JP4158056B2 - 血清および血漿検体中の干渉体測定機器用較正材料 - Google Patents
血清および血漿検体中の干渉体測定機器用較正材料 Download PDFInfo
- Publication number
- JP4158056B2 JP4158056B2 JP50101898A JP50101898A JP4158056B2 JP 4158056 B2 JP4158056 B2 JP 4158056B2 JP 50101898 A JP50101898 A JP 50101898A JP 50101898 A JP50101898 A JP 50101898A JP 4158056 B2 JP4158056 B2 JP 4158056B2
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- Prior art keywords
- substance
- quality control
- mimics
- control material
- mimicking
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000463 material Substances 0.000 title claims description 55
- 239000000126 substance Substances 0.000 title claims description 51
- 210000002966 serum Anatomy 0.000 title description 11
- 230000002452 interceptive effect Effects 0.000 title description 2
- 238000003908 quality control method Methods 0.000 claims description 45
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 claims description 42
- 235000009328 Amaranthus caudatus Nutrition 0.000 claims description 18
- 240000001592 Amaranthus caudatus Species 0.000 claims description 18
- 239000004178 amaranth Substances 0.000 claims description 18
- 235000012735 amaranth Nutrition 0.000 claims description 18
- 102000001554 Hemoglobins Human genes 0.000 claims description 17
- 108010054147 Hemoglobins Proteins 0.000 claims description 17
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 claims description 15
- 229960003531 phenolsulfonphthalein Drugs 0.000 claims description 15
- 238000002835 absorbance Methods 0.000 claims description 14
- GWZYPXHJIZCRAJ-UHFFFAOYSA-N Biliverdin Natural products CC1=C(C=C)C(=C/C2=NC(=Cc3[nH]c(C=C/4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)C(=C2C)CCC(=O)O)NC1=O GWZYPXHJIZCRAJ-UHFFFAOYSA-N 0.000 claims description 13
- RCNSAJSGRJSBKK-NSQVQWHSSA-N Biliverdin IX Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(\C=C/2C(=C(C)C(=C/C=3C(=C(C=C)C(=O)N=3)C)/N\2)CCC(O)=O)N1 RCNSAJSGRJSBKK-NSQVQWHSSA-N 0.000 claims description 13
- QBUVFDKTZJNUPP-UHFFFAOYSA-N biliverdin-IXalpha Natural products N1C(=O)C(C)=C(C=C)C1=CC1=C(C)C(CCC(O)=O)=C(C=C2C(=C(C)C(C=C3C(=C(C=C)C(=O)N3)C)=N2)CCC(O)=O)N1 QBUVFDKTZJNUPP-UHFFFAOYSA-N 0.000 claims description 13
- 229910000365 copper sulfate Inorganic materials 0.000 claims description 8
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical group [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 238000012544 monitoring process Methods 0.000 claims description 7
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 claims description 7
- STZCRXQWRGQSJD-GEEYTBSJSA-M methyl orange Chemical compound [Na+].C1=CC(N(C)C)=CC=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 STZCRXQWRGQSJD-GEEYTBSJSA-M 0.000 claims description 6
- 230000003278 mimic effect Effects 0.000 claims description 6
- JUQPZRLQQYSMEQ-UHFFFAOYSA-N CI Basic red 9 Chemical compound [Cl-].C1=CC(N)=CC=C1C(C=1C=CC(N)=CC=1)=C1C=CC(=[NH2+])C=C1 JUQPZRLQQYSMEQ-UHFFFAOYSA-N 0.000 claims description 5
- WLDHEUZGFKACJH-UHFFFAOYSA-K amaranth Chemical compound [Na+].[Na+].[Na+].C12=CC=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(O)=C1N=NC1=CC=C(S([O-])(=O)=O)C2=CC=CC=C12 WLDHEUZGFKACJH-UHFFFAOYSA-K 0.000 claims description 5
- 229940052223 basic fuchsin Drugs 0.000 claims description 5
- 229940012189 methyl orange Drugs 0.000 claims description 5
- 239000008351 acetate buffer Substances 0.000 claims description 4
- 229960000907 methylthioninium chloride Drugs 0.000 claims description 3
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 claims 2
- IRERQBUNZFJFGC-UHFFFAOYSA-L azure blue Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[S-]S[S-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-] IRERQBUNZFJFGC-UHFFFAOYSA-L 0.000 claims 2
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims 2
- 239000012491 analyte Substances 0.000 description 11
- 239000000203 mixture Substances 0.000 description 9
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 6
- 238000011481 absorbance measurement Methods 0.000 description 5
- 206010018910 Haemolysis Diseases 0.000 description 4
- 230000008588 hemolysis Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000003809 bile pigment Substances 0.000 description 3
- 229960000355 copper sulfate Drugs 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000003595 spectral effect Effects 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 239000011550 stock solution Substances 0.000 description 3
- 239000004408 titanium dioxide Substances 0.000 description 3
- GNLHFBAZSKVVCQ-DKUYZEAMSA-N 3-[(2z,5e)-2-[[3-(2-carboxyethyl)-5-[(z)-(3-ethenyl-4-methyl-5-oxopyrrol-2-ylidene)methyl]-4-methyl-1h-pyrrol-2-yl]methylidene]-5-[(4-ethenyl-3-methyl-5-oxopyrrol-2-yl)methylidene]-4-methylpyrrol-3-yl]propanoic acid;hydron;dichloride Chemical compound Cl.Cl.N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(\C=C/2C(=C(C)C(=C\C=3C(=C(C=C)C(=O)N=3)C)/N\2)CCC(O)=O)N1 GNLHFBAZSKVVCQ-DKUYZEAMSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 238000000862 absorption spectrum Methods 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000002798 spectrophotometry method Methods 0.000 description 2
- PVPBBTJXIKFICP-UHFFFAOYSA-N (7-aminophenothiazin-3-ylidene)azanium;chloride Chemical compound [Cl-].C1=CC(=[NH2+])C=C2SC3=CC(N)=CC=C3N=C21 PVPBBTJXIKFICP-UHFFFAOYSA-N 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 208000036796 hyperbilirubinemia Diseases 0.000 description 1
- 229940028435 intralipid Drugs 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 239000002960 lipid emulsion Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000004154 testing of material Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2496/00—Reference solutions for assays of biological material
- G01N2496/15—Reference solutions for assays of biological material containing dyes to mimic optical absorption of, e.g. hemoglobin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/102499—Blood gas standard or control
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/103332—Bilirubin or uric acid standard or control
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/106664—Blood serum or blood plasma standard or control
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9612264.3 | 1996-06-12 | ||
| GBGB9612264.3A GB9612264D0 (en) | 1996-06-12 | 1996-06-12 | Quality control material for monitoring calibration of instruments designed to measure serum and plasma specimen integrity |
| PCT/CA1997/000418 WO1997047972A1 (en) | 1996-06-12 | 1997-06-12 | Calibrator material for instruments which measure interferents in serum and plasma specimens |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2000512752A JP2000512752A (ja) | 2000-09-26 |
| JP2000512752A5 JP2000512752A5 (2) | 2005-02-10 |
| JP4158056B2 true JP4158056B2 (ja) | 2008-10-01 |
Family
ID=10795161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50101898A Expired - Fee Related JP4158056B2 (ja) | 1996-06-12 | 1997-06-12 | 血清および血漿検体中の干渉体測定機器用較正材料 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6372503B1 (2) |
| EP (1) | EP0975976B1 (2) |
| JP (1) | JP4158056B2 (2) |
| DE (1) | DE69732716T2 (2) |
| GB (1) | GB9612264D0 (2) |
| WO (1) | WO1997047972A1 (2) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7157282B2 (en) * | 1996-06-12 | 2007-01-02 | Spectromedical Inc. | Quality control material for reagentless measurement of analytes |
| US6828152B2 (en) | 1996-06-12 | 2004-12-07 | Spectromedical Inc. | Quality control material for reagentless measurement of analytes |
| US20050037505A1 (en) * | 2000-05-11 | 2005-02-17 | James Samsoondar | Spectroscopic method and apparatus for analyte measurement |
| US6651015B2 (en) | 1999-11-23 | 2003-11-18 | James Samsoondar | Method for calibrating spectrophotometric apparatus |
| US7449339B2 (en) | 1999-11-23 | 2008-11-11 | Nir Diagnostics Inc. | Spectroscopic method and apparatus for total hemoglobin measurement |
| US6470279B1 (en) | 1999-11-23 | 2002-10-22 | James Samsoondar | Method for calibrating spectrophotometric apparatus with synthetic fluids to measure plasma and serum analytes |
| US6711516B2 (en) | 1999-11-23 | 2004-03-23 | Spectromedical Inc. | Method for calibrating spectrophotometric apparatus |
| US6611777B2 (en) | 1999-11-23 | 2003-08-26 | James Samsoondar | Method for calibrating spectrophotometric apparatus |
| US6949384B2 (en) | 2001-12-21 | 2005-09-27 | Spectromedical Inc. | Method for monitoring degradation of Hb-based blood substitutes |
| GB2385663B (en) * | 2001-12-21 | 2006-08-02 | James Samsoondar | Quality control material for reagentless measurement of analytes |
| US7613488B1 (en) | 2002-12-20 | 2009-11-03 | Niresults Inc. | Apparatus and methods for compensation of blood volume effects on NIR spectroscopic measurements of blood analytes |
| CA2579001C (en) * | 2004-09-01 | 2014-07-08 | Maine Standards Company, Llc | Novel stable lipid standards |
| US7312083B2 (en) * | 2005-06-07 | 2007-12-25 | Beckman Coulter, Inc. | Control value assignment method |
| US7521244B2 (en) * | 2006-10-26 | 2009-04-21 | Bionostics, Inc. | Standard reference solutions |
| US20100117666A1 (en) * | 2006-12-28 | 2010-05-13 | Wada Henry G | Method and System for Internal Standardization of Assays |
| EP2281191A4 (en) | 2008-04-30 | 2011-10-05 | Instrumentation Lab Co | BILIRUBIN REFERENCE MATERIAL AT HÄMOGLOBINBASIS |
| JP5859439B2 (ja) | 2009-08-13 | 2016-02-10 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | 臨床分析機によって分析される液体サンプルおよび容器の中の干渉物質および物理的寸法を確定するための方法ならびに装置 |
| JP2012090862A (ja) * | 2010-10-28 | 2012-05-17 | Fujifilm Corp | 光音響検査用探触子および光音響検査装置 |
| JP6374148B2 (ja) * | 2013-08-30 | 2018-08-15 | シスメックス株式会社 | 検体分析装置及び検体分析方法 |
| DE102017001484A1 (de) * | 2017-02-16 | 2018-08-16 | Fresenius Medical Care Deutschland Gmbh | Verfahren und Anordnung zum Kalibrieren von Vorrichtungen zur Erkennung von Blut oder Blutbestandteilen in einer Flüssigkeit |
| US11161109B2 (en) | 2019-09-19 | 2021-11-02 | Invidx Corp. | Point-of-care testing cartridge with sliding cap |
| US11327084B2 (en) | 2019-09-19 | 2022-05-10 | Invidx Corp. | Joint hematology and biochemistry point-of-care testing system |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3705110A (en) * | 1971-04-21 | 1972-12-05 | Baxter Laboratories Inc | Calibrating fluid for automated hematology instruments |
| US4116336A (en) * | 1975-05-30 | 1978-09-26 | Radiometer A/S | Package containing a reference liquid for blood gas equipment |
| US4001142A (en) * | 1975-07-25 | 1977-01-04 | Warner-Lambert Company | Blood gas control |
| US4069016A (en) * | 1977-01-14 | 1978-01-17 | Eastman Kodak Company | Assay for bilirubin |
| DE2931810A1 (de) * | 1979-08-06 | 1981-02-19 | Degussa | Temperaturstabilisiertes siliciumdioxid-mischoxid, das verfahren zu seiner herstellung und verwendung |
| US4603044A (en) * | 1983-01-06 | 1986-07-29 | Technology Unlimited, Inc. | Hepatocyte Directed Vesicle delivery system |
| JPS6027861A (ja) | 1983-07-21 | 1985-02-12 | コ−ニング・グラス・ワ−クス | コオキシメトリ−特性制御組成物 |
| US5310679A (en) * | 1985-05-13 | 1994-05-10 | Artiss Joseph D | Composition for reducing turbidity in samples of biological fluids |
| DK282085D0 (da) | 1985-06-21 | 1985-06-21 | Radiometer As | Fremgangsmaade og apparat til bestemmelse af blodkomponenter |
| US4772561A (en) * | 1985-12-23 | 1988-09-20 | Miles Inc. | Test device and method of determining concentration of a sample component |
| US4753888A (en) * | 1986-04-09 | 1988-06-28 | Bionostics, Inc. | Multiple control standard for blood analysis |
| US5134284A (en) * | 1991-04-25 | 1992-07-28 | Volgyesi George A | Method of testing the accuracy of pulse oximeters and device therefor |
| US5278073A (en) * | 1991-05-08 | 1994-01-11 | Streck Laboratories, Inc. | Method of bilirubin assay |
| US5447838A (en) * | 1992-08-05 | 1995-09-05 | Hybritech Incorporated | Protein-dye conjugate for confirmation of correct dilution of calibrators |
-
1996
- 1996-06-12 GB GBGB9612264.3A patent/GB9612264D0/en active Pending
-
1997
- 1997-06-12 US US09/147,373 patent/US6372503B1/en not_active Expired - Lifetime
- 1997-06-12 WO PCT/CA1997/000418 patent/WO1997047972A1/en not_active Ceased
- 1997-06-12 JP JP50101898A patent/JP4158056B2/ja not_active Expired - Fee Related
- 1997-06-12 DE DE69732716T patent/DE69732716T2/de not_active Expired - Lifetime
- 1997-06-12 EP EP97924842A patent/EP0975976B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69732716T2 (de) | 2006-04-13 |
| WO1997047972A1 (en) | 1997-12-18 |
| JP2000512752A (ja) | 2000-09-26 |
| EP0975976A1 (en) | 2000-02-02 |
| DE69732716D1 (de) | 2005-04-14 |
| GB9612264D0 (en) | 1996-08-14 |
| US6372503B1 (en) | 2002-04-16 |
| EP0975976B1 (en) | 2005-03-09 |
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