JP4109111B2 - 縮合複素環式芳香族グルコキナーゼアクチベーター - Google Patents

縮合複素環式芳香族グルコキナーゼアクチベーター Download PDF

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Publication number
JP4109111B2
JP4109111B2 JP2002547912A JP2002547912A JP4109111B2 JP 4109111 B2 JP4109111 B2 JP 4109111B2 JP 2002547912 A JP2002547912 A JP 2002547912A JP 2002547912 A JP2002547912 A JP 2002547912A JP 4109111 B2 JP4109111 B2 JP 4109111B2
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JP
Japan
Prior art keywords
cyclopentyl
phenyl
propionamide
methanesulfonyl
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2002547912A
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English (en)
Japanese (ja)
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JP2004517087A (ja
JP2004517087A5 (US06448399-20020910-C00006.png
Inventor
コーベット，ウェンディ・リー
グリムブシー，ジョセフ・サミュエル
ヘインズ，ナンシー−エレン
ケスター，ロバート・フランシス
マハニー，ペイジ・エリン
サラブ，ラマカンス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
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Filing date
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Publication of JP2004517087A publication Critical patent/JP2004517087A/ja
Publication of JP2004517087A5 publication Critical patent/JP2004517087A5/ja
Application granted granted Critical
Publication of JP4109111B2 publication Critical patent/JP4109111B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
JP2002547912A 2000-12-06 2001-11-28 縮合複素環式芳香族グルコキナーゼアクチベーター Expired - Fee Related JP4109111B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25163700P 2000-12-06 2000-12-06
PCT/EP2001/013870 WO2002046173A1 (en) 2000-12-06 2001-11-28 Fused heteroaromatic glucokinase activators

Publications (3)

Publication Number Publication Date
JP2004517087A JP2004517087A (ja) 2004-06-10
JP2004517087A5 JP2004517087A5 (US06448399-20020910-C00006.png) 2005-05-26
JP4109111B2 true JP4109111B2 (ja) 2008-07-02

Family

ID=22952803

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002547912A Expired - Fee Related JP4109111B2 (ja) 2000-12-06 2001-11-28 縮合複素環式芳香族グルコキナーゼアクチベーター

Country Status (21)

Country Link
US (3) US6448399B1 (US06448399-20020910-C00006.png)
EP (1) EP1341774B1 (US06448399-20020910-C00006.png)
JP (1) JP4109111B2 (US06448399-20020910-C00006.png)
KR (1) KR100545431B1 (US06448399-20020910-C00006.png)
CN (1) CN1226294C (US06448399-20020910-C00006.png)
AR (1) AR031627A1 (US06448399-20020910-C00006.png)
AT (1) ATE316965T1 (US06448399-20020910-C00006.png)
AU (2) AU2002221902B2 (US06448399-20020910-C00006.png)
BR (1) BR0115999A (US06448399-20020910-C00006.png)
CA (1) CA2429642C (US06448399-20020910-C00006.png)
DE (1) DE60117059T2 (US06448399-20020910-C00006.png)
DK (1) DK1341774T3 (US06448399-20020910-C00006.png)
ES (1) ES2256340T3 (US06448399-20020910-C00006.png)
GT (1) GT200100243A (US06448399-20020910-C00006.png)
MX (1) MXPA03005119A (US06448399-20020910-C00006.png)
PA (1) PA8534301A1 (US06448399-20020910-C00006.png)
PE (1) PE20020753A1 (US06448399-20020910-C00006.png)
PT (1) PT1341774E (US06448399-20020910-C00006.png)
UY (1) UY27055A1 (US06448399-20020910-C00006.png)
WO (1) WO2002046173A1 (US06448399-20020910-C00006.png)
ZA (1) ZA200303748B (US06448399-20020910-C00006.png)

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Also Published As

Publication number Publication date
CN1476438A (zh) 2004-02-18
JP2004517087A (ja) 2004-06-10
AR031627A1 (es) 2003-09-24
KR100545431B1 (ko) 2006-01-24
AU2002221902B2 (en) 2006-11-23
CN1226294C (zh) 2005-11-09
US6448399B1 (en) 2002-09-10
US6545155B2 (en) 2003-04-08
US20020107396A1 (en) 2002-08-08
CA2429642A1 (en) 2002-06-13
US6441184B1 (en) 2002-08-27
PE20020753A1 (es) 2002-08-27
US20020103241A1 (en) 2002-08-01
AU2190202A (en) 2002-06-18
US20020103199A1 (en) 2002-08-01
EP1341774B1 (en) 2006-02-01
PT1341774E (pt) 2006-05-31
UY27055A1 (es) 2002-07-31
PA8534301A1 (es) 2002-08-26
MXPA03005119A (es) 2004-10-15
KR20030068555A (ko) 2003-08-21
GT200100243A (es) 2002-06-04
ATE316965T1 (de) 2006-02-15
DK1341774T3 (da) 2006-06-12
WO2002046173A1 (en) 2002-06-13
DE60117059T2 (de) 2006-10-26
DE60117059D1 (de) 2006-04-13
ES2256340T3 (es) 2006-07-16
EP1341774A1 (en) 2003-09-10
ZA200303748B (en) 2004-08-16
CA2429642C (en) 2007-11-20
BR0115999A (pt) 2003-09-30

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