JP4182218B2 - アポトーシスを誘導する新規なグルコース誘導体、その製造方法及び医薬としてのその用途 - Google Patents

アポトーシスを誘導する新規なグルコース誘導体、その製造方法及び医薬としてのその用途 Download PDF

Info

Publication number
JP4182218B2
JP4182218B2 JP2003500100A JP2003500100A JP4182218B2 JP 4182218 B2 JP4182218 B2 JP 4182218B2 JP 2003500100 A JP2003500100 A JP 2003500100A JP 2003500100 A JP2003500100 A JP 2003500100A JP 4182218 B2 JP4182218 B2 JP 4182218B2
Authority
JP
Japan
Prior art keywords
group
hydrogen
formula
same
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2003500100A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2002096921A1 (ja
Inventor
利男 勝呂
恒二 川村
浩一 勝山
靖一 田沼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tokyo University of Science
Original Assignee
Tokyo University of Science
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tokyo University of Science filed Critical Tokyo University of Science
Publication of JPWO2002096921A1 publication Critical patent/JPWO2002096921A1/ja
Application granted granted Critical
Publication of JP4182218B2 publication Critical patent/JP4182218B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2003500100A 2001-05-30 2002-05-29 アポトーシスを誘導する新規なグルコース誘導体、その製造方法及び医薬としてのその用途 Expired - Fee Related JP4182218B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001162641 2001-05-30
JP2001162641 2001-05-30
PCT/JP2002/005197 WO2002096921A1 (fr) 2001-05-30 2002-05-29 Nouveau derive glucose induisant l'apoptose, procede de production et utilisation comme medicament

Publications (2)

Publication Number Publication Date
JPWO2002096921A1 JPWO2002096921A1 (ja) 2004-09-09
JP4182218B2 true JP4182218B2 (ja) 2008-11-19

Family

ID=19005736

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003500100A Expired - Fee Related JP4182218B2 (ja) 2001-05-30 2002-05-29 アポトーシスを誘導する新規なグルコース誘導体、その製造方法及び医薬としてのその用途

Country Status (2)

Country Link
JP (1) JP4182218B2 (fr)
WO (1) WO2002096921A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140138748A (ko) * 2012-03-08 2014-12-04 고쿠리쓰다이가쿠호진 규슈다이가쿠 신규 당유도체 겔화제
KR101680182B1 (ko) * 2012-03-07 2016-11-28 시노팜 (창수) 파마슈티컬즈, 리미티드 로플루밀라스트의 제조 방법

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101157711B (zh) * 2007-09-28 2010-12-08 西安交通大学 一种具有抗肿瘤活性的化合物及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5137578A (en) * 1991-02-26 1992-08-11 Philip Morris Incorporated Smoking compositions containing a flavorant-release saccharide additive
NO309305B1 (no) * 1999-02-19 2001-01-15 Norsk Hydro As Anvendelse av benzaldehydderivater ved fremstilling av farmasöytiske preparater for forebygging og/eller behandling av kreft, samt visse nye benzaldehydderivater

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101680182B1 (ko) * 2012-03-07 2016-11-28 시노팜 (창수) 파마슈티컬즈, 리미티드 로플루밀라스트의 제조 방법
KR20140138748A (ko) * 2012-03-08 2014-12-04 고쿠리쓰다이가쿠호진 규슈다이가쿠 신규 당유도체 겔화제
KR102073769B1 (ko) 2012-03-08 2020-02-05 고쿠리쓰다이가쿠호진 규슈다이가쿠 신규 당유도체 겔화제

Also Published As

Publication number Publication date
WO2002096921A1 (fr) 2002-12-05
JPWO2002096921A1 (ja) 2004-09-09

Similar Documents

Publication Publication Date Title
JPH05194470A (ja) 抗−エンドトキシン化合物
EP1112742B1 (fr) Moyens de traitement ou de prevention contenant des composes de cyclopentenone comme principe actif
JP7083394B2 (ja) パナキサジオールサポニン誘導体、その調製方法および使用
JP5036557B2 (ja) 抗炎症活性デクラジノシル−マクロライド
JP4182218B2 (ja) アポトーシスを誘導する新規なグルコース誘導体、その製造方法及び医薬としてのその用途
JP2009527563A (ja) ウイルス感染症を治療するのに有用な置換タラキサスタン
JPH08245505A (ja) ジテルペン誘導体、その製造法及びそれを有効成分として含有する抗腫瘍剤
JPH08269063A (ja) ピリピロペン誘導体
WO2022138735A1 (fr) Composition pharmaceutique pour atténuer des pathologies malignes
WO2004026298A1 (fr) Derives de triptolide presentant un puissant effet immunosuppresseur et une forte solubilite dans l'eau, utilisations de ces derives de triptolide
JPH10287617A (ja) 新規ジテルペン類及びジテルペン類を有効成分とする抗ウイルス剤
JPH0560478B2 (fr)
KR920007273B1 (ko) 프로토카테큐알데히드류의 당유도체
FR2646081A1 (fr)
CN115477681B (zh) 一种五环三萜皂苷衍生物及制备方法与应用
JPH08217672A (ja) キサントン誘導体を含有する抗ヘリコバクター・ピロリ薬
JPH03173896A (ja) 新規オキセタノシン誘導体、その塩およびその用途
CN114190092B (zh) 3-去氧-2-酮糖酸含氮衍生物及其制备方法和用途
JP2790335B2 (ja) 共役γ―オキシブテノライド化合物およびこれを有効成分とする抗潰瘍剤
HU208019B (en) Process for producing alkoxy-methyliden-epi-podofillotoxin-glucosides and pharmaceutical compositions containing them
KR100445683B1 (ko) 신규의 루판 유도체, 그의 제조방법 및 그를 포함하는항암제
US5405948A (en) 1,5-diyne-3-cycloalkene compounds
JP6359409B2 (ja) トール様受容体４活性化作用を有するフニクロシン誘導体及びその用途
JP5516894B2 (ja) 成人ｔ細胞白血病治療薬
JPS6110543A (ja) カフェ−酸誘導体

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20041105

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20080617

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080715

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080718

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20080807

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20080807

A521 Written amendment

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20080807

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110912

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120912

Year of fee payment: 4

LAPS Cancellation because of no payment of annual fees