MX9700950A - Metodos para medir la longitud de un telomero. - Google Patents

Metodos para medir la longitud de un telomero.

Info

Publication number
MX9700950A
MX9700950A MX9700950A MX9700950A MX9700950A MX 9700950 A MX9700950 A MX 9700950A MX 9700950 A MX9700950 A MX 9700950A MX 9700950 A MX9700950 A MX 9700950A MX 9700950 A MX9700950 A MX 9700950A
Authority
MX
Mexico
Prior art keywords
methods
telomere length
probe
telomere
primer extension
Prior art date
Application number
MX9700950A
Other languages
English (en)
Spanish (es)
Other versions
MXPA97000950A (en
Inventor
Michael R Kozlowski
Karen R Prowse
Sy-Shi Wang
Sharon Wong
Nam Woo Kim
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geron Corp filed Critical Geron Corp
Publication of MXPA97000950A publication Critical patent/MXPA97000950A/xx
Publication of MX9700950A publication Critical patent/MX9700950A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
MX9700950A 1995-06-07 1996-06-06 Metodos para medir la longitud de un telomero. MX9700950A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08479916 1995-06-07
US08/479,916 US5741677A (en) 1995-06-07 1995-06-07 Methods for measuring telomere length
PCT/US1996/010035 WO1996041016A1 (en) 1995-06-07 1996-06-06 Methods for measuring telomere length

Publications (2)

Publication Number Publication Date
MXPA97000950A MXPA97000950A (en) 1998-01-01
MX9700950A true MX9700950A (es) 1998-01-31

Family

ID=23905964

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9700950A MX9700950A (es) 1995-06-07 1996-06-06 Metodos para medir la longitud de un telomero.

Country Status (7)

Country Link
US (2) US5741677A (enExample)
EP (1) EP0774014A4 (enExample)
JP (2) JP4294092B2 (enExample)
AU (1) AU697882B2 (enExample)
CA (1) CA2196898C (enExample)
MX (1) MX9700950A (enExample)
WO (1) WO1996041016A1 (enExample)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE362546T1 (de) 1995-10-12 2007-06-15 Lansdorp Peter M Verfahren zum nachweis von mehrfachkopien einer wiederholungssequenz in einem nukleinsäuremolekül
WO1998000537A1 (en) 1996-07-01 1998-01-08 Universite De Sherbrooke Composition and methods for modulating the length of telomeres
FI990655A7 (fi) 1996-10-01 1999-06-01 Geron Corp Ihmistelomeraasin katalyyttinen alayksikkö
US6117634A (en) * 1997-03-05 2000-09-12 The Reagents Of The University Of Michigan Nucleic acid sequencing and mapping
US6197557B1 (en) * 1997-03-05 2001-03-06 The Regents Of The University Of Michigan Compositions and methods for analysis of nucleic acids
US5871926A (en) * 1997-04-21 1999-02-16 The University Of New Mexico Sensitive method for measurement of telomeric DNA content in human tissues
JP4013333B2 (ja) * 1998-06-05 2007-11-28 株式会社Ｂ＆Ｃラボラトリーズ 皮膚の老化度の測定方法および測定用キット
US7981599B1 (en) 1998-07-31 2011-07-19 Boston Probes, Inc. Non-nucleic acid probes, probe sets, methods and kits pertaining to the detection of individual human chromosomes X, Y, 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 16, 17, 18 and 20 as 13/21 as a pair
US7270958B2 (en) 1998-09-10 2007-09-18 The Regents Of The University Of Michigan Compositions and methods for analysis of nucleic acids
US6280947B1 (en) 1999-08-11 2001-08-28 Exact Sciences Corporation Methods for detecting nucleotide insertion or deletion using primer extension
US6503718B2 (en) 1999-01-10 2003-01-07 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
US8114850B2 (en) * 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US7314926B1 (en) 1999-04-08 2008-01-01 Antisoma Research Limited Antiproliferative activity of g-rich oligonucleotides and method of using same to bind to nucleolin
US20080318889A1 (en) * 1999-04-08 2008-12-25 Antisoma Research Limited Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US7960540B2 (en) * 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US20080318890A1 (en) * 1999-04-08 2008-12-25 Antisoma Research Limited Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
WO2000074667A2 (en) * 1999-06-04 2000-12-14 Au Jessie L S Compositions active in telomere damage comprising a taxane and telomerase inhibitor
US6995145B1 (en) 1999-06-04 2006-02-07 Au Jessie L-S Methods and compositions for modulating drug activity through telomere damage
GB0005281D0 (en) * 2000-03-07 2000-04-26 Secr Defence Analytical method
GB0009784D0 (en) * 2000-04-20 2000-06-07 Simeg Limited Methods for clinical diagnosis
WO2003000927A2 (en) * 2001-06-23 2003-01-03 University Of Wales College Of Medicine Method for the determination of telomere length
US20030124549A1 (en) * 2001-10-11 2003-07-03 Xerox Corporation Devices and methods for detecting genetic sequences
DE10161829B4 (de) * 2001-12-15 2006-02-16 Peter Lahnert Neue Methode zur Bestimmung der Telomerlänge und ihre Verwendung zur Abschätzung des Lebensalters
JP4515767B2 (ja) * 2002-01-31 2010-08-04 ユニバーシティ・オブ・ユタ 非標的核酸依存性増幅の低減：反復核酸配列の増幅
WO2003071252A2 (en) 2002-02-15 2003-08-28 Exact Sciences Corporation Methods for analysis of molecular events
US6916621B2 (en) 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
US20040234961A1 (en) * 2002-04-22 2004-11-25 Fordyce Colleen A. Telomere length determination and applications
GB0214842D0 (en) * 2002-06-27 2002-08-07 Simeg Ltd Diagnostic method
AU2003284234A1 (en) * 2002-10-16 2004-05-04 Women And Infants Hospital Of Rhode Island, Inc. Methods of assessing the risk of reproductive failure by measuring telomere length
KR100479264B1 (ko) * 2002-11-01 2005-03-28 한국전자통신연구원 주기적 가열과 냉각을 통한 혼성화 방법 및 이를 사용하는폴리뉴클레오타이드 검출 장치
EP2474822A1 (en) 2003-01-24 2012-07-11 University of Utah Methods of predicting mortality risk by determining telomere length
WO2004106490A2 (en) * 2003-05-28 2004-12-09 The Johns Hopkins University NOVEL METHODS FOR FINDING MUTATIONS CAUSED BY THE INSERTION OF REPETEAD DNAs
US20080108057A1 (en) * 2004-06-22 2008-05-08 Griffith Jeffrey K Allelic imbalance in the diagnosis and prognosis of cancer
WO2006026654A2 (en) 2004-08-27 2006-03-09 Exact Sciences Corporation Method for detecting a recombinant event
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence
US9777314B2 (en) 2005-04-21 2017-10-03 Esoterix Genetic Laboratories, Llc Analysis of heterogeneous nucleic acid samples
US20100291560A1 (en) * 2007-03-27 2010-11-18 The Johns Hopkins University Methods and compositions for diagnosis and treatment of dyskeratosis congenita and related disorders
EP2191013A1 (en) * 2007-08-10 2010-06-02 Tina Holding APS Method for estimating telomere length
US20090131351A1 (en) * 2007-11-16 2009-05-21 Antisoma Research Limited Methods, compositions, and kits for modulating tumor cell proliferation
WO2009138117A1 (en) * 2008-05-12 2009-11-19 Fundación Centro Nacional De Investigaciones Oncológicas Carlos Iii Methods and reagents for the determination of telomere length in a semi-automatic manner of every single cell in a immobilized cell population
US8084203B2 (en) 2008-05-12 2011-12-27 Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii Methods for the determination of telomere length in a semi-automatic manner of every single cell in a immobilized cell population
US20090298709A1 (en) * 2008-05-28 2009-12-03 Affymetrix, Inc. Assays for determining telomere length and repeated sequence copy number
PT3029154T (pt) 2008-10-17 2017-12-06 Geron Corp Método para identificação de sensibilidade de um paciente à terapia de inibição da telomerase
CA2748265C (en) 2008-12-22 2018-04-03 University Of Utah Research Foundation Monochrome multiplex quantitative pcr
CN102791877A (zh) * 2009-11-06 2012-11-21 酶学有限公司 使用双链核酸复合物与耐热聚合酶用于合成脱氧核糖核苷酸链的组合物和方法
US20130217585A1 (en) * 2010-08-25 2013-08-22 The Trustees Of The University Of Columbia In The City Of New York Quantitative Total Definition of Biologically Active Sequence Elements
US20120196284A1 (en) * 2010-12-16 2012-08-02 University Of Medicine And Dentistry Of New Jersey Method of Measuring Telomere Length
RU2508407C9 (ru) * 2012-10-10 2014-05-20 Елена Андреевна Чирясова Способ количественной оценки терминальных нуклеотидов g-цепи теломерной днк человека с помощью полимеразной цепной реакции и дуплекс-специфического анализа, наборы синтетических олигонуклеотидных праймеров и зондов для осуществления этого способа
US9200327B2 (en) 2012-11-30 2015-12-01 Geron Corporation Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors
CA3176825A1 (en) 2013-03-15 2014-09-18 Elixirgen Therapeutics, Inc. Methods of using zscan4 for treating a disease or condition associated with a karyotype abnormality
EP2999800B1 (en) 2013-05-22 2019-09-25 Telomere Diagnostics Inc. Measures of short telomere abundance
JP2016537345A (ja) 2013-11-13 2016-12-01 ノバルティス アーゲー 免疫応答を増強するためのｍＴＯＲ阻害剤
EP3087101B1 (en) 2013-12-20 2024-06-05 Novartis AG Regulatable chimeric antigen receptor
JP2017528433A (ja) 2014-07-21 2017-09-28 ノバルティス アーゲー 低い免疫増強用量のｍＴＯＲ阻害剤とＣＡＲの組み合わせ
WO2016014553A1 (en) 2014-07-21 2016-01-28 Novartis Ag Sortase synthesized chimeric antigen receptors
KR102255304B1 (ko) 2014-09-26 2021-05-24 삼성전자주식회사 텔로미어 증폭 방법
GB201418144D0 (en) * 2014-10-14 2014-11-26 Univ Cardiff High throughput sequencing
CA2971169A1 (en) 2014-12-30 2016-07-07 Telomere Diagnostics, Inc. Multiplex quantitative pcr
WO2016149612A2 (en) * 2015-03-19 2016-09-22 The Johns Hopkins University Assay for telomere length regulators
CN107847491A (zh) 2015-05-20 2018-03-27 诺华公司 依维莫司(everolimus)与达托里昔布(dactolisib)的医药组合
CN110114070A (zh) 2016-11-23 2019-08-09 诺华公司 使用依维莫司(everolimus)、达托里昔布(dactolisib)或二者增强免疫反应的方法
CN106755429A (zh) * 2016-12-27 2017-05-31 上海三誉生物科技有限公司 一种精确测量人群端粒长度的方法
IL303660A (en) 2017-05-02 2023-08-01 Revolution Medicines Inc Rapamycin analogs as mtor inhibitors
EP3676609A4 (en) * 2017-09-01 2021-06-02 Children's Medical Research Institute TELOMERES EVALUATION PROCESS
US10098922B1 (en) 2017-11-30 2018-10-16 Optigenex, Inc. Increasing telomere length in a cell
WO2019157516A1 (en) 2018-02-12 2019-08-15 resTORbio, Inc. Combination therapies
CA3098692A1 (en) 2018-05-01 2019-11-07 Revolution Medicines, Inc. C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors
WO2019212991A1 (en) 2018-05-01 2019-11-07 Revolution Medicines, Inc. C26-linked rapamycin analogs as mtor inhibitors
EP3674418A1 (en) * 2018-12-26 2020-07-01 Life Length S.L. Method for measuring telomere associated variables and uses thereof for the diagnosis and/or prognosis of telomeric-associated diseases
WO2021025935A1 (en) * 2019-08-02 2021-02-11 Georgetown University Dna-fish method for measurement of telomere length
AU2023275778A1 (en) 2022-05-25 2024-12-12 Revolution Medicines, Inc. Methods of treating cancer with an mtor inhibitor
CN117230169B (zh) * 2023-11-13 2024-02-13 元码基因科技（北京）股份有限公司 用于长片段端粒序列测序的接头、预文库及其构建方法
CN117248003B (zh) * 2023-11-13 2024-04-12 元码基因科技（北京）股份有限公司 用于完整端粒扩增子测序的组合物、预文库及其构建方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4737454A (en) * 1983-07-14 1988-04-12 Molecular Diagnostics, Inc. Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays
US5629154A (en) * 1993-11-12 1997-05-13 Geron Corporation Telomerase activity assays
US5489508A (en) * 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
IL107150A0 (en) * 1992-09-29 1993-12-28 Isis Pharmaceuticals Inc Oligonucleotides having a conserved g4 core sequence
WO1995013382A1 (en) * 1993-11-12 1995-05-18 Geron Corporation Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
EP0787203A1 (en) * 1994-10-21 1997-08-06 Zeneca Limited Method for characterising variability in telomere dna by pcr

Also Published As

Publication number Publication date
AU6272496A (en) 1996-12-30
EP0774014A4 (en) 2002-01-02
CA2196898C (en) 2007-10-30
WO1996041016A1 (en) 1996-12-19
US5741677A (en) 1998-04-21
JP4294092B2 (ja) 2009-07-08
EP0774014A1 (en) 1997-05-21
AU697882B2 (en) 1998-10-22
US5834193A (en) 1998-11-10
CA2196898A1 (en) 1996-12-19
JP2008119005A (ja) 2008-05-29
JPH10507085A (ja) 1998-07-14

Similar Documents

Publication Publication Date Title
MX9700950A (es) Metodos para medir la longitud de un telomero.
O'brien et al. A new, small-color-difference equation for dental shades
ATE446045T1 (de) Verfahren und vorrichtung zur glukosemessung
IL139637A0 (en) Mechanical stress induced genes, expression products therefrom, and uses thereof
Ranatunga et al. Correlation between shortening velocity, force—velocity relation and histochemical fibre-type composition in rat muscles
EP0684575A4 (en) MEDICAL MEASURING APPARATUS.
EP0353985A3 (en) Nucleic acid probe for detection of neisseria gonorrhoea
Bertrand-Burggraf et al. A new experimental approach for studying the association between RNA polymerase and the tet promoter of pBR322
ATE255726T1 (de) Verfahren zur vorhersage von frühgeburten
Nomoto et al. A simple acid erosion test for dental water-based cements
AU614489B2 (en) Compositions and methods for clones containing dna sequences associated with multidrug resistance in human cells
BR0005660A (pt) Processo para medir por ultra-sons a tensão redisual de uma barra de pré-esforço
Tam et al. Effect of dentine depth on the fracture toughness of dentine-composite adhesive interfaces
DE602004025676D1 (de) Verfahren zur untersuchung einer zelle
BR9911097A (pt) Método para ensaio fagocìtico
Meiser Jr et al. Internal setting expansion of a dental casting investment measured with strain gauges
Harada et al. Standardization of examiners using a dental model for pocket probe training: adequacy of evaluation with a model and standard accuracy rate of skilled examiners
Henricsson Objective evaluation of mouth dryness: A methodological study.
Krstajic TESTS ON THE PROTECTIVE PROPERTIES OF POLYURETHANE COATINGS
Cavalieri et al. The interpretation of bacterial transformation data
Pilcer et al. AN ELASTIC-PLASTIC ANALYSIS OF RELATIONSHIPS BETWEEN KI, J AND CTOD
Vlachodimitropoulos et al. Characterization of the development of elasticity in dental luting cements
Li et al. A study about plastic rotational factor rp
JPS5262070A (en) Measurement of observation waveforms of oscilloscope
WO2020101367A3 (ko) 체온 또는 복강내압을 측정할 수 있는 폴리카테터 및 그 이용방법