JP3957195B2 - 局所用口腔ケア組成物 - Google Patents
局所用口腔ケア組成物 Download PDFInfo
- Publication number
- JP3957195B2 JP3957195B2 JP2002558996A JP2002558996A JP3957195B2 JP 3957195 B2 JP3957195 B2 JP 3957195B2 JP 2002558996 A JP2002558996 A JP 2002558996A JP 2002558996 A JP2002558996 A JP 2002558996A JP 3957195 B2 JP3957195 B2 JP 3957195B2
- Authority
- JP
- Japan
- Prior art keywords
- agent
- tooth
- ascorbyl
- oral
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- VSJRDSLPNMGNFG-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate;trihydrate Chemical compound O.O.O.[Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O VSJRDSLPNMGNFG-UHFFFAOYSA-H 0.000 description 1
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- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
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- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
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- 239000009637 wintergreen oil Substances 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26388401P | 2001-01-24 | 2001-01-24 | |
| PCT/US2002/002324 WO2002058662A2 (en) | 2001-01-24 | 2002-01-24 | Topical oral care compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2007009929A Division JP2007131636A (ja) | 2001-01-24 | 2007-01-19 | 局所用口腔ケア組成物 |
Publications (3)
| Publication Number | Publication Date |
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| JP2005503322A JP2005503322A (ja) | 2005-02-03 |
| JP2005503322A5 JP2005503322A5 (enExample) | 2006-01-05 |
| JP3957195B2 true JP3957195B2 (ja) | 2007-08-15 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002558996A Expired - Fee Related JP3957195B2 (ja) | 2001-01-24 | 2002-01-24 | 局所用口腔ケア組成物 |
| JP2007009929A Pending JP2007131636A (ja) | 2001-01-24 | 2007-01-19 | 局所用口腔ケア組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007009929A Pending JP2007131636A (ja) | 2001-01-24 | 2007-01-19 | 局所用口腔ケア組成物 |
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| US (2) | US20020137728A1 (enExample) |
| EP (1) | EP1370226A2 (enExample) |
| JP (2) | JP3957195B2 (enExample) |
| KR (1) | KR20040002855A (enExample) |
| AU (1) | AU2002240115B2 (enExample) |
| WO (1) | WO2002058662A2 (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7245596A (en) * | 1995-09-25 | 1997-04-17 | Robert Eric Montgomery | Tooth bleaching compositions |
| US6162055A (en) * | 1998-02-13 | 2000-12-19 | Britesmile, Inc. | Light activated tooth whitening composition and method of using same |
| US8283135B2 (en) * | 2000-06-30 | 2012-10-09 | The Procter & Gamble Company | Oral care compositions containing combinations of anti-bacterial and host-response modulating agents |
| US6818150B2 (en) * | 2000-12-22 | 2004-11-16 | Chevron Phillips Chemical Company Lp | UV- or heat-triggered low oxygen packaging system employing an oxidizable polymer resin and a peroxide |
| US20040175332A1 (en) * | 2001-05-10 | 2004-09-09 | Horst Westenfelder | Dentrifice |
| US6899897B2 (en) | 2001-06-18 | 2005-05-31 | Jaleva, Inc. | Gum resin as a carrier for topical application of pharmacologically active agents |
| JP2004107231A (ja) * | 2002-09-17 | 2004-04-08 | Showa Yakuhin Kako Kk | 口腔用組成物 |
| WO2004041228A1 (en) * | 2002-11-04 | 2004-05-21 | Dsm Ip Assets B.V. | Oral care compositions comprising ascorbic acid derivative |
| WO2004041229A1 (ja) * | 2002-11-07 | 2004-05-21 | Nippon Zettoc Co.,Ltd. | 口腔用組成物用基剤及び口腔用組成物 |
| US7198487B2 (en) * | 2002-12-31 | 2007-04-03 | Water Pik, Inc. | Whitening tip for dental flossing device |
| US20040156884A1 (en) * | 2003-02-10 | 2004-08-12 | Brown Dale G. | Emulsion impregnated rawhide chews with antimicrobially active chlorhexidine |
| KR20060024418A (ko) * | 2003-06-16 | 2006-03-16 | 디에스엠 아이피 어셋츠 비.브이. | 애완동물 사료 조성물 |
| US20050036957A1 (en) | 2003-08-15 | 2005-02-17 | Michael Prencipe | Tooth whitening dental tray and method of use |
| US8815215B2 (en) | 2003-08-15 | 2014-08-26 | Colgate-Palmolive Company | Hydrophobic tooth whitening system and methods of use |
| US9554984B2 (en) * | 2003-11-03 | 2017-01-31 | Jaleva Pharmaceuticals, Llc | Oral care compositions for topical application |
| US9241885B2 (en) * | 2004-01-29 | 2016-01-26 | The Procter & Gamble Company | Oral care compositions comprising increased bioavailable levels of quaternary ammonium antimicrobials |
| US20050249678A1 (en) * | 2004-05-10 | 2005-11-10 | Mahmoud Hassan | Multilayer tooth whitening strips |
| JP2005325080A (ja) * | 2004-05-17 | 2005-11-24 | Daiichi Fine Chemical Co Ltd | パントテン酸カルシウム及びビタミン類を含む組成物 |
| US20060045854A1 (en) * | 2004-08-27 | 2006-03-02 | Lynette Zaidel | Oral care composition with cross-linked polymer peroxide |
| US8168161B2 (en) * | 2004-12-22 | 2012-05-01 | Hill's Pet Nutrition, Inc. | Method to promote oral health in companion animals |
| US20060198795A1 (en) * | 2005-11-07 | 2006-09-07 | Giniger Martin S | Multi-component oral care compositions |
| US20080112902A1 (en) * | 2005-04-25 | 2008-05-15 | Joseph Perechocky | Protective Dental Balm and Method |
| US20060239938A1 (en) * | 2005-04-25 | 2006-10-26 | Joseph Perechocky | Dental balm and method of prevention of damage to teeth |
| BRPI0502145A (pt) * | 2005-06-03 | 2007-01-23 | Mauricio Duarte Da Conceicao | enxaguatório para prevenção e tratamento da halitose |
| US7504045B2 (en) * | 2005-06-07 | 2009-03-17 | Cryovac, Inc. | Method of triggering a film containing an oxygen scavenger |
| US7799331B2 (en) | 2005-08-04 | 2010-09-21 | Taro Pharmaceutical North America, Inc. | Oral suspension of prednisolone acetate |
| CA2629810A1 (en) * | 2005-11-07 | 2007-05-18 | Jaleva, Llc | Film-forming resins as a carrier for topical application of pharmacologically active agents |
| EP2099464B1 (en) * | 2006-11-09 | 2016-05-25 | BERNSTEIN, Lawrence Richard | Local administration of gallium compositions to treat pain |
| US20080118446A1 (en) * | 2006-11-17 | 2008-05-22 | Jennifer Jablow | Smile shower |
| GB2450477A (en) * | 2007-06-18 | 2008-12-31 | Ethicon Inc | Stabilized wound dressing |
| US8765155B2 (en) * | 2007-08-30 | 2014-07-01 | Colgate-Palmolive Company | Oral care strip or tape and methods of use and manufacture thereof |
| JP5007820B2 (ja) * | 2007-12-21 | 2012-08-22 | ライオン株式会社 | 歯磨剤組成物 |
| US20090208543A1 (en) * | 2008-01-22 | 2009-08-20 | Oral Health Clinical Services | Method and apparatus for applying a protective oral care composition |
| KR20110039461A (ko) * | 2008-07-15 | 2011-04-18 | 바스프 코포레이션 | 이산화염소 투여를 위한 방법, 시스템 및 장치 |
| WO2010009063A2 (en) * | 2008-07-15 | 2010-01-21 | Basf Corporation | Non-cytotoxic chlorine dioxide fluids |
| WO2010009131A2 (en) * | 2008-07-15 | 2010-01-21 | Basf Catalysts Llc | Tooth polishing compositions and methods of tooth polishing without mechanical abrasion |
| JP2010126506A (ja) * | 2008-11-28 | 2010-06-10 | Tokyo Medical & Dental Univ | 口腔洗浄用キット |
| JP5589849B2 (ja) * | 2008-12-24 | 2014-09-17 | ライオン株式会社 | 歯磨剤組成物 |
| US8311625B2 (en) * | 2009-02-04 | 2012-11-13 | Basf Corporation | Chlorine dioxide treatment for biological tissue |
| JP5600346B2 (ja) * | 2009-05-26 | 2014-10-01 | コルゲート・パーモリブ・カンパニー | 歯磨剤組成物 |
| US8741268B2 (en) * | 2009-09-10 | 2014-06-03 | Preventive Technologies, Inc. | Dental prophylactic paste |
| US9642687B2 (en) | 2010-06-15 | 2017-05-09 | The Procter & Gamble Company | Methods for whitening teeth |
| ES2666363T3 (es) | 2011-05-02 | 2018-05-04 | Water Pik, Inc. | Cepillo de dientes sónico accionado mecánicamente |
| WO2014066951A1 (en) * | 2012-11-02 | 2014-05-08 | Ozdent Pty Ltd | Dental compositions |
| KR20150097495A (ko) | 2012-12-19 | 2015-08-26 | 콜게이트-파아므올리브캄파니 | 구강 관리 조성물 |
| US9468511B2 (en) | 2013-03-15 | 2016-10-18 | Water Pik, Inc. | Electronic toothbrush with vibration dampening |
| CN107661153B (zh) | 2013-03-15 | 2021-01-12 | 洁碧有限公司 | 机械驱动式声波牙刷和水牙线 |
| US9668970B2 (en) * | 2013-12-02 | 2017-06-06 | Intelgenx Corp. | Film dosage form with extended release mucoadhesive particles |
| US10272038B2 (en) | 2013-12-02 | 2019-04-30 | Intelgenx Corp. | Film dosage form with extended release mucoadhesive particles |
| US11033493B2 (en) | 2013-12-02 | 2021-06-15 | Intelgenx Corp. | Film dosage form with extended release mucoadhesive particles |
| CN205568226U (zh) | 2015-07-08 | 2016-09-14 | 洁碧有限公司 | 刷牙装置 |
| US10561480B2 (en) | 2016-05-09 | 2020-02-18 | Water Pik, Inc. | Load sensing for oral devices |
| USD845636S1 (en) | 2016-12-15 | 2019-04-16 | Water Pik, Inc. | Toothbrush handle |
| USD844997S1 (en) | 2016-12-15 | 2019-04-09 | Water Pik, Inc. | Toothbrush handle |
| CA3128828C (en) | 2016-12-15 | 2023-09-19 | Water Pik, Inc. | Brushing device with illumination features |
| WO2019118452A1 (en) * | 2017-12-15 | 2019-06-20 | Colgate-Palmolive Company | Novel compounds |
| US20230404893A1 (en) * | 2020-12-09 | 2023-12-21 | Colgate-Palmolive Company | Oral Care Compositions Comprising Ascorbic Acid Derivatives |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4684518A (en) * | 1982-06-22 | 1987-08-04 | The Procter & Gamble Company | Oral compositions |
| JPS6296408A (ja) * | 1985-10-23 | 1987-05-02 | Showa Denko Kk | 口腔用薬剤 |
| US4775525A (en) * | 1985-12-16 | 1988-10-04 | Ivo Pera | Oral hygiene formulation containing sodium alginate |
| JPS63141921A (ja) * | 1986-12-04 | 1988-06-14 | Kao Corp | 口腔用組成物 |
| DE3909198A1 (de) * | 1989-03-21 | 1990-09-27 | Basf Ag | Verfahren zur herstellung von ascorbinsaeure-2-phosphat sowie von 5,6-isorpropyliden-ascorbinsaeure als ausgangsprodukt |
| JP2814549B2 (ja) * | 1989-05-08 | 1998-10-22 | ライオン株式会社 | 口腔用組成物 |
| JP2936579B2 (ja) * | 1989-05-08 | 1999-08-23 | ライオン株式会社 | 口腔用組成物 |
| US5011682A (en) * | 1990-04-18 | 1991-04-30 | Conopco, Inc. | Hypophosphite-containing cotelomers as antitartar agents |
| US5149829A (en) * | 1991-01-14 | 1992-09-22 | Hoffmann-La Roche Inc. | Method of preparing dry, concentrated salts of ascorbate 2-polyphosphate |
| US5202111A (en) * | 1991-05-09 | 1993-04-13 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Phosphorylated polyhydroxy compounds for tartar control |
| US5110950A (en) * | 1991-06-12 | 1992-05-05 | Kansas State University Research Foundation | Method of preparing 2-phosphorylated compounds of ascorbic acid |
| US5244651A (en) * | 1991-09-04 | 1993-09-14 | Kao Corporation | Method of desensitizing hypersensitive dentin |
| DE4226625A1 (de) * | 1992-08-12 | 1994-02-17 | Basf Ag | Verfahren zur Herstellung von Calcium-L-ascorbat-2-phosphat |
| US5807542A (en) * | 1993-11-27 | 1998-09-15 | Knoll Aktiengesellschaft | Chemical compositions for inhibiting nitrosation reaction in toiletries and cosmetics |
| JPH10501242A (ja) * | 1994-06-09 | 1998-02-03 | ザ、プロクター、エンド、ギャンブル、カンパニー | 義歯安定化組成物 |
| JP3582537B2 (ja) * | 1994-09-30 | 2004-10-27 | ライオン株式会社 | 口腔用組成物 |
| US5607968A (en) * | 1995-06-07 | 1997-03-04 | Avon Products, Inc. | Topical alkyl-2-O-L-ascorbyl-phosphates |
| ATE444760T1 (de) * | 1997-01-13 | 2009-10-15 | Univ Emory | Glutathion zur behandlung von influenzainfektionen |
| CA2230774C (en) * | 1997-03-18 | 2007-06-26 | F. Hoffmann-La Roche Ag | Manufacture of ascorbyl monophosphates |
| US6582708B1 (en) * | 2000-06-28 | 2003-06-24 | The Procter & Gamble Company | Tooth whitening substance |
| JPH1112142A (ja) * | 1997-06-19 | 1999-01-19 | Lion Corp | 口腔用組成物 |
| JPH1149625A (ja) * | 1997-08-04 | 1999-02-23 | Lion Corp | 義歯安定剤組成物 |
| JP2002503520A (ja) * | 1998-02-19 | 2002-02-05 | オラシューティカル エルエルシー | 抗菌義歯接着組成物 |
| JPH11349595A (ja) * | 1998-06-05 | 1999-12-21 | Showa Denko Kk | Ｌ−アスコルビン酸−２−リン酸エステルカリウム塩結晶およびその製造方法 |
| DE19831056A1 (de) * | 1998-07-13 | 2000-01-20 | Basf Ag | Verfahren zur Herstellung von Salzen von Ascorbyl-2-phosphorsäureestern |
| US6184247B1 (en) * | 1999-05-21 | 2001-02-06 | Amway Corporation | Method of increasing cell renewal rate |
| JP4257479B2 (ja) * | 2000-06-30 | 2009-04-22 | ライオン株式会社 | アスコルビン酸リン酸エステル又はその塩含有歯磨剤組成物の製造方法 |
-
2002
- 2002-01-24 EP EP02706004A patent/EP1370226A2/en not_active Withdrawn
- 2002-01-24 AU AU2002240115A patent/AU2002240115B2/en not_active Ceased
- 2002-01-24 WO PCT/US2002/002324 patent/WO2002058662A2/en not_active Ceased
- 2002-01-24 JP JP2002558996A patent/JP3957195B2/ja not_active Expired - Fee Related
- 2002-01-24 US US10/056,296 patent/US20020137728A1/en not_active Abandoned
- 2002-01-24 KR KR10-2003-7009818A patent/KR20040002855A/ko not_active Ceased
-
2007
- 2007-01-19 JP JP2007009929A patent/JP2007131636A/ja active Pending
- 2007-10-31 US US11/932,097 patent/US20080112903A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002240115B2 (en) | 2007-01-04 |
| US20020137728A1 (en) | 2002-09-26 |
| JP2005503322A (ja) | 2005-02-03 |
| EP1370226A2 (en) | 2003-12-17 |
| WO2002058662A3 (en) | 2003-02-20 |
| KR20040002855A (ko) | 2004-01-07 |
| US20080112903A1 (en) | 2008-05-15 |
| WO2002058662A2 (en) | 2002-08-01 |
| JP2007131636A (ja) | 2007-05-31 |
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