JP4082864B2 - 粉末吸入器 - Google Patents
粉末吸入器 Download PDFInfo
- Publication number
- JP4082864B2 JP4082864B2 JP2000535398A JP2000535398A JP4082864B2 JP 4082864 B2 JP4082864 B2 JP 4082864B2 JP 2000535398 A JP2000535398 A JP 2000535398A JP 2000535398 A JP2000535398 A JP 2000535398A JP 4082864 B2 JP4082864 B2 JP 4082864B2
- Authority
- JP
- Japan
- Prior art keywords
- coating
- capsule
- inhaler
- polymer
- nickel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000843 powder Substances 0.000 title abstract description 3
- 239000002775 capsule Substances 0.000 claims abstract description 26
- 229920000642 polymer Polymers 0.000 claims abstract description 21
- 229910000831 Steel Inorganic materials 0.000 claims abstract description 10
- 239000010959 steel Substances 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 8
- 238000000576 coating method Methods 0.000 claims description 26
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 22
- 239000011248 coating agent Substances 0.000 claims description 18
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 13
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 13
- 229910052759 nickel Inorganic materials 0.000 claims description 11
- 229910001096 P alloy Inorganic materials 0.000 claims description 10
- OFNHPGDEEMZPFG-UHFFFAOYSA-N phosphanylidynenickel Chemical compound [P].[Ni] OFNHPGDEEMZPFG-UHFFFAOYSA-N 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 7
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 4
- 229910052698 phosphorus Inorganic materials 0.000 claims description 4
- 239000011574 phosphorus Substances 0.000 claims description 4
- 239000010935 stainless steel Substances 0.000 claims description 2
- 229910001220 stainless steel Inorganic materials 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 7
- 229910045601 alloy Inorganic materials 0.000 description 9
- 239000000956 alloy Substances 0.000 description 9
- 239000006185 dispersion Substances 0.000 description 7
- 229910052751 metal Inorganic materials 0.000 description 7
- 239000002184 metal Substances 0.000 description 7
- 238000007747 plating Methods 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 239000002131 composite material Substances 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 238000000151 deposition Methods 0.000 description 3
- -1 for example Chemical class 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- KWSLGOVYXMQPPX-UHFFFAOYSA-N 5-[3-(trifluoromethyl)phenyl]-2h-tetrazole Chemical compound FC(F)(F)C1=CC=CC(C2=NNN=N2)=C1 KWSLGOVYXMQPPX-UHFFFAOYSA-N 0.000 description 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 229910052804 chromium Inorganic materials 0.000 description 2
- 239000011651 chromium Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000006722 reduction reaction Methods 0.000 description 2
- 229910001379 sodium hypophosphite Inorganic materials 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 description 1
- 239000004338 Dichlorodifluoromethane Substances 0.000 description 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
- 230000000181 anti-adherent effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 description 1
- 229940092705 beclomethasone Drugs 0.000 description 1
- 150000001639 boron compounds Chemical class 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 150000001721 carbon Chemical class 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
- 235000019404 dichlorodifluoromethane Nutrition 0.000 description 1
- 229940087091 dichlorotetrafluoroethane Drugs 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 229940112141 dry powder inhaler Drugs 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 229920002313 fluoropolymer Polymers 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229910021472 group 8 element Inorganic materials 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-N phosphinic acid Chemical compound O[PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-N 0.000 description 1
- 238000001552 radio frequency sputter deposition Methods 0.000 description 1
- 229910052703 rhodium Inorganic materials 0.000 description 1
- 239000010948 rhodium Substances 0.000 description 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 1
- 229910052707 ruthenium Inorganic materials 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Powder Metallurgy (AREA)
- Materials For Photolithography (AREA)
- Gyroscopes (AREA)
- Steroid Compounds (AREA)
- Valve Device For Special Equipments (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9805102.2A GB9805102D0 (en) | 1998-03-10 | 1998-03-10 | Device |
| GB9805102.2 | 1998-03-10 | ||
| PCT/EP1999/001487 WO1999045987A1 (en) | 1998-03-10 | 1999-03-08 | Powder inhaler |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002505922A JP2002505922A (ja) | 2002-02-26 |
| JP2002505922A5 JP2002505922A5 (https=) | 2006-05-11 |
| JP4082864B2 true JP4082864B2 (ja) | 2008-04-30 |
Family
ID=10828321
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000535398A Expired - Lifetime JP4082864B2 (ja) | 1998-03-10 | 1999-03-08 | 粉末吸入器 |
| JP2000600054U Expired - Lifetime JP3094437U (ja) | 1998-03-10 | 1999-03-08 | 粉末吸入器 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000600054U Expired - Lifetime JP3094437U (ja) | 1998-03-10 | 1999-03-08 | 粉末吸入器 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6488027B1 (https=) |
| EP (1) | EP1061979B1 (https=) |
| JP (2) | JP4082864B2 (https=) |
| KR (1) | KR100585483B1 (https=) |
| CN (1) | CN1212868C (https=) |
| AT (1) | ATE283083T1 (https=) |
| AU (1) | AU750844B2 (https=) |
| BR (2) | BR9908587A (https=) |
| CA (1) | CA2322575C (https=) |
| CO (1) | CO5080779A1 (https=) |
| DE (2) | DE29923581U1 (https=) |
| ES (1) | ES2232119T3 (https=) |
| GB (1) | GB9805102D0 (https=) |
| IL (1) | IL138121A (https=) |
| NZ (1) | NZ506645A (https=) |
| PL (1) | PL187578B1 (https=) |
| PT (1) | PT1061979E (https=) |
| WO (2) | WO1999045986A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| DE19835346A1 (de) * | 1998-08-05 | 2000-02-10 | Boehringer Ingelheim Pharma | Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren |
| GB9928311D0 (en) | 1999-11-30 | 2000-01-26 | Novartis Ag | Organic compounds |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| EP1443996B1 (en) | 2001-11-14 | 2011-05-18 | Novartis AG | Aerosolization apparatus comprising connectable body and endpiece |
| JP2005514393A (ja) | 2001-12-19 | 2005-05-19 | ネクター セラピューティクス | アミノグリコシドの肺への供給 |
| US20040173211A1 (en) * | 2003-01-14 | 2004-09-09 | Boehringer Ingelheim International Gmbh | Powder inhaler |
| HUE026950T2 (en) | 2003-04-09 | 2016-08-29 | Novartis Ag | Nozzle with guide wire for puncturing the capsule |
| US20090285900A1 (en) * | 2003-07-31 | 2009-11-19 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
| US20050026884A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
| US20050113318A1 (en) * | 2003-07-31 | 2005-05-26 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
| US7861712B2 (en) * | 2004-04-23 | 2011-01-04 | Manta Product Development | Sealed capsule including an integrated puncturing mechanism |
| DE102005001332A1 (de) * | 2005-01-11 | 2006-07-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Zweiteilige Kapsel mit Vorverschluss zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren |
| DE102006009637A1 (de) | 2005-10-28 | 2007-05-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator mit Mundstück mit mikrobiologischer Schutzfunktion |
| DE102005054383B4 (de) | 2005-11-15 | 2013-10-31 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Nadel zum Lochen von Pulverkapseln für die Inhalation |
| WO2007089477A2 (en) | 2006-01-31 | 2007-08-09 | Oriel Therapeutics, Inc. | Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods |
| US8464712B2 (en) * | 2006-03-10 | 2013-06-18 | Dose One, Llc | Medication inhaler |
| US7832399B2 (en) * | 2006-03-10 | 2010-11-16 | One Dose, Llc | Medication inhaler |
| US8360057B2 (en) * | 2006-03-10 | 2013-01-29 | Dose One, Llc | Medication inhaler for dispensing multiple capsules |
| DE102006016904A1 (de) | 2006-04-11 | 2007-10-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator |
| DE102006016901A1 (de) | 2006-04-11 | 2007-10-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Mundstück für einen Inhalator |
| DE102006016903A1 (de) | 2006-04-11 | 2007-10-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator |
| NL1033047C2 (nl) * | 2006-12-13 | 2008-06-16 | Pharmachemie Bv | Capsule, gevuld met een medicijn, in het bijzonder een inhaleerbaar medicijn. |
| DE102007033860A1 (de) | 2007-07-20 | 2009-01-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Prüfvorrichtung |
| DE102007052871A1 (de) | 2007-11-02 | 2009-05-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Kapsel zur Aufnahme von pharmazeutischen Wirkstoffformulierungen |
| EP2349034A4 (en) * | 2008-10-24 | 2013-12-11 | Gvd Corp | COATING PROCESSES, SYSTEMS AND RELATED ARTICLES |
| DE202008015493U1 (de) | 2008-11-21 | 2009-02-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Faltschachtel |
| US9603907B2 (en) | 2012-02-01 | 2017-03-28 | Protalix Ltd. | Dry powder formulations of dNase I |
| US20150174158A1 (en) | 2012-03-07 | 2015-06-25 | Advanced Inhalation Therapies (Ait) Ltd. | Inhalation of nitric oxide for treating respiratory diseases |
| US20170304459A1 (en) | 2014-10-10 | 2017-10-26 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for inhalation delivery of conjugated oligonucleotide |
| JP7455144B2 (ja) | 2019-04-29 | 2024-03-25 | インスメッド インコーポレイテッド | トレプロスチニルプロドラッグの乾燥粉末組成物およびその使用方法 |
| KR20230096998A (ko) | 2020-10-28 | 2023-06-30 | 인스메드 인코포레이티드 | 트레프로스티닐 전구약물의 건조 분말 조성물 및 이의 사용 방법 |
| WO2023150747A1 (en) | 2022-02-07 | 2023-08-10 | Insmed Incorporated | Dry powder compositions of bedaquiline and salts and methods of use thereof |
| KR102815643B1 (ko) * | 2022-10-27 | 2025-06-02 | 주식회사 케이티앤지 | 인헤일러 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2814296A (en) | 1954-04-15 | 1957-11-26 | S & R J Everett & Co Ltd | Surgical needles |
| NL123398C (https=) | 1959-12-31 | |||
| US3209754A (en) | 1961-08-10 | 1965-10-05 | Ernest C Wood | Surgical clip |
| US3203829A (en) | 1962-09-25 | 1965-08-31 | Eversharp Inc | Razor blades |
| US3379552A (en) | 1963-11-15 | 1968-04-23 | Sutures Inc | Impregnation of stretched multifilament polyester suture with polytetrafluoroethylene |
| US3518110A (en) | 1964-07-23 | 1970-06-30 | Gillette Co | Razor blade and method of making same |
| US3652342A (en) | 1967-06-07 | 1972-03-28 | Gillette Co | Razor blades and processes for the preparation thereof |
| US3949751A (en) * | 1970-03-03 | 1976-04-13 | Fisons Limited | Method and device for dispensing medicament to the body |
| US3700489A (en) | 1970-07-30 | 1972-10-24 | Ethicon Inc | Process for applying a thin coating of polytetrafluoroethylene |
| GB1352241A (en) | 1971-04-13 | 1974-05-08 | Wilkinson Sword Ltd | Razor blades |
| DE2354428C2 (de) | 1972-11-03 | 1985-06-13 | Ethicon, Inc., Somerville, N.J. | Mehrfädiges chirurgisches Nahtmaterial |
| US4012551A (en) | 1974-02-05 | 1977-03-15 | Warner-Lambert Company | Coated razor blade |
| IT1016489B (it) | 1974-03-18 | 1977-05-30 | Isf Spa | Inalatore |
| US3958570A (en) * | 1974-09-03 | 1976-05-25 | Vogelman Joseph H | Syringes and syringe capsules |
| US4275813A (en) | 1979-06-04 | 1981-06-30 | United States Surgical Corporation | Coherent surgical staple array |
| US4307984A (en) * | 1979-11-19 | 1981-12-29 | Patterson James A | Cutting elements |
| US4621026A (en) * | 1981-12-09 | 1986-11-04 | Richmond Metal Finishers, Inc. | Process for providing metallic articles and the like with wear-resistant coatings, and improved coated metallic articles and the like |
| US4484988A (en) | 1981-12-09 | 1984-11-27 | Richmond Metal Finishers, Inc. | Process for providing metallic articles and the like with wear-resistant coatings |
| DK103483A (da) | 1982-04-15 | 1983-10-16 | Ethicon Inc | Siliconebelagt kirurgisk haefteklamme |
| DE3927170A1 (de) | 1989-08-17 | 1991-02-21 | Boehringer Ingelheim Kg | Inhalator |
| US5266359A (en) * | 1991-01-14 | 1993-11-30 | Becton, Dickinson And Company | Lubricative coating composition, article and assembly containing same and method thereof |
| US5197962A (en) * | 1991-06-05 | 1993-03-30 | Megadyne Medical Products, Inc. | Composite electrosurgical medical instrument |
| EP0528764B1 (en) | 1991-08-16 | 1996-06-12 | Sandoz Ltd. | Inhaler for administration of powdery substances |
| US5685961A (en) | 1992-03-27 | 1997-11-11 | P & D Medical Coatings, Inc. | Method for fabrication of metallized medical devices |
| US5352378A (en) | 1993-05-27 | 1994-10-04 | Minnesota Mining And Manufacturing Company | Nonflammable lubricious composition |
| AU4927096A (en) | 1995-03-02 | 1996-09-18 | Sanofi Pharmaceuticals, Inc. | Low friction coating for cartridge seal cap |
| US6026809A (en) * | 1996-01-25 | 2000-02-22 | Microdose Technologies, Inc. | Inhalation device |
| US5743251A (en) * | 1996-05-15 | 1998-04-28 | Philip Morris Incorporated | Aerosol and a method and apparatus for generating an aerosol |
| US5919172A (en) * | 1996-07-17 | 1999-07-06 | Becton, Dickinson And Company | Hypodermic needle having a differential surface finish |
| EP0916313A4 (en) * | 1997-01-07 | 2006-04-12 | Mani Inc | SURGICAL NEEDLE, ITS SUPPORT AND DEVICE |
| JP3303288B2 (ja) * | 1997-05-12 | 2002-07-15 | ニプロ株式会社 | 穿刺針 |
| DE19722880C1 (de) * | 1997-05-24 | 1998-11-19 | Ethicon Gmbh | Verfahren zum Beschichten von chirurgischen Nadeln |
| US6298256B1 (en) * | 1999-09-10 | 2001-10-02 | Frank-Egbert Meyer | Device and method for the location and catheterization of the surroundings of a nerve |
-
1998
- 1998-03-10 GB GBGB9805102.2A patent/GB9805102D0/en not_active Ceased
-
1999
- 1999-03-05 CO CO99013725A patent/CO5080779A1/es unknown
- 1999-03-08 DE DE29923581U patent/DE29923581U1/de not_active Expired - Lifetime
- 1999-03-08 EP EP99911753A patent/EP1061979B1/en not_active Expired - Lifetime
- 1999-03-08 IL IL13812199A patent/IL138121A/xx not_active IP Right Cessation
- 1999-03-08 NZ NZ506645A patent/NZ506645A/en not_active IP Right Cessation
- 1999-03-08 AU AU30323/99A patent/AU750844B2/en not_active Expired
- 1999-03-08 JP JP2000535398A patent/JP4082864B2/ja not_active Expired - Lifetime
- 1999-03-08 KR KR1020007009055A patent/KR100585483B1/ko not_active Expired - Lifetime
- 1999-03-08 WO PCT/EP1999/001486 patent/WO1999045986A1/en not_active Ceased
- 1999-03-08 WO PCT/EP1999/001487 patent/WO1999045987A1/en not_active Ceased
- 1999-03-08 AT AT99911753T patent/ATE283083T1/de active
- 1999-03-08 PL PL99342825A patent/PL187578B1/pl unknown
- 1999-03-08 CA CA002322575A patent/CA2322575C/en not_active Expired - Lifetime
- 1999-03-08 CN CNB998037435A patent/CN1212868C/zh not_active Expired - Lifetime
- 1999-03-08 BR BR9908587-9A patent/BR9908587A/pt not_active IP Right Cessation
- 1999-03-08 PT PT99911753T patent/PT1061979E/pt unknown
- 1999-03-08 ES ES99911753T patent/ES2232119T3/es not_active Expired - Lifetime
- 1999-03-08 BR BR9908626-3A patent/BR9908626A/pt unknown
- 1999-03-08 DE DE69922175T patent/DE69922175T2/de not_active Expired - Lifetime
- 1999-03-08 JP JP2000600054U patent/JP3094437U/ja not_active Expired - Lifetime
-
2000
- 2000-09-08 US US09/657,967 patent/US6488027B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999045986A1 (en) | 1999-09-16 |
| CO5080779A1 (es) | 2001-09-25 |
| JP2002505922A (ja) | 2002-02-26 |
| PT1061979E (pt) | 2005-02-28 |
| BR9908587A (pt) | 2000-11-14 |
| CN1212868C (zh) | 2005-08-03 |
| IL138121A0 (en) | 2001-10-31 |
| WO1999045987A1 (en) | 1999-09-16 |
| ES2232119T3 (es) | 2005-05-16 |
| HK1035151A1 (en) | 2001-11-16 |
| CA2322575C (en) | 2008-02-05 |
| CA2322575A1 (en) | 1999-09-16 |
| NZ506645A (en) | 2002-06-28 |
| DE69922175D1 (de) | 2004-12-30 |
| KR20010041023A (ko) | 2001-05-15 |
| US6488027B1 (en) | 2002-12-03 |
| JP3094437U (ja) | 2003-06-20 |
| GB9805102D0 (en) | 1998-05-06 |
| PL187578B1 (pl) | 2004-08-31 |
| DE29923581U1 (de) | 2001-02-08 |
| BR9908626A (pt) | 2000-11-14 |
| AU3032399A (en) | 1999-09-27 |
| EP1061979B1 (en) | 2004-11-24 |
| ATE283083T1 (de) | 2004-12-15 |
| IL138121A (en) | 2005-06-19 |
| PL342825A1 (en) | 2001-07-02 |
| KR100585483B1 (ko) | 2006-06-02 |
| DE69922175T2 (de) | 2005-11-03 |
| CN1292715A (zh) | 2001-04-25 |
| AU750844B2 (en) | 2002-08-01 |
| EP1061979A1 (en) | 2000-12-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4082864B2 (ja) | 粉末吸入器 | |
| CA1170514A (en) | Method for forming an anticorrosive coating on a metal substrate | |
| Rademeyer et al. | Permanent iridium modifier for electrothermal atomic absorption spectrometry | |
| CN102037158A (zh) | 碳包覆铝材及其制造方法 | |
| Li et al. | Ag‐enriched Ag‐Pd bimetallic nanoframes and their catalytic properties | |
| FR2513272A1 (fr) | Cathode pour l'electrolyse de solutions acides et son procede de preparation | |
| DE20023858U1 (de) | Unabhängig von Aktivierungsbehandlungen zur Wasserstoffsorption befähigte Verbundmaterialien | |
| US20060135030A1 (en) | Metallization of carbon nanotubes for field emission applications | |
| MXPA00008806A (en) | Powder inhaler | |
| US5284683A (en) | Method for metallization of plastics using poly-diamine-quinone polymers as a binder | |
| HK1035151B (en) | Powder inhaler | |
| JPS596387A (ja) | 酸性溶液電解用陰極及びその製造方法 | |
| JP2887174B2 (ja) | 複合粉末の製造方法 | |
| JPH0781161B2 (ja) | 金属被覆粉末の製造方法 | |
| MXPA05009357A (es) | Composicion antiestatica y sujetador de parte. | |
| AU2016291606B2 (en) | Polymer coating with antimicrobial materials and methods for producing | |
| Byeon et al. | Fabrication of a metal membrane on a perforated polymer substrate by palladium aerosol activation and subsequent electroless plating | |
| CUI et al. | Palladium free activation and electroless nickel plating on ceramic surface | |
| JP2025153836A (ja) | 銀粒子、銀粒子組成物、金属接合用組成物、半導体素子、および銀粒子の製造方法 | |
| JP2025153837A (ja) | 銀粒子、銀粒子組成物、金属接合用組成物、半導体素子、および銀粒子の製造方法 | |
| DE102024209547A1 (de) | Verfahren und Anlage zum Aufbringen einer Schicht, die Metall enthält oder daraus besteht, auf einen Membranträger, und Membranträger, der als eine Membranträger-Membran-Anordnung ausgebildet sein kann | |
| JP3504930B2 (ja) | 皮膜の形成方法および皮膜被付与物 | |
| Venkatesh et al. | Self-cleaning and superhydrophobic CuO coating by jet-nebulizer spray pyrolysis technique | |
| JP2000057843A (ja) | 耐マイグレ−ション性に優れた導電性粒子 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060303 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060303 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20070612 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20070911 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20070919 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20071010 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20080205 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20080212 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110222 Year of fee payment: 3 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120222 Year of fee payment: 4 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120222 Year of fee payment: 4 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130222 Year of fee payment: 5 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130222 Year of fee payment: 5 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20140222 Year of fee payment: 6 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |