JP4187410B2 - 分子ヨウ素経口投与のための方法および医薬組成物 - Google Patents
分子ヨウ素経口投与のための方法および医薬組成物 Download PDFInfo
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- JP4187410B2 JP4187410B2 JP2000517725A JP2000517725A JP4187410B2 JP 4187410 B2 JP4187410 B2 JP 4187410B2 JP 2000517725 A JP2000517725 A JP 2000517725A JP 2000517725 A JP2000517725 A JP 2000517725A JP 4187410 B2 JP4187410 B2 JP 4187410B2
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- Prior art keywords
- iodine
- iodide
- iodate
- molecular
- molecular iodine
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- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 title claims abstract description 356
- 238000000034 method Methods 0.000 title abstract description 20
- 239000008194 pharmaceutical composition Substances 0.000 title description 8
- 229910052740 iodine Inorganic materials 0.000 claims abstract description 176
- 239000011630 iodine Substances 0.000 claims abstract description 175
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- 241000124008 Mammalia Species 0.000 claims abstract description 20
- 241000894007 species Species 0.000 claims abstract description 19
- 238000001727 in vivo Methods 0.000 claims abstract description 18
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- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract description 12
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- 230000001590 oxidative effect Effects 0.000 claims abstract description 6
- 238000006479 redox reaction Methods 0.000 claims abstract description 6
- 239000003937 drug carrier Substances 0.000 claims abstract description 5
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- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims description 88
- 239000000203 mixture Substances 0.000 claims description 65
- 235000009518 sodium iodide Nutrition 0.000 claims description 37
- ICIWUVCWSCSTAQ-UHFFFAOYSA-M iodate Chemical compound [O-]I(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-M 0.000 claims description 29
- NALMPLUMOWIVJC-UHFFFAOYSA-N n,n,4-trimethylbenzeneamine oxide Chemical compound CC1=CC=C([N+](C)(C)[O-])C=C1 NALMPLUMOWIVJC-UHFFFAOYSA-N 0.000 claims description 19
- 239000011697 sodium iodate Substances 0.000 claims description 19
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- -1 iodate anion Chemical class 0.000 claims description 16
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 10
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 claims description 10
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 8
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- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 4
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| US08/960,149 US5885592A (en) | 1997-10-29 | 1997-10-29 | Methods and pharmaceutical compositions for oral delivery of molecular iodine |
| PCT/US1998/022720 WO1999021567A1 (en) | 1997-10-29 | 1998-10-27 | Pharmaceutical compositions for oral administration of molecular iodine |
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Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6248335B1 (en) * | 1997-10-29 | 2001-06-19 | Symbollon Corporation | Stabilized oral pharmaceutical composition containing iodide and iodate and method |
| AU1693099A (en) * | 1998-01-06 | 1999-07-26 | Fujisawa Pharmaceutical Co., Ltd. | Solid preparation of iodophor and its manufacturing methods |
| JP2002518351A (ja) * | 1998-06-19 | 2002-06-25 | オキシバイオ・インコーポレイテッド | 抗感染および避妊特性を有する医療装置 |
| US6154672A (en) * | 1998-06-22 | 2000-11-28 | Pacesetter, Inc. | Method and apparatus for improving the probability of success of defibrillation shocks |
| GB2395901A (en) * | 1999-02-26 | 2004-06-09 | Symbollon Corp | Stabilised tablets containing iodide and iodate |
| ATE320831T1 (de) * | 2000-10-06 | 2006-04-15 | Dmg Italia Srl | Immunotrophische preparation zur behandlung von tonsilläre hypertrophie |
| RU2201229C1 (ru) * | 2002-03-26 | 2003-03-27 | Миронов Владимир Андреевич | Способ оздоровления организма |
| JP4586018B2 (ja) * | 2003-06-20 | 2010-11-24 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 猫における甲状腺機能亢進症を予防する方法及び限定されたヨウ素を含む組成物 |
| US8501223B2 (en) * | 2003-06-20 | 2013-08-06 | Hill's Pet Nutrition, Inc. | Methods for dietary management of cats to avoid hyperthyroidism |
| RU2432941C2 (ru) * | 2006-01-26 | 2011-11-10 | Хилл'С Пет Ньютришн, Инк. | Способы и композиции для лечения гипертиреоза у кошачьих |
| AU2007249806B2 (en) * | 2006-05-12 | 2011-07-07 | Hill's Pet Nutrition, Inc. | Compositions and methods for preventing or treating chronic renal failure in felines with hyperthyroidism |
| US8303994B2 (en) * | 2006-06-22 | 2012-11-06 | Jack Howard Kessler | Method for the eradication of pathogens including S. aureus and antibiotic resistant microbes from the upper respiratory tract of mammals and for inhibiting the activation of immune cells |
| CN101511205A (zh) * | 2006-07-03 | 2009-08-19 | 希尔氏宠物营养品公司 | 用于在甲状腺机能亢进的猫科动物中预防或治疗心血管疾病的组合物和方法 |
| US8021610B2 (en) * | 2006-09-07 | 2011-09-20 | Biolargo Life Technologies, Inc. | Systems providing antimicrobial activity to an environment |
| US9414601B2 (en) * | 2006-09-07 | 2016-08-16 | Biolargo Life Technologies, Incorporated | Material having antimicrobial activity when wet |
| US7943158B2 (en) * | 2006-09-07 | 2011-05-17 | BioLargo Life Technologies, Inc | Absorbent systems providing antimicrobial activity |
| US20080063560A1 (en) * | 2006-09-07 | 2008-03-13 | Biolargo Life Technologies, Incorporated | Ground treatment for reducing microbial content |
| US8226964B2 (en) * | 2006-09-07 | 2012-07-24 | Biolargo Life Technologies, Inc. | Systems and methods for cleaning liquid carriers related applications data |
| US7867510B2 (en) * | 2006-09-07 | 2011-01-11 | BioLargo Life Technologies, Inc | Material having antimicrobial activity when wet |
| US8257749B2 (en) * | 2007-02-08 | 2012-09-04 | Biolargo Life Technologies, Incorporated | Systems providing at least pesticidal activity |
| WO2009087647A1 (en) * | 2008-01-07 | 2009-07-16 | Council Of Scientific & Industrial Research | A stabilized iodine-water concentrate formulation useful for protection against iodine deficiency disorders |
| MX340005B (es) * | 2010-04-23 | 2016-05-18 | Univ Nac Autónoma De México | Composicion de yodo molecular de uso humano para la prevencion y tratamiento de patologias prostaticas. |
| KR20140033123A (ko) * | 2011-05-16 | 2014-03-17 | 쇼칸 사비르하노비치 베갈리예프 | 항바이러스성, 항궤양 및 면역 자극 작용을 가지고, 르네상스라는 이름을 가지는 의학 조제물 |
| CN102697804B (zh) * | 2012-06-07 | 2014-02-12 | 维尔信科技（潍坊）有限公司 | 一种固态分子碘消毒制剂及其制备方法 |
| US10034899B2 (en) * | 2013-11-27 | 2018-07-31 | BioPharmX, Inc. | Solid oral dosage form for breast symptoms |
| MX386702B (es) | 2014-02-10 | 2025-03-19 | Fred Hutchinson Cancer Center | Tratamiento con halogeno de ataque cardiaco y lesion isquemica. |
| WO2015153258A1 (en) | 2014-03-31 | 2015-10-08 | Iotech International, Llc | Stable compositions of uncomplexed iodine and methods of use |
| EA031907B1 (ru) * | 2016-03-11 | 2019-03-29 | Тимур Хусаинович Измайлов | Шашка иодная дымовая |
| US20170304359A1 (en) | 2016-04-21 | 2017-10-26 | BioPharmX, Inc. | Oral iodine dosage form |
| AU2017300497A1 (en) | 2016-07-21 | 2019-03-14 | I2Pure Corp. | Emollient topical disinfectants |
| CN106727683A (zh) * | 2016-12-23 | 2017-05-31 | 刘海涛 | 一种药物制剂在制备治疗幽门螺杆菌感染性疾病的药物中的应用 |
| WO2021198938A1 (ja) * | 2020-03-31 | 2021-10-07 | タイ ミン ファーマシューティカルズ ジェイエスシー | 癌または子宮内膜症の患者における癌、子宮内膜症および疼痛の治療のためのジイソプロピルアミン化合物およびヨウ素 |
| BR112023001995A2 (pt) | 2020-08-13 | 2023-02-28 | I2Pure Corp | Composições de alta concentração de iodo molecular, formulações farmacêuticas, preparação e usos |
| WO2024201560A1 (en) * | 2023-03-24 | 2024-10-03 | Me.Link Co., Ltd. | Iodine containing colloidal liquid composition |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2540170C3 (de) * | 1975-09-10 | 1979-01-18 | Basf Ag, 6700 Ludwigshafen | Verwendung von in organischer Lösung hergestelltem Polyvinylpyrrolidon zur Herstellung von stabilen wäßrigen PoIyvinylpyrrolidon-Jod-Lösungen |
| US4259322A (en) * | 1978-03-20 | 1981-03-31 | Helong Lim | Method of treatment of tuberculosis |
| US4187294A (en) * | 1978-07-06 | 1980-02-05 | Nihon Nousan Kougyou Co., Ltd. | Method for producing eggs containing a high amount of iodinated amino acids |
| JPS5663919A (en) * | 1979-10-29 | 1981-05-30 | Nippon Nousan Kogyo Kk | Remedial composition for diabetes |
| JPS57140723A (en) * | 1981-02-25 | 1982-08-31 | Nippon Nousan Kogyo Kk | Preventing composition for hyperlipemia due to neutral fat |
| US5171582A (en) * | 1985-07-31 | 1992-12-15 | Ghent William R | Treatment of iodine deficiency diseases |
| US5250304A (en) * | 1985-07-31 | 1993-10-05 | Ghent William R | Treatment of iodine deficiency diseases |
| US4816255A (en) * | 1985-07-31 | 1989-03-28 | Ghent William R | Treatment of iodine deficiency breast syndrome |
| US5589198A (en) * | 1985-07-31 | 1996-12-31 | 943038 Ontario, Inc. | Treatment of iodine deficiency diseases |
| US4849237A (en) * | 1987-10-30 | 1989-07-18 | Hurst William D | Method for sanitizing poultry carcasses in a poultry processing plant utilizing ozonated water |
| US5629024A (en) * | 1994-08-22 | 1997-05-13 | Symbollon Corporation | Method of forming an iodine based germicide composition |
-
1997
- 1997-10-29 US US08/960,149 patent/US5885592A/en not_active Expired - Lifetime
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1998
- 1998-10-21 IL IL13477898A patent/IL134778A0/xx not_active IP Right Cessation
- 1998-10-27 BR BR9812588-5A patent/BR9812588A/pt not_active Application Discontinuation
- 1998-10-27 PT PT98954002T patent/PT1024815E/pt unknown
- 1998-10-27 CA CA002301503A patent/CA2301503C/en not_active Expired - Fee Related
- 1998-10-27 AU AU11227/99A patent/AU750627B2/en not_active Ceased
- 1998-10-27 DK DK98954002T patent/DK1024815T3/da active
- 1998-10-27 WO PCT/US1998/022720 patent/WO1999021567A1/en not_active Ceased
- 1998-10-27 JP JP2000517725A patent/JP4187410B2/ja not_active Expired - Fee Related
- 1998-10-27 CN CNB988097648A patent/CN1150904C/zh not_active Expired - Fee Related
- 1998-10-27 AT AT98954002T patent/ATE231725T1/de not_active IP Right Cessation
- 1998-10-27 RU RU2000107852/14A patent/RU2213564C2/ru not_active IP Right Cessation
- 1998-10-27 KR KR10-2000-7003542A patent/KR100412219B1/ko not_active Expired - Fee Related
- 1998-10-27 DE DE69811105T patent/DE69811105T2/de not_active Expired - Lifetime
- 1998-10-27 EP EP98954002A patent/EP1024815B1/en not_active Expired - Lifetime
- 1998-10-27 ES ES98954002T patent/ES2191973T3/es not_active Expired - Lifetime
-
2000
- 2000-03-31 NO NO20001673A patent/NO20001673L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL134778A0 (en) | 2001-04-30 |
| AU750627B2 (en) | 2002-07-25 |
| ES2191973T3 (es) | 2003-09-16 |
| PT1024815E (pt) | 2003-06-30 |
| EP1024815B1 (en) | 2003-01-29 |
| AU1122799A (en) | 1999-05-17 |
| DE69811105D1 (de) | 2003-03-06 |
| CA2301503A1 (en) | 1999-05-06 |
| RU2213564C2 (ru) | 2003-10-10 |
| DK1024815T3 (da) | 2003-05-19 |
| NO20001673L (no) | 2000-05-24 |
| ATE231725T1 (de) | 2003-02-15 |
| JP2003510243A (ja) | 2003-03-18 |
| KR20010030861A (ko) | 2001-04-16 |
| WO1999021567A1 (en) | 1999-05-06 |
| EP1024815A1 (en) | 2000-08-09 |
| CA2301503C (en) | 2005-01-04 |
| KR100412219B1 (ko) | 2003-12-24 |
| NO20001673D0 (no) | 2000-03-31 |
| BR9812588A (pt) | 2000-07-25 |
| CN1150904C (zh) | 2004-05-26 |
| CN1272789A (zh) | 2000-11-08 |
| DE69811105T2 (de) | 2003-11-06 |
| US5885592A (en) | 1999-03-23 |
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