JP2004508017A5 - - Google Patents

Info

Publication number

JP2004508017A5

JP2004508017A5 JP2002512413A JP2002512413A JP2004508017A5 JP 2004508017 A5 JP2004508017 A5 JP 2004508017A5 JP 2002512413 A JP2002512413 A JP 2002512413A JP 2002512413 A JP2002512413 A JP 2002512413A JP 2004508017 A5 JP2004508017 A5 JP 2004508017A5

Authority

JP

Japan

Prior art keywords

seq

exon

depending

nucleotide sequence

ugt1a7

Prior art date

2001-07-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 239000002773 nucleotide Substances 0.000 claims 54
• 125000003729 nucleotide group Chemical group 0.000 claims 54
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 44
• 101710205340 UDP-glucuronosyltransferase 1A7 Proteins 0.000 claims 31
• 102100040213 UDP-glucuronosyltransferase 1A7 Human genes 0.000 claims 29
• 101710008381 UGT1A6 Proteins 0.000 claims 25
• 102100040198 UDP-glucuronosyltransferase 1-6 Human genes 0.000 claims 23
• 150000007523 nucleic acids Chemical class 0.000 claims 16
• 108020004707 nucleic acids Proteins 0.000 claims 13
• 102000039446 nucleic acids Human genes 0.000 claims 13
• 238000000034 method Methods 0.000 claims 11
• 102000016354 Glucuronosyltransferase Human genes 0.000 claims 10
• 108010092364 Glucuronosyltransferase Proteins 0.000 claims 10
• 108700028369 Alleles Proteins 0.000 claims 4
• 101150024327 UGT1 gene Proteins 0.000 claims 4
• 239000012634 fragment Substances 0.000 claims 4
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
• 239000000523 sample Substances 0.000 claims 3
• 108020005187 Oligonucleotide Probes Proteins 0.000 claims 2
• 230000000295 complement effect Effects 0.000 claims 2
• 231100000334 hepatotoxic Toxicity 0.000 claims 2
• 230000003082 hepatotoxic effect Effects 0.000 claims 2
• 239000002751 oligonucleotide probe Substances 0.000 claims 2
• 102000054765 polymorphisms of proteins Human genes 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 229940126062 Compound A Drugs 0.000 claims 1
• 238000009007 Diagnostic Kit Methods 0.000 claims 1
• NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
• 108091034117 Oligonucleotide Proteins 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 238000003752 polymerase chain reaction Methods 0.000 claims 1
• 229920001184 polypeptide Chemical group 0.000 claims 1
• 108090000765 processed proteins & peptides Chemical group 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 238000012163 sequencing technique Methods 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• MIQPIUSUKVNLNT-UHFFFAOYSA-N tolcapone Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC(O)=C(O)C([N+]([O-])=O)=C1 MIQPIUSUKVNLNT-UHFFFAOYSA-N 0.000 claims 1
• 229960004603 tolcapone Drugs 0.000 claims 1