JP4233113B2 - 多糖類抗原−キャリア蛋白接合体および遊離キャリア蛋白を有してなるワクチン - Google Patents
多糖類抗原−キャリア蛋白接合体および遊離キャリア蛋白を有してなるワクチン Download PDFInfo
- Publication number
- JP4233113B2 JP4233113B2 JP50014697A JP50014697A JP4233113B2 JP 4233113 B2 JP4233113 B2 JP 4233113B2 JP 50014697 A JP50014697 A JP 50014697A JP 50014697 A JP50014697 A JP 50014697A JP 4233113 B2 JP4233113 B2 JP 4233113B2
- Authority
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- Japan
- Prior art keywords
- vaccine
- carrier protein
- polysaccharide
- antigen
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
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- A61K39/092—Streptococcus
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- A61K39/02—Bacterial antigens
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47263995A | 1995-06-07 | 1995-06-07 | |
| GBGB9512827.8A GB9512827D0 (en) | 1995-06-23 | 1995-06-23 | Vaccines |
| GB9512827.8 | 1995-06-23 | ||
| GB9513443.3 | 1995-07-01 | ||
| GBGB9513443.3A GB9513443D0 (en) | 1995-07-01 | 1995-07-01 | Vaccines |
| GB08/472,639 | 1995-12-15 | ||
| GBGB9525657.4A GB9525657D0 (en) | 1995-12-15 | 1995-12-15 | Vaccines |
| GB9525657.4 | 1995-12-15 | ||
| PCT/EP1996/002436 WO1996040242A1 (en) | 1995-06-07 | 1996-06-04 | Vaccine comprising a polysaccharide antigen-carrier protein conjugate and free carrier protein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007061946A Division JP4653131B2 (ja) | 1995-06-07 | 2007-03-12 | 多糖類抗原−キャリア蛋白接合体および遊離キャリア蛋白を有してなるワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPH11507026A JPH11507026A (ja) | 1999-06-22 |
| JPH11507026A5 JPH11507026A5 (enExample) | 2004-07-08 |
| JP4233113B2 true JP4233113B2 (ja) | 2009-03-04 |
Family
ID=27451300
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50014697A Expired - Lifetime JP4233113B2 (ja) | 1995-06-07 | 1996-06-04 | 多糖類抗原−キャリア蛋白接合体および遊離キャリア蛋白を有してなるワクチン |
| JP2007061946A Expired - Lifetime JP4653131B2 (ja) | 1995-06-07 | 2007-03-12 | 多糖類抗原−キャリア蛋白接合体および遊離キャリア蛋白を有してなるワクチン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007061946A Expired - Lifetime JP4653131B2 (ja) | 1995-06-07 | 2007-03-12 | 多糖類抗原−キャリア蛋白接合体および遊離キャリア蛋白を有してなるワクチン |
Country Status (18)
| Country | Link |
|---|---|
| EP (2) | EP0831901B2 (enExample) |
| JP (2) | JP4233113B2 (enExample) |
| AT (2) | ATE205724T1 (enExample) |
| AU (1) | AU695720B2 (enExample) |
| BR (1) | BR9608612A (enExample) |
| CA (1) | CA2221511C (enExample) |
| CZ (1) | CZ390297A3 (enExample) |
| DE (2) | DE69637597D1 (enExample) |
| DK (1) | DK1090642T3 (enExample) |
| ES (2) | ES2164251T5 (enExample) |
| HU (1) | HUP9802199A3 (enExample) |
| IL (1) | IL122431A0 (enExample) |
| NO (1) | NO975555L (enExample) |
| NZ (1) | NZ311000A (enExample) |
| PT (1) | PT1090642E (enExample) |
| SI (1) | SI1090642T1 (enExample) |
| TR (1) | TR199701547T1 (enExample) |
| WO (1) | WO1996040242A1 (enExample) |
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| WO1996040242A1 (en) * | 1995-06-07 | 1996-12-19 | Smithkline Beecham Biologicals S.A. | Vaccine comprising a polysaccharide antigen-carrier protein conjugate and free carrier protein |
| AU714493B2 (en) * | 1996-07-02 | 2000-01-06 | Connaught Laboratories Limited | Multivalent DTP-polio vaccines |
| US6248334B1 (en) | 1997-01-08 | 2001-06-19 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process |
| AU763349B2 (en) * | 1998-02-05 | 2003-07-17 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Simplified method for removing free protein during preparation of protein-polysaccharide conjugates and vaccines using restricted-access media |
| US7018637B2 (en) * | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
| DK1163000T3 (da) | 1999-03-19 | 2008-04-28 | Glaxosmithkline Biolog Sa | Vacciner imod antigener fra bakterier |
| FR2806304B1 (fr) * | 2000-03-17 | 2002-05-10 | Aventis Pasteur | Conjugues polysaccharidiques du pneumocoque a usage vaccinal contre le tetanos et la diphterie |
| YU66103A (sh) | 2001-01-23 | 2006-05-25 | Aventis Pasteur | Vakcina multivalentnog konjugata meningokokalnog polisaharid-proteina |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| MXPA05003863A (es) | 2002-10-11 | 2005-09-08 | Chiron Srl | Vacunas polipeptidicas para amplia proteccion contra lineas hipervirulentas de meningococos. |
| ATE352316T1 (de) | 2002-11-01 | 2007-02-15 | Glaxosmithkline Biolog Sa | Immunogene zusammensetzung |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| JP4827726B2 (ja) | 2003-01-30 | 2011-11-30 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | 複数の髄膜炎菌血清群に対する注射可能ワクチン |
| CA2744997A1 (en) | 2003-09-26 | 2005-04-07 | Exelixis, Inc. | C-met modulators and method of use |
| ES2397923T3 (es) | 2003-10-02 | 2013-03-12 | Novartis Ag | Vacunas líquidas para múltiples serogrupos meningocócicos |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| GB0406013D0 (en) | 2004-03-17 | 2004-04-21 | Chiron Srl | Analysis of saccharide vaccines without interference |
| NZ550533A (en) | 2004-04-30 | 2010-02-26 | Novartis Vaccines & Diagnostic | Meningococcal conjugate vaccination comprising N. meningitidis and diphtheria toxin |
| GB0409745D0 (en) | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
| GB0500787D0 (en) | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
| GB0411387D0 (en) | 2004-05-21 | 2004-06-23 | Chiron Srl | Analysis of saccharide length |
| GB0413868D0 (en) | 2004-06-21 | 2004-07-21 | Chiron Srl | Dimensional anlaysis of saccharide conjugates |
| GB0428394D0 (en) * | 2004-12-24 | 2005-02-02 | Chiron Srl | Saccharide conjugate vaccines |
| GB0502095D0 (en) | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
| GB0502096D0 (en) | 2005-02-01 | 2005-03-09 | Chiron Srl | Purification of streptococcal capsular polysaccharide |
| GB0505518D0 (en) | 2005-03-17 | 2005-04-27 | Chiron Srl | Combination vaccines with whole cell pertussis antigen |
| SG175456A1 (en) | 2005-04-18 | 2011-11-28 | Novartis Vaccines & Diagnostic | Expressing hepatitis b virus surface antigen for vaccine preparation |
| KR101359953B1 (ko) | 2005-06-27 | 2014-02-21 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 면역원성 조성물 |
| ES2443529T3 (es) | 2005-09-01 | 2014-02-19 | Novartis Vaccines And Diagnostics Gmbh | Vacunación múltiple incluyendo meningococo del serogrupo C |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
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| US10828361B2 (en) | 2006-03-22 | 2020-11-10 | Glaxosmithkline Biologicals Sa | Regimens for immunisation with meningococcal conjugates |
| CN103585624A (zh) | 2006-09-07 | 2014-02-19 | 葛兰素史密丝克莱恩生物有限公司 | 疫苗 |
| GB0700136D0 (en) | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Process for manufacturing vaccines |
| DK2349520T3 (en) | 2008-10-27 | 2016-08-15 | Glaxosmithkline Biologicals Sa | Purification Procedure for Group A Streptococcus Carbohydrate |
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| GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
| MX373250B (es) | 2009-09-30 | 2020-05-04 | Glaxosmithkline Biologicals S A Star | Conjugación de polisacáridos capsulares de tipo 5 y de tipo 8 de staphylococcus aureus. |
| BR112012010223A2 (pt) | 2009-10-30 | 2016-12-06 | Novartis Ag | purificação de staphylococcus aureus tipo 5 e tipo 8 sacarídeos capsulares |
| US9173954B2 (en) | 2009-12-30 | 2015-11-03 | Glaxosmithkline Biologicals Sa | Polysaccharide immunogens conjugated to E. coli carrier proteins |
| CN102802662A (zh) | 2010-03-18 | 2012-11-28 | 诺华有限公司 | 用于脑膜炎球菌血清组b的含佐剂疫苗 |
| EP2612148B1 (en) | 2010-09-04 | 2019-06-12 | GlaxoSmithKline Biologicals SA | Bactericidal antibody assays to assess immunogenicity and potency of meningococcal capsular saccharide vaccines |
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| GB201106340D0 (en) * | 2011-04-14 | 2011-06-01 | Isis Innovation | Composition |
| US9358284B2 (en) | 2011-09-14 | 2016-06-07 | Glaxosmithkline Biologicals Sa | Methods for making saccharide-protein glycoconjugates |
| US9493517B2 (en) | 2011-11-07 | 2016-11-15 | Glaxosmithkline Biologicals Sa | Conjugates comprising an antigen and a carrier molecule |
| DE102011118371B4 (de) | 2011-11-11 | 2014-02-13 | Novartis Ag | Zur Impfung von Menschen geeignete Zusammensetzung, die ein Diphtherie-Toxoid umfasst, sowie Verfahren zu deren Herstellung |
| EP2592137A1 (en) | 2011-11-11 | 2013-05-15 | Novartis AG | Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use |
| GB2495341B (en) | 2011-11-11 | 2013-09-18 | Novartis Ag | Fermentation methods and their products |
| DE102011122891B4 (de) | 2011-11-11 | 2014-12-24 | Novartis Ag | Fermentationsmedium, das frei von tierischen Bestandteilen ist, zur Herstellung von Diphtherie-Toxoiden zur Verwendung bei der Impfung von Menschen |
| GB201121301D0 (en) | 2011-12-12 | 2012-01-25 | Novartis Ag | Method |
| EP2822584A1 (en) | 2012-03-08 | 2015-01-14 | Novartis AG | Combination vaccines with tlr4 agonists |
| MX2014014067A (es) | 2012-05-22 | 2015-02-04 | Novartis Ag | Conjugado de serogrupo x de meningococo. |
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| EP3482770B1 (en) | 2012-10-03 | 2020-11-25 | GlaxoSmithKline Biologicals S.A. | Immunogenic compositions |
| RU2015111987A (ru) | 2012-10-12 | 2016-12-10 | Глаксосмитклайн Байолоджикалс Са | Несшитые бесклеточные коклюшные антигены для применения в комбинированных вакцинах |
| CN105007935A (zh) | 2012-12-18 | 2015-10-28 | 葛兰素史密丝克莱恩生物有限公司 | 用于保护免于白喉和/或破伤风的缀合物 |
| CN111499679B (zh) | 2013-01-04 | 2021-07-06 | 台湾浩鼎生技股份有限公司 | 具有较高碳水化合物抗原密度的疫苗及新颖皂素佐剂 |
| CN104174019A (zh) * | 2014-09-23 | 2014-12-03 | 成都康华生物制品有限公司 | 四价脑膜炎球菌多糖载体蛋白结合疫苗 |
| US9107906B1 (en) | 2014-10-28 | 2015-08-18 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| EP3034516A1 (en) | 2014-12-19 | 2016-06-22 | Novartis AG | Purification of streptococcal capsular polysaccharide |
| BE1024634B1 (fr) | 2016-04-05 | 2018-05-14 | Gsk Vaccines S.R.L. | Compositions immunogenes |
| US11027005B2 (en) | 2016-10-20 | 2021-06-08 | Km Biologics Co., Ltd. | Method for producing Hib conjugate vaccine using PRP with lowered molecular weight |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| EP3799884A1 (en) | 2019-10-01 | 2021-04-07 | GlaxoSmithKline Biologicals S.A. | Immunogenic compositions |
| US11173199B2 (en) * | 2019-11-13 | 2021-11-16 | Alopexx Inc. | Low contaminant compositions |
| WO2021174330A1 (en) * | 2020-03-05 | 2021-09-10 | Nuecology Biomedical Inc. | Amphiphilic alginate-oleic acid macromolecules and process for preparation therof |
| JP2023548935A (ja) | 2020-11-13 | 2023-11-21 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 新規担体及びコンジュゲーション法 |
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| US4902506A (en) * | 1983-07-05 | 1990-02-20 | The University Of Rochester | Immunogenic conjugates |
| US4644059A (en) * | 1982-07-06 | 1987-02-17 | Connaught Laboratories, Inc. | Haemophilus influenzae B polysaccharide-diptheria toxoid conjugate vaccine |
| IT1187753B (it) * | 1985-07-05 | 1987-12-23 | Sclavo Spa | Coniugati glicoproteici ad attivita' immunogenica trivalente |
| ATE121947T1 (de) * | 1989-12-14 | 1995-05-15 | Ca Nat Research Council | Verbessertes meningokokkale polysaccharidkonjugatvakzin. |
| ZA937034B (en) * | 1992-09-24 | 1995-06-23 | Brigham & Womens Hospital | Group B streptococcus type II and type V polysaccharide-protein conjugate vaccines |
| EP0594950B1 (en) * | 1992-10-27 | 1999-01-27 | American Cyanamid Company | Combination pediatric vaccine with enhanced immunogenicity of each vaccine component |
| WO1996040242A1 (en) * | 1995-06-07 | 1996-12-19 | Smithkline Beecham Biologicals S.A. | Vaccine comprising a polysaccharide antigen-carrier protein conjugate and free carrier protein |
-
1996
- 1996-06-04 WO PCT/EP1996/002436 patent/WO1996040242A1/en not_active Ceased
- 1996-06-04 HU HU9802199A patent/HUP9802199A3/hu unknown
- 1996-06-04 DE DE69637597T patent/DE69637597D1/de not_active Expired - Lifetime
- 1996-06-04 AT AT96920790T patent/ATE205724T1/de not_active IP Right Cessation
- 1996-06-04 EP EP96920790A patent/EP0831901B2/en not_active Expired - Lifetime
- 1996-06-04 AU AU62221/96A patent/AU695720B2/en not_active Ceased
- 1996-06-04 BR BR9608612A patent/BR9608612A/pt unknown
- 1996-06-04 CA CA2221511A patent/CA2221511C/en not_active Expired - Lifetime
- 1996-06-04 DE DE69615362T patent/DE69615362T3/de not_active Expired - Lifetime
- 1996-06-04 EP EP00203772A patent/EP1090642B8/en not_active Revoked
- 1996-06-04 DK DK00203772T patent/DK1090642T3/da active
- 1996-06-04 SI SI9630763T patent/SI1090642T1/sl unknown
- 1996-06-04 CZ CZ973902A patent/CZ390297A3/cs unknown
- 1996-06-04 NZ NZ311000A patent/NZ311000A/en unknown
- 1996-06-04 ES ES96920790T patent/ES2164251T5/es not_active Expired - Lifetime
- 1996-06-04 JP JP50014697A patent/JP4233113B2/ja not_active Expired - Lifetime
- 1996-06-04 PT PT00203772T patent/PT1090642E/pt unknown
- 1996-06-04 TR TR97/01547T patent/TR199701547T1/xx unknown
- 1996-06-04 IL IL12243196A patent/IL122431A0/xx unknown
- 1996-06-04 AT AT00203772T patent/ATE400295T1/de active
- 1996-06-04 ES ES00203772T patent/ES2308962T3/es not_active Expired - Lifetime
-
1997
- 1997-12-02 NO NO975555A patent/NO975555L/no unknown
-
2007
- 2007-03-12 JP JP2007061946A patent/JP4653131B2/ja not_active Expired - Lifetime
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