JP4081137B2 - 複数のｃｔｐ付加を有するホルモンアナログ - Google Patents

複数のｃｔｐ付加を有するホルモンアナログ Download PDF

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Publication number
JP4081137B2
JP4081137B2 JP50709393A JP50709393A JP4081137B2 JP 4081137 B2 JP4081137 B2 JP 4081137B2 JP 50709393 A JP50709393 A JP 50709393A JP 50709393 A JP50709393 A JP 50709393A JP 4081137 B2 JP4081137 B2 JP 4081137B2
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JP
Japan
Prior art keywords
fsh
ctp
human
amino acid
biological activity
Prior art date
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Expired - Lifetime
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JP50709393A
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English (en)
Japanese (ja)
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JPH07502166A (ja
Inventor
ボイム，アーヴィング
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Washington University in St Louis WUSTL
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Washington University in St Louis WUSTL
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Publication of JPH07502166A publication Critical patent/JPH07502166A/ja
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Publication of JP4081137B2 publication Critical patent/JP4081137B2/ja
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Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/11—Gonadotropin; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP50709393A 1991-10-04 1992-10-02 複数のｃｔｐ付加を有するホルモンアナログ Expired - Lifetime JP4081137B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/771,262 US6225449B1 (en) 1991-10-04 1991-10-04 Hormone analogs with multiple CTP extensions
US771,262 1991-10-04
PCT/US1992/008424 WO1993006844A1 (en) 1991-10-04 1992-10-02 Hormone analogs with multiple ctp extensions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007306928A Division JP2008073057A (ja) 1991-10-04 2007-11-28 複数のｃｔｐ付加を有するホルモンアナログ

Publications (2)

Publication Number Publication Date
JPH07502166A JPH07502166A (ja) 1995-03-09
JP4081137B2 true JP4081137B2 (ja) 2008-04-23

Family

ID=25091246

Family Applications (2)

Application Number Title Priority Date Filing Date
JP50709393A Expired - Lifetime JP4081137B2 (ja) 1991-10-04 1992-10-02 複数のｃｔｐ付加を有するホルモンアナログ
JP2007306928A Pending JP2008073057A (ja) 1991-10-04 2007-11-28 複数のｃｔｐ付加を有するホルモンアナログ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2007306928A Pending JP2008073057A (ja) 1991-10-04 2007-11-28 複数のｃｔｐ付加を有するホルモンアナログ

Country Status (11)

Country Link
US (2) US6225449B1 (es)
EP (1) EP0607297B1 (es)
JP (2) JP4081137B2 (es)
KR (1) KR100281811B1 (es)
AT (1) ATE248922T1 (es)
CA (1) CA2120358A1 (es)
DE (1) DE69233188T2 (es)
ES (1) ES2204893T3 (es)
FI (1) FI941500A (es)
NO (1) NO941186D0 (es)
WO (1) WO1993006844A1 (es)

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* Cited by examiner, † Cited by third party
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US5792460A (en) * 1989-02-21 1998-08-11 Washington University Modified glycoprotein hormones having a CTP at the amino terminus
US6225449B1 (en) * 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
EP0461200B1 (en) 1989-02-21 1997-01-22 Washington University Modified forms of reproductive hormones
FR2710845B1 (fr) * 1993-10-08 1996-03-29 Lafon Labor Composition destinée à l'immunothérapie d'un cancer sécrétant l'hCG ou des fragments d'hCG.
ES2141229T3 (es) * 1993-04-20 2000-03-16 Univ Washington Productos farmaceuticos de proteinas y peptidos modificados.
US6737515B2 (en) 1993-11-19 2004-05-18 Washington University Follicle stimulating hormone-glycosylation analogs
US5657411A (en) * 1995-12-15 1997-08-12 Honeywell Inc. Negative trimming of fiber optic winding
ATE295887T1 (de) * 1996-02-20 2005-06-15 Applied Research Systems Heterodimerebildende hybrid-proteine
WO1999011655A1 (en) 1997-09-04 1999-03-11 Gryphon Sciences Modular protein libraries and methods of preparation
PE20010288A1 (es) * 1999-07-02 2001-03-07 Hoffmann La Roche Derivados de eritropoyetina
US20030036181A1 (en) * 2000-06-30 2003-02-20 Okkels Jens Sigurd Peptide extended glycosylated polypeptides
WO2002048194A1 (en) * 2000-12-11 2002-06-20 Cheil Jedang Corporation Fusion protein having the enhanced in vivo activity of erythropoietin
KR101229995B1 (ko) * 2000-12-11 2013-02-06 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
US6987172B2 (en) * 2001-03-05 2006-01-17 Washington University In St. Louis Multifunctional single chain glycoprotein hormones comprising three or more β subunits
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US7173113B2 (en) * 2002-01-31 2007-02-06 The Trustees Of Columbia University In The City Of New York Long-acting hormone and growth factor compositions and uses thereof
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US7855279B2 (en) 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
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US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
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US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
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CN103119057B (zh) 2010-06-24 2016-06-15 印第安纳大学研究及科技有限公司 基于酰胺的胰岛素前药
JP2014520869A (ja) 2011-07-18 2014-08-25 アルツ バイオロジクス アクティーゼルスカブ 長期作用性で生物学的活性が有る黄体形成ホルモン（ｌｈ）化合物
JP6392123B2 (ja) * 2011-12-20 2018-09-19 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ 糖尿病治療のためのｃｔｐ系インスリンアナローグ
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Also Published As

Publication number Publication date
US5759818A (en) 1998-06-02
JP2008073057A (ja) 2008-04-03
DE69233188T2 (de) 2004-05-27
AU667489B2 (en) 1996-03-28
EP0607297A1 (en) 1994-07-27
AU2864892A (en) 1993-05-03
KR100281811B1 (ko) 2001-02-15
EP0607297A4 (en) 1995-10-25
US6225449B1 (en) 2001-05-01
FI941500A0 (fi) 1994-03-30
DE69233188D1 (de) 2003-10-09
JPH07502166A (ja) 1995-03-09
ATE248922T1 (de) 2003-09-15
NO941186L (no) 1994-03-30
WO1993006844A1 (en) 1993-04-15
CA2120358A1 (en) 1993-04-15
ES2204893T3 (es) 2004-05-01
NO941186D0 (no) 1994-03-30
EP0607297B1 (en) 2003-09-03
FI941500A (fi) 1994-05-23

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