JP3951035B2 - 分泌及び膜貫通ポリペプチドとそれをコードしている核酸 - Google Patents
分泌及び膜貫通ポリペプチドとそれをコードしている核酸 Download PDFInfo
- Publication number
- JP3951035B2 JP3951035B2 JP2001520864A JP2001520864A JP3951035B2 JP 3951035 B2 JP3951035 B2 JP 3951035B2 JP 2001520864 A JP2001520864 A JP 2001520864A JP 2001520864 A JP2001520864 A JP 2001520864A JP 3951035 B2 JP3951035 B2 JP 3951035B2
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- Prior art keywords
- seq
- polypeptide
- acid sequence
- nucleic acid
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1999/020111 WO2000012708A2 (en) | 1998-09-01 | 1999-09-01 | Further pro polypeptides and sequences thereof |
| PCT/US1999/021090 WO2000015796A2 (en) | 1998-09-16 | 1999-09-15 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US16949599P | 1999-12-07 | 1999-12-07 | |
| US17026299P | 1999-12-09 | 1999-12-09 | |
| US17548100P | 2000-01-11 | 2000-01-11 | |
| PCT/US2000/004341 WO2000053756A2 (en) | 1999-03-08 | 2000-02-18 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| PCT/US2000/004342 WO2000078961A1 (en) | 1999-06-23 | 2000-02-18 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| PCT/US2000/004414 WO2001004311A1 (en) | 1999-07-07 | 2000-02-22 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| PCT/US2000/005601 WO2000056889A2 (en) | 1999-03-23 | 2000-03-01 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US18720200P | 2000-03-03 | 2000-03-03 | |
| US19100700P | 2000-03-21 | 2000-03-21 | |
| PCT/US2000/008439 WO2000073454A1 (en) | 1999-06-02 | 2000-03-30 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US19939700P | 2000-04-25 | 2000-04-25 | |
| PCT/US2000/014042 WO2000077037A2 (en) | 1999-06-15 | 2000-05-22 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US20983200P | 2000-06-05 | 2000-06-05 | |
| PCT/US2000/023328 WO2001016318A2 (en) | 1999-09-01 | 2000-08-24 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005054646A Division JP2005224245A (ja) | 1999-09-01 | 2005-02-28 | 分泌及び膜貫通ポリペプチドとそれをコードしている核酸 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004507204A JP2004507204A (ja) | 2004-03-11 |
| JP2004507204A5 JP2004507204A5 (enExample) | 2005-12-22 |
| JP3951035B2 true JP3951035B2 (ja) | 2007-08-01 |
Family
ID=40299613
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001520864A Expired - Lifetime JP3951035B2 (ja) | 1999-09-01 | 2000-08-24 | 分泌及び膜貫通ポリペプチドとそれをコードしている核酸 |
| JP2005054646A Pending JP2005224245A (ja) | 1999-09-01 | 2005-02-28 | 分泌及び膜貫通ポリペプチドとそれをコードしている核酸 |
| JP2005118701A Withdrawn JP2005253469A (ja) | 1999-09-01 | 2005-04-15 | 分泌及び膜貫通ポリペプチドとそれをコードしている核酸 |
| JP2005118579A Pending JP2005253468A (ja) | 1999-09-01 | 2005-04-15 | 分泌及び膜貫通ポリペプチドとそれをコードしている核酸 |
| JP2005118968A Withdrawn JP2005270107A (ja) | 1999-09-01 | 2005-04-15 | 分泌及び膜貫通ポリペプチドとそれをコードしている核酸 |
| JP2005118817A Pending JP2005245460A (ja) | 1999-09-01 | 2005-04-15 | 分泌及び膜貫通ポリペプチドとそれをコードしている核酸 |
| JP2005119030A Withdrawn JP2005261437A (ja) | 1999-09-01 | 2005-04-15 | 分泌及び膜貫通ポリペプチドとそれをコードしている核酸 |
| JP2008256822A Withdrawn JP2009095345A (ja) | 1999-09-01 | 2008-10-01 | 分泌及び膜貫通ポリペプチドとそれをコードしている核酸 |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005054646A Pending JP2005224245A (ja) | 1999-09-01 | 2005-02-28 | 分泌及び膜貫通ポリペプチドとそれをコードしている核酸 |
| JP2005118701A Withdrawn JP2005253469A (ja) | 1999-09-01 | 2005-04-15 | 分泌及び膜貫通ポリペプチドとそれをコードしている核酸 |
| JP2005118579A Pending JP2005253468A (ja) | 1999-09-01 | 2005-04-15 | 分泌及び膜貫通ポリペプチドとそれをコードしている核酸 |
| JP2005118968A Withdrawn JP2005270107A (ja) | 1999-09-01 | 2005-04-15 | 分泌及び膜貫通ポリペプチドとそれをコードしている核酸 |
| JP2005118817A Pending JP2005245460A (ja) | 1999-09-01 | 2005-04-15 | 分泌及び膜貫通ポリペプチドとそれをコードしている核酸 |
| JP2005119030A Withdrawn JP2005261437A (ja) | 1999-09-01 | 2005-04-15 | 分泌及び膜貫通ポリペプチドとそれをコードしている核酸 |
| JP2008256822A Withdrawn JP2009095345A (ja) | 1999-09-01 | 2008-10-01 | 分泌及び膜貫通ポリペプチドとそれをコードしている核酸 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1208202A2 (enExample) |
| JP (8) | JP3951035B2 (enExample) |
| AU (1) | AU7573000A (enExample) |
| CA (1) | CA2380355A1 (enExample) |
| WO (1) | WO2001016318A2 (enExample) |
Families Citing this family (145)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7057017B2 (en) | 1997-04-16 | 2006-06-06 | Millennium Pharmaceuticals, Inc. | Human dickkopf-related protein and nucleic acid molecules and uses therefor |
| US20030130182A1 (en) * | 1997-11-05 | 2003-07-10 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US6562578B1 (en) | 1999-01-11 | 2003-05-13 | Schering Corporation | IL-17-like cytokine binding compounds and antibodies |
| NZ505881A (en) | 1998-01-09 | 2003-05-30 | Immunex Corp | IL-1 delta DNA and polypeptides |
| US7446181B2 (en) | 1998-01-15 | 2008-11-04 | Millennium Pharmaceuticals, Inc. | Antibodies that bind human Dickkopf-1 proteins |
| ES2292242T5 (es) | 1998-05-15 | 2011-05-04 | Genentech, Inc. | Utilizaciones terapéuticas de polipéptidos homólogos de il-17. |
| US7771719B1 (en) | 2000-01-11 | 2010-08-10 | Genentech, Inc. | Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E |
| US20030065154A1 (en) | 2000-03-30 | 2003-04-03 | Genentech, Inc. | Interleukin-8 homologous polypeptides and therapeutic uses thereof |
| AU5447899A (en) * | 1998-09-03 | 2000-03-27 | Takeda Chemical Industries Ltd. | Novel protein and process for producing the same |
| US7244428B2 (en) * | 1998-09-10 | 2007-07-17 | Genentech, Inc. | PRO1357 antibodies |
| US7244817B2 (en) * | 1998-09-10 | 2007-07-17 | Genentech, Inc. | Pro1357 polypeptide |
| US6344541B1 (en) | 1998-09-25 | 2002-02-05 | Amgen Inc. | DKR polypeptides |
| AU2007216683B2 (en) * | 1998-12-17 | 2011-07-14 | Corixa Corporation | Compositions and methods for therapy and diagnosis of ovarian cancer |
| US6699664B1 (en) | 1998-12-17 | 2004-03-02 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of ovarian cancer |
| US6858710B2 (en) | 1998-12-17 | 2005-02-22 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of ovarian cancer |
| US6962980B2 (en) | 1999-09-24 | 2005-11-08 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of ovarian cancer |
| US7888477B2 (en) | 1998-12-17 | 2011-02-15 | Corixa Corporation | Ovarian cancer-associated antibodies and kits |
| US6468546B1 (en) | 1998-12-17 | 2002-10-22 | Corixa Corporation | Compositions and methods for therapy and diagnosis of ovarian cancer |
| US20030009013A1 (en) * | 1998-12-30 | 2003-01-09 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US6943235B1 (en) | 1999-04-12 | 2005-09-13 | Agensys, Inc. | Transmembrane protein expressed in prostate cancer |
| EP1200590B1 (en) | 1999-08-12 | 2009-01-07 | Agensys, Inc. | C-type lectin transmembrane antigen expressed in human prostate cancer and uses thereof |
| DE60044138D1 (de) * | 1999-09-29 | 2010-05-20 | Teijin Ltd | POLYPEPTIDE UND FüR DIESE KODIERENDE GENE |
| EP1235843A4 (en) * | 1999-10-29 | 2005-04-20 | Human Genome Sciences Inc | 26 HUMAN SECRETED PROTEINS |
| CA2393369A1 (en) | 1999-12-03 | 2001-06-07 | Zymogenetics, Inc. | Human cytokine receptor |
| US20030170823A1 (en) | 1999-12-23 | 2003-09-11 | Presnell Scott R. | Novel cytokine ZCYTO18 |
| US20020042122A1 (en) * | 1999-12-23 | 2002-04-11 | Bazan J. Fernando | Mammalian proteins; related reagents and methods |
| US20040043397A1 (en) | 2000-01-11 | 2004-03-04 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
| DK1897944T3 (da) * | 1999-12-23 | 2011-10-24 | Genentech Inc | IL-17 homologe polypeptider og terapeutisk anvendelse deraf |
| MXPA02007119A (es) * | 2000-01-19 | 2003-04-14 | Amgen Inc | Peptido relacionado a condromodulina-1. |
| AU2001255168A1 (en) * | 2000-03-03 | 2001-09-17 | Genentech Inc. | Compositions and methods for the treatment of immune related diseases |
| US7094566B2 (en) | 2000-03-16 | 2006-08-22 | Amgen Inc., | IL-17 receptor like molecules and uses thereof |
| US7718397B2 (en) | 2000-03-21 | 2010-05-18 | Genentech, Inc. | Nucleic acids encoding receptor for IL-17 homologous polypeptides and uses thereof |
| AU2001249697A1 (en) * | 2000-03-31 | 2001-10-15 | Millennium Pharmaceuticals, Inc. | 32449, a novel human transporter and uses thereof |
| GB0009907D0 (en) * | 2000-04-20 | 2000-06-07 | Smithkline Beecham Biolog | Novel compounds |
| US20030096969A1 (en) | 2000-06-02 | 2003-05-22 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| AU2001268440A1 (en) * | 2000-06-15 | 2002-01-08 | Millennium Pharmaceuticals, Inc. | 53320, a human acyltransferase and uses therefor |
| AU2001273194A1 (en) * | 2000-06-30 | 2002-01-14 | Amgen Inc. | B7-Like Molecules and Uses Thereof |
| EP1736545A3 (en) * | 2000-08-08 | 2007-03-28 | ZymoGenetics, Inc. | Soluble zcytor 11 cytokine receptors |
| AU2001290524A1 (en) * | 2000-08-08 | 2002-02-18 | Zymogenetics Inc. | Soluble zcytor 11 cytokine receptors |
| WO2002038764A2 (en) * | 2000-11-10 | 2002-05-16 | The Regents Of The University Of California | Il-17 receptor-like protein, uses thereof, and modulation of catabolic activity of il-17 cytokines on bone and cartilage |
| EP1873245A1 (en) * | 2001-02-28 | 2008-01-02 | Genentech, Inc. | Interleukin-8 homologous polypeptides and therapeutic uses thereof |
| CA2439961A1 (en) | 2001-03-27 | 2002-10-03 | Zymogenetics, Inc. | Human cytokine receptor |
| US7033790B2 (en) | 2001-04-03 | 2006-04-25 | Curagen Corporation | Proteins and nucleic acids encoding same |
| WO2003008589A1 (en) * | 2001-07-18 | 2003-01-30 | Asahi Kasei Kabushiki Kaisha | Elk1 PHOSPHORYLATION-ASSOCIATED GENE |
| US20030023042A1 (en) * | 2001-12-06 | 2003-01-30 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| EP1546358A4 (en) | 2002-03-22 | 2006-06-07 | Zymogenetics Inc | ANTI-IL-TIF ANTIBODIES AND METHOD FOR USE ON INFLAMMATION |
| EP2305710A3 (en) | 2002-06-03 | 2013-05-29 | Genentech, Inc. | Synthetic antibody phage libraries |
| DE10254601A1 (de) * | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| EP1572116A4 (en) * | 2002-11-26 | 2007-12-12 | Genentech Inc | COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE DISEASES |
| CA2515115A1 (en) * | 2003-02-05 | 2004-08-26 | Genentech, Inc. | Identification of cellular polypeptides differentially expressed by tumor cells |
| US7312197B2 (en) | 2003-02-24 | 2007-12-25 | University Of Maryland, Baltimore | Method of modifying glucose activity using polypeptides selectively expressed in fat tissue |
| DE602004028347D1 (de) | 2003-03-24 | 2010-09-09 | Zymogenetics Inc | Anti-il-22ra antikörper und bindungspartner und verwendungsmethoden bei entzündung |
| US20050025763A1 (en) | 2003-05-08 | 2005-02-03 | Protein Design Laboratories, Inc. | Therapeutic use of anti-CS1 antibodies |
| US7709610B2 (en) | 2003-05-08 | 2010-05-04 | Facet Biotech Corporation | Therapeutic use of anti-CS1 antibodies |
| DK1641822T3 (da) | 2003-07-08 | 2013-07-22 | Genentech Inc | Heterologe il-17-a/f-polypeptider og terapeutiske anvendelser deraf. |
| ES2605443T3 (es) | 2003-11-06 | 2017-03-14 | Seattle Genetics, Inc. | Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia |
| US20100031378A1 (en) | 2008-08-04 | 2010-02-04 | Edwards Joel A | Novel gene disruptions, compositions and methods relating thereto |
| CA2555340A1 (en) * | 2004-02-12 | 2005-09-01 | Lexicon Genetics Incorporated | Gene disruptions, compositions and methods relating thereto |
| DE102004024617A1 (de) | 2004-05-18 | 2005-12-29 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| NZ551180A (en) | 2004-06-01 | 2009-10-30 | Genentech Inc | Antibody drug conjugates and methods |
| ES2414460T3 (es) | 2004-08-04 | 2013-07-19 | Amgen Inc. | Anticuerpos para Dkk-1 |
| TR201808537T4 (tr) | 2004-09-23 | 2018-07-23 | Genentech Inc | Sistein değiştirilmiş antikorlar ve konjugatlar. |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| EA015706B1 (ru) | 2004-10-22 | 2011-10-31 | Займоджинетикс, Инк. | Моноклональное антитело или его фрагмент, связывающиеся с полипептидом il-22ra, гуманизированное антитело, полученное из указанного антитела, гибридомы, продуцирующие антитело, и применение указанного антитела |
| EP1790664A1 (en) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against claudin-18 for treatment of cancer |
| JP2009518314A (ja) | 2005-12-02 | 2009-05-07 | ジェネンテック・インコーポレーテッド | Il−22に結合する抗体およびil−22rに結合する抗体を含む、サイトカインシグナリングに関連する疾患および障害の処置のための組成物および方法 |
| WO2008042826A2 (en) | 2006-09-29 | 2008-04-10 | University Of Maryland, Baltimore | Use of omentin 1 and omentin 2 in the diagnosis and treatment of disease |
| BRPI0908312A2 (pt) | 2008-05-05 | 2015-08-18 | Novimmune Sa | '' anticorpo monoclonal totalmente humano isolado, composição farmacêutica, método de alívio de um sintoma de uma indicação clínica e método de alívio de um sintoma de uma doença autoimune, distúrbio inflamatório ou distúrbio da proliferação celular'' |
| EP2427203B1 (en) | 2009-05-05 | 2018-10-17 | Novimmune S.A. | Anti-il-17f antibodies and use thereof |
| AU2010292172A1 (en) | 2009-09-09 | 2012-05-03 | Centrose, Llc | Extracellular targeted drug conjugates |
| PT2528625E (pt) | 2010-04-15 | 2013-10-17 | Spirogen Sarl | Pirrolobenzodiazepinas e conjugados das mesmas |
| CA3220104A1 (en) | 2010-06-08 | 2011-12-15 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| EP2640727B1 (en) | 2010-11-17 | 2015-05-13 | Genentech, Inc. | Alaninyl maytansinol antibody conjugates |
| EP2707723B1 (en) | 2011-05-12 | 2016-02-10 | Genentech, Inc. | Multiple reaction monitoring lc-ms/ms method to detect therapeutic antibodies in animal samples using framework signature pepides |
| JP6104257B2 (ja) | 2011-10-14 | 2017-03-29 | メドイミューン・リミテッドMedImmune Limited | ピロロベンゾジアゼピンおよびそのコンジュゲート |
| WO2013130093A1 (en) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarkers for treatment with anti-tubulin chemotherapeutic compounds |
| WO2013167153A1 (en) | 2012-05-09 | 2013-11-14 | Ganymed Pharmaceuticals Ag | Antibodies useful in cancer diagnosis |
| WO2013174404A1 (en) | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| KR101995620B1 (ko) | 2012-10-12 | 2019-07-03 | 에이디씨 테라퓨틱스 에스에이 | 피롤로벤조디아제핀-항체 컨주게이트 |
| DK2839860T3 (da) | 2012-10-12 | 2019-06-17 | Medimmune Ltd | Pyrrolobenzodiazepiner og konjugater deraf |
| DK2906298T3 (en) | 2012-10-12 | 2018-12-17 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| EP2906297B1 (en) | 2012-10-12 | 2017-12-06 | ADC Therapeutics SA | Pyrrolobenzodiazepine-antibody conjugates |
| WO2014057114A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-anti-psma antibody conjugates |
| PT2906253T (pt) | 2012-10-12 | 2018-11-05 | Medimmune Ltd | Conjugados de anticorpo anti-psma de pirrolobenzodiazepina |
| BR112015008238A2 (pt) | 2012-10-12 | 2017-11-28 | Adc Therapeutics Sarl | conjugados de pirrolbenzodiazepina-anticorpo anti-cd22 |
| IL282953B2 (en) | 2012-11-13 | 2026-02-01 | Tron Translationale Onkologie An Der Johannes Gutenberg Univ Mainz Gemeinnutzige Gmbh | Agents for the treatment of claudin-expressing cancers |
| US9567340B2 (en) | 2012-12-21 | 2017-02-14 | Medimmune Limited | Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases |
| AU2013366493B2 (en) | 2012-12-21 | 2017-08-24 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| WO2014127785A1 (en) | 2013-02-20 | 2014-08-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| ES2687439T3 (es) | 2013-03-13 | 2018-10-25 | Medimmune Limited | Pirrolobenzodiazepinas y conjugados de las mismas |
| MX363787B (es) | 2013-03-13 | 2019-04-03 | Medimmune Ltd | Pirrolobenzodiazepinas y conjugados de los mismos. |
| KR102066318B1 (ko) | 2013-03-13 | 2020-01-14 | 메디뮨 리미티드 | 피롤로벤조디아제핀 및 그의 컨쥬게이트 |
| WO2014146672A1 (en) | 2013-03-18 | 2014-09-25 | Ganymed Pharmaceuticals Ag | Therapy involving antibodies against claudin 18.2 for treatment of cancer |
| BR112016002829A2 (pt) | 2013-08-12 | 2017-09-19 | Genentech Inc | Composto e processo para preparar o composto de conjugado anticorpo-¿droga, composição farmacêutica, método de tratamento do câncer, kit para o tratamento do câncer, intermediário ligante¿-droga, porção e composto de porção droga de dímero cbi |
| GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| WO2015052534A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| US10010624B2 (en) | 2013-10-11 | 2018-07-03 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| WO2015052535A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| UA118113C2 (uk) | 2013-12-16 | 2018-11-26 | Дженентек, Інк. | Пептидоміметичні сполуки та їх кон'югати антитіла з лікарським засобом |
| JP6980384B2 (ja) | 2013-12-16 | 2021-12-15 | ジェネンテック, インコーポレイテッド | 1−(クロロメチル)−2,3−ジヒドロ−1h−ベンゾ[e]インドール二量体抗体−薬物コンジュゲート化合物、並びに使用及び処置の方法 |
| BR112016012410A2 (pt) | 2013-12-16 | 2017-09-26 | Genentech Inc | conjugado de droga e anticorpo, composto conjugado de droga e anticorpo, composto não-peptídico, método de tratamento de doenças em seres humanos e composição farmacêutica |
| EP3193940A1 (en) | 2014-09-10 | 2017-07-26 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| US10149913B2 (en) | 2014-09-12 | 2018-12-11 | Genentech, Inc. | Anthracycline disulfide intermediates, antibody-drug conjugates and methods |
| GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| JP2017531620A (ja) | 2014-09-12 | 2017-10-26 | ジェネンテック, インコーポレイテッド | システイン操作抗体及びコンジュゲート |
| JP2017533887A (ja) | 2014-09-17 | 2017-11-16 | ジェネンテック, インコーポレイテッド | ピロロベンゾジアゼピン類及びその抗体ジスルフィドコンジュゲート |
| CN107148285B (zh) | 2014-11-25 | 2022-01-04 | Adc治疗股份有限公司 | 吡咯并苯并二氮杂䓬-抗体缀合物 |
| CA2969689A1 (en) | 2014-12-03 | 2016-06-09 | Genentech, Inc. | Quaternary amine compounds and antibody-drug conjugates thereof |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| CR20180243A (es) | 2015-10-02 | 2018-07-31 | Genentech Inc | Conjugados de anticuerpo-fármaco de pirrolobenzodiazepina y métodos de uso |
| MA43354A (fr) | 2015-10-16 | 2018-08-22 | Genentech Inc | Conjugués médicamenteux à pont disulfure encombré |
| JP6852065B2 (ja) | 2015-10-20 | 2021-03-31 | ジェネンテック, インコーポレイテッド | カリケアマイシン−抗体−薬物コンジュゲート及び使用方法 |
| GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
| GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| CN108700598A (zh) | 2016-03-25 | 2018-10-23 | 豪夫迈·罗氏有限公司 | 多路总抗体和抗体缀合的药物量化测定法 |
| GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| CN109152843A (zh) | 2016-05-20 | 2019-01-04 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| CN109313200B (zh) | 2016-05-27 | 2022-10-04 | 豪夫迈·罗氏有限公司 | 用于表征位点特异性抗体-药物缀合物的生物分析性方法 |
| JP7043425B2 (ja) | 2016-06-06 | 2022-03-29 | ジェネンテック, インコーポレイテッド | シルベストロール抗体-薬物コンジュゲート及び使用方法 |
| WO2018031662A1 (en) | 2016-08-11 | 2018-02-15 | Genentech, Inc. | Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof |
| JP7050770B2 (ja) | 2016-10-05 | 2022-04-08 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 抗体薬物コンジュゲートの調製方法 |
| GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
| RS61795B1 (sr) | 2017-02-08 | 2021-06-30 | Adc Therapeutics Sa | Konjugati pirolobenzodiazepin antitela |
| GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
| SMT202200490T1 (it) | 2017-04-18 | 2023-01-13 | Medimmune Ltd | Coniugati di pirrolobenzodiazepina |
| WO2018193102A1 (en) | 2017-04-20 | 2018-10-25 | Adc Therapeutics Sa | Combination therapy with an anti-axl antibody-drug conjugate |
| KR102442736B1 (ko) | 2017-06-14 | 2022-09-16 | 에이디씨 테라퓨틱스 에스에이 | 항-cd19 adc의 투여를 위한 투약량 체제 |
| SI3668874T1 (sl) | 2017-08-18 | 2022-04-29 | Medimmune Limited | Pirolobenzodiazepinski konjugati |
| ES3075078T3 (es) | 2017-09-20 | 2026-07-27 | Ph Pharma Co Ltd | Análogos de tailanstatina |
| GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
| GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
| AU2019365238A1 (en) | 2018-10-24 | 2021-05-13 | F. Hoffmann-La Roche Ag | Conjugated chemical inducers of degradation and methods of use |
| EP3894427A1 (en) | 2018-12-10 | 2021-10-20 | Genentech, Inc. | Photocrosslinking peptides for site specific conjugation to fc-containing proteins |
| GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
| JP7232925B2 (ja) | 2019-02-15 | 2023-03-03 | ウーシー バイオロジクス アイルランド リミテッド | 改善された均一性を有する抗体薬物コンジュゲートの調製するプロセス |
| CN113631560B (zh) | 2019-03-15 | 2025-02-18 | 麦迪穆有限责任公司 | 氮杂环丁烷并苯并二氮杂䓬二聚体和用于治疗癌症的包含它们的缀合物 |
| GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
| CN117980327A (zh) | 2021-11-03 | 2024-05-03 | 杭州多禧生物科技有限公司 | 抗体的特异性偶联 |
| CN120417934A (zh) | 2022-12-23 | 2025-08-01 | 基因泰克公司 | Cereblon降解剂缀合物及其用途 |
| KR20260012304A (ko) | 2023-04-17 | 2026-01-26 | 피크 바이오, 인크. | 항체 및 항체-약물 접합체 및 사용 방법 및 합성 공정 및 중간체 |
| WO2026006688A2 (en) | 2024-06-28 | 2026-01-02 | Firefly Bio, Inc. | Degrader antibody conjugates and uses thereof |
| TW202617186A (zh) | 2024-06-28 | 2026-05-01 | 美商飛爾富來生物公司 | Bcl-xl降解劑抗體結合物及其用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5707829A (en) * | 1995-08-11 | 1998-01-13 | Genetics Institute, Inc. | DNA sequences and secreted proteins encoded thereby |
| JP2001501447A (ja) * | 1996-01-11 | 2001-02-06 | コリクサ コーポレイション | 乳癌の処置および診断のための組成物および方法 |
| US5824504A (en) * | 1996-09-26 | 1998-10-20 | Elshourbagy; Nabil A. | Human 7-transmembrane receptor and DNA |
| WO1999024836A1 (en) * | 1997-11-07 | 1999-05-20 | Human Genome Sciences, Inc. | 125 human secreted proteins |
| EP1029045A2 (en) * | 1997-11-13 | 2000-08-23 | Genset | EXTENDED cDNAs FOR SECRETED PROTEINS |
| JP2002505870A (ja) * | 1998-03-11 | 2002-02-26 | ジェネティックス・インスチチュート・インコーポレーテッド | 分泌蛋白およびそれらをコードするポリヌクレオチド |
| WO1999055865A1 (en) * | 1998-04-29 | 1999-11-04 | Genesis Research And Development Corporation Limited | Polynucleotides isolated from skin cells and methods for their use |
| IL139686A0 (en) * | 1998-06-02 | 2002-02-10 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| JP2004522402A (ja) * | 1999-06-02 | 2004-07-29 | ジェネンテック・インコーポレーテッド | 同一のものをコードする分泌及び膜貫通ポリペプチドと核酸 |
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- 2000-08-24 CA CA002380355A patent/CA2380355A1/en not_active Abandoned
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| JP2004507204A (ja) | 2004-03-11 |
| WO2001016318A3 (en) | 2001-11-29 |
| JP2005261437A (ja) | 2005-09-29 |
| JP2009095345A (ja) | 2009-05-07 |
| JP2005253469A (ja) | 2005-09-22 |
| JP2005270107A (ja) | 2005-10-06 |
| CA2380355A1 (en) | 2001-03-08 |
| JP2005253468A (ja) | 2005-09-22 |
| AU7573000A (en) | 2001-03-26 |
| JP2005224245A (ja) | 2005-08-25 |
| WO2001016318A2 (en) | 2001-03-08 |
| EP1208202A2 (en) | 2002-05-29 |
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