JP4099239B2 - ＧＡＬα１、３ＧＡＬエピトープを有する抗原性融合タンパク質 - Google Patents
ＧＡＬα１、３ＧＡＬエピトープを有する抗原性融合タンパク質 Download PDFInfo
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- JP4099239B2 JP4099239B2 JP54556998A JP54556998A JP4099239B2 JP 4099239 B2 JP4099239 B2 JP 4099239B2 JP 54556998 A JP54556998 A JP 54556998A JP 54556998 A JP54556998 A JP 54556998A JP 4099239 B2 JP4099239 B2 JP 4099239B2
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- galα1
- 3gal
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4727—Mucins, e.g. human intestinal mucin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9701127-4 | 1997-03-26 | ||
| SE9701127A SE9701127D0 (sv) | 1997-03-26 | 1997-03-26 | Antigenic fusionprotein carrying GALal, 3GAL epitopes |
| PCT/SE1998/000555 WO1998042750A1 (en) | 1997-03-26 | 1998-03-26 | ANTIGENIC FUSIONPROTEIN CARRYING GALα1,3GAL EPITOPES |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2000511782A JP2000511782A (ja) | 2000-09-12 |
| JP2000511782A5 JP2000511782A5 (OSRAM) | 2005-11-10 |
| JP4099239B2 true JP4099239B2 (ja) | 2008-06-11 |
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| JP54556998A Expired - Fee Related JP4099239B2 (ja) | 1997-03-26 | 1998-03-26 | ＧＡＬα１、３ＧＡＬエピトープを有する抗原性融合タンパク質 |
Country Status (12)
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|---|---|
| US (3) | US6943239B2 (OSRAM) |
| EP (2) | EP1700868A3 (OSRAM) |
| JP (1) | JP4099239B2 (OSRAM) |
| AT (1) | ATE315047T1 (OSRAM) |
| AU (1) | AU751760B2 (OSRAM) |
| BR (1) | BR9804826A (OSRAM) |
| CA (1) | CA2255765A1 (OSRAM) |
| DE (1) | DE69833106T2 (OSRAM) |
| DK (1) | DK0923606T3 (OSRAM) |
| ES (1) | ES2258297T3 (OSRAM) |
| SE (1) | SE9701127D0 (OSRAM) |
| WO (1) | WO1998042750A1 (OSRAM) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP4421894B2 (ja) * | 2001-07-20 | 2010-02-24 | アブソーバー アクチボラゲット | 血液型抗原融合ポリペプチドおよびその使用方法 |
| AU2003228067B2 (en) * | 2002-04-22 | 2008-05-29 | Recopharma Ab | Mucin fusion polypeptide vaccines, compositions and methods of use thereof |
| AU2003233008B2 (en) * | 2002-04-22 | 2008-04-24 | Recopharma Ab | Fusion polypeptides and methods for inhibiting microbial adhesion |
| AU2003249641B2 (en) | 2002-05-16 | 2009-08-20 | Glycomimetics, Inc. | Compounds and methods for inhibiting selectin-mediated function |
| JP2006502986A (ja) * | 2002-07-03 | 2006-01-26 | グリコミメティクス， インコーポレイテッド | 新脈管形成に関与する医学的状態の診断および治療のための組成物および方法 |
| EP1534748A2 (en) * | 2002-08-09 | 2005-06-01 | Recopharma AB | Fusion proteins and methods of producing same |
| US20050076759A1 (en) * | 2003-10-08 | 2005-04-14 | Brian Westfall | Linear saw with stab-cut bevel capability |
| US20040219158A1 (en) * | 2003-05-02 | 2004-11-04 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria |
| US7459523B2 (en) * | 2003-11-12 | 2008-12-02 | Wisconsin Alumni Research Foundation | Equine P-selectin glycoprotein ligand-1 and uses thereof |
| EP1685145A2 (en) * | 2003-11-19 | 2006-08-02 | GlycoMimetics, Inc. | Glycomimetic antagonists for both e- and p-selectins |
| US7361644B2 (en) * | 2003-11-19 | 2008-04-22 | Glycomimetics, Inc. | Specific antagonist for both E- and P-selectins |
| EP1782838A4 (en) * | 2004-06-23 | 2007-08-01 | Japan Science & Tech Agency | INHIBITION OF INFILTRATION AND CELL-COOLING MEDIUM |
| US8201377B2 (en) * | 2004-11-05 | 2012-06-19 | Faus Group, Inc. | Flooring system having multiple alignment points |
| WO2006127906A1 (en) * | 2005-05-25 | 2006-11-30 | Glycomimetics, Inc. | Heterobifunctional compounds for selectin inhibition |
| JP5175190B2 (ja) * | 2005-08-09 | 2013-04-03 | グリコミメティクス， インコーポレイテッド | シュードモナス由来のｐａ−ｉｌレクチン、ｐａ−ｉｉｌレクチンまたは両方のレクチンのグリコミメティック阻害剤 |
| US7728117B2 (en) | 2005-09-02 | 2010-06-01 | Glycomimetics, Inc. | Heterobifunctional pan-selectin inhibitors |
| WO2007033221A2 (en) * | 2005-09-13 | 2007-03-22 | The General Hospital Corporation | Methods and compositions for inhibition of immune responses |
| EP2264061A1 (en) * | 2006-01-26 | 2010-12-22 | Recopharma AB | Compositions and methods for inhibiting viral adhesion |
| US20070178447A1 (en) * | 2006-01-31 | 2007-08-02 | Bethyl Laboratories, Inc. | Method for decreasing interference in results of immunochemical methods |
| US20090176717A1 (en) * | 2006-06-01 | 2009-07-09 | Glycomimetics, Inc. | Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas |
| EP2074132B1 (en) | 2006-10-12 | 2013-05-15 | GlycoMimetics, Inc. | Glycomimetic replacements for hexoses and n-acetyl hexosamines |
| US7998486B2 (en) | 2006-10-25 | 2011-08-16 | Newlink Genetics Corporation | Enhanced immunogenicity of tumor associated antigens by addition of alphaGal epitopes |
| EP2457573A1 (en) * | 2007-02-09 | 2012-05-30 | GlycoMimetics, Inc. | Methods of use of glycomimetics with replacements for hexoses and N-Acetyl hexosamines |
| US8039442B2 (en) * | 2007-07-18 | 2011-10-18 | Glycomimetics, Inc. | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
| WO2009126556A1 (en) * | 2008-04-08 | 2009-10-15 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| CA2727788A1 (en) * | 2008-06-13 | 2009-12-17 | Glycomimetics, Inc. | Treatment of cancers of the blood using selected glycomimetic compounds |
| US8410066B2 (en) | 2009-05-01 | 2013-04-02 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors |
| US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
| US8921328B2 (en) | 2010-09-14 | 2014-12-30 | Glycomimetics, Inc. | E-selectin antagonists |
| AU2011347237A1 (en) * | 2010-12-21 | 2013-07-11 | Recopharma Ab | Tear substitutes |
| SI2794626T1 (en) | 2011-12-22 | 2018-02-28 | Glycomimetics, Inc. | E-SELECTINE ANTAGONIST COMPOUNDS |
| LT2928476T (lt) | 2012-12-07 | 2018-05-25 | Glycomimetics, Inc. | Junginiai, kompozicijos ir būdai, naudojant e-selektino antagonistus, hemopoetinių ląstelių mobilizacijai |
| HUE045542T2 (hu) | 2014-12-03 | 2019-12-30 | Glycomimetics Inc | E-szelektinek és CXCR4 kemokin receptorok heterobifunkcionális inhibitorai |
| WO2017127422A1 (en) | 2016-01-22 | 2017-07-27 | Glycomimetics, Inc. | Glycomimetic inhibitors of pa-il and pa-iil lectins |
| WO2017151708A1 (en) | 2016-03-02 | 2017-09-08 | Glycomimetics, Inc. | Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin |
| EP3497131B1 (en) | 2016-08-08 | 2022-03-09 | GlycoMimetics, Inc. | Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4. |
| CA3037850A1 (en) | 2016-10-07 | 2018-04-12 | Glycomimetics, Inc. | Highly potent multimeric e-selectin antagonists |
| CA3054605A1 (en) | 2017-03-15 | 2018-09-20 | Glycomimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
| EP3717013A1 (en) | 2017-11-30 | 2020-10-07 | GlycoMimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
| EP3732186A1 (en) | 2017-12-29 | 2020-11-04 | GlycoMimetics, Inc. | Heterobifunctional inhibitors of e-selectin and galectin-3 |
| US11707474B2 (en) | 2018-03-05 | 2023-07-25 | Glycomimetics, Inc. | Methods for treating acute myeloid leukemia and related conditions |
| US20210260250A1 (en) * | 2018-06-12 | 2021-08-26 | Rush University Medical Center | Methods for Enhanced Endothelialization of Implanted Material |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
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| EP0606217B2 (en) * | 1991-06-27 | 2008-12-03 | Bristol-Myers Squibb Company | Ctl4a receptor, fusion proteins containing it and uses thereof |
| CA2497857C (en) * | 1992-10-23 | 2009-05-26 | Genetics Institute, Llc | Novel p-selectin ligand protein |
| EP0689597A4 (en) | 1993-03-16 | 1998-10-21 | Austin Research Inst | USE OF PIG GAL-g (a) (1,3) GALACTOSYL TRANSFERASE FOR XENOGENE THERAPIES |
| GB9517758D0 (en) | 1995-08-31 | 1995-11-01 | Imutran Ltd | Compositions and their uses |
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1997
- 1997-03-26 SE SE9701127A patent/SE9701127D0/xx unknown
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1998
- 1998-03-26 US US09/194,396 patent/US6943239B2/en not_active Expired - Fee Related
- 1998-03-26 AT AT98912863T patent/ATE315047T1/de not_active IP Right Cessation
- 1998-03-26 BR BR9804826-0A patent/BR9804826A/pt not_active Application Discontinuation
- 1998-03-26 DK DK98912863T patent/DK0923606T3/da active
- 1998-03-26 ES ES98912863T patent/ES2258297T3/es not_active Expired - Lifetime
- 1998-03-26 JP JP54556998A patent/JP4099239B2/ja not_active Expired - Fee Related
- 1998-03-26 DE DE69833106T patent/DE69833106T2/de not_active Expired - Lifetime
- 1998-03-26 AU AU67551/98A patent/AU751760B2/en not_active Ceased
- 1998-03-26 WO PCT/SE1998/000555 patent/WO1998042750A1/en not_active Ceased
- 1998-03-26 EP EP06075010A patent/EP1700868A3/en not_active Withdrawn
- 1998-03-26 CA CA002255765A patent/CA2255765A1/en not_active Abandoned
- 1998-03-26 EP EP98912863A patent/EP0923606B1/en not_active Expired - Lifetime
-
2005
- 2005-06-15 US US11/153,082 patent/US20050255099A1/en not_active Abandoned
-
2009
- 2009-07-22 US US12/507,626 patent/US20090286963A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0923606A1 (en) | 1999-06-23 |
| US20050255099A1 (en) | 2005-11-17 |
| ATE315047T1 (de) | 2006-02-15 |
| CA2255765A1 (en) | 1998-10-01 |
| AU751760B2 (en) | 2002-08-29 |
| DE69833106D1 (de) | 2006-03-30 |
| SE9701127D0 (sv) | 1997-03-26 |
| ES2258297T3 (es) | 2006-08-16 |
| US20020028205A1 (en) | 2002-03-07 |
| EP1700868A2 (en) | 2006-09-13 |
| DK0923606T3 (da) | 2006-05-22 |
| AU6755198A (en) | 1998-10-20 |
| BR9804826A (pt) | 2000-01-25 |
| WO1998042750A1 (en) | 1998-10-01 |
| US6943239B2 (en) | 2005-09-13 |
| JP2000511782A (ja) | 2000-09-12 |
| EP1700868A3 (en) | 2007-12-12 |
| US20090286963A1 (en) | 2009-11-19 |
| EP0923606B1 (en) | 2006-01-04 |
| DE69833106T2 (de) | 2006-08-31 |
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