JP4163963B2 - ２−｛２−［４−（４−クロロ−１，２−ジフェニルブト−１−エニル）フェノキシ］エトキシ｝エタノールおよびその異性体の新規製造方法 - Google Patents

２−｛２−［４−（４−クロロ−１，２−ジフェニルブト−１−エニル）フェノキシ］エトキシ｝エタノールおよびその異性体の新規製造方法 Download PDF

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Publication number
JP4163963B2
JP4163963B2 JP2002587388A JP2002587388A JP4163963B2 JP 4163963 B2 JP4163963 B2 JP 4163963B2 JP 2002587388 A JP2002587388 A JP 2002587388A JP 2002587388 A JP2002587388 A JP 2002587388A JP 4163963 B2 JP4163963 B2 JP 4163963B2
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JP
Japan
Prior art keywords
compound
formula
benzyl
protecting group
ethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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JP2002587388A
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English (en)
Japanese (ja)
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JP2004526799A (ja
Inventor
カラプダス、アルヤ
セデルバッル、マルヤ
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Hormos Medical Ltd
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Hormos Medical Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
JP2002587388A 2001-05-04 2002-03-21 ２−｛２−［４−（４−クロロ−１，２−ジフェニルブト−１−エニル）フェノキシ］エトキシ｝エタノールおよびその異性体の新規製造方法 Expired - Lifetime JP4163963B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20010927A FI111710B (fi) 2001-05-04 2001-05-04 Menetelmä terapeuttisesti aktiivisen yhdisteen valmistamiseksi
PCT/FI2002/000235 WO2002090305A1 (en) 2001-05-04 2002-03-21 A new method for the preparation of 2-{2-[4-(4-chloro-1,2-diphenylbut-1-enyl)phenoxy]ethoxy}ethanol and its isomers

Publications (2)

Publication Number Publication Date
JP2004526799A JP2004526799A (ja) 2004-09-02
JP4163963B2 true JP4163963B2 (ja) 2008-10-08

Family

ID=8561118

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002587388A Expired - Lifetime JP4163963B2 (ja) 2001-05-04 2002-03-21 ２−｛２−［４−（４−クロロ−１，２−ジフェニルブト−１−エニル）フェノキシ］エトキシ｝エタノールおよびその異性体の新規製造方法

Country Status (6)

Country Link
US (1) US6891070B2 (fi)
EP (1) EP1383724A1 (fi)
JP (1) JP4163963B2 (fi)
CA (1) CA2443784C (fi)
FI (1) FI111710B (fi)
WO (1) WO2002090305A1 (fi)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040248989A1 (en) * 2003-06-05 2004-12-09 Risto Santti Method for the treatment or prevention of lower urinary tract symptoms
CN101636372B (zh) 2007-02-14 2013-03-27 霍尔莫斯医疗有限公司 有治疗价值的三苯基丁烯衍生物的制备方法
WO2008099060A2 (en) * 2007-02-14 2008-08-21 Hormos Medical Ltd Methods for the preparation of fispemifene from ospemifene
WO2014060639A1 (en) 2012-10-19 2014-04-24 Fermion Oy A process for the preparation of ospemifene

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI77839C (fi) 1982-05-27 1989-05-10 Farmos Oy Foerfarande foer framstaellning av nya terapeutiskt effektiva trifenylalkan- och alkenderivat.
US5491173A (en) * 1982-06-25 1996-02-13 Orion-Yhtyma Oy Tri-phenyl alkene derivatives and their preparation and use
TW593256B (en) * 1999-11-16 2004-06-21 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators

Also Published As

Publication number Publication date
FI20010927A (fi) 2002-11-05
JP2004526799A (ja) 2004-09-02
US6891070B2 (en) 2005-05-10
CA2443784C (en) 2008-10-14
US20040116538A1 (en) 2004-06-17
CA2443784A1 (en) 2002-11-14
EP1383724A1 (en) 2004-01-28
WO2002090305A1 (en) 2002-11-14
FI20010927A0 (fi) 2001-05-04
FI111710B (fi) 2003-09-15

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