US3876380A - Mixing device - Google Patents

Mixing device Download PDF

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Publication number
US3876380A
US3876380A US349511A US34951173A US3876380A US 3876380 A US3876380 A US 3876380A US 349511 A US349511 A US 349511A US 34951173 A US34951173 A US 34951173A US 3876380 A US3876380 A US 3876380A
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United States
Prior art keywords
test surface
test
reagents
support means
employed
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Expired - Lifetime
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US349511A
Inventor
Bruce John Helriegel
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Ortho Pharmaceutical Corp
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Ortho Pharmaceutical Corp
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Filing date
Publication date
Priority to US474090A priority Critical patent/US1447935A/en
Priority to US604046A priority patent/US3415361A/en
Priority to US678405A priority patent/US3503709A/en
Priority to IL28921A priority patent/IL28921A/en
Priority to GB53405/67A priority patent/GB1206807A/en
Priority to CH1752967A priority patent/CH519172A/en
Priority to NL6717112A priority patent/NL6717112A/xx
Priority to SE17419/67A priority patent/SE338882B/xx
Priority to FR1549783D priority patent/FR1549783A/fr
Priority to BE708276D priority patent/BE708276A/xx
Priority to DE19671648991 priority patent/DE1648991A1/en
Priority to ES1969146103U priority patent/ES146103Y/en
Priority to ES1969154261U priority patent/ES154261Y/en
Priority to US55180A priority patent/US3627276A/en
Priority to GB3253171A priority patent/GB1320281A/en
Priority to SE7109010A priority patent/SE374209B/xx
Priority to DE19712134808 priority patent/DE2134808A1/en
Priority to FR7125846A priority patent/FR2101711A5/fr
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Priority to US349511A priority patent/US3876380A/en
Priority to FR7412156A priority patent/FR2224199B1/fr
Priority to SE7404625A priority patent/SE421456B/en
Priority to IT50248/74A priority patent/IT1004481B/en
Priority to GB1555174A priority patent/GB1459903A/en
Priority to NO741299A priority patent/NO142595C/en
Priority to CA197,014A priority patent/CA988507A/en
Priority to NL7404834A priority patent/NL7404834A/xx
Priority to DE2417338A priority patent/DE2417338C2/en
Priority to BE143007A priority patent/BE813493A/en
Priority to CH492474A priority patent/CH586065A5/xx
Application granted granted Critical
Publication of US3876380A publication Critical patent/US3876380A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures

Definitions

  • ABSTRACT A device for mixing test reagents comprising a curved, concave test surface rotatably mounted on an inclined support is described. The reagents are mixed in the cavity of the concave test surface with a predetermined circular motion which results in uniform mixing of the reagents.
  • the present invention relates to a device for mixing reagents. More particularly, the invention relates to a dial turntable device for performing immunochemical and serodiagnostic test reactions which utilizes a predetermined circular motion to bring about uniform mixing of the reagents. The uniform mixing of the test reagents results in an easy, reproducible reaction which enables the user to achieve a more accurate reading of the test result.
  • Immunochemical and serodiagnostic test reactions are most commonly laboratory tests which have as their objective the determination of the presence or absence of antigens or antibodies in body fluids, such as, for example serum and urine. The results of the determination are used as an aid in the diagnosis of certain physiological or pathological conditions in humans and animals.
  • the immunochemical reaction may result in the formation of a precipitate at the end point, in which case it is known as a precipitation reaction. Where the reaction is between substances distributed in a liquid medium and at least one of the substances is a solid which becomes agglomerated, the reaction is known as an agglutination reaction.
  • Tests for blood group, pregnancy, mononucleosis and similar phenomena are just a few of the immunochemical tests which may be carried out in this manner. The difficulty encountered with most of these tests, however, is that a trained eye is usually required to determine unequivocally whether a proper test reading has been obtained.
  • the reagents are mixed on the slide, usually with a rod or spatula etc., the slide is gently rocked and the presence or absence of agglutination is determined.
  • the success of these tests often depends upon the ex tent to which the reactants are mixed.
  • An inconclusive test reading may result from improper mixing of the reagents as well as other factors. Therefore, in order to obtain uniform results, it is desirable to have a means by which the reagents can be uniformly mixed each time so that the results obtained will be reproducible and, as a result, more reliable.
  • a mixing device which achieves uniform mixing of the test reagents via the predetermined motion of a curved, concave test surface.
  • the reagents are mixed on a concave surface, which is rotatably mounted on a support, and the surface is rotated in a circular motion so as to form a wave traversing 360. This circular motion results in uniform mixing of the reagents ultimately producing an end point which is easily discernible and reproducible.
  • the mixing device which is the subject of this invention, is comprised of a curved, concave test surface for the receipt of the reagents, and means for supporting the test surface in a position such that the angle formed between the planar surface of the support means and the horizontal is no less than 5 and no greater than 45.
  • an angle greater than 45 or less than 5 is employed, generally poor or ambiguous test results are obtained.
  • Optimum results are obtained when the planar surface of the support means is maintained at an angle of about 15 with the horizontal.
  • the cavity in the test surface may be eccentrically located from the axis of rotation of the test surface.
  • the curved test surface is mounted on the support means so as to be rotatable around its axis. The test surface is rotated on the support means in a circular fashion and the angle of rotation causes the liquid medium to form a wave-like pattern which results in thorough. mixing of the reagents.
  • the support means may comprise a planar surface having a raised portion set at an angle between 5 and 45 with the base.
  • the raised portion should be adapted so that the test surface can be rotatably mounted thereon.
  • the test surface may be mounted in the raised portion of the planar surface. Any convenient way for mounting the test surface on the support may be employed. It is only necessary that the angle formed between the support means and the horizontal be no greater than 45 and no less than 5.
  • test surface has been described as being rotatably mounted on a support, in another embodiment of the invention the test surface is comprised of a single unit such as, for example, a portion of a sphere.
  • the sphere like test surface is then manually or mechanically rotated at the desired angle on a hard surface such as, a desk, for example, in order to mix the reagents.
  • the dimensions of the curved, concave test surface are not critical.
  • the surface need only be curved sufficiently to retain the test reagents.
  • the test surface may be any shape so long as it contains a cavity for the receipt of the test reagents. It is preferred, however, to use a semispheroidal test surface.
  • the concavity in the test surface may occupy all or only a portion of the semispheroid.
  • the test is carried out directly in the cavity of the test surface.
  • a slide or disc such as a watch glass, for example, which is adapted to fit into the curvature of the test surface, may be used for receipt of the test reagents.
  • the slide When such a slide is employed, the slide rests in the cavity of the test surface while the surface is rotated. It is advantageous to use a slide or disc for the reaction since the slide or disc can be disposed of after each test, thus allowing the test surface to be used indefinitely.
  • the dimensions of the disposable, concave slide are not critical; the cavity need only be large enough to receive the particular reagents employed. Both glass and plastic materials may be employed for the disposable slide. Where a plastic material is employed, the surface of the plastic should be wettable. Suitable plastic materials for this purpose are general-purpose styrene and acrylic resins. Other materials such as waxed paper or other specially treated paper products, for example, also may be employed as the test surface. The test surface and the support may be made from various materials known in the art. For example, any of the known plastics, cardboard, metals, etc. would be suitable materials for this purpose.
  • Slides having varying dimensions and concavities may be employed.
  • the dimensions of the particular slide employed will depend upon the particular test to be made and the amount of material to be employed. It is convenient, however, to employ a watch glass having a diameter between about 40 mm. and 65 mm. and a concavity ranging from about 3.08 mm. to about 7.30 mm.
  • the particular dimensions of the slide employed are not critical. Similar dimensions may be employed conveniently for the cavity in the test surface where a disposable slide is not employed.
  • the test surface may optionally contain means for effecting rotation of the surface in a circular motion.
  • Such means may consist of a raised knob suitable for guiding the disc with the finger or some instrument.
  • the means may also consist of a small concavity in the test surface, such as a finger hole, for example, suitable for guiding the slide in a circular motion.
  • the support surface may also include means for supporting the equipment used in carrying out the test.
  • Such equipment may consist of a liquid dispenser such as an eye dropper, for example, and/or a container for the reagents to be employed.
  • These means may consist of a concavity in the body of the support large enough to hold the dispenser and the container for the reagent. Neither means, however, is essential to the operation of the device.
  • the rotatable test surface may be rotated manually, it is also contemplated that the surface may be rotated by mechanical means, such as, for example, by a shaft driven by a motor attached to the support.
  • FIG. 1 is a perspective view of one embodiment of the invention.
  • FIG. 2 is a partial view in cross section of the mixing device of FIG. 1 taken on lines 22 of FIG. 1.
  • FIG. 3 is a perspective view of a second embodiment of the invention.
  • FIG. 4 is a partial view in cross section of the mixing device of FIG. 3 taken on lines 44 of FIG. 3.
  • FIG. 5 is a cross section of the mixing device and illustrates the test surface mounted so as to be operated mechanically.
  • the mixing device illustrated in FIGS. 1 & 2, comprises a test surface, 1, rotatably mounted on a support, 3, such that the angle formed between the planar surface of the support means and the horizontal is no less than 5 and no greater than 45.
  • the test surface has a curved, concavity, 2, for receipt of the reagents.
  • a means by which the test surface can be turned manually is depicted, as a concavity, 5, in the plane of the test surface. It is to be understood, however, that any suitable means may be employed for turning the test surface.
  • Finger holes, 6, in FIG. 1 are not essential to the operation of the test surface. They are generally employed in those cases wherea disposable slide or disc is employed in conjunction with the test surface and are useful for easy removal of the slide or disc.
  • test surface, 1 is rotatably mounted over the support, 3.
  • a support resting on three legs is shown, it is understood that the particular support means employed is not critical as long as the axis of the test surface forms an angle no greater than and not less than 45 with the horizontal, 4.
  • the test surface, 1, is mounted on the surface of a support, 3, and is mechanically rotated by means of a motor, 7.
  • the motor is operated by a switch, 8, and the test surface, 1, is rotated by means of a shaft, 10, through the opening, 9.
  • a motor is shown in FIG. 5, it should be understood that any conventional means maybe employed to effect mechanical rotation of the test surface.
  • the user will place the reagents and the sample of body fluid in the concavity of the test surface.
  • Primary mixing of reagents is done manually, by means of a mixing stick, for example.
  • the immunochemical reaction is then carried out by turning the test surface in a circular motion for the prescribed number of revolutions. The exact number of revolutions employed will depend upon the particular test to be carried out. For example, when the test for pregnancy is carried out on the test surface, best results are obtained when the surface is rotated about 25 times for about half a minute. The reaction mixture is then observed to determine whether the result is positive or negative.
  • test surface may contain two or more concavities for the purpose of carrying out multiple test reactions.
  • a device for mixing test reagents which comprises a test surface having at least one concave portion for the receipt of said reagents and support means for supporting said test surface, said support means having at least one planar surface and fixedly supporting said test surface in a position such that the angle formed between the planar surface of the support means and the horizontal is no less than 5 and no greater than 45, said test surface being mounted on said support means so as to be rotatable around an axis central of and normal to said test surface.

Abstract

A device for mixing test reagents comprising a curved, concave test surface rotatably mounted on an inclined support is described. The reagents are mixed in the cavity of the concave test surface with a predetermined circular motion which results in uniform mixing of the reagents.

Description

United States Patent n 1 Helriegel [451. Apr. 8, 1975 1 MIXING DEVICE [75] lnventor: Bruce John Helriegel, Chatham, NJ.
[73] Assignee: Ortho Pharmaceutical Corporation,
Raritan, NJ.
[22] Filed: Apr. 9, 1973 [21] Appl. No.3 349,511
[52] U.S. Cl. 23/259; 23/230 B; 23/253 R; 23/292; 259/89 [51] int. Cl. B011 3/00; BOlf 9/02 [58] Field of Search 23/259, 230 B, 253 R, 292; 259/81 R, 89; 195/140 [56} References Cited UNITED STATES PATENTS 1.370673 3/1921 Scholes et a1. 259/81 X 2,520.556 8/1950 Massey 23/259 X 2,755,173 7/1956 Shore 23/253 R 2,914,384 11/1959 Marachy 23/253 R 3,163,404 12/1964 I Kraft et a1... 259/81 R X 3,310,292 3/1967 Moore 259/81 R X 3,415,361 12/1968 Adams, Jr. et a1. 23/253 R UX 3,503,709 3/1970 Yochem 23/253 R X Primary ExaminerMorris O. Wolk Assistant Examiner-Arnold Turk Attorney, Agent, or FirmBenjamin F. Lambert [57] ABSTRACT A device for mixing test reagents comprising a curved, concave test surface rotatably mounted on an inclined support is described. The reagents are mixed in the cavity of the concave test surface with a predetermined circular motion which results in uniform mixing of the reagents.
6 Claims, 5 Drawing Figures MIXING DEVICE The present invention relates to a device for mixing reagents. More particularly, the invention relates to a dial turntable device for performing immunochemical and serodiagnostic test reactions which utilizes a predetermined circular motion to bring about uniform mixing of the reagents. The uniform mixing of the test reagents results in an easy, reproducible reaction which enables the user to achieve a more accurate reading of the test result.
Immunochemical and serodiagnostic test reactions are most commonly laboratory tests which have as their objective the determination of the presence or absence of antigens or antibodies in body fluids, such as, for example serum and urine. The results of the determination are used as an aid in the diagnosis of certain physiological or pathological conditions in humans and animals. The immunochemical reaction may result in the formation of a precipitate at the end point, in which case it is known as a precipitation reaction. Where the reaction is between substances distributed in a liquid medium and at least one of the substances is a solid which becomes agglomerated, the reaction is known as an agglutination reaction. Tests for blood group, pregnancy, mononucleosis and similar phenomena are just a few of the immunochemical tests which may be carried out in this manner. The difficulty encountered with most of these tests, however, is that a trained eye is usually required to determine unequivocally whether a proper test reading has been obtained.
It is known in the art that certain immunochemical tests, such as pregnancy tests, for example, can be carried out on slides wherein the end point is determined by the presence or absence of agglutination. As indicated above, immunochemical tests carried out in this manner often result in inconclusive readingsdue to the difficulties encountered in determining the end point.
In US. Application Ser. No. 328,219, filed Jan. 31, 1973, a method is described wherein the immunochemical tests are carried out on a concave test surface which. in many cases results in the formation of an easily discernible pattern at the end point which can be easily detected even by an untrained eye. This is particularly true in the case of the pregnancy test where a mosaic like pattern forms at the end point.
In all of the immunochemical tests involving agglutination, the reagents are mixed on the slide, usually with a rod or spatula etc., the slide is gently rocked and the presence or absence of agglutination is determined. The success of these tests often depends upon the ex tent to which the reactants are mixed. An inconclusive test reading may result from improper mixing of the reagents as well as other factors. Therefore, in order to obtain uniform results, it is desirable to have a means by which the reagents can be uniformly mixed each time so that the results obtained will be reproducible and, as a result, more reliable.
GENERAL DESCRIPTION OF THE INVENTION The uncertainty involved in obtaining a proper test reading when performing immunochemical and serodiagnostic test reactions, due to improper mixing of the reagents, has now been largely eliminated by the present invention. By means of the present invention, a mixing device is provided which achieves uniform mixing of the test reagents via the predetermined motion of a curved, concave test surface. The reagents are mixed on a concave surface, which is rotatably mounted on a support, and the surface is rotated in a circular motion so as to form a wave traversing 360. This circular motion results in uniform mixing of the reagents ultimately producing an end point which is easily discernible and reproducible.
The mixing device, which is the subject of this invention, is comprised of a curved, concave test surface for the receipt of the reagents, and means for supporting the test surface in a position such that the angle formed between the planar surface of the support means and the horizontal is no less than 5 and no greater than 45. When an angle greater than 45 or less than 5 is employed, generally poor or ambiguous test results are obtained. Optimum results are obtained when the planar surface of the support means is maintained at an angle of about 15 with the horizontal. The cavity in the test surface may be eccentrically located from the axis of rotation of the test surface. The curved test surface is mounted on the support means so as to be rotatable around its axis. The test surface is rotated on the support means in a circular fashion and the angle of rotation causes the liquid medium to form a wave-like pattern which results in thorough. mixing of the reagents.
Any means which can be used to support the test surface such that the test surface may rotate freely will serve as the support means. For example, the support means may comprise a planar surface having a raised portion set at an angle between 5 and 45 with the base. The raised portion should be adapted so that the test surface can be rotatably mounted thereon. The test surface may be mounted in the raised portion of the planar surface. Any convenient way for mounting the test surface on the support may be employed. It is only necessary that the angle formed between the support means and the horizontal be no greater than 45 and no less than 5.
Although the test surface has been described as being rotatably mounted on a support, in another embodiment of the invention the test surface is comprised of a single unit such as, for example, a portion of a sphere.
The sphere like test surface is then manually or mechanically rotated at the desired angle on a hard surface such as, a desk, for example, in order to mix the reagents.
The dimensions of the curved, concave test surface are not critical. The surface need only be curved sufficiently to retain the test reagents. The test surface may be any shape so long as it contains a cavity for the receipt of the test reagents. It is preferred, however, to use a semispheroidal test surface. The concavity in the test surface may occupy all or only a portion of the semispheroid. In one embodiment of the invention the test is carried out directly in the cavity of the test surface. Alternatively, a slide or disc, such as a watch glass, for example, which is adapted to fit into the curvature of the test surface, may be used for receipt of the test reagents. When such a slide is employed, the slide rests in the cavity of the test surface while the surface is rotated. It is advantageous to use a slide or disc for the reaction since the slide or disc can be disposed of after each test, thus allowing the test surface to be used indefinitely.
The dimensions of the disposable, concave slide are not critical; the cavity need only be large enough to receive the particular reagents employed. Both glass and plastic materials may be employed for the disposable slide. Where a plastic material is employed, the surface of the plastic should be wettable. Suitable plastic materials for this purpose are general-purpose styrene and acrylic resins. Other materials such as waxed paper or other specially treated paper products, for example, also may be employed as the test surface. The test surface and the support may be made from various materials known in the art. For example, any of the known plastics, cardboard, metals, etc. would be suitable materials for this purpose.
Slides having varying dimensions and concavities may be employed. The dimensions of the particular slide employed will depend upon the particular test to be made and the amount of material to be employed. It is convenient, however, to employ a watch glass having a diameter between about 40 mm. and 65 mm. and a concavity ranging from about 3.08 mm. to about 7.30 mm. The particular dimensions of the slide employed are not critical. Similar dimensions may be employed conveniently for the cavity in the test surface where a disposable slide is not employed.
The test surface may optionally contain means for effecting rotation of the surface in a circular motion. Such means may consist of a raised knob suitable for guiding the disc with the finger or some instrument. The means may also consist of a small concavity in the test surface, such as a finger hole, for example, suitable for guiding the slide in a circular motion.
The support surface may also include means for supporting the equipment used in carrying out the test. Such equipment may consist of a liquid dispenser such as an eye dropper, for example, and/or a container for the reagents to be employed. These means may consist of a concavity in the body of the support large enough to hold the dispenser and the container for the reagent. Neither means, however, is essential to the operation of the device.
Although the rotatable test surface may be rotated manually, it is also contemplated that the surface may be rotated by mechanical means, such as, for example, by a shaft driven by a motor attached to the support.
The invention will be more fully understood by reference to the drawings in which FIG. 1 is a perspective view of one embodiment of the invention.
FIG. 2 is a partial view in cross section of the mixing device of FIG. 1 taken on lines 22 of FIG. 1.
FIG. 3 is a perspective view of a second embodiment of the invention.
FIG. 4 is a partial view in cross section of the mixing device of FIG. 3 taken on lines 44 of FIG. 3.
FIG. 5 is a cross section of the mixing device and illustrates the test surface mounted so as to be operated mechanically.
Referring specifically now to the drawings, the mixing device, illustrated in FIGS. 1 & 2, comprises a test surface, 1, rotatably mounted on a support, 3, such that the angle formed between the planar surface of the support means and the horizontal is no less than 5 and no greater than 45. The test surface has a curved, concavity, 2, for receipt of the reagents. A means by which the test surface can be turned manually is depicted, as a concavity, 5, in the plane of the test surface. It is to be understood, however, that any suitable means may be employed for turning the test surface.
Finger holes, 6, in FIG. 1 are not essential to the operation of the test surface. They are generally employed in those cases wherea disposable slide or disc is employed in conjunction with the test surface and are useful for easy removal of the slide or disc.
In the embodiment of the invention depicted in FIGS. 3 and 4, the test surface, 1, is rotatably mounted over the support, 3. Although a support resting on three legs is shown, it is understood that the particular support means employed is not critical as long as the axis of the test surface forms an angle no greater than and not less than 45 with the horizontal, 4.
In FIG. 5, the test surface, 1, is mounted on the surface of a support, 3, and is mechanically rotated by means of a motor, 7. In this particular embodiment, the motor is operated by a switch, 8, and the test surface, 1, is rotated by means of a shaft, 10, through the opening, 9. Although a motor is shown in FIG. 5, it should be understood that any conventional means maybe employed to effect mechanical rotation of the test surface.
In utilizing the mixing device, the user will place the reagents and the sample of body fluid in the concavity of the test surface. Primary mixing of reagents is done manually, by means ofa mixing stick, for example. The immunochemical reaction is then carried out by turning the test surface in a circular motion for the prescribed number of revolutions. The exact number of revolutions employed will depend upon the particular test to be carried out. For example, when the test for pregnancy is carried out on the test surface, best results are obtained when the surface is rotated about 25 times for about half a minute. The reaction mixture is then observed to determine whether the result is positive or negative.
It is also contemplated that the test surface may contain two or more concavities for the purpose of carrying out multiple test reactions.
1 claim:
1. A device for mixing test reagents which comprises a test surface having at least one concave portion for the receipt of said reagents and support means for supporting said test surface, said support means having at least one planar surface and fixedly supporting said test surface in a position such that the angle formed between the planar surface of the support means and the horizontal is no less than 5 and no greater than 45, said test surface being mounted on said support means so as to be rotatable around an axis central of and normal to said test surface.
2. The device of claim 1 wherein mechanical means for rotating the test surface are additionally present.
3. The device of claim 1 wherein the angle formed between the planar surface of the support means and the horizontal is 15.
4. The device of claim 1 wherein the angle formed between the planar surface of the support means and the horizontal is 45.
5. The device of claim 1 wherein the concave portion of the test surface is a semi-spheroid.
6. The device of claim 5 wherein the concavity of the semi-spheroid has a depth of between 3.08 mm. and 7.30 mm.

Claims (6)

1. A DEVICE FOR MIXING TEST REAGENTS WHICH COMPRISES A TEST SURFACE, HAVING AT LEAST ONE CONCAVE PORTION FOR THE RECEIPT OF SAID REAGENTS AND SUPPORT MEANS FOR SUPPORTING SAID TEST SURFACE SAID SUPPORT MEANS HAVING AT LEAST ONE PLANAR SURFACEAND FIXEDLY SUPPORTING SAID TEST SURFACE IN A POSITION SUCH THAT THE ANGLE FORMED BETWEEN THE PLANAR SURFACE OF THE SUPPORT MEANS AND THE HORIZONTAL IS NO LESS THAN 5* AND NO GREATER THAN 45*, SAID TEST SURFACE BEING MOUNTED ON SAID SUPPORT MEANS SO AS TO BE ROTATABLE AROUND AN AXIS CENTRAL OF AND NORMAL TO SAID TEST SURFACE.
2. The device of claim 1 wherein mechanical means for rotating the test surface are additionally present.
3. The device of claim 1 wherein the angle formed between the planar surface of the support means and the horizontal is 15.degree..
4. The device of claim 1 wherein the angle formed between the planar surface of the support means and the horizontal is 45.degree..
5. The device of claim 1 wherein the concave portion of the test surface is a semi-spheroid.
6. The device of claim 5 wherein the concavity of the semi-spheroid has a depth of between 3.08 mm. and 7.30 mm.
US349511A 1921-06-01 1973-04-09 Mixing device Expired - Lifetime US3876380A (en)

Priority Applications (29)

Application Number Priority Date Filing Date Title
US474090A US1447935A (en) 1921-06-01 1921-06-01 Thermometer
US604046A US3415361A (en) 1966-12-22 1966-12-22 Test device and container therefor
US678405A US3503709A (en) 1966-12-22 1967-10-26 Method and system for testing blood samples for thrombus formation time
IL28921A IL28921A (en) 1966-12-22 1967-11-12 Test device and container therefor
GB53405/67A GB1206807A (en) 1966-12-22 1967-11-23 Improvements in or relating to test devices
CH1752967A CH519172A (en) 1966-12-22 1967-12-13 Test arrangement
NL6717112A NL6717112A (en) 1966-12-22 1967-12-15
SE17419/67A SE338882B (en) 1966-12-22 1967-12-19
FR1549783D FR1549783A (en) 1966-12-22 1967-12-20
BE708276D BE708276A (en) 1966-12-22 1967-12-20
DE19671648991 DE1648991A1 (en) 1966-12-22 1967-12-21 Device for carrying out examinations
ES1969146103U ES146103Y (en) 1966-12-22 1969-02-28 CONTAINER TO PERFORM CHEMICAL AND IMMUNE TESTS.
ES1969154261U ES154261Y (en) 1966-12-22 1969-12-21 DEVICE FOR CHEMICAL AND IMMUNE TESTING.
US55180A US3627276A (en) 1966-12-22 1970-07-15 Sample container and mixing apparatus
GB3253171A GB1320281A (en) 1966-12-22 1971-07-12 Sample container and mixing apparatus
SE7109010A SE374209B (en) 1966-12-22 1971-07-12
DE19712134808 DE2134808A1 (en) 1966-12-22 1971-07-12 Method and device for automatic mixing of the contents of a sample container
FR7125846A FR2101711A5 (en) 1966-12-22 1971-07-15
US349511A US3876380A (en) 1973-04-09 1973-04-09 Mixing device
SE7404625A SE421456B (en) 1966-12-22 1974-04-05 DEVICE FOR MIXING THE TESTREAGS DURING SEROLOGICAL TEST REACTIONS
FR7412156A FR2224199B1 (en) 1966-12-22 1974-04-05
IT50248/74A IT1004481B (en) 1966-12-22 1974-04-08 DEVICE FOR MIXING REAGENTS
GB1555174A GB1459903A (en) 1966-12-22 1974-04-08 Mixing device
NO741299A NO142595C (en) 1966-12-22 1974-04-08 MIXING DEVICE FOR TEST REAGENTS.
CA197,014A CA988507A (en) 1966-12-22 1974-04-08 Device for mixing test reagents comprising rotating test surface
NL7404834A NL7404834A (en) 1966-12-22 1974-04-09
DE2417338A DE2417338C2 (en) 1966-12-22 1974-04-09 Device for mixing test reagents
BE143007A BE813493A (en) 1966-12-22 1974-04-09 MIXING DEVICE
CH492474A CH586065A5 (en) 1966-12-22 1974-04-09

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4303616A (en) * 1979-06-20 1981-12-01 Olympus Optical Co. Ltd. Agglutination analyzing vessel
US5380493A (en) * 1992-03-27 1995-01-10 Chavez; Jeffery B. Cell well plate holder and well marking system
KR20000049597A (en) * 2000-04-15 2000-08-05 윤선주 Development of various uses mortars
US20080113450A1 (en) * 2004-06-11 2008-05-15 Roche Diagnostics Operations, Inc. Method and device for mixing samples on a support
CN109331718A (en) * 2018-11-08 2019-02-15 长兴盛纺织有限公司 A kind of automatic beating equipment of chemical fabric production

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1370673A (en) * 1919-10-08 1921-03-08 Samuel R Scholes Method of and apparatus for removing strlae from melted glass
US2520556A (en) * 1947-01-06 1950-08-29 George F Massey Babcock test mixer
US2755173A (en) * 1953-12-01 1956-07-17 Vernon W Shore Apparatus for effecting tests for pullorum and the like
US2914384A (en) * 1954-07-22 1959-11-24 Al-Marachy Pierre Fauzy Apparatus for effecting chemical reactions on glass or like plates
US3163404A (en) * 1962-10-09 1964-12-29 Scientific Industries Rotary apparatus for agitating fluids
US3310292A (en) * 1964-03-13 1967-03-21 American Hospital Supply Corp Serological testing device
US3415361A (en) * 1966-12-22 1968-12-10 Miles Lab Test device and container therefor

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1370673A (en) * 1919-10-08 1921-03-08 Samuel R Scholes Method of and apparatus for removing strlae from melted glass
US2520556A (en) * 1947-01-06 1950-08-29 George F Massey Babcock test mixer
US2755173A (en) * 1953-12-01 1956-07-17 Vernon W Shore Apparatus for effecting tests for pullorum and the like
US2914384A (en) * 1954-07-22 1959-11-24 Al-Marachy Pierre Fauzy Apparatus for effecting chemical reactions on glass or like plates
US3163404A (en) * 1962-10-09 1964-12-29 Scientific Industries Rotary apparatus for agitating fluids
US3310292A (en) * 1964-03-13 1967-03-21 American Hospital Supply Corp Serological testing device
US3415361A (en) * 1966-12-22 1968-12-10 Miles Lab Test device and container therefor
US3503709A (en) * 1966-12-22 1970-03-31 Donald E Yochem Method and system for testing blood samples for thrombus formation time

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4303616A (en) * 1979-06-20 1981-12-01 Olympus Optical Co. Ltd. Agglutination analyzing vessel
US5380493A (en) * 1992-03-27 1995-01-10 Chavez; Jeffery B. Cell well plate holder and well marking system
KR20000049597A (en) * 2000-04-15 2000-08-05 윤선주 Development of various uses mortars
US20080113450A1 (en) * 2004-06-11 2008-05-15 Roche Diagnostics Operations, Inc. Method and device for mixing samples on a support
US9156012B2 (en) * 2004-06-11 2015-10-13 Roche Diagnostics Operations, Inc. Method and device for mixing samples on a support
CN109331718A (en) * 2018-11-08 2019-02-15 长兴盛纺织有限公司 A kind of automatic beating equipment of chemical fabric production

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