JP4082864B2 - 粉末吸入器 - Google Patents
粉末吸入器 Download PDFInfo
- Publication number
- JP4082864B2 JP4082864B2 JP2000535398A JP2000535398A JP4082864B2 JP 4082864 B2 JP4082864 B2 JP 4082864B2 JP 2000535398 A JP2000535398 A JP 2000535398A JP 2000535398 A JP2000535398 A JP 2000535398A JP 4082864 B2 JP4082864 B2 JP 4082864B2
- Authority
- JP
- Japan
- Prior art keywords
- coating
- capsule
- inhaler
- polymer
- nickel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000843 powder Substances 0.000 title abstract description 3
- 239000002775 capsule Substances 0.000 claims abstract description 26
- 229920000642 polymer Polymers 0.000 claims abstract description 21
- 229910000831 Steel Inorganic materials 0.000 claims abstract description 10
- 239000010959 steel Substances 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 8
- 238000000576 coating method Methods 0.000 claims description 26
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 22
- 239000011248 coating agent Substances 0.000 claims description 18
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 13
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 13
- 229910052759 nickel Inorganic materials 0.000 claims description 11
- 229910001096 P alloy Inorganic materials 0.000 claims description 10
- OFNHPGDEEMZPFG-UHFFFAOYSA-N phosphanylidynenickel Chemical compound [P].[Ni] OFNHPGDEEMZPFG-UHFFFAOYSA-N 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 7
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 4
- 229910052698 phosphorus Inorganic materials 0.000 claims description 4
- 239000011574 phosphorus Substances 0.000 claims description 4
- 239000010935 stainless steel Substances 0.000 claims description 2
- 229910001220 stainless steel Inorganic materials 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 7
- 229910045601 alloy Inorganic materials 0.000 description 9
- 239000000956 alloy Substances 0.000 description 9
- 239000006185 dispersion Substances 0.000 description 7
- 229910052751 metal Inorganic materials 0.000 description 7
- 239000002184 metal Substances 0.000 description 7
- 238000007747 plating Methods 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 239000002131 composite material Substances 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 238000000151 deposition Methods 0.000 description 3
- -1 for example Chemical class 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- KWSLGOVYXMQPPX-UHFFFAOYSA-N 5-[3-(trifluoromethyl)phenyl]-2h-tetrazole Chemical compound FC(F)(F)C1=CC=CC(C2=NNN=N2)=C1 KWSLGOVYXMQPPX-UHFFFAOYSA-N 0.000 description 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 229910052804 chromium Inorganic materials 0.000 description 2
- 239000011651 chromium Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000006722 reduction reaction Methods 0.000 description 2
- 229910001379 sodium hypophosphite Inorganic materials 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 description 1
- 239000004338 Dichlorodifluoromethane Substances 0.000 description 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
- 230000000181 anti-adherent effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 description 1
- 229940092705 beclomethasone Drugs 0.000 description 1
- 150000001639 boron compounds Chemical class 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 150000001721 carbon Chemical class 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
- 235000019404 dichlorodifluoromethane Nutrition 0.000 description 1
- 229940087091 dichlorotetrafluoroethane Drugs 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 229940112141 dry powder inhaler Drugs 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 229920002313 fluoropolymer Polymers 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229910021472 group 8 element Inorganic materials 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-N phosphinic acid Chemical compound O[PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-N 0.000 description 1
- 238000001552 radio frequency sputter deposition Methods 0.000 description 1
- 229910052703 rhodium Inorganic materials 0.000 description 1
- 239000010948 rhodium Substances 0.000 description 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 1
- 229910052707 ruthenium Inorganic materials 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Gyroscopes (AREA)
- Valve Device For Special Equipments (AREA)
- Materials For Photolithography (AREA)
- Powder Metallurgy (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9805102.2A GB9805102D0 (en) | 1998-03-10 | 1998-03-10 | Device |
| GB9805102.2 | 1998-03-10 | ||
| PCT/EP1999/001487 WO1999045987A1 (en) | 1998-03-10 | 1999-03-08 | Powder inhaler |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002505922A JP2002505922A (ja) | 2002-02-26 |
| JP2002505922A5 JP2002505922A5 (enExample) | 2006-05-11 |
| JP4082864B2 true JP4082864B2 (ja) | 2008-04-30 |
Family
ID=10828321
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000535398A Expired - Lifetime JP4082864B2 (ja) | 1998-03-10 | 1999-03-08 | 粉末吸入器 |
| JP2000600054U Expired - Lifetime JP3094437U (ja) | 1998-03-10 | 1999-03-08 | 粉末吸入器 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000600054U Expired - Lifetime JP3094437U (ja) | 1998-03-10 | 1999-03-08 | 粉末吸入器 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6488027B1 (enExample) |
| EP (1) | EP1061979B1 (enExample) |
| JP (2) | JP4082864B2 (enExample) |
| KR (1) | KR100585483B1 (enExample) |
| CN (1) | CN1212868C (enExample) |
| AT (1) | ATE283083T1 (enExample) |
| AU (1) | AU750844B2 (enExample) |
| BR (2) | BR9908587A (enExample) |
| CA (1) | CA2322575C (enExample) |
| CO (1) | CO5080779A1 (enExample) |
| DE (2) | DE29923581U1 (enExample) |
| ES (1) | ES2232119T3 (enExample) |
| GB (1) | GB9805102D0 (enExample) |
| IL (1) | IL138121A (enExample) |
| NZ (1) | NZ506645A (enExample) |
| PL (1) | PL187578B1 (enExample) |
| PT (1) | PT1061979E (enExample) |
| WO (2) | WO1999045986A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| DE19835346A1 (de) * | 1998-08-05 | 2000-02-10 | Boehringer Ingelheim Pharma | Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren |
| GB9928311D0 (en) | 1999-11-30 | 2000-01-26 | Novartis Ag | Organic compounds |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| WO2003041776A1 (en) | 2001-11-14 | 2003-05-22 | Nektar Therapeutics | Aerosolization apparatus comprising connectable body and endpiece |
| ES2364636T3 (es) | 2001-12-19 | 2011-09-08 | Novartis Ag | Administración pulmonar de aminoglucósidos. |
| US20040173211A1 (en) * | 2003-01-14 | 2004-09-09 | Boehringer Ingelheim International Gmbh | Powder inhaler |
| EP1615689B1 (en) | 2003-04-09 | 2016-02-03 | Novartis AG | Aerosolization apparatus with capsule puncture alignment guide |
| US20090285900A1 (en) * | 2003-07-31 | 2009-11-19 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
| US20050026884A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
| US20050113318A1 (en) * | 2003-07-31 | 2005-05-26 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
| US7861712B2 (en) * | 2004-04-23 | 2011-01-04 | Manta Product Development | Sealed capsule including an integrated puncturing mechanism |
| DE102005001332A1 (de) * | 2005-01-11 | 2006-07-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Zweiteilige Kapsel mit Vorverschluss zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren |
| DE102006009637A1 (de) | 2005-10-28 | 2007-05-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator mit Mundstück mit mikrobiologischer Schutzfunktion |
| DE102005054383B4 (de) | 2005-11-15 | 2013-10-31 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Nadel zum Lochen von Pulverkapseln für die Inhalation |
| CA2635622C (en) | 2006-01-31 | 2015-03-31 | Oriel Therapeutics, Inc. | Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods |
| US8360057B2 (en) * | 2006-03-10 | 2013-01-29 | Dose One, Llc | Medication inhaler for dispensing multiple capsules |
| US8464712B2 (en) * | 2006-03-10 | 2013-06-18 | Dose One, Llc | Medication inhaler |
| US7832399B2 (en) * | 2006-03-10 | 2010-11-16 | One Dose, Llc | Medication inhaler |
| DE102006016901A1 (de) | 2006-04-11 | 2007-10-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Mundstück für einen Inhalator |
| DE102006016903A1 (de) | 2006-04-11 | 2007-10-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator |
| DE102006016904A1 (de) | 2006-04-11 | 2007-10-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator |
| NL1033047C2 (nl) * | 2006-12-13 | 2008-06-16 | Pharmachemie Bv | Capsule, gevuld met een medicijn, in het bijzonder een inhaleerbaar medicijn. |
| DE102007033860A1 (de) | 2007-07-20 | 2009-01-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Prüfvorrichtung |
| DE102007052871A1 (de) | 2007-11-02 | 2009-05-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Kapsel zur Aufnahme von pharmazeutischen Wirkstoffformulierungen |
| EP2349034A4 (en) * | 2008-10-24 | 2013-12-11 | Gvd Corp | COATING PROCESSES, SYSTEMS AND RELATED ARTICLES |
| DE202008015493U1 (de) | 2008-11-21 | 2009-02-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Faltschachtel |
| US9603906B2 (en) | 2012-02-01 | 2017-03-28 | Protalix Ltd. | Inhalable liquid formulations of DNase I |
| ES2690398T3 (es) | 2012-03-07 | 2018-11-20 | Advanced Inhalation Therapies (Ait) Ltd. | Inhalación de óxido nítrico para el tratamiento de enfermedades respiratorias |
| WO2016057693A1 (en) | 2014-10-10 | 2016-04-14 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for inhalation delivery of conjugated oligonucleotide |
| KR20220002600A (ko) | 2019-04-29 | 2022-01-06 | 인스메드 인코포레이티드 | 트레프로스티닐 전구약물의 건조 분말 조성물 및 이의 사용 방법 |
| WO2023150747A1 (en) | 2022-02-07 | 2023-08-10 | Insmed Incorporated | Dry powder compositions of bedaquiline and salts and methods of use thereof |
| KR102815643B1 (ko) * | 2022-10-27 | 2025-06-02 | 주식회사 케이티앤지 | 인헤일러 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2814296A (en) | 1954-04-15 | 1957-11-26 | S & R J Everett & Co Ltd | Surgical needles |
| NL123398C (enExample) | 1959-12-31 | |||
| US3209754A (en) | 1961-08-10 | 1965-10-05 | Ernest C Wood | Surgical clip |
| US3203829A (en) | 1962-09-25 | 1965-08-31 | Eversharp Inc | Razor blades |
| US3379552A (en) | 1963-11-15 | 1968-04-23 | Sutures Inc | Impregnation of stretched multifilament polyester suture with polytetrafluoroethylene |
| US3518110A (en) | 1964-07-23 | 1970-06-30 | Gillette Co | Razor blade and method of making same |
| US3652342A (en) | 1967-06-07 | 1972-03-28 | Gillette Co | Razor blades and processes for the preparation thereof |
| US3949751A (en) * | 1970-03-03 | 1976-04-13 | Fisons Limited | Method and device for dispensing medicament to the body |
| US3700489A (en) | 1970-07-30 | 1972-10-24 | Ethicon Inc | Process for applying a thin coating of polytetrafluoroethylene |
| GB1352241A (en) | 1971-04-13 | 1974-05-08 | Wilkinson Sword Ltd | Razor blades |
| CH591245A5 (enExample) | 1972-11-03 | 1977-09-15 | Ethicon Inc | |
| US4012551A (en) | 1974-02-05 | 1977-03-15 | Warner-Lambert Company | Coated razor blade |
| IT1016489B (it) | 1974-03-18 | 1977-05-30 | Isf Spa | Inalatore |
| US3958570A (en) * | 1974-09-03 | 1976-05-25 | Vogelman Joseph H | Syringes and syringe capsules |
| US4275813A (en) | 1979-06-04 | 1981-06-30 | United States Surgical Corporation | Coherent surgical staple array |
| US4307984A (en) * | 1979-11-19 | 1981-12-29 | Patterson James A | Cutting elements |
| US4484988A (en) | 1981-12-09 | 1984-11-27 | Richmond Metal Finishers, Inc. | Process for providing metallic articles and the like with wear-resistant coatings |
| US4621026A (en) * | 1981-12-09 | 1986-11-04 | Richmond Metal Finishers, Inc. | Process for providing metallic articles and the like with wear-resistant coatings, and improved coated metallic articles and the like |
| DK103483A (da) | 1982-04-15 | 1983-10-16 | Ethicon Inc | Siliconebelagt kirurgisk haefteklamme |
| DE3927170A1 (de) | 1989-08-17 | 1991-02-21 | Boehringer Ingelheim Kg | Inhalator |
| US5266359A (en) * | 1991-01-14 | 1993-11-30 | Becton, Dickinson And Company | Lubricative coating composition, article and assembly containing same and method thereof |
| US5197962A (en) * | 1991-06-05 | 1993-03-30 | Megadyne Medical Products, Inc. | Composite electrosurgical medical instrument |
| ES2089474T3 (es) | 1991-08-16 | 1996-10-01 | Sandoz Ltd | Inhalador para la administracion de sustancias en polvo. |
| US5685961A (en) | 1992-03-27 | 1997-11-11 | P & D Medical Coatings, Inc. | Method for fabrication of metallized medical devices |
| US5352378A (en) | 1993-05-27 | 1994-10-04 | Minnesota Mining And Manufacturing Company | Nonflammable lubricious composition |
| EP0902692A1 (en) | 1995-03-02 | 1999-03-24 | Abbott Laboratories | Low friction coating for cartridge seal cap |
| US6026809A (en) * | 1996-01-25 | 2000-02-22 | Microdose Technologies, Inc. | Inhalation device |
| US5743251A (en) * | 1996-05-15 | 1998-04-28 | Philip Morris Incorporated | Aerosol and a method and apparatus for generating an aerosol |
| US5919172A (en) * | 1996-07-17 | 1999-07-06 | Becton, Dickinson And Company | Hypodermic needle having a differential surface finish |
| EP0916313A4 (en) * | 1997-01-07 | 2006-04-12 | Mani Inc | SURGICAL NEEDLE, ITS SUPPORT AND DEVICE |
| JP3303288B2 (ja) * | 1997-05-12 | 2002-07-15 | ニプロ株式会社 | 穿刺針 |
| DE19722880C1 (de) * | 1997-05-24 | 1998-11-19 | Ethicon Gmbh | Verfahren zum Beschichten von chirurgischen Nadeln |
| US6298256B1 (en) * | 1999-09-10 | 2001-10-02 | Frank-Egbert Meyer | Device and method for the location and catheterization of the surroundings of a nerve |
-
1998
- 1998-03-10 GB GBGB9805102.2A patent/GB9805102D0/en not_active Ceased
-
1999
- 1999-03-05 CO CO99013725A patent/CO5080779A1/es unknown
- 1999-03-08 ES ES99911753T patent/ES2232119T3/es not_active Expired - Lifetime
- 1999-03-08 PL PL99342825A patent/PL187578B1/pl unknown
- 1999-03-08 DE DE29923581U patent/DE29923581U1/de not_active Expired - Lifetime
- 1999-03-08 CA CA002322575A patent/CA2322575C/en not_active Expired - Lifetime
- 1999-03-08 PT PT99911753T patent/PT1061979E/pt unknown
- 1999-03-08 DE DE69922175T patent/DE69922175T2/de not_active Expired - Lifetime
- 1999-03-08 CN CNB998037435A patent/CN1212868C/zh not_active Expired - Lifetime
- 1999-03-08 KR KR1020007009055A patent/KR100585483B1/ko not_active Expired - Lifetime
- 1999-03-08 BR BR9908587-9A patent/BR9908587A/pt not_active IP Right Cessation
- 1999-03-08 AU AU30323/99A patent/AU750844B2/en not_active Expired
- 1999-03-08 NZ NZ506645A patent/NZ506645A/en not_active IP Right Cessation
- 1999-03-08 EP EP99911753A patent/EP1061979B1/en not_active Expired - Lifetime
- 1999-03-08 WO PCT/EP1999/001486 patent/WO1999045986A1/en not_active Ceased
- 1999-03-08 IL IL13812199A patent/IL138121A/xx not_active IP Right Cessation
- 1999-03-08 AT AT99911753T patent/ATE283083T1/de active
- 1999-03-08 BR BR9908626-3A patent/BR9908626A/pt unknown
- 1999-03-08 JP JP2000535398A patent/JP4082864B2/ja not_active Expired - Lifetime
- 1999-03-08 JP JP2000600054U patent/JP3094437U/ja not_active Expired - Lifetime
- 1999-03-08 WO PCT/EP1999/001487 patent/WO1999045987A1/en not_active Ceased
-
2000
- 2000-09-08 US US09/657,967 patent/US6488027B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999045987A1 (en) | 1999-09-16 |
| ES2232119T3 (es) | 2005-05-16 |
| NZ506645A (en) | 2002-06-28 |
| CA2322575A1 (en) | 1999-09-16 |
| BR9908587A (pt) | 2000-11-14 |
| PL187578B1 (pl) | 2004-08-31 |
| IL138121A0 (en) | 2001-10-31 |
| US6488027B1 (en) | 2002-12-03 |
| KR20010041023A (ko) | 2001-05-15 |
| EP1061979B1 (en) | 2004-11-24 |
| PT1061979E (pt) | 2005-02-28 |
| DE69922175T2 (de) | 2005-11-03 |
| DE69922175D1 (de) | 2004-12-30 |
| CN1212868C (zh) | 2005-08-03 |
| HK1035151A1 (en) | 2001-11-16 |
| CA2322575C (en) | 2008-02-05 |
| CO5080779A1 (es) | 2001-09-25 |
| IL138121A (en) | 2005-06-19 |
| AU750844B2 (en) | 2002-08-01 |
| PL342825A1 (en) | 2001-07-02 |
| EP1061979A1 (en) | 2000-12-27 |
| AU3032399A (en) | 1999-09-27 |
| ATE283083T1 (de) | 2004-12-15 |
| CN1292715A (zh) | 2001-04-25 |
| JP2002505922A (ja) | 2002-02-26 |
| WO1999045986A1 (en) | 1999-09-16 |
| JP3094437U (ja) | 2003-06-20 |
| BR9908626A (pt) | 2000-11-14 |
| GB9805102D0 (en) | 1998-05-06 |
| KR100585483B1 (ko) | 2006-06-02 |
| DE29923581U1 (de) | 2001-02-08 |
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