JP3981328B2 - 蛍光タグを使用した生体分子濃縮物をインビボで検出するための方法、回路、および物質の組成物 - Google Patents
蛍光タグを使用した生体分子濃縮物をインビボで検出するための方法、回路、および物質の組成物 Download PDFInfo
- Publication number
- JP3981328B2 JP3981328B2 JP2002541386A JP2002541386A JP3981328B2 JP 3981328 B2 JP3981328 B2 JP 3981328B2 JP 2002541386 A JP2002541386 A JP 2002541386A JP 2002541386 A JP2002541386 A JP 2002541386A JP 3981328 B2 JP3981328 B2 JP 3981328B2
- Authority
- JP
- Japan
- Prior art keywords
- optical radiation
- fluorescently labeled
- binding molecule
- labeled binding
- vivo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000001727 in vivo Methods 0.000 title claims abstract description 42
- 238000000034 method Methods 0.000 title description 22
- 239000000203 mixture Substances 0.000 title description 14
- 239000012141 concentrate Substances 0.000 title description 2
- 230000003287 optical effect Effects 0.000 claims abstract description 90
- 230000005855 radiation Effects 0.000 claims abstract description 85
- 230000027455 binding Effects 0.000 claims abstract description 29
- 230000004044 response Effects 0.000 claims abstract description 10
- 230000005284 excitation Effects 0.000 claims abstract description 9
- 239000000427 antigen Substances 0.000 claims description 33
- 102000036639 antigens Human genes 0.000 claims description 33
- 108091007433 antigens Proteins 0.000 claims description 33
- 239000000227 bioadhesive Substances 0.000 claims description 11
- 210000004881 tumor cell Anatomy 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 8
- 238000010521 absorption reaction Methods 0.000 claims description 6
- 238000002955 isolation Methods 0.000 claims 2
- 239000011159 matrix material Substances 0.000 description 50
- 210000001519 tissue Anatomy 0.000 description 40
- 206010028980 Neoplasm Diseases 0.000 description 30
- 210000004027 cell Anatomy 0.000 description 21
- 229920000642 polymer Polymers 0.000 description 14
- 230000003211 malignant effect Effects 0.000 description 12
- 238000001514 detection method Methods 0.000 description 9
- 238000010586 diagram Methods 0.000 description 9
- 238000011282 treatment Methods 0.000 description 9
- 239000007850 fluorescent dye Substances 0.000 description 6
- 239000012634 fragment Substances 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 5
- 230000002062 proliferating effect Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 102100028662 Sigma intracellular receptor 2 Human genes 0.000 description 4
- 101710109012 Sigma intracellular receptor 2 Proteins 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- 230000001613 neoplastic effect Effects 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 206010006187 Breast cancer Diseases 0.000 description 3
- 208000026310 Breast neoplasm Diseases 0.000 description 3
- 229920000954 Polyglycolide Polymers 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 210000004408 hybridoma Anatomy 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229920000747 poly(lactic acid) Polymers 0.000 description 3
- 239000004633 polyglycolic acid Substances 0.000 description 3
- 239000004626 polylactic acid Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 230000004565 tumor cell growth Effects 0.000 description 3
- 208000003174 Brain Neoplasms Diseases 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 2
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 2
- 238000011256 aggressive treatment Methods 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000004621 biodegradable polymer Substances 0.000 description 2
- 229920002988 biodegradable polymer Polymers 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 239000005090 green fluorescent protein Substances 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 230000003463 hyperproliferative effect Effects 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 229920000128 polypyrrole Polymers 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 230000009870 specific binding Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 201000003076 Angiosarcoma Diseases 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 201000008808 Fibrosarcoma Diseases 0.000 description 1
- 208000000321 Gardner Syndrome Diseases 0.000 description 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 description 1
- 208000016177 Genetic intestinal polyposis Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 208000001258 Hemangiosarcoma Diseases 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 208000002260 Keloid Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010029260 Neuroblastoma Diseases 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 208000023915 Ureteral Neoplasms Diseases 0.000 description 1
- 206010046392 Ureteric cancer Diseases 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 208000008385 Urogenital Neoplasms Diseases 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 206010047642 Vitiligo Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000003322 aneuploid effect Effects 0.000 description 1
- 208000036878 aneuploidy Diseases 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000002715 bioenergetic effect Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 201000008275 breast carcinoma Diseases 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000005754 cellular signaling Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 229920001940 conductive polymer Polymers 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 229940097362 cyclodextrins Drugs 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 238000007877 drug screening Methods 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000005518 electrochemistry Effects 0.000 description 1
- 230000005670 electromagnetic radiation Effects 0.000 description 1
- 238000006056 electrooxidation reaction Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000013265 extended release Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000002518 glial effect Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 201000011066 hemangioma Diseases 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 210000001117 keloid Anatomy 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000003068 molecular probe Substances 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 239000007793 ph indicator Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 102000034285 signal transducing proteins Human genes 0.000 description 1
- 108091006024 signal transducing proteins Proteins 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 229960001603 tamoxifen Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 238000000427 thin-film deposition Methods 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0058—Antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24757400P | 2000-11-09 | 2000-11-09 | |
| PCT/US2001/047373 WO2002039112A2 (en) | 2000-11-09 | 2001-11-07 | In vivo detection of biomolecule concentrations using fluorescent tags |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004523257A JP2004523257A (ja) | 2004-08-05 |
| JP2004523257A5 JP2004523257A5 (https=) | 2005-12-22 |
| JP3981328B2 true JP3981328B2 (ja) | 2007-09-26 |
Family
ID=22935419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002541386A Expired - Fee Related JP3981328B2 (ja) | 2000-11-09 | 2001-11-07 | 蛍光タグを使用した生体分子濃縮物をインビボで検出するための方法、回路、および物質の組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7378056B2 (https=) |
| EP (1) | EP1332364B1 (https=) |
| JP (1) | JP3981328B2 (https=) |
| AT (1) | ATE441110T1 (https=) |
| AU (2) | AU2002236590B2 (https=) |
| CA (1) | CA2429127A1 (https=) |
| DE (1) | DE60139705D1 (https=) |
| WO (1) | WO2002039112A2 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004075032A2 (en) * | 2003-02-19 | 2004-09-02 | Sicel Technologies Inc. | In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes |
| JP4733918B2 (ja) * | 2003-10-01 | 2011-07-27 | オリンパス株式会社 | カプセル投薬システム |
| US8195276B2 (en) * | 2004-03-25 | 2012-06-05 | Olympus Corporation | In-vivo information acquisition apparatus and in-vivo information acquisition apparatus system |
| US20060027756A1 (en) * | 2004-08-09 | 2006-02-09 | Ian Thomson | Dosimeter having an array of sensors for measuring ionizing radiation, and dosimetry system and method using such a dosimeter |
| US7415482B2 (en) * | 2005-02-11 | 2008-08-19 | Rivet Software, Inc. | XBRL enabler for business documents |
| US20060270919A1 (en) * | 2005-05-11 | 2006-11-30 | Mytek, Llc | Biomarkers sensing |
| GB0712109D0 (en) * | 2007-06-22 | 2007-08-01 | Edinburgh Instr | Fluorescence lifetime and fluorescence assays |
| ATE508679T1 (de) * | 2008-02-26 | 2011-05-15 | Biostems Ltd | Vorrichtung zur mikroinvasiven in-vivo- untersuchung, die einen metallischen leiter umfasst |
| DK2291640T3 (en) | 2008-05-20 | 2019-03-11 | Univ Health Network | Device and method for fluorescence-based imaging and monitoring |
| US20100249550A1 (en) * | 2009-03-25 | 2010-09-30 | Neilcor Puritan Bennett LLC | Method And Apparatus For Optical Filtering Of A Broadband Emitter In A Medical Sensor |
| US11861696B1 (en) | 2013-02-14 | 2024-01-02 | Capital Confirmation, Inc. | Systems and methods for obtaining accountant prepared financial statement confirmation |
| EP3957232B1 (en) | 2014-07-24 | 2025-12-31 | University Health Network | DATA COLLECTION AND ANALYSIS FOR DIAGNOSTIC PURPOSES |
| US11013436B2 (en) | 2017-09-06 | 2021-05-25 | Medtronic, Inc. | Marker monitoring via a medical device |
| EP3684463B1 (en) | 2017-09-19 | 2025-05-14 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement |
| US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
| US11478603B2 (en) | 2017-12-31 | 2022-10-25 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to enhance emotional response |
| US12280219B2 (en) | 2017-12-31 | 2025-04-22 | NeuroLight, Inc. | Method and apparatus for neuroenhancement to enhance emotional response |
| US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
| CN113382683A (zh) | 2018-09-14 | 2021-09-10 | 纽罗因恒思蒙特实验有限责任公司 | 改善睡眠的系统和方法 |
| US11786694B2 (en) | 2019-05-24 | 2023-10-17 | NeuroLight, Inc. | Device, method, and app for facilitating sleep |
Family Cites Families (188)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS36022343B1 (https=) | 1959-12-24 | 1961-11-18 | Univ Tokyo | |
| US3638640A (en) | 1967-11-01 | 1972-02-01 | Robert F Shaw | Oximeter and method for in vivo determination of oxygen saturation in blood using three or more different wavelengths |
| US3972320A (en) | 1974-08-12 | 1976-08-03 | Gabor Ujhelyi Kalman | Patient monitoring system |
| US4163380A (en) | 1977-10-11 | 1979-08-07 | Lockheed Corporation | Forming of preconsolidated metal matrix composites |
| USRE32361E (en) | 1979-05-14 | 1987-02-24 | Medtronic, Inc. | Implantable telemetry transmission system for analog and digital data |
| US4326535A (en) | 1980-05-13 | 1982-04-27 | Akron City Hospital | Circuit and method for the radiotelemetry of esophageal pH in an ECG radiotelemetry system |
| US4494545A (en) | 1980-05-27 | 1985-01-22 | Cordis Corporation | Implant telemetry system |
| US4361153A (en) | 1980-05-27 | 1982-11-30 | Cordis Corporation | Implant telemetry system |
| US4556063A (en) | 1980-10-07 | 1985-12-03 | Medtronic, Inc. | Telemetry system for a medical device |
| US4523279A (en) | 1980-11-24 | 1985-06-11 | Oximetrix, Inc. | Apparatus for determining oxygen saturation levels in blood |
| US4397313A (en) | 1981-08-03 | 1983-08-09 | Clini-Therm Corporation | Multiple microwave applicator system and method for microwave hyperthermia treatment |
| US4397314A (en) | 1981-08-03 | 1983-08-09 | Clini-Therm Corporation | Method and apparatus for controlling and optimizing the heating pattern for a hyperthermia system |
| US4416283A (en) | 1981-08-31 | 1983-11-22 | Cordis Corporation | Programming and telemetry system for biomedical implantable device |
| CA1188431A (en) | 1981-10-02 | 1985-06-04 | Canadian Astronautics Limited | Direct reading dosimeter |
| US4431004A (en) | 1981-10-27 | 1984-02-14 | Bessman Samuel P | Implantable glucose sensor |
| US5186172A (en) | 1982-03-22 | 1993-02-16 | Mountpelier Investments, S.A. | Remote sensing tonometric catheter apparatus |
| DE3219558C2 (de) | 1982-05-25 | 1986-10-23 | Norbert H.L. Dr.-Ing. 5173 Aldenhoven Koster | Vorrichtung zur Bestimmung der lokalen Temperatur in lebendem Gewebe |
| US4571292A (en) | 1982-08-12 | 1986-02-18 | Case Western Reserve University | Apparatus for electrochemical measurements |
| CH658729A5 (de) | 1982-09-17 | 1986-11-28 | Lehner Max & Co Ag | Vorrichtung zur registrierung der strahlenbelastung von mit strahlung umgehenden personen. |
| US4571589A (en) | 1982-11-22 | 1986-02-18 | Cordis Corporation | Biomedical implant with high speed, low power two-way telemetry |
| AU577519B2 (en) | 1983-01-21 | 1988-09-29 | Jose A. Marchosky | Implantable hyperthermia device and system |
| US4961422A (en) | 1983-01-21 | 1990-10-09 | Marchosky J Alexander | Method and apparatus for volumetric interstitial conductive hyperthermia |
| US4575676A (en) | 1983-04-04 | 1986-03-11 | Advanced Research And Applications Corporation | Method and apparatus for radiation testing of electron devices |
| GB2140563B (en) | 1983-04-27 | 1987-03-04 | Critikon Inc | Method and apparatus for zero calibration of oxygen-sensing polarographic devices |
| US4543953A (en) | 1983-07-18 | 1985-10-01 | Cordis Corporation | Analog telemetry system for biomedical implant |
| US4655880A (en) | 1983-08-01 | 1987-04-07 | Case Western Reserve University | Apparatus and method for sensing species, substances and substrates using oxidase |
| US4519401A (en) | 1983-09-20 | 1985-05-28 | Case Western Reserve University | Pressure telemetry implant |
| FI68734C (fi) | 1983-11-11 | 1985-10-10 | Seppo Saeynaejaekangas | Foerfarande och anordning foer telemetrisk maetning av hjaertslag och ekg-signal med anvaendande av ett magnetiskt naerfaelt |
| GB8422876D0 (en) | 1984-09-11 | 1984-10-17 | Secr Defence | Silicon implant devices |
| US4638436A (en) | 1984-09-24 | 1987-01-20 | Labthermics Technologies, Inc. | Temperature control and analysis system for hyperthermia treatment |
| US4681111A (en) | 1985-04-05 | 1987-07-21 | Siemens-Pacesetter, Inc. | Analog and digital telemetry system for an implantable device |
| US4651741A (en) | 1985-05-30 | 1987-03-24 | Baxter Travenol Laboratories, Inc. | Method and apparatus for determining oxygen saturation in vivo |
| US5012411A (en) | 1985-07-23 | 1991-04-30 | Charles J. Policastro | Apparatus for monitoring, storing and transmitting detected physiological information |
| CA1204885A (en) | 1985-09-18 | 1986-05-20 | Thomson & Nielson Electronics Ltd. | Dosimeter |
| US4703756A (en) | 1986-05-06 | 1987-11-03 | The Regents Of The University Of California | Complete glucose monitoring system with an implantable, telemetered sensor module |
| NO872732L (no) | 1986-07-01 | 1988-01-04 | Terumo Corp | Mleinstrument for biologiske parametre. |
| US4976266A (en) | 1986-08-29 | 1990-12-11 | United States Department Of Energy | Methods of in vivo radiation measurement |
| DE3700119A1 (de) | 1987-01-03 | 1988-07-14 | Inst Diabetestechnologie Gemei | Implantierbarer elektrochemischer sensor |
| GB8701432D0 (en) * | 1987-01-22 | 1987-02-25 | Unilever Plc | Assays |
| US4804847A (en) | 1987-01-27 | 1989-02-14 | Medrad, Inc. | Radiation detector with an ionizable gas atop an integrated circuit |
| US4970391A (en) | 1987-01-27 | 1990-11-13 | Medrad, Inc. | Radiation detector with an ionizable gas atop an integrated circuit |
| US4769547A (en) | 1987-01-27 | 1988-09-06 | Medrad, Inc. | Personal dosimeter having a volume of gas atop an integrated circuit |
| US4935345A (en) | 1987-04-07 | 1990-06-19 | Arizona Board Of Regents | Implantable microelectronic biochemical sensor incorporating thin film thermopile |
| US4750495A (en) | 1987-06-05 | 1988-06-14 | Medtronic, Inc. | Oxygen sensing pacemaker |
| US4796641A (en) | 1987-07-06 | 1989-01-10 | Data Sciences, Inc. | Device and method for chronic in-vivo measurement of internal body pressure |
| US4847617A (en) | 1987-08-14 | 1989-07-11 | Siemens-Pacesetter, Inc. | High speed digital telemetry system for implantable devices |
| GB8726933D0 (en) | 1987-11-18 | 1987-12-23 | Cadell T E | Telemetry system |
| US4989601A (en) | 1988-05-02 | 1991-02-05 | Medical Engineering & Development Institute, Inc. | Method, apparatus, and substance for treating tissue having neoplastic cells |
| US4846191A (en) | 1988-05-27 | 1989-07-11 | Data Sciences, Inc. | Device for chronic measurement of internal body pressure |
| US4900422A (en) | 1988-07-05 | 1990-02-13 | Bryan Avron I | System for monitoring and reporting the operability and calibration status of a dissolved oxygen sensor |
| EP0386218B1 (en) | 1988-08-26 | 1996-01-10 | Mountpelier Investments, S.A. | Remote sensing tonometric catheter apparatus and method |
| US5098547A (en) | 1988-10-11 | 1992-03-24 | Bryan Avron I | Dissolved oxygen sensor calibration, monitoring and reporting system |
| EP0372122A1 (en) * | 1988-12-08 | 1990-06-13 | Koninklijke Philips Electronics N.V. | Dental X-ray image detection system |
| US5354314A (en) | 1988-12-23 | 1994-10-11 | Medical Instrumentation And Diagnostics Corporation | Three-dimensional beam localization apparatus and microscope for stereotactic diagnoses or surgery mounted on robotic type arm |
| EP0458850B1 (en) | 1989-02-14 | 1994-04-27 | Pacesetter AB | In a living body implantable electromedical device |
| US5264843A (en) | 1989-04-05 | 1993-11-23 | Siemens Pacesetter, Inc. | High speed reflected impedance telemetry system for implantable medical device |
| US5166073A (en) | 1989-05-05 | 1992-11-24 | The Dow Chemical Company | Miniaturized sensor for ionizing radiation |
| US4944299A (en) | 1989-08-08 | 1990-07-31 | Siemens-Pacesetter, Inc. | High speed digital telemetry system for implantable device |
| DE3932428A1 (de) | 1989-09-28 | 1991-04-11 | Argumens Gmbh | Vorrichtung zur drahtlosen messung einer lokalen physikalischen groesse |
| US5127404A (en) | 1990-01-22 | 1992-07-07 | Medtronic, Inc. | Telemetry format for implanted medical device |
| US5354319A (en) | 1990-01-22 | 1994-10-11 | Medtronic, Inc. | Telemetry system for an implantable medical device |
| US5109850A (en) | 1990-02-09 | 1992-05-05 | Massachusetts Institute Of Technology | Automatic blood monitoring for medication delivery method and apparatus |
| US5008546A (en) | 1990-06-18 | 1991-04-16 | The Regents Of The University Of California | Intraoperative beta probe and method of using the same |
| US5117113A (en) | 1990-07-06 | 1992-05-26 | Thompson And Nielson Electronics Ltd. | Direct reading dosimeter |
| US5137022A (en) | 1990-07-13 | 1992-08-11 | Cook Pacemaker Corporation | Synchronous telemetry system and method for an implantable medical device |
| US5252962A (en) | 1990-08-03 | 1993-10-12 | Bio Medic Data Systems | System monitoring programmable implantable transponder |
| US5163380A (en) | 1990-08-09 | 1992-11-17 | United States Of America | Method and apparatus for assessing metabolic behavioral and physiological status of animals |
| US5438989A (en) * | 1990-08-10 | 1995-08-08 | Hochman; Darryl | Solid tumor, cortical function, and nerve tissue imaging methods and device |
| KR930002824B1 (ko) | 1990-08-21 | 1993-04-10 | 손병기 | 감이온 전계효과 트랜지스터를 이용한 바이오 센서용 측정회로 |
| US5117824A (en) | 1990-11-14 | 1992-06-02 | Medtronic, Inc. | Apparatus for monitoring electrical physiologic signals |
| JP2646848B2 (ja) | 1990-11-30 | 1997-08-27 | 日本電気株式会社 | グルコースセンサの測定方法 |
| FR2671405B1 (fr) * | 1991-01-04 | 1994-07-08 | Inst Nat Sante Rech Med | Dispositif de mesure du ph d'une cible, procede d'utilisation dudit dispositif et ses applications. |
| US5205294A (en) | 1991-02-19 | 1993-04-27 | Pacific Communications, Inc. | Apparatus and methodology for digital telemetry of biomedical signals |
| US5377676A (en) | 1991-04-03 | 1995-01-03 | Cedars-Sinai Medical Center | Method for determining the biodistribution of substances using fluorescence spectroscopy |
| US5318023A (en) | 1991-04-03 | 1994-06-07 | Cedars-Sinai Medical Center | Apparatus and method of use for a photosensitizer enhanced fluorescence based biopsy needle |
| US5159262A (en) | 1991-07-09 | 1992-10-27 | Cascade Microtech, Inc. | Method for measuring the electrical and optical performance of on-wafer microwave devices |
| US5264103A (en) | 1991-10-18 | 1993-11-23 | Matsushita Electric Industrial Co., Ltd. | Biosensor and a method for measuring a concentration of a substrate in a sample |
| DE4139122C1 (https=) | 1991-11-28 | 1993-04-08 | Fenzlein, Paul-Gerhard, 8500 Nuernberg, De | |
| GB9200569D0 (en) | 1992-01-11 | 1992-03-11 | Atomic Energy Authority Uk | Semiconductor dosimeter |
| NL9200207A (nl) | 1992-02-05 | 1993-09-01 | Nedap Nv | Implanteerbare biomedische sensorinrichting, in het bijzonder voor meting van de glucoseconcentratie. |
| US6217869B1 (en) * | 1992-06-09 | 2001-04-17 | Neorx Corporation | Pretargeting methods and compounds |
| US5444254A (en) | 1992-06-12 | 1995-08-22 | Thomson And Nielsen Electronics Ltd. | Flexible radiation probe |
| US5355880A (en) | 1992-07-06 | 1994-10-18 | Sandia Corporation | Reliable noninvasive measurement of blood gases |
| US5676651A (en) | 1992-08-06 | 1997-10-14 | Electric Boat Corporation | Surgically implantable pump arrangement and method for pumping body fluids |
| US5330634A (en) | 1992-08-28 | 1994-07-19 | Via Medical Corporation | Calibration solutions useful for analyses of biological fluids and methods employing same |
| ATE213924T1 (de) | 1992-11-09 | 2002-03-15 | Ilife Systems Inc | Vorrichtung und verfahren zur fernmessung von physiologischen grössen |
| US5620479A (en) | 1992-11-13 | 1997-04-15 | The Regents Of The University Of California | Method and apparatus for thermal therapy of tumors |
| US5383909A (en) | 1993-01-29 | 1995-01-24 | Medtronic, Inc. | Diagnostic telemetry system for an apparatus for detection and treatment of tachycardia and fibrillation |
| US5383912A (en) | 1993-05-05 | 1995-01-24 | Intermedics, Inc. | Apparatus for high speed data communication between an external medical device and an implantable medical device |
| US5431171A (en) | 1993-06-25 | 1995-07-11 | The Regents Of The University Of California | Monitoring fetal characteristics by radiotelemetric transmission |
| US5324315A (en) | 1993-08-12 | 1994-06-28 | Medtronic, Inc. | Closed-loop downlink telemetry and method for implantable medical device |
| US5791344A (en) | 1993-11-19 | 1998-08-11 | Alfred E. Mann Foundation For Scientific Research | Patient monitoring system |
| US5497772A (en) | 1993-11-19 | 1996-03-12 | Alfred E. Mann Foundation For Scientific Research | Glucose monitoring system |
| DE4341903A1 (de) | 1993-12-09 | 1995-06-14 | Josef Prof Dr Rer Nat Binder | Implantierbares telemetrisches Endosystem |
| US5476488A (en) | 1993-12-15 | 1995-12-19 | Pacesetter, Inc. | Telemetry system power control for implantable medical devices |
| DE4444577B4 (de) | 1993-12-15 | 2005-02-10 | Bridgestone Corp. | Verfahren zur Herstellung eines Lichtwellenleiters |
| IES66403B2 (en) | 1993-12-31 | 1995-12-27 | Rodney Arthur Stafford | Electronic animal identification device |
| SE9400622D0 (sv) | 1994-02-23 | 1994-02-23 | Siemens Elema Ab | Medicinskt implantat |
| NL9400534A (nl) | 1994-04-05 | 1995-11-01 | Rijksuniversiteit | Systeem voor het bepalen van een samenstelling van radionucliden. |
| US5507786A (en) | 1994-04-14 | 1996-04-16 | Pacesetter, Inc. | System and method for measuring and storing parametric data pertaining to operating characteristics of an implantable medical device |
| US5549654A (en) | 1994-04-15 | 1996-08-27 | Medtronic, Inc. | Interactive interpretation of event markers in body-implantable medical device |
| SE9401402D0 (sv) | 1994-04-25 | 1994-04-25 | Siemens Elema Ab | Medicinskt implantat |
| US5470345A (en) | 1994-06-16 | 1995-11-28 | Medtronic, Inc. | Implantable medical device with multi-layered ceramic enclosure |
| US6093381A (en) | 1994-07-13 | 2000-07-25 | Neoprobe Corporation | Modulation of the sensitivity of tumor cells to chemotherapeutics |
| US5466246A (en) | 1994-07-29 | 1995-11-14 | Pacesetter, Inc. | Telemetry receiver for implantable device, incorporating digital signal processing |
| US5626862A (en) | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
| US5571148A (en) | 1994-08-10 | 1996-11-05 | Loeb; Gerald E. | Implantable multichannel stimulator |
| US5572996A (en) | 1994-09-19 | 1996-11-12 | Pdt Systems, Inc. | In vivo pharmacokinetics of photosensitive drugs and method |
| US5626630A (en) | 1994-10-13 | 1997-05-06 | Ael Industries, Inc. | Medical telemetry system using an implanted passive transponder |
| US5591217A (en) | 1995-01-04 | 1997-01-07 | Plexus, Inc. | Implantable stimulator with replenishable, high value capacitive power source and method therefor |
| US5606163A (en) | 1995-01-11 | 1997-02-25 | The United States Of America As Represented By The Secretary Of The Navy | All-optical, rapid readout, fiber-coupled thermoluminescent dosimeter system |
| US5620472A (en) | 1995-01-12 | 1997-04-15 | Pacesetter, Inc. | Apparatus and method for dynamically interpreting and displaying a real-time telemetry link |
| US5562713A (en) | 1995-01-18 | 1996-10-08 | Pacesetter, Inc. | Bidirectional telemetry apparatus and method for implantable device |
| US5593430A (en) | 1995-01-27 | 1997-01-14 | Pacesetter, Inc. | Bus system for interconnecting an implantable medical device with a plurality of sensors |
| ATE160079T1 (de) | 1995-02-04 | 1997-11-15 | Baumann & Haldi Sa | Einzelne anordnung zur messung, verarbeitung und übertragung von im wesentlichen physiologischen parametern |
| US5596199A (en) | 1995-02-06 | 1997-01-21 | Clemson University | Passive solid state microdosimeter with electronic readout |
| US5517313A (en) | 1995-02-21 | 1996-05-14 | Colvin, Jr.; Arthur E. | Fluorescent optical sensor |
| US5556421A (en) | 1995-02-22 | 1996-09-17 | Intermedics, Inc. | Implantable medical device with enclosed physiological parameter sensors or telemetry link |
| US5564434A (en) | 1995-02-27 | 1996-10-15 | Medtronic, Inc. | Implantable capacitive absolute pressure and temperature sensor |
| US5535752A (en) | 1995-02-27 | 1996-07-16 | Medtronic, Inc. | Implantable capacitive absolute pressure and temperature monitor system |
| US5633161A (en) | 1995-03-29 | 1997-05-27 | Millennium Pharmaceuticals, Inc. | Murine gene fomy030 coding for tumor progression inhibitor |
| US5856174A (en) * | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| US5840148A (en) | 1995-06-30 | 1998-11-24 | Bio Medic Data Systems, Inc. | Method of assembly of implantable transponder |
| US5720771A (en) | 1995-08-02 | 1998-02-24 | Pacesetter, Inc. | Method and apparatus for monitoring physiological data from an implantable medical device |
| US5759199A (en) | 1995-08-02 | 1998-06-02 | Pacesetter, Inc. | System and method for ambulatory monitoring and programming of an implantable medical device |
| US5732704A (en) | 1995-10-13 | 1998-03-31 | Neoprobe Corporation | Radiation based method locating and differentiating sentinel nodes |
| US5857463A (en) | 1995-10-13 | 1999-01-12 | Neoprobe Corporation | Remotely controlled apparatus and system for tracking and locating a source of photoemissions |
| US5656815A (en) | 1996-02-08 | 1997-08-12 | The United States Of America As Represented By The Secretary Of The Navy | Thermoluminescence radiation dosimetry using transparent glass containing nanocrystalline phosphor |
| US5811814A (en) | 1996-02-12 | 1998-09-22 | Cordis Corporation | Radiation measuring catheter apparatus and method |
| JP3796635B2 (ja) | 1996-03-06 | 2006-07-12 | 富士写真フイルム株式会社 | 蛍光検出装置 |
| US5833603A (en) * | 1996-03-13 | 1998-11-10 | Lipomatrix, Inc. | Implantable biosensing transponder |
| US5932879A (en) | 1996-05-07 | 1999-08-03 | Regents Of The University Of Michigan | Solid state beta-sensitive surgical probe |
| US5744805A (en) | 1996-05-07 | 1998-04-28 | University Of Michigan | Solid state beta-sensitive surgical probe |
| US6076009A (en) | 1997-05-05 | 2000-06-13 | The University Of Michigan | Solid state beta-sensitive surgical probe |
| JP3896176B2 (ja) * | 1996-05-21 | 2007-03-22 | 浜松ホトニクス株式会社 | 近赤外線蛍光トレーサーおよび蛍光イメージング方法 |
| DE19621996C2 (de) | 1996-05-31 | 1998-04-09 | Siemens Ag | Verfahren zur Herstellung einer Kombination eines Drucksensors und eines elektrochemischen Sensors |
| US5682888A (en) | 1996-06-13 | 1997-11-04 | Neoprobe Corporation | Apparatus and system for detecting and locating photon emissions with remote switch control |
| DE69734599T2 (de) | 1996-07-11 | 2007-02-08 | Medtronic, Inc., Minneapolis | Minimalinvasive implantierbare vorrichtung zur überwachung physiologischer vorgänge |
| WO1998022820A1 (en) * | 1996-11-21 | 1998-05-28 | Lawrence Livermore National Laboratory | Detection of biological molecules using boronate-based chemical amplification and optical sensors |
| US6119031A (en) * | 1996-11-21 | 2000-09-12 | Boston Scientific Corporation | Miniature spectrometer |
| US5814089A (en) | 1996-12-18 | 1998-09-29 | Medtronic, Inc. | Leadless multisite implantable stimulus and diagnostic system |
| USD424453S (en) | 1997-03-18 | 2000-05-09 | Neoprobe Corporation | Detector unit for radiation detecting probe |
| USD423377S (en) | 1997-03-18 | 2000-04-25 | Neoprobe Corporation | Radiation detecting probe |
| DE69841076D1 (de) | 1997-03-27 | 2009-10-01 | Advanced Bionics Corp | System implantierbarer geräte zur beobachtung und beeinflussung von körperparametern |
| CA2294610A1 (en) | 1997-06-16 | 1998-12-23 | George Moshe Katz | Methods of calibrating and testing a sensor for in vivo measurement of an analyte and devices for use in such methods |
| CA2215369C (en) | 1997-09-12 | 2008-11-18 | Nicholas Garry Tarr | Method of monitoring radiation using a floating gate field effect transistor dosimeter, and dosimeter for use therein |
| US5928150A (en) | 1997-10-04 | 1999-07-27 | Neoprobe Corporation | System for locating and detecting a source of photon emissions |
| US5987350A (en) | 1997-10-10 | 1999-11-16 | Neoprobe Corporation | Surgical probe apparatus and system |
| US5916167A (en) | 1997-10-10 | 1999-06-29 | Neoprobe Corporation | Surgical probe apparatus and system |
| US6240312B1 (en) | 1997-10-23 | 2001-05-29 | Robert R. Alfano | Remote-controllable, micro-scale device for use in in vivo medical diagnosis and/or treatment |
| US5891179A (en) | 1997-11-20 | 1999-04-06 | Paceseter, Inc. | Method and apparatus for monitoring and displaying lead impedance in real-time for an implantable medical device |
| US6239724B1 (en) | 1997-12-30 | 2001-05-29 | Remon Medical Technologies, Ltd. | System and method for telemetrically providing intrabody spatial position |
| US6099821A (en) | 1998-01-06 | 2000-08-08 | University Of Virginia | Nuclear scintigraphic assessment of mucosal function |
| US6289229B1 (en) * | 1998-01-20 | 2001-09-11 | Scimed Life Systems, Inc. | Readable probe array for in vivo use |
| US6087666A (en) | 1998-02-18 | 2000-07-11 | The United States Of America As Represented By The Secretary Of The Navy | Optically stimulated luminescent fiber optic radiation dosimeter |
| GB9805896D0 (en) | 1998-03-20 | 1998-05-13 | Eglise David | Remote analysis system |
| EP2289423A1 (en) | 1998-05-14 | 2011-03-02 | David N. Krag | System for bracketing tissue |
| AU2001217746A1 (en) | 1998-05-14 | 2002-05-27 | Calypso Medical, Inc. | Systems and methods for locating and defining a target location within a human body |
| US6363940B1 (en) | 1998-05-14 | 2002-04-02 | Calypso Medical Technologies, Inc. | System and method for bracketing and removing tissue |
| US5939453A (en) | 1998-06-04 | 1999-08-17 | Advanced Polymer Systems, Inc. | PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers |
| US6047214A (en) | 1998-06-09 | 2000-04-04 | North Carolina State University | System and method for powering, controlling, and communicating with multiple inductively-powered devices |
| US6015390A (en) | 1998-06-12 | 2000-01-18 | D. Krag Llc | System and method for stabilizing and removing tissue |
| DE19828840C1 (de) * | 1998-06-27 | 1999-10-28 | Sartorius Gmbh | Mehrfachfiltergehäuse mit Verriegelungseinrichtung für Filterelemente |
| US6295680B1 (en) | 1998-07-05 | 2001-10-02 | The Regents Of The University Of Michigan | Method for detecting early atherosclerosis and vascular damage using radioactive tracers and intravascular radiation detection devices |
| JP4689825B2 (ja) * | 1998-08-26 | 2011-05-25 | センサーズ・フォー・メデセン・アンド・サイエンス・インコーポレーテッド | 光学式検知装置 |
| US6304766B1 (en) | 1998-08-26 | 2001-10-16 | Sensors For Medicine And Science | Optical-based sensing devices, especially for in-situ sensing in humans |
| EP1117328B1 (en) | 1998-09-30 | 2008-09-17 | Sicel Technologies, Inc. | Methods, systems, and associated implantable devices for dynamic monitoring of tumors |
| US6076666A (en) * | 1998-10-08 | 2000-06-20 | Santa-Maria; Toni M. | Garment bag |
| US6272373B1 (en) | 1998-10-23 | 2001-08-07 | Neoprobe Corporation | Scanning system and method for locating sources of radiation emission |
| US6259095B1 (en) | 1998-10-23 | 2001-07-10 | Neoprobe Corporation | System and apparatus for detecting and locating sources of radiation |
| US6242741B1 (en) | 1998-10-23 | 2001-06-05 | United States Surgical Corporation | Radiation detection apparatus |
| US6274159B1 (en) | 1998-10-28 | 2001-08-14 | University Of Florida | Surface modified silicone drug depot |
| US6113795A (en) | 1998-11-17 | 2000-09-05 | The University Of Kansas | Process and apparatus for size selective separation of micro- and nano-particles |
| EP1135677A1 (en) * | 1998-12-02 | 2001-09-26 | UT-Battelle, LLC | In vivo biosensor apparatus and method of use |
| WO2000040299A1 (en) | 1999-01-06 | 2000-07-13 | Ball Semiconductor, Inc. | Radiation dosimetry system |
| US8636648B2 (en) * | 1999-03-01 | 2014-01-28 | West View Research, Llc | Endoscopic smart probe |
| US6444475B1 (en) | 1999-08-02 | 2002-09-03 | Alltech Associates, Inc. | Ion chromatography apparatus and method for removing gas prior to sample detection |
| AU770395B2 (en) * | 1999-11-17 | 2004-02-19 | Boston Scientific Limited | Microfabricated devices for the delivery of molecules into a carrier fluid |
| US6551838B2 (en) * | 2000-03-02 | 2003-04-22 | Microchips, Inc. | Microfabricated devices for the storage and selective exposure of chemicals and devices |
| US6614025B2 (en) | 2000-03-28 | 2003-09-02 | Thomson & Nielsen Electronics Ltd. | Radiation sensor and dosimeter incorporating same |
| US6717154B2 (en) | 2000-08-02 | 2004-04-06 | Sicel Technologies, Inc. | Evaluation of irradiated foods and other items with telemetric dosimeters and associated methods |
| US7226442B2 (en) * | 2000-10-10 | 2007-06-05 | Microchips, Inc. | Microchip reservoir devices using wireless transmission of power and data |
| CA2324048A1 (en) | 2000-10-20 | 2002-04-20 | Wei Ding | Computer assisted radiotherapy dosimeter system and software therefor |
| US20020193685A1 (en) | 2001-06-08 | 2002-12-19 | Calypso Medical, Inc. | Guided Radiation Therapy System |
| JP2006512109A (ja) * | 2002-08-01 | 2006-04-13 | ザ ジョンズ ホプキンズ ユニバーシティ | 蛍光発光を用いた、分子構造の特定技術、および身体内腔の内側に並ぶ細胞種の治療技術 |
| ATE505224T1 (de) * | 2002-08-16 | 2011-04-15 | Microchips Inc | Vorrichtung mit kontrollierter abgabe und verfahren |
| US8738106B2 (en) * | 2005-01-31 | 2014-05-27 | Given Imaging, Ltd | Device, system and method for in vivo analysis |
| US7616111B2 (en) * | 2005-06-20 | 2009-11-10 | Carestream Health, Inc. | System to monitor the ingestion of medicines |
-
2001
- 2001-11-07 JP JP2002541386A patent/JP3981328B2/ja not_active Expired - Fee Related
- 2001-11-07 US US10/005,889 patent/US7378056B2/en not_active Expired - Lifetime
- 2001-11-07 AU AU2002236590A patent/AU2002236590B2/en not_active Ceased
- 2001-11-07 AT AT01986125T patent/ATE441110T1/de not_active IP Right Cessation
- 2001-11-07 EP EP01986125A patent/EP1332364B1/en not_active Expired - Lifetime
- 2001-11-07 DE DE60139705T patent/DE60139705D1/de not_active Expired - Lifetime
- 2001-11-07 CA CA002429127A patent/CA2429127A1/en not_active Abandoned
- 2001-11-07 WO PCT/US2001/047373 patent/WO2002039112A2/en not_active Ceased
- 2001-11-07 AU AU3659002A patent/AU3659002A/xx active Pending
-
2008
- 2008-05-23 US US12/126,500 patent/US20080228049A1/en not_active Abandoned
-
2011
- 2011-06-09 US US13/157,032 patent/US20110237909A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU3659002A (en) | 2002-05-21 |
| AU2002236590B2 (en) | 2006-05-25 |
| US20110237909A1 (en) | 2011-09-29 |
| WO2002039112A2 (en) | 2002-05-16 |
| JP2004523257A (ja) | 2004-08-05 |
| WO2002039112A3 (en) | 2003-02-06 |
| US20020102212A1 (en) | 2002-08-01 |
| US7378056B2 (en) | 2008-05-27 |
| ATE441110T1 (de) | 2009-09-15 |
| EP1332364B1 (en) | 2009-08-26 |
| US20080228049A1 (en) | 2008-09-18 |
| EP1332364A2 (en) | 2003-08-06 |
| DE60139705D1 (de) | 2009-10-08 |
| CA2429127A1 (en) | 2002-05-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3981328B2 (ja) | 蛍光タグを使用した生体分子濃縮物をインビボで検出するための方法、回路、および物質の組成物 | |
| AU2002236590A1 (en) | In vivo detection of biomolecule concentrations using fluorescent tags | |
| JP4607859B2 (ja) | 蛍光分析物と連動して作動するインビボ蛍光センサ、システム及び関連方法 | |
| US20040186359A1 (en) | Afinity biosensor for monitoring biological process | |
| CA2336397C (en) | Optical sensor for in situ measurement of analytes | |
| JP2000506410A (ja) | 移植可能なバイオセンシングトランスポンダ | |
| JP2012516186A (ja) | 出血検出のためのデバイス、システムおよび方法 | |
| US10288568B2 (en) | Raman probe and methods of imaging | |
| WO2000002048A1 (en) | Optical sensor for in situ measurement of analytes | |
| US9861710B1 (en) | Composite particles, methods, and in vivo diagnostic system | |
| WO2002080756A2 (en) | Imaging systems for in vivo protocols | |
| US20180228917A1 (en) | Shielded Targeting Agents, Methods, and In Vivo Diagnostic System | |
| US20210364507A1 (en) | Swcnt-dna-antibody conjugates, related compositions, and systems, methods and devices for their use | |
| US20110184279A1 (en) | Self-contained detection capsule for insertion in a human or animal body | |
| Baeten et al. | In vivo investigation of breast cancer progression by use of an internal control | |
| CN103868862A (zh) | 用于侦测一有兴趣的标的物的传感器 | |
| CN114945322A (zh) | 鉴定降解物质 | |
| US10352931B2 (en) | Diagnostic device for the detection of disease related target structures | |
| KR101320097B1 (ko) | 고유 형광 공명 에너지 전이용 탐침을 이용한 단백질 검출 또는 이미지화 현미경 장치 및 이를 이용한 단백질 검출 또는 이미징방법 | |
| CN119510768A (zh) | 凝血因子活性检测系统、方法及存储介质 | |
| Zubkovs et al. | Single-walled carbon nanotube biosensor for real-time monitoring of nitric oxide in inflammatory responses | |
| KR102648399B1 (ko) | 형광 스크리닝을 이용한 감시림프절 동물 모델 제조방법 | |
| Silvestre et al. | Hollow fiber: a biophotonic implant for live cells | |
| AU2014314247A1 (en) | Diagnostic device for the detection of disease related target structures |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20041108 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20041108 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20061117 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20070216 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20070313 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070514 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20070605 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20070629 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100706 Year of fee payment: 3 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110706 Year of fee payment: 4 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120706 Year of fee payment: 5 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130706 Year of fee payment: 6 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |