JP3947103B2 - 肝細胞毒性に対する素因を検出する方法 - Google Patents

肝細胞毒性に対する素因を検出する方法 Download PDF

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Publication number
JP3947103B2
JP3947103B2 JP2002512413A JP2002512413A JP3947103B2 JP 3947103 B2 JP3947103 B2 JP 3947103B2 JP 2002512413 A JP2002512413 A JP 2002512413A JP 2002512413 A JP2002512413 A JP 2002512413A JP 3947103 B2 JP3947103 B2 JP 3947103B2
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seq
exon
polymorphism
ugt1
gene
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JP2004508017A (ja
JP2004508017A5 (https=
Inventor
アクーナ，ゴンツァロ
フォエルンツラー，ドロシー
レオング，ダイアン・ウラツ
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2002512413A 2000-07-14 2001-07-02 肝細胞毒性に対する素因を検出する方法 Expired - Fee Related JP3947103B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00115353 2000-07-14
PCT/EP2001/007524 WO2002006523A2 (en) 2000-07-14 2001-07-02 Method for detecting pre-disposition to hepatotoxicity

Publications (3)

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JP2004508017A JP2004508017A (ja) 2004-03-18
JP2004508017A5 JP2004508017A5 (https=) 2005-02-03
JP3947103B2 true JP3947103B2 (ja) 2007-07-18

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ID=8169277

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JP2002512413A Expired - Fee Related JP3947103B2 (ja) 2000-07-14 2001-07-02 肝細胞毒性に対する素因を検出する方法

Country Status (5)

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US (1) US20040076968A1 (https=)
EP (1) EP1325152A2 (https=)
JP (1) JP3947103B2 (https=)
AU (1) AU2001281930A1 (https=)
WO (1) WO2002006523A2 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395481B1 (en) * 1999-02-16 2002-05-28 Arch Development Corp. Methods for detection of promoter polymorphism in a UGT gene promoter
US20030099960A1 (en) * 2001-01-26 2003-05-29 The University Of Chicago Compositions and methods for optimizing UGT2B7 substrate dosings and for predicting UGT2B7 substrate toxicity
DE10207971A1 (de) * 2002-02-25 2003-09-11 Norbert Dahmen Verfahren zur Identifizierung Nebenwirkungs-relevanter Markerprofile
AU2003228425A1 (en) * 2002-04-01 2003-10-20 Phase-1 Molecular Toxicology, Inc. Liver necrosis predictive genes
US20040203034A1 (en) * 2003-01-03 2004-10-14 The University Of Chicago Optimization of cancer treatment with irinotecan
ES2308208T3 (es) 2003-05-30 2008-12-01 University Of Chicago Metodos y composiciones para predecir la toxicidad del irinotecano.
US20090247475A1 (en) * 2004-03-05 2009-10-01 The Regents Of The University Of California Methods and compositions relating to pharmacogenetics of different gene variants in the context of irinotecan-based therapies
WO2006027182A1 (en) * 2004-09-06 2006-03-16 Medizinische Hochschule Hannover Methods and its kits based on ugt1a7 promoter polymorphism
WO2006070666A1 (ja) * 2004-12-28 2006-07-06 Takara Bio Inc. 遺伝子多型の同時検出方法
EP1790343A1 (en) * 2005-11-11 2007-05-30 Emotional Brain B.V. Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction
CN106755388B (zh) * 2016-11-24 2019-08-23 厦门艾德生物医药科技股份有限公司 一种改进的ARMS引物结构(Super-ARMS)及其使用方法
CN108315420A (zh) * 2018-04-04 2018-07-24 广西中医药大学附属瑞康医院 一种用于检测乙肝癌变多态性的试剂盒

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012987A1 (en) 1991-01-10 1992-08-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services The genetic locus ugt1 and a mutation therein
TW221441B (https=) 1991-01-25 1994-03-01 Taiho Pharmaceutical Co Ltd
JP2000508912A (ja) 1996-04-19 2000-07-18 スペクトラ バイオメディカル，インコーポレイテッド 多型形態と複数の表現型との相関付け
GB2321190B (en) * 1997-01-16 2000-09-20 Britannia Pharmaceuticals Ltd Pharmaceutical composition
EP1084271A2 (en) * 1998-05-07 2001-03-21 Axys Pharmaceuticals, Inc. Genotyping the human udp-glucuronosyltransferase 1 (ugt1) gene

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Publication number Publication date
WO2002006523A2 (en) 2002-01-24
JP2004508017A (ja) 2004-03-18
EP1325152A2 (en) 2003-07-09
WO2002006523A3 (en) 2003-04-17
AU2001281930A1 (en) 2002-01-30
US20040076968A1 (en) 2004-04-22

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