JP4047723B2 - インドリン誘導体、および５−ｈｔ２受容体リガンドとしてのその使用 - Google Patents

インドリン誘導体、および５−ｈｔ２受容体リガンドとしてのその使用 Download PDF

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Publication number
JP4047723B2
JP4047723B2 JP2002546522A JP2002546522A JP4047723B2 JP 4047723 B2 JP4047723 B2 JP 4047723B2 JP 2002546522 A JP2002546522 A JP 2002546522A JP 2002546522 A JP2002546522 A JP 2002546522A JP 4047723 B2 JP4047723 B2 JP 4047723B2
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Prior art keywords
diabetes
compound
hydrogen
treatment
formula
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Expired - Fee Related
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JP2002546522A
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Japanese (ja)
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JP2004527467A (ja
JP2004527467A5 (https=
Inventor
ベントレー，ジョナサン・マーク
デービッドソン，ジェームス・エドワード・ポール
マンセル，ハワード・ランガム
マンク，ナサニエル・ジュリアス・トーマス
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of JP2004527467A5 publication Critical patent/JP2004527467A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
JP2002546522A 2000-10-16 2001-10-12 インドリン誘導体、および５−ｈｔ２受容体リガンドとしてのその使用 Expired - Fee Related JP4047723B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00122539 2000-10-16
PCT/EP2001/011814 WO2002044152A1 (en) 2000-10-16 2001-10-12 Indoline derivatives and their use as 5-ht2 receptor ligands

Publications (3)

Publication Number Publication Date
JP2004527467A JP2004527467A (ja) 2004-09-09
JP2004527467A5 JP2004527467A5 (https=) 2005-03-17
JP4047723B2 true JP4047723B2 (ja) 2008-02-13

Family

ID=8170101

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002546522A Expired - Fee Related JP4047723B2 (ja) 2000-10-16 2001-10-12 インドリン誘導体、および５−ｈｔ２受容体リガンドとしてのその使用

Country Status (15)

Country Link
US (1) US6479534B1 (https=)
EP (1) EP1328515B1 (https=)
JP (1) JP4047723B2 (https=)
KR (1) KR100545435B1 (https=)
CN (1) CN100334076C (https=)
AR (1) AR038762A1 (https=)
AT (1) ATE403647T1 (https=)
AU (2) AU2167002A (https=)
BR (1) BR0114708A (https=)
CA (1) CA2422698C (https=)
DE (1) DE60135239D1 (https=)
ES (1) ES2311563T3 (https=)
MX (1) MXPA03003246A (https=)
WO (1) WO2002044152A1 (https=)
ZA (1) ZA200302516B (https=)

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Also Published As

Publication number Publication date
WO2002044152A1 (en) 2002-06-06
CN100334076C (zh) 2007-08-29
AR038762A1 (es) 2005-01-26
AU2167002A (en) 2002-06-11
US6479534B1 (en) 2002-11-12
US20020183349A1 (en) 2002-12-05
DE60135239D1 (de) 2008-09-18
ES2311563T3 (es) 2009-02-16
JP2004527467A (ja) 2004-09-09
EP1328515A1 (en) 2003-07-23
EP1328515B1 (en) 2008-08-06
CA2422698C (en) 2009-12-15
KR20030048437A (ko) 2003-06-19
CA2422698A1 (en) 2002-06-06
CN1630636A (zh) 2005-06-22
ZA200302516B (en) 2004-06-30
ATE403647T1 (de) 2008-08-15
MXPA03003246A (es) 2003-06-06
AU2002221670B2 (en) 2006-11-02
BR0114708A (pt) 2003-07-01
KR100545435B1 (ko) 2006-01-24

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