JP4210781B2 - 高速液体クロマトグラフィー装置 - Google Patents
高速液体クロマトグラフィー装置 Download PDFInfo
- Publication number
- JP4210781B2 JP4210781B2 JP27645099A JP27645099A JP4210781B2 JP 4210781 B2 JP4210781 B2 JP 4210781B2 JP 27645099 A JP27645099 A JP 27645099A JP 27645099 A JP27645099 A JP 27645099A JP 4210781 B2 JP4210781 B2 JP 4210781B2
- Authority
- JP
- Japan
- Prior art keywords
- flow path
- measurement
- path
- channel
- liquid chromatography
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004128 high performance liquid chromatography Methods 0.000 title claims description 18
- 238000005259 measurement Methods 0.000 claims description 67
- 239000007788 liquid Substances 0.000 claims description 37
- 239000003480 eluent Substances 0.000 claims description 25
- 102000017011 Glycated Hemoglobin A Human genes 0.000 claims description 21
- 108091005995 glycated hemoglobin Proteins 0.000 claims description 21
- 238000012360 testing method Methods 0.000 claims description 21
- 239000012085 test solution Substances 0.000 claims description 17
- 239000008280 blood Substances 0.000 claims description 14
- 210000004369 blood Anatomy 0.000 claims description 14
- 102000001554 Hemoglobins Human genes 0.000 claims description 12
- 108010054147 Hemoglobins Proteins 0.000 claims description 12
- 230000007423 decrease Effects 0.000 claims description 5
- 239000003085 diluting agent Substances 0.000 claims description 5
- 238000002835 absorbance Methods 0.000 claims description 4
- 238000007865 diluting Methods 0.000 claims description 4
- 238000002347 injection Methods 0.000 description 27
- 239000007924 injection Substances 0.000 description 27
- 238000002360 preparation method Methods 0.000 description 18
- 238000004458 analytical method Methods 0.000 description 14
- 238000009792 diffusion process Methods 0.000 description 13
- 238000010790 dilution Methods 0.000 description 9
- 239000012895 dilution Substances 0.000 description 9
- 108010013766 hemoglobin A(0) Proteins 0.000 description 8
- 238000010586 diagram Methods 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 238000013459 approach Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/105—Mixing heads, i.e. compact mixing units or modules, using mixing valves for feeding and mixing at least two components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/74—Optical detectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/74—Optical detectors
- G01N2030/746—Optical detectors detecting along the line of flow, e.g. axial
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8822—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Optical Measuring Cells (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27645099A JP4210781B2 (ja) | 1999-09-29 | 1999-09-29 | 高速液体クロマトグラフィー装置 |
| US10/089,399 US7364701B1 (en) | 1999-09-29 | 2000-09-28 | Liquid homogenizing unit and high speed liquid chromatograph equipped with the same |
| PCT/JP2000/006744 WO2001023879A1 (en) | 1999-09-29 | 2000-09-28 | Liquid homogenizing unit and high speed liquid chromatograph equipped with the same |
| EP00962958.5A EP1219962B1 (en) | 1999-09-29 | 2000-09-28 | Liquid homogenizing unit and high speed liquid chromatograph equipped with the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27645099A JP4210781B2 (ja) | 1999-09-29 | 1999-09-29 | 高速液体クロマトグラフィー装置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001099822A JP2001099822A (ja) | 2001-04-13 |
| JP2001099822A5 JP2001099822A5 (enExample) | 2006-11-09 |
| JP4210781B2 true JP4210781B2 (ja) | 2009-01-21 |
Family
ID=17569613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP27645099A Expired - Lifetime JP4210781B2 (ja) | 1999-09-29 | 1999-09-29 | 高速液体クロマトグラフィー装置 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US7364701B1 (enExample) |
| EP (1) | EP1219962B1 (enExample) |
| JP (1) | JP4210781B2 (enExample) |
| WO (1) | WO2001023879A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002031626A (ja) * | 2000-05-09 | 2002-01-31 | Tosoh Corp | 糖化ヘモグロビン分析計 |
| EP1154270B1 (en) * | 2000-05-09 | 2015-01-21 | Tosoh Corporation | Glycated hemoglobin analyzer |
| US10255591B2 (en) * | 2009-12-18 | 2019-04-09 | Visa International Service Association | Payment channel returning limited use proxy dynamic value |
| JP5579888B2 (ja) * | 2013-02-20 | 2014-08-27 | 日立オートモティブシステムズ株式会社 | 燃料噴射弁 |
| US9880090B2 (en) | 2014-08-15 | 2018-01-30 | Bio-Rad Laboratories, Inc. | HPLC reverse-flow flow cell |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1449409A (fr) * | 1964-10-08 | 1966-08-12 | Ceskoslovenska Akademie Ved | Cuvette pour photomètre de passage, ainsi que photomètre équipé avec ladite cuvette |
| CH452233A (de) | 1964-10-08 | 1968-05-31 | Ceskoslovenska Akademie Ved | Durchflussphotometer-Anordnung |
| US3822947A (en) * | 1973-02-28 | 1974-07-09 | R Aday | Fluid sample flow cell |
| GB2089062A (en) * | 1980-12-10 | 1982-06-16 | Applied Chromatography Systems | Chromatographic flow cell |
| JPH0197857A (ja) * | 1987-07-14 | 1989-04-17 | Kyoto Daiichi Kagaku:Kk | グリコヘモグロビンの自動測定方法及び試料導入バルブ |
| EP0299419B1 (en) | 1987-07-14 | 1993-10-20 | Kabushiki Kaisha Kyoto Daiichi Kagaku | Automatic measurement method of glycohemoglobin |
| DE9107564U1 (de) * | 1991-06-19 | 1991-09-12 | Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig | Mischmodule zur Zusammenführung von Trägerströmen |
| JP3505906B2 (ja) | 1996-04-04 | 2004-03-15 | 東ソー株式会社 | 糖化ヘモグロビン分析装置 |
| JPH11166886A (ja) * | 1997-12-04 | 1999-06-22 | Hitachi Ltd | 液体クロマトグラフ装置 |
-
1999
- 1999-09-29 JP JP27645099A patent/JP4210781B2/ja not_active Expired - Lifetime
-
2000
- 2000-09-28 US US10/089,399 patent/US7364701B1/en not_active Expired - Lifetime
- 2000-09-28 WO PCT/JP2000/006744 patent/WO2001023879A1/ja not_active Ceased
- 2000-09-28 EP EP00962958.5A patent/EP1219962B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1219962B1 (en) | 2013-07-31 |
| JP2001099822A (ja) | 2001-04-13 |
| EP1219962A1 (en) | 2002-07-03 |
| EP1219962A4 (en) | 2005-04-13 |
| US7364701B1 (en) | 2008-04-29 |
| WO2001023879A1 (en) | 2001-04-05 |
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