JP4194865B2 - エナンチオマーが富化されたアリールアミノプロパノールの製造方法 - Google Patents

エナンチオマーが富化されたアリールアミノプロパノールの製造方法 Download PDF

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Publication number
JP4194865B2
JP4194865B2 JP2003078367A JP2003078367A JP4194865B2 JP 4194865 B2 JP4194865 B2 JP 4194865B2 JP 2003078367 A JP2003078367 A JP 2003078367A JP 2003078367 A JP2003078367 A JP 2003078367A JP 4194865 B2 JP4194865 B2 JP 4194865B2
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Prior art keywords
formula
compound
amino
ruthenium
alkyl
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Japanese (ja)
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JP2003313184A5 (https=
JP2003313184A (ja
Inventor
エッケルト マルクス
ドライスバッハ クラウス
ボッシュ ボリス
シュトレ アンドレーアス
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Lanxess Deutschland GmbH
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Lanxess Deutschland GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2003078367A 2002-03-20 2003-03-20 エナンチオマーが富化されたアリールアミノプロパノールの製造方法 Expired - Fee Related JP4194865B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10212301A DE10212301A1 (de) 2002-03-20 2002-03-20 Verfahren zur Herstellung von Aryl-aminopropanolen
DE10212301.2 2002-03-20

Publications (3)

Publication Number Publication Date
JP2003313184A JP2003313184A (ja) 2003-11-06
JP2003313184A5 JP2003313184A5 (https=) 2007-11-01
JP4194865B2 true JP4194865B2 (ja) 2008-12-10

Family

ID=27771441

Family Applications (1)

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JP2003078367A Expired - Fee Related JP4194865B2 (ja) 2002-03-20 2003-03-20 エナンチオマーが富化されたアリールアミノプロパノールの製造方法

Country Status (6)

Country Link
US (3) US7169938B2 (https=)
EP (1) EP1346977B1 (https=)
JP (1) JP4194865B2 (https=)
CN (2) CN102321066B (https=)
DE (2) DE10212301A1 (https=)
ES (1) ES2328235T3 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003221028A1 (en) * 2002-03-19 2003-09-29 Mitsubishi Chemical Corporation 3-hydroxy-3-(2-thienyl)propionamide compound, process for producing the same, and process for producing 3-amino-1-(2-thienyl)-1-propanol compound therefrom
US7659409B2 (en) 2002-03-19 2010-02-09 Mitsubishi Chemical Corporation 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same
JP2004155756A (ja) * 2002-04-30 2004-06-03 Mitsubishi Chemicals Corp 光学活性アルコールの製造方法
GB0221438D0 (en) * 2002-09-16 2002-10-23 Avecia Ltd Processes and compounds
US20050197503A1 (en) * 2004-03-05 2005-09-08 Boehringer Ingelheim International Gmbh Process for the preparation of N-alkyl-N-methyl-3-hydroxy-3-(2-thienyl)-propylamines
GB0425320D0 (en) * 2004-11-17 2004-12-22 Johnson Matthey Plc Diamines
CZ299270B6 (cs) 2006-01-04 2008-06-04 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu
CA2656128A1 (en) 2006-07-03 2008-01-10 Ranbaxy Laboratories Limited Process for the preparation of enantiomerically pure salts of n-methyl-3(1-naphthaleneoxy)-3-(2-thienyl)propanamine
WO2008077645A1 (en) * 2006-12-22 2008-07-03 Synthon B.V. Process for making duloxetine and related compounds
EP2182929A2 (en) * 2007-07-13 2010-05-12 Synthon B.V. Duloxetine formulations
WO2009054887A1 (en) * 2007-10-22 2009-04-30 Merck & Co., Inc. Process for preparing an anti-hypercholesterolemic compound
CZ304602B6 (cs) 2009-09-02 2014-07-30 Zentiva, K. S. Způsob krystalizace hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (hydrochloridu duloxetinu)
DK2426116T3 (da) * 2010-08-30 2013-09-08 Saltigo Gmbh Fremgangsmåde til fremstilling af (S)-3-N-methylamino-1-(2-thienyl)-1-propanol
CN104130239B (zh) * 2014-08-16 2016-05-04 瑞阳制药有限公司 度洛西汀手性中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7902991A (en) * 1990-05-01 1991-11-27 Smithkline Beecham Corporation Five-membered ring alkanoic acid leukotriene antagonists
US5104899A (en) 1990-08-13 1992-04-14 Sepracor, Inc. Methods and compositions for treating depression using optically pure fluoxetine
DE4128787A1 (de) 1991-08-30 1993-03-04 Bayer Ag Neue zwischenprodukte und ihre verwendung bei der herstellung von s-ketoprofen
DE4209616A1 (de) * 1992-03-25 1993-09-30 Basf Ag Verfahren zur Herstellung von µ-Hydroxycarbonsäureestern
IL105716A0 (en) * 1992-06-08 1993-09-22 Richter Gedeon Vegyeszet Aminopropanol derivatives,their preparation and pharmaceutical compositions containing them
DE4330730A1 (de) 1993-09-10 1995-03-16 Bayer Ag Neue Bisphosphine für asymmetrische Hydrierkatalysatoren
US5362886A (en) 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
DE19522293A1 (de) 1995-06-20 1997-01-02 Bayer Ag Neue Bisphospine als Katalysatoren für asymmetrische Reaktionen
DE19535243A1 (de) 1995-09-22 1997-03-27 Bayer Ag Neue Zwischenprodukte für die Synthese von Bisphosphinverbindungen
US7659409B2 (en) 2002-03-19 2010-02-09 Mitsubishi Chemical Corporation 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same

Also Published As

Publication number Publication date
US20080262247A1 (en) 2008-10-23
EP1346977A1 (de) 2003-09-24
US7582776B2 (en) 2009-09-01
US7893281B2 (en) 2011-02-22
CN1445224A (zh) 2003-10-01
DE50311721D1 (de) 2009-09-03
CN1445224B (zh) 2012-07-11
CN102321066B (zh) 2014-07-23
ES2328235T3 (es) 2009-11-11
US20030225153A1 (en) 2003-12-04
JP2003313184A (ja) 2003-11-06
EP1346977B1 (de) 2009-07-22
DE10212301A1 (de) 2003-10-02
CN102321066A (zh) 2012-01-18
US20090286997A1 (en) 2009-11-19
US7169938B2 (en) 2007-01-30

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