JP4294092B2 - テロメア長を測定するための方法 - Google Patents

テロメア長を測定するための方法 Download PDF

Info

Publication number
JP4294092B2
JP4294092B2 JP50217097A JP50217097A JP4294092B2 JP 4294092 B2 JP4294092 B2 JP 4294092B2 JP 50217097 A JP50217097 A JP 50217097A JP 50217097 A JP50217097 A JP 50217097A JP 4294092 B2 JP4294092 B2 JP 4294092B2
Authority
JP
Japan
Prior art keywords
dna
telomere
cells
telomere length
probe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP50217097A
Other languages
English (en)
Japanese (ja)
Other versions
JPH10507085A5 (enExample
JPH10507085A (ja
Inventor
マイケル アール． コズロウスキー，
カレン アール． プロウズ，
シ−シ ウァン，
シャロン ウォン，
ナム ウォー キム，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Geron Corp
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geron Corp filed Critical Geron Corp
Publication of JPH10507085A publication Critical patent/JPH10507085A/ja
Publication of JPH10507085A5 publication Critical patent/JPH10507085A5/ja
Application granted granted Critical
Publication of JP4294092B2 publication Critical patent/JP4294092B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
JP50217097A 1995-06-07 1996-06-06 テロメア長を測定するための方法 Expired - Lifetime JP4294092B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/479,916 1995-06-07
US08/479,916 US5741677A (en) 1995-06-07 1995-06-07 Methods for measuring telomere length
PCT/US1996/010035 WO1996041016A1 (en) 1995-06-07 1996-06-06 Methods for measuring telomere length

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007329366A Division JP2008119005A (ja) 1995-06-07 2007-12-20 テロメア長を測定するための方法

Publications (3)

Publication Number Publication Date
JPH10507085A JPH10507085A (ja) 1998-07-14
JPH10507085A5 JPH10507085A5 (enExample) 2004-07-08
JP4294092B2 true JP4294092B2 (ja) 2009-07-08

Family

ID=23905964

Family Applications (2)

Application Number Title Priority Date Filing Date
JP50217097A Expired - Lifetime JP4294092B2 (ja) 1995-06-07 1996-06-06 テロメア長を測定するための方法
JP2007329366A Pending JP2008119005A (ja) 1995-06-07 2007-12-20 テロメア長を測定するための方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2007329366A Pending JP2008119005A (ja) 1995-06-07 2007-12-20 テロメア長を測定するための方法

Country Status (7)

Country Link
US (2) US5741677A (enExample)
EP (1) EP0774014A4 (enExample)
JP (2) JP4294092B2 (enExample)
AU (1) AU697882B2 (enExample)
CA (1) CA2196898C (enExample)
MX (1) MX9700950A (enExample)
WO (1) WO1996041016A1 (enExample)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0870055B1 (en) * 1995-10-12 2007-05-16 LANSDORP, Peter, M. Method for detecting multiple copies of a repeat sequence in a nucleic acid molecule
ATE417926T1 (de) 1996-07-01 2009-01-15 Gemin X Pharmaceuticals Canada Zusammensetzungen zur modulierung der länge von telomeren
CN1254376A (zh) 1996-10-01 2000-05-24 杰龙公司 端粒酶逆转录酶
US6197557B1 (en) * 1997-03-05 2001-03-06 The Regents Of The University Of Michigan Compositions and methods for analysis of nucleic acids
US6117634A (en) * 1997-03-05 2000-09-12 The Reagents Of The University Of Michigan Nucleic acid sequencing and mapping
US5871926A (en) * 1997-04-21 1999-02-16 The University Of New Mexico Sensitive method for measurement of telomeric DNA content in human tissues
JP4013333B2 (ja) * 1998-06-05 2007-11-28 株式会社Ｂ＆Ｃラボラトリーズ 皮膚の老化度の測定方法および測定用キット
US7981599B1 (en) 1998-07-31 2011-07-19 Boston Probes, Inc. Non-nucleic acid probes, probe sets, methods and kits pertaining to the detection of individual human chromosomes X, Y, 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 16, 17, 18 and 20 as 13/21 as a pair
US7270958B2 (en) 1998-09-10 2007-09-18 The Regents Of The University Of Michigan Compositions and methods for analysis of nucleic acids
US6503718B2 (en) 1999-01-10 2003-01-07 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
US6280947B1 (en) 1999-08-11 2001-08-28 Exact Sciences Corporation Methods for detecting nucleotide insertion or deletion using primer extension
US20080318890A1 (en) * 1999-04-08 2008-12-25 Antisoma Research Limited Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US7314926B1 (en) * 1999-04-08 2008-01-01 Antisoma Research Limited Antiproliferative activity of g-rich oligonucleotides and method of using same to bind to nucleolin
US8114850B2 (en) * 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US7960540B2 (en) * 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US20080318889A1 (en) * 1999-04-08 2008-12-25 Antisoma Research Limited Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US6995145B1 (en) 1999-06-04 2006-02-07 Au Jessie L-S Methods and compositions for modulating drug activity through telomere damage
AU5466500A (en) * 1999-06-04 2000-12-28 Jessie L.S. Au Methods and compositions for modulating drug activity through telomere damage
GB0005281D0 (en) * 2000-03-07 2000-04-26 Secr Defence Analytical method
GB0009784D0 (en) * 2000-04-20 2000-06-07 Simeg Limited Methods for clinical diagnosis
WO2003000927A2 (en) * 2001-06-23 2003-01-03 University Of Wales College Of Medicine Method for the determination of telomere length
US20030124549A1 (en) * 2001-10-11 2003-07-03 Xerox Corporation Devices and methods for detecting genetic sequences
DE10161829B4 (de) * 2001-12-15 2006-02-16 Peter Lahnert Neue Methode zur Bestimmung der Telomerlänge und ihre Verwendung zur Abschätzung des Lebensalters
US7695904B2 (en) * 2002-01-31 2010-04-13 University Of Utah Research Foundation Reducing non-target nucleic acid dependent amplifications: amplifying repetitive nucleic acid sequences
WO2003071252A2 (en) 2002-02-15 2003-08-28 Exact Sciences Corporation Methods for analysis of molecular events
US6916621B2 (en) 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
US20040234961A1 (en) * 2002-04-22 2004-11-25 Fordyce Colleen A. Telomere length determination and applications
GB0214842D0 (en) * 2002-06-27 2002-08-07 Simeg Ltd Diagnostic method
WO2004035597A2 (en) * 2002-10-16 2004-04-29 Women And Infants Hospital Of Rhode Island, Inc. Methods of assessing the risk of reproductive failure by measuring telomere length
KR100479264B1 (ko) * 2002-11-01 2005-03-28 한국전자통신연구원 주기적 가열과 냉각을 통한 혼성화 방법 및 이를 사용하는폴리뉴클레오타이드 검출 장치
JP5686493B2 (ja) * 2003-01-24 2015-03-18 ユニバーシティ・オブ・ユタＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｕｔａｈ テロメアの長さを決定することによって死亡の危険性を予測する方法
US7544470B2 (en) * 2003-05-28 2009-06-09 The Johns Hopkins University Method for finding mutations caused by the insertion of repeated DNAs
US20080108057A1 (en) * 2004-06-22 2008-05-08 Griffith Jeffrey K Allelic imbalance in the diagnosis and prognosis of cancer
US7981607B2 (en) 2004-08-27 2011-07-19 Esoterix Genetic Laboratories LLC Method for detecting recombinant event
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence
WO2007044071A2 (en) 2005-04-21 2007-04-19 Exact Sciences Corporation Analysis of heterogeneous nucleic acid samples
US20100291560A1 (en) * 2007-03-27 2010-11-18 The Johns Hopkins University Methods and compositions for diagnosis and treatment of dyskeratosis congenita and related disorders
EP2191013A1 (en) * 2007-08-10 2010-06-02 Tina Holding APS Method for estimating telomere length
US20090131351A1 (en) * 2007-11-16 2009-05-21 Antisoma Research Limited Methods, compositions, and kits for modulating tumor cell proliferation
CA2723950C (en) * 2008-05-12 2016-07-12 Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii Methods and reagents for the determination of telomere length in a semi-automatic manner of every single cell in a immobilized cell population
US8084203B2 (en) 2008-05-12 2011-12-27 Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii Methods for the determination of telomere length in a semi-automatic manner of every single cell in a immobilized cell population
US20090298709A1 (en) * 2008-05-28 2009-12-03 Affymetrix, Inc. Assays for determining telomere length and repeated sequence copy number
PT3330383T (pt) 2008-10-17 2020-05-06 Geron Corp Grn163l para utiliização como inibidor de telomerase no tratamento de cancro
JP5840950B2 (ja) 2008-12-22 2016-01-06 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション 単色マルチプレックス定量ｐｃｒ
US20110111462A1 (en) * 2009-11-06 2011-05-12 Stephen Picone Composition and Method for Synthesizing a Deoxyribonucleotide Chain Using a Double Stranded Nucleic Acid Complex with a Thermostable Polymerase
US20130217585A1 (en) * 2010-08-25 2013-08-22 The Trustees Of The University Of Columbia In The City Of New York Quantitative Total Definition of Biologically Active Sequence Elements
US20120196284A1 (en) * 2010-12-16 2012-08-02 University Of Medicine And Dentistry Of New Jersey Method of Measuring Telomere Length
RU2508407C9 (ru) * 2012-10-10 2014-05-20 Елена Андреевна Чирясова Способ количественной оценки терминальных нуклеотидов g-цепи теломерной днк человека с помощью полимеразной цепной реакции и дуплекс-специфического анализа, наборы синтетических олигонуклеотидных праймеров и зондов для осуществления этого способа
US9200327B2 (en) 2012-11-30 2015-12-01 Geron Corporation Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors
RU2735141C2 (ru) 2013-03-15 2020-10-28 Иликсиэджен Терапьютикс, Инк. Способы применения zscan4 для омоложения человеческих клеток
CN105283559A (zh) * 2013-05-22 2016-01-27 端粒诊断公司 短端粒丰度的量度
CN105899232A (zh) 2013-11-13 2016-08-24 诺华股份有限公司 用于增强免疫应答的mTOR抑制剂
EP3087101B1 (en) 2013-12-20 2024-06-05 Novartis AG Regulatable chimeric antigen receptor
US11542488B2 (en) 2014-07-21 2023-01-03 Novartis Ag Sortase synthesized chimeric antigen receptors
WO2016014530A1 (en) 2014-07-21 2016-01-28 Novartis Ag Combinations of low, immune enhancing. doses of mtor inhibitors and cars
KR102255304B1 (ko) 2014-09-26 2021-05-24 삼성전자주식회사 텔로미어 증폭 방법
GB201418144D0 (en) 2014-10-14 2014-11-26 Univ Cardiff High throughput sequencing
AU2015372584A1 (en) 2014-12-30 2017-06-29 Telomere Diagnostics, Inc. Multiplex quantitative PCR
US11156599B2 (en) * 2015-03-19 2021-10-26 The Johns Hopkins University Assay for telomere length regulators
EP3297629A1 (en) 2015-05-20 2018-03-28 Novartis AG Pharmaceutical combination of everolimus with dactolisib
BR112019010470A2 (pt) 2016-11-23 2019-09-10 Novartis Ag métodos de realce de resposta imune com everolimo, dactolisib ou ambos
CN106755429A (zh) * 2016-12-27 2017-05-31 上海三誉生物科技有限公司 一种精确测量人群端粒长度的方法
IL303660A (en) 2017-05-02 2023-08-01 Revolution Medicines Inc Rapamycin analogs as mtor inhibitors
WO2019040993A1 (en) * 2017-09-01 2019-03-07 Children's Medical Research Institute TELOMER EVALUATION METHOD
US10098922B1 (en) 2017-11-30 2018-10-16 Optigenex, Inc. Increasing telomere length in a cell
US10596165B2 (en) 2018-02-12 2020-03-24 resTORbio, Inc. Combination therapies
CN118978535A (zh) 2018-05-01 2024-11-19 锐新医药公司 作为mTOR抑制剂的C40-、C28-及C-32连接的雷帕霉素类似物
CA3098698A1 (en) 2018-05-01 2019-11-07 Revolution Medicines, Inc. C26-linked rapamycin analogs as mtor inhibitors
EP3674418A1 (en) * 2018-12-26 2020-07-01 Life Length S.L. Method for measuring telomere associated variables and uses thereof for the diagnosis and/or prognosis of telomeric-associated diseases
WO2021025935A1 (en) * 2019-08-02 2021-02-11 Georgetown University Dna-fish method for measurement of telomere length
JP2025522296A (ja) 2022-05-25 2025-07-15 レヴォリューション・メディスンズ，インコーポレイテッド ｍＴＯＲ阻害剤によりがんを処置する方法
CN117248003B (zh) * 2023-11-13 2024-04-12 元码基因科技（北京）股份有限公司 用于完整端粒扩增子测序的组合物、预文库及其构建方法
CN117230169B (zh) * 2023-11-13 2024-02-13 元码基因科技（北京）股份有限公司 用于长片段端粒序列测序的接头、预文库及其构建方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4737454A (en) * 1983-07-14 1988-04-12 Molecular Diagnostics, Inc. Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays
US5629154A (en) * 1993-11-12 1997-05-13 Geron Corporation Telomerase activity assays
US5489508A (en) * 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
IL107150A0 (en) * 1992-09-29 1993-12-28 Isis Pharmaceuticals Inc Oligonucleotides having a conserved g4 core sequence
WO1995013382A1 (en) * 1993-11-12 1995-05-18 Geron Corporation Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
JPH10507366A (ja) * 1994-10-21 1998-07-21 ゼネカ・リミテッド Ｐｃｒによるテロメアｄｎａの可変性の特性決定法

Also Published As

Publication number Publication date
AU6272496A (en) 1996-12-30
JP2008119005A (ja) 2008-05-29
US5834193A (en) 1998-11-10
EP0774014A1 (en) 1997-05-21
US5741677A (en) 1998-04-21
MX9700950A (es) 1998-01-31
JPH10507085A (ja) 1998-07-14
AU697882B2 (en) 1998-10-22
EP0774014A4 (en) 2002-01-02
CA2196898A1 (en) 1996-12-19
CA2196898C (en) 2007-10-30
WO1996041016A1 (en) 1996-12-19

Similar Documents

Publication Publication Date Title
AU697882B2 (en) Methods for measuring telomere length
MXPA97000950A (en) Methods to measure the length of a clip
US20230279480A1 (en) Methods and compositions for improved probe specificity
JP4318856B2 (ja) チモーゲン性核酸検出方法、および関連分子およびキット
CA2513747C (en) Methods of predicting mortality risk by determining telomere length
EP0664339A1 (en) Method of discriminating nucleic acid and testing set for discriminating nucleic acid
AU2012236880B2 (en) Telomere length measurement in formalin-fixed, paraffin embedded (FFPE) samples by quantitative PCR
JP6910295B2 (ja) 診断治療融合的な応用のための方法及びキット
US6063567A (en) Method, reagents and kit for diagnosis and targeted screening for retinoblastoma
KR102370550B1 (ko) Egfr 돌연변이 검출을 위한 dna 중합효소 및 이를 포함하는 키트
JP2006506068A (ja) テロメラーゼ活性を検出するための方法及び組成物
KR20200087726A (ko) Tert 돌연변이 검출을 위한 dna 중합효소 및 이를 포함하는 키트
US8637654B1 (en) Messenger RNA profiling: body fluid identification using multiplex real time-polymerase chain reaction (q-PCR)
JP2003510011A (ja) カップル性ポリメラーゼ連鎖反応−制限エンドヌクレアーゼ消化−リガーゼ検出反応法
TW200404891A (en) Method for preparation of expressed gene identification cDNA tags and method for analysis of gene expression
JP2982304B2 (ja) 核酸の識別方法及び核酸の識別用検査セット
KR20200087725A (ko) Jak2 돌연변이 검출을 위한 dna 중합효소 및 이를 포함하는 키트
EA013373B1 (ru) Определение нуклеиновой кислоты
KR20200087724A (ko) Braf 돌연변이 검출을 위한 dna 중합효소 및 이를 포함하는 키트
JP2763278B2 (ja) Ｄｎａ分子索引法
JP2763277B2 (ja) Ｄｎａ分子索引法
WO2021249825A1 (en) Methods and compositions for detecting structural rearrangements in a genome
JP2000069969A (ja) プライマーＤＮＡ及びこれを用いる前立腺特異抗原をコードするｍＲＮＡの検出方法
JPH0630798A (ja) ヒトの性別決定法
JP2007151409A (ja) ゲノムｄｎａコピー数の測定方法

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070821

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20071120

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080111

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20071220

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20080408

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080806

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20081009

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20090401

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20090408

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120417

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120417

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130417

Year of fee payment: 4

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130417

Year of fee payment: 4

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20140417

Year of fee payment: 5

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term