JP4026848B2 - 免疫原の受容体特異的経上皮輸送 - Google Patents

免疫原の受容体特異的経上皮輸送 Download PDF

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JP4026848B2
JP4026848B2 JP52235696A JP52235696A JP4026848B2 JP 4026848 B2 JP4026848 B2 JP 4026848B2 JP 52235696 A JP52235696 A JP 52235696A JP 52235696 A JP52235696 A JP 52235696A JP 4026848 B2 JP4026848 B2 JP 4026848B2
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molecule
antigen
igg
epithelial barrier
fcrn
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Expired - Lifetime
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Japanese (ja)
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JP2002515850A (ja
JP2002515850A5 (enExample
Inventor
ブルムバーグ，リチャード・エス
シミスター，ニール・イー
ランサー，ウェイン・アイ
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Brandeis University
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Brandeis University
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Priority claimed from US08/374,159 external-priority patent/US6086875A/en
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gastroenterology & Hepatology (AREA)
JP52235696A 1995-01-17 1996-01-17 免疫原の受容体特異的経上皮輸送 Expired - Lifetime JP4026848B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/374,159 1995-01-17
US08/374,159 US6086875A (en) 1995-01-17 1995-01-17 Receptor specific transepithelial transport of immunogens
US57817195A 1995-12-29 1995-12-29
US08/578,171 1995-12-29
PCT/US1996/000597 WO1996022024A1 (en) 1995-01-17 1996-01-17 Receptor specific transepithelial transport of immunogens

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007200621A Division JP2008007513A (ja) 1995-01-17 2007-08-01 免疫原の受容体特異的経上皮輸送

Publications (3)

Publication Number Publication Date
JP2002515850A JP2002515850A (ja) 2002-05-28
JP2002515850A5 JP2002515850A5 (enExample) 2006-07-20
JP4026848B2 true JP4026848B2 (ja) 2007-12-26

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ID=27006452

Family Applications (2)

Application Number Title Priority Date Filing Date
JP52235696A Expired - Lifetime JP4026848B2 (ja) 1995-01-17 1996-01-17 免疫原の受容体特異的経上皮輸送
JP2007200621A Pending JP2008007513A (ja) 1995-01-17 2007-08-01 免疫原の受容体特異的経上皮輸送

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2007200621A Pending JP2008007513A (ja) 1995-01-17 2007-08-01 免疫原の受容体特異的経上皮輸送

Country Status (9)

Country Link
EP (3) EP1323346B1 (enExample)
JP (2) JP4026848B2 (enExample)
AT (2) ATE238668T1 (enExample)
CA (1) CA2210656C (enExample)
DE (2) DE69627820T2 (enExample)
DK (2) DK0805628T3 (enExample)
ES (2) ES2194973T3 (enExample)
PT (1) PT1323346E (enExample)
WO (1) WO1996022024A1 (enExample)

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US6086875A (en) * 1995-01-17 2000-07-11 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of immunogens
US6485726B1 (en) 1995-01-17 2002-11-26 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
IT1289608B1 (it) * 1997-02-05 1998-10-15 Angelini Ricerche Spa Composizione per uso terapeutico o diagnostico somministrabile per via intranasale,sublinguale o vaginale
NZ520472A (en) * 2000-02-03 2004-03-26 Lennart Hammarstrom Ruminant MHC class I-like Fc receptors
US20030031675A1 (en) 2000-06-06 2003-02-13 Mikesell Glen E. B7-related nucleic acids and polypeptides useful for immunomodulation
DK1294769T3 (da) 2000-06-16 2011-04-26 Human Genome Sciences Inc Antistoffer der immunspecifikt binder til BLyS
DK1355919T3 (da) 2000-12-12 2011-03-14 Medimmune Llc Molekyler med længere halveringstider, sammensætninger og anvendelser deraf
EP1683865A3 (en) 2001-02-02 2006-10-25 Eli Lilly & Company Mammalian proteins and in particular CD200
CA2437811A1 (en) 2001-02-09 2002-08-22 Human Genome Sciences, Inc. Human g-protein chemokine receptor (ccr5) hdgnr10
JP2004536579A (ja) 2001-04-13 2004-12-09 ヒューマン　ジノーム　サイエンシーズ，　インコーポレイテッド 血管内皮増殖因子２
US7265208B2 (en) 2001-05-01 2007-09-04 The Regents Of The University Of California Fusion molecules and treatment of IgE-mediated allergic diseases
WO2002088317A2 (en) * 2001-05-01 2002-11-07 The Regents Of The University Of California Fusion molecules and methods for treatment of immune diseases
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US8188231B2 (en) 2002-09-27 2012-05-29 Xencor, Inc. Optimized FC variants
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
US7662925B2 (en) 2002-03-01 2010-02-16 Xencor, Inc. Optimized Fc variants and methods for their generation
CN101143221A (zh) * 2002-03-15 2008-03-19 布赖汉姆妇女医院 适合治疗剂全身性递送的中央气道给药
WO2003086458A1 (en) 2002-04-12 2003-10-23 Medimmune, Inc. Recombinant anti-interleukin-9 antibodies
AT502293B1 (de) * 2002-05-15 2008-03-15 Igeneon Krebs Immuntherapie Immunogener, monoklonaler antikörper
AU2003232081B2 (en) * 2002-07-03 2009-02-05 Brandeis University Central airway administration for systemic delivery of therapeutics
WO2004022736A1 (ja) 2002-08-30 2004-03-18 Japan Science And Technology Corporation 遺伝子のターゲティング破壊法および超耐熱菌ゲノム、ならびにこれらを利用したゲノムチップ
WO2004065551A2 (en) 2003-01-21 2004-08-05 Bristol-Myers Squibb Company Polynucleotide encoding a novel acyl coenzyme a, monoacylglycerol acyltransferase-3 (mgat3), and uses thereof
US8388955B2 (en) 2003-03-03 2013-03-05 Xencor, Inc. Fc variants
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