DE (1) | DE69907190T2 (https=) |
| ES (1) | ES2193722T3 (https=) |
| WO (1) | WO1999067198A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20010428A1 (it) * | 2001-03-02 | 2002-09-02 | Chemo Breath S A | Composizioni ad uso inalatorio a base di formoterolo |
| US6667344B2 (en) | 2001-04-17 | 2003-12-23 | Dey, L.P. | Bronchodilating compositions and methods |
| US20030055026A1 (en) * | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
| US20040023935A1 (en) * | 2002-08-02 | 2004-02-05 | Dey, L.P. | Inhalation compositions, methods of use thereof, and process for preparation of same |
| US20050158248A1 (en) * | 2002-08-21 | 2005-07-21 | Xian-Ming Zeng | Method of preparing dry powder inhalation compositions |
| AU2003269989B8 (en) * | 2002-08-21 | 2009-11-12 | Norton Healthcare Ltd. | Inhalation composition |
| GB0219511D0 (en) * | 2002-08-21 | 2002-10-02 | Norton Healthcare Ltd | Method of preparing dry powder inhalation compositions |
| US20040109826A1 (en) * | 2002-12-06 | 2004-06-10 | Dey, L.P. | Stabilized albuterol compositions and method of preparation thereof |
| TWI359675B (en) | 2003-07-10 | 2012-03-11 | Dey L P | Bronchodilating β-agonist compositions |
| WO2008035380A2 (en) * | 2006-09-19 | 2008-03-27 | Natco Pharma Limited | An improved process for the preparation of high purity formoterol and its pharmaceutically acceptable salts |
| CN101391962A (zh) * | 2007-09-21 | 2009-03-25 | 北京德众万全药物技术开发有限公司 | 一种高纯度的(R)-α-(溴甲基)-4-苄氧基-3-硝基苯甲醇及其制备方法 |
| CN101462971B (zh) * | 2007-12-19 | 2014-05-07 | 北京德众万全药物技术开发有限公司 | 高纯度的用于制备福莫特罗的关键中间体及其制备方法 |
| ES2539947T3 (es) | 2008-06-02 | 2015-07-07 | Cipla Limited | Procedimiento para la síntesis de arformoterol |
| WO2010128355A2 (en) | 2008-12-26 | 2010-11-11 | Actavis Group Ptc Ehf | Improved processes for preparing substantially pure arformoterol and its intermediates |
| US8282512B1 (en) | 2009-03-26 | 2012-10-09 | Warrior Sports, Inc. | Lacrosse head |
| CN101921200B (zh) * | 2009-06-16 | 2014-01-15 | 上海医药工业研究院 | 一种n-苄基-1-(4-甲氧基苯基)-2-丙胺的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2031407A6 (es) * | 1988-10-05 | 1992-12-01 | Lasa Lab | Mejoras introducidas en el objeto de la patente principal n{ 8703715 por: procedimiento de obtencion de n-(2-hidroxi-5-(1-hidroxi-2-((2-(4-metoxifenil)-1-metiletil)amino)etil)fenil)formamida". |
-
1998
- 1998-06-23 US US09/103,212 patent/US5965622A/en not_active Expired - Lifetime
-
1999
- 1999-05-05 US US09/305,534 patent/US6071971A/en not_active Expired - Lifetime
- 1999-06-22 CA CA002335154A patent/CA2335154C/en not_active Expired - Lifetime
- 1999-06-22 EP EP99930556A patent/EP1093450B1/en not_active Expired - Lifetime
- 1999-06-22 AT AT99930556T patent/ATE238271T1/de not_active IP Right Cessation
- 1999-06-22 AU AU47072/99A patent/AU747329B2/en not_active Expired
- 1999-06-22 DE DE69907190T patent/DE69907190T2/de not_active Expired - Lifetime
- 1999-06-22 WO PCT/US1999/014082 patent/WO1999067198A1/en not_active Ceased
- 1999-06-22 JP JP2000555854A patent/JP4328021B2/ja not_active Expired - Lifetime
- 1999-06-22 ES ES99930556T patent/ES2193722T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5965622A (en) | 1999-10-12 |
| ATE238271T1 (de) | 2003-05-15 |
| CA2335154C (en) | 2008-11-18 |
| JP2002518468A (ja) | 2002-06-25 |
| AU4707299A (en) | 2000-01-10 |
| DE69907190T2 (de) | 2004-02-12 |
| EP1093450B1 (en) | 2003-04-23 |
| US6071971A (en) | 2000-06-06 |
| EP1093450A1 (en) | 2001-04-25 |
| CA2335154A1 (en) | 1999-12-29 |
| DE69907190D1 (de) | 2003-05-28 |
| AU747329B2 (en) | 2002-05-16 |
| ES2193722T3 (es) | 2003-11-01 |
| WO1999067198A1 (en) | 1999-12-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6268533B1 (en) | Formoterol process | |
| JP4328021B2 (ja) | デスフォルモテロール及びその製造方法 | |
| JP4034366B2 (ja) | 薬理学的作用を有する１ − フエニル−３− ジメチルアミノ− プロパン化合物 | |
| USRE37355E1 (en) | 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds as pharmaceutical active ingredients | |
| CA2271004C (en) | Process for the preparation of optically pure isomers of formoterol | |
| EP2285770B1 (en) | Process for the synthesis of arformoterol | |
| JPH107624A (ja) | 医薬有効物質としてのジメチル−（３−アリール− ブト−３− エニル）−アミノ化合物 | |
| WO2011034849A1 (en) | Novel compounds advantageous in the treatment of central nervous system diseases and disorders | |
| EP1451145A1 (en) | Novel crystalline polymorph of venlafaxine hydrochloride and methods for the preparation thereof | |
| AU748508B2 (en) | Formoterol polymorphs | |
| NO172115B (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive bronkospasmolytiske forbindelser | |
| WO2025059259A1 (en) | New process for phenylephrine and salbutamol and related compounds via asymetric transfer hydrogenation of unprotected amino ketones | |
| HK1204960B (zh) | 高纯度的2-[4-(3-或2-氟苄氧基)苄氨基]丙酰胺类及其用途 |
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