JP4205696B2 - アナライトを検出する方法及び装置 - Google Patents

アナライトを検出する方法及び装置 Download PDF

Info

Publication number
JP4205696B2
JP4205696B2 JP2005171345A JP2005171345A JP4205696B2 JP 4205696 B2 JP4205696 B2 JP 4205696B2 JP 2005171345 A JP2005171345 A JP 2005171345A JP 2005171345 A JP2005171345 A JP 2005171345A JP 4205696 B2 JP4205696 B2 JP 4205696B2
Authority
JP
Japan
Prior art keywords
liquid
jet nozzle
support
holder
gas flow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2005171345A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005351900A (ja
Inventor
マン カルル−ヘインツ
マイアー トーマス
フィート フリードハルム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2005351900A publication Critical patent/JP2005351900A/ja
Application granted granted Critical
Publication of JP4205696B2 publication Critical patent/JP4205696B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/40—Mixers using gas or liquid agitation, e.g. with air supply tubes
    • B01F33/407—Mixers using gas or liquid agitation, e.g. with air supply tubes by blowing gas on the material from above
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00479—Means for mixing reactants or products in the reaction vessels
    • B01J2219/00493—Means for mixing reactants or products in the reaction vessels by sparging or bubbling with gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00511—Walls of reactor vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00534—Mixing by a special element, e.g. stirrer
    • G01N2035/00544—Mixing by a special element, e.g. stirrer using fluid flow
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2005171345A 2004-06-11 2005-06-10 アナライトを検出する方法及び装置 Expired - Fee Related JP4205696B2 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004028303A DE102004028303A1 (de) 2004-06-11 2004-06-11 Verfahren und Vorrichtung zum Nachweis von Analyten

Publications (2)

Publication Number Publication Date
JP2005351900A JP2005351900A (ja) 2005-12-22
JP4205696B2 true JP4205696B2 (ja) 2009-01-07

Family

ID=34937345

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2005171345A Expired - Fee Related JP4205696B2 (ja) 2004-06-11 2005-06-10 アナライトを検出する方法及び装置

Country Status (11)

Country Link
US (2) US20060019243A1 (de)
EP (1) EP1604734B1 (de)
JP (1) JP4205696B2 (de)
KR (1) KR101035525B1 (de)
CN (1) CN1707264B (de)
AT (1) ATE395968T1 (de)
CA (1) CA2508919C (de)
DE (2) DE102004028303A1 (de)
ES (1) ES2305945T3 (de)
HK (1) HK1084446A1 (de)
TW (1) TWI368025B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005034175A1 (de) 2005-07-21 2007-01-25 Roche Diagnostics Gmbh Verfahren und Vorrichtung zur Erzeugung eines Feuchtluftstromes mit definierter relativer Feuchte
FR2938062B1 (fr) * 2008-11-05 2014-02-28 Biomerieux Sa Dispositif de preparation et/ou de traitement d'un echantillon biologique
EP2316563A1 (de) 2009-10-28 2011-05-04 Roche Diagnostics GmbH Verfahren zum Nachweis von Analyten in einer Probenflüssigkeit sowie Vorrichtung zu dessen Durchführung
DE102013204646B4 (de) * 2013-03-15 2018-04-05 Leica Biosystems Nussloch Gmbh Gerät zum Bearbeiten von histologischen Proben
EP3714251B1 (de) * 2017-11-21 2024-04-03 Ventana Medical Systems, Inc. Berührungsloses mischen mit modulierten luftstrahlen
US10512911B1 (en) * 2018-12-07 2019-12-24 Ultima Genomics, Inc. Implementing barriers for controlled environments during sample processing and detection
CN111112764A (zh) * 2019-12-26 2020-05-08 广东工业大学 一种脉冲气辅助掩模电解加工装置及方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3876380A (en) * 1973-04-09 1975-04-08 Ortho Pharma Corp Mixing device
US3398935A (en) * 1964-03-25 1968-08-27 Bausch & Lomb Mixing means
BE788877A (fr) * 1971-09-17 1973-01-02 Vickers Ltd Agitation d'echantillons liquides pour l'obtention de melanges homogenes
JPS52104185A (en) 1976-02-26 1977-09-01 Nippon Steel Corp Preparing way of fluorescent x-ray analyzing specimen by means of fusi ng method
JPS5861469A (ja) 1981-10-08 1983-04-12 Mochida Pharmaceut Co Ltd 免疫学的反応装置
DE3434931A1 (de) * 1984-09-22 1986-03-27 Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg Verfahren und vorrichtung zum mischen einer zu analysierenden fluessigkeitsprobe
EP0216026B1 (de) * 1985-06-26 1992-01-22 Japan Tectron Instruments Corporation Automatischer Analysenapparat
US4815978A (en) * 1986-04-30 1989-03-28 Baxter Travenol Laboratories, Inc. Clinical analysis methods and systems
DE3707368A1 (de) 1987-03-07 1988-09-15 Hoechst Ag Vorrichtung zum thermostatisieren und mischen des inhaltes von gefaessen einer mikrotitrationsplatte
US5009998A (en) * 1987-06-26 1991-04-23 E. I. Du Pont De Nemours And Company Method for performing heterogeneous immunoassay
US5595707A (en) * 1990-03-02 1997-01-21 Ventana Medical Systems, Inc. Automated biological reaction apparatus
DE4232096A1 (de) * 1992-09-25 1994-03-31 Boehringer Mannheim Gmbh Verfahren und Vorrichtung zum berührungslosen automatischen Mischen eines Reaktionsgemisches in einem Analysegerät
DE4331997A1 (de) * 1993-09-21 1995-03-23 Boehringer Mannheim Gmbh Verfahren und System zur Mischung von Flüssigkeiten
DK171572B1 (da) 1994-01-12 1997-01-20 Topsoe Haldor As Fremgangsmåde og indretning til blanding af gasser
US6630833B2 (en) * 1994-07-26 2003-10-07 Phase Dynamics, Inc. Measurement by concentration of a material within a structure
US5897837A (en) * 1997-02-06 1999-04-27 Toa Medical Electronics Co., Ltd. Dispensing device and Immunoassay apparatus using the same
EP0905516A1 (de) * 1997-07-31 1999-03-31 Sumitomo Pharmaceuticals Company, Limited Zirkulierendes Dünnschicht-Flüssigphasenverfahren
DE19836110C2 (de) 1998-08-10 2002-07-11 Jandratek Gmbh Sensorvorrichtung mit einer Mischeinrichtung
WO2000011163A1 (en) * 1998-08-20 2000-03-02 Regeneron Pharmaceuticals, Inc. Dcr5, a bmp-binding protein, and applications thereof
US6180417B1 (en) * 1999-04-22 2001-01-30 Bayer Corporation Immunochromatographic assay
JP2003510571A (ja) 1999-09-24 2003-03-18 ジョナサン コヘン 組織試料中の分子標的の臨床的有用性を評価するための高処理量システム
US6656685B2 (en) * 2001-01-29 2003-12-02 Ventana Medical Systems, Inc. Hybridization buffers using low molecular weight dextran sulfate and methods for their use
US20020182603A1 (en) * 2001-04-20 2002-12-05 Chapman William H. Uniformly functionalized surfaces for microarrays
AU2002305394A1 (en) 2001-05-04 2002-11-18 Biosite, Inc. Diagnostic markers of acute coronary syndromes and methods of use thereof
US6485918B1 (en) * 2001-07-02 2002-11-26 Packard Bioscience Corporation Method and apparatus for incubation of a liquid reagent and target spots on a microarray substrate
US6881579B2 (en) * 2001-07-30 2005-04-19 Agilent Technologies, Inc. Sample processing apparatus and methods
US7008788B2 (en) * 2001-07-30 2006-03-07 Agilent Technologies, Inc. Containers for supports comprising biopolymers
CA2464531A1 (en) 2001-11-05 2003-05-15 Brigham And Women's Hospital, Inc. Soluble cd40l(cd154) as a prognostic marker of atherosclerotic diseases
US20030219890A1 (en) * 2002-05-21 2003-11-27 Gordon Gary B. Probe array bio-analysis by centrifuging shallow reaction cell
US8409815B2 (en) 2002-11-16 2013-04-02 Siemens Healthcare Diagnostics Products Gmbh sCD40L and placental growth factor (PLGF) used as a biochemical marker combination in cardiovascular diseases
EP1530047A1 (de) 2003-11-07 2005-05-11 Roche Diagnostics GmbH Proximale Markermoleküle der Arterienthrombose und der Entzündung zur Risikostratifizierung einer koronaren Herzkrankheit

Also Published As

Publication number Publication date
EP1604734A3 (de) 2006-04-19
US9156012B2 (en) 2015-10-13
CA2508919A1 (en) 2005-12-11
KR20060049190A (ko) 2006-05-18
EP1604734A2 (de) 2005-12-14
CN1707264A (zh) 2005-12-14
TW200540405A (en) 2005-12-16
US20060019243A1 (en) 2006-01-26
TWI368025B (en) 2012-07-11
EP1604734B1 (de) 2008-05-21
CN1707264B (zh) 2012-01-11
ES2305945T3 (es) 2008-11-01
DE502005004166D1 (de) 2008-07-03
US20080113450A1 (en) 2008-05-15
KR101035525B1 (ko) 2011-05-23
CA2508919C (en) 2010-01-12
DE102004028303A1 (de) 2005-12-29
ATE395968T1 (de) 2008-06-15
HK1084446A1 (en) 2006-07-28
JP2005351900A (ja) 2005-12-22

Similar Documents

Publication Publication Date Title
JP4205696B2 (ja) アナライトを検出する方法及び装置
US8453507B2 (en) Acoustic assessment of characteristics of a fluid relevant to acoustic ejection
US6938995B2 (en) Acoustic assessment of fluids in a plurality of reservoirs
US6932097B2 (en) Acoustic control of the composition and/or volume of fluid in a reservoir
US7900505B2 (en) Acoustic assessment of fluids in a plurality of reservoirs
JP2004535916A (ja) 高速液滴処理システム及び方法
JP3661076B2 (ja) 化学分析装置
Gutmann et al. Fast and reliable protein microarray production by a new drop-in-drop technique
US7883901B2 (en) Biogenic substance detector and biogenic substance detection method
JP3326108B2 (ja) ガス吹付式濃縮装置
JP2007010345A (ja) 攪拌装置、攪拌方法及び攪拌装置を備えた分析装置
JP2004536694A (ja) 標的−受容体との結合を促進および強化する方法、およびそのための装置
JP3641992B2 (ja) 化学分析装置
EP1534526B1 (de) Akustische bewertung und/oder steuerung des fluidgehalts in einem behälter
JP4027492B2 (ja) 洗浄装置
US20120264624A1 (en) Method and device for detecting analytes in a sample liquid
JP3607557B2 (ja) 自動分析装置
JP2007278886A (ja) 反応容器、分析装置および分析方法
JP2009271031A (ja) 生体物質検出チップ、生体物質検出装置、および生体物質検出方法
US20050254998A1 (en) Reactive detection chip and spotter suitable for manufacturing the chip
US20090257918A1 (en) Reaction cuvette for automatic analyzer and method of surface treatment for reaction cuvette
JP4302023B2 (ja) 処理具
JP2007085805A (ja) 自動分析装置
JP2005304479A (ja) 処理具

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20051222

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20070918

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20071113

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080207

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080213

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080509

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080617

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080814

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20080924

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20081016

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20111024

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20121024

Year of fee payment: 4

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20121024

Year of fee payment: 4

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20121024

Year of fee payment: 4

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20121024

Year of fee payment: 4

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20121024

Year of fee payment: 4

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20131024

Year of fee payment: 5

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees