DE69627820T2 - Rezeptorspezifischer transepithelialer transport von immunogenen - Google Patents

Rezeptorspezifischer transepithelialer transport von immunogenen Download PDF

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Publication number
DE69627820T2
DE69627820T2 DE69627820T DE69627820T DE69627820T2 DE 69627820 T2 DE69627820 T2 DE 69627820T2 DE 69627820 T DE69627820 T DE 69627820T DE 69627820 T DE69627820 T DE 69627820T DE 69627820 T2 DE69627820 T2 DE 69627820T2
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Prior art keywords
fcrn
igg
antigen
molecule
conjugate
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE69627820T
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German (de)
English (en)
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DE69627820D1 (de
Inventor
S. Richard BLUMBERG
E. Neil SIMISTER
I. Wayne LENCER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham and Womens Hospital Inc
Brandeis University
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Brigham and Womens Hospital Inc
Brandeis University
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Priority claimed from US08/374,159 external-priority patent/US6086875A/en
Application filed by Brigham and Womens Hospital Inc, Brandeis University filed Critical Brigham and Womens Hospital Inc
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Publication of DE69627820D1 publication Critical patent/DE69627820D1/de
Publication of DE69627820T2 publication Critical patent/DE69627820T2/de
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Expired - Lifetime legal-status Critical Current

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K2039/55516—Proteins; Peptides
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    • A61K2039/6031—Proteins
    • A61K2039/6056—Antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
DE69627820T 1995-01-17 1996-01-17 Rezeptorspezifischer transepithelialer transport von immunogenen Expired - Lifetime DE69627820T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US374159 1989-06-29
US08/374,159 US6086875A (en) 1995-01-17 1995-01-17 Receptor specific transepithelial transport of immunogens
US57817195A 1995-12-29 1995-12-29
US578171 1995-12-29
PCT/US1996/000597 WO1996022024A1 (en) 1995-01-17 1996-01-17 Receptor specific transepithelial transport of immunogens

Publications (2)

Publication Number Publication Date
DE69627820D1 DE69627820D1 (de) 2003-06-05
DE69627820T2 true DE69627820T2 (de) 2004-04-08

Family

ID=27006452

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69636312T Expired - Lifetime DE69636312T2 (de) 1995-01-17 1996-01-17 Rezeptorspezifischer Transepithelealer Transport von Immunogenen
DE69627820T Expired - Lifetime DE69627820T2 (de) 1995-01-17 1996-01-17 Rezeptorspezifischer transepithelialer transport von immunogenen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69636312T Expired - Lifetime DE69636312T2 (de) 1995-01-17 1996-01-17 Rezeptorspezifischer Transepithelealer Transport von Immunogenen

Country Status (9)

Country Link
EP (3) EP1323346B1 (enExample)
JP (2) JP4026848B2 (enExample)
AT (2) ATE331438T1 (enExample)
CA (1) CA2210656C (enExample)
DE (2) DE69636312T2 (enExample)
DK (2) DK0805628T3 (enExample)
ES (2) ES2268182T3 (enExample)
PT (1) PT1323346E (enExample)
WO (1) WO1996022024A1 (enExample)

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US6030613A (en) 1995-01-17 2000-02-29 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
IT1289608B1 (it) * 1997-02-05 1998-10-15 Angelini Ricerche Spa Composizione per uso terapeutico o diagnostico somministrabile per via intranasale,sublinguale o vaginale
CA2399561A1 (en) * 2000-02-03 2001-08-09 Lennart Hammarstrom Ruminant mhc class i-like fc receptors
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EP1683865A3 (en) 2001-02-02 2006-10-25 Eli Lilly & Company Mammalian proteins and in particular CD200
CA2437811A1 (en) 2001-02-09 2002-08-22 Human Genome Sciences, Inc. Human g-protein chemokine receptor (ccr5) hdgnr10
WO2002083704A1 (en) 2001-04-13 2002-10-24 Human Genome Sciences, Inc. Vascular endothelial growth factor 2
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US7265208B2 (en) 2001-05-01 2007-09-04 The Regents Of The University Of California Fusion molecules and treatment of IgE-mediated allergic diseases
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
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