JP3921175B2 - 口腔内疾患の予防及び／又は治療用組成物 - Google Patents
口腔内疾患の予防及び／又は治療用組成物 Download PDFInfo
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- JP3921175B2 JP3921175B2 JP2002578985A JP2002578985A JP3921175B2 JP 3921175 B2 JP3921175 B2 JP 3921175B2 JP 2002578985 A JP2002578985 A JP 2002578985A JP 2002578985 A JP2002578985 A JP 2002578985A JP 3921175 B2 JP3921175 B2 JP 3921175B2
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- Prior art keywords
- extract
- lactic acid
- medium
- xylitol
- acid bacterium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001102752 | 2001-04-02 | ||
| JP2001102752 | 2001-04-02 | ||
| JP2001267943 | 2001-09-04 | ||
| JP2001267943 | 2001-09-04 | ||
| PCT/JP2002/003293 WO2002080946A1 (fr) | 2001-04-02 | 2002-04-02 | Compositions servant a prevenir et/ou a traiter les maladies orales |
Publications (2)
| Publication Number | Publication Date |
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| JPWO2002080946A1 JPWO2002080946A1 (ja) | 2004-07-29 |
| JP3921175B2 true JP3921175B2 (ja) | 2007-05-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2002578985A Expired - Lifetime JP3921175B2 (ja) | 2001-04-02 | 2002-04-02 | 口腔内疾患の予防及び／又は治療用組成物 |
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| Country | Link |
|---|---|
| JP (1) | JP3921175B2 (fr) |
| AU (1) | AU2002243023A1 (fr) |
| WO (1) | WO2002080946A1 (fr) |
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| KR20200121173A (ko) * | 2019-04-15 | 2020-10-23 | 주식회사 오라팜 | 녹차 추출물 및 유산균, 그 배양물, 그 파쇄물 또는 그 추출물을 유효성분으로 포함하는 치주질환 예방 또는 개선용 조성물 |
| KR102488050B1 (ko) * | 2021-10-29 | 2023-01-13 | 주식회사 쎌바이오텍 | 락토바실러스계 균주 배양여액을 포함하는 항균 조성물 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7029702B2 (en) | 1998-07-07 | 2006-04-18 | Ritter Natural Sciences Llc | Method for increasing lactose tolerance in mammals exhibiting lactose intolerance |
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| WO2011137249A1 (fr) | 2010-04-28 | 2011-11-03 | Ritter Pharmaceuticals, Inc. | Formulations prébiotiques et méthodes d'utilisation |
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| KR20170043576A (ko) * | 2014-08-15 | 2017-04-21 | 가부시키가이샤 카스케도 시겐겡큐쇼 | 리그닌 추출물을 유효 성분으로 하는 약제 |
| JP6181254B1 (ja) * | 2016-08-11 | 2017-08-16 | 日東薬品工業株式会社 | 乳酸菌含有チョコレートおよびその製造方法 |
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| JP2019059754A (ja) * | 2018-11-29 | 2019-04-18 | 株式会社カスケード資源研究所 | リグニン抽出物を有効成分とする薬剤 |
| WO2021167845A1 (fr) | 2020-02-18 | 2021-08-26 | Sunstar Americas, Inc. | Composition de soin buccal |
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| IT202100011609A1 (it) | 2021-05-06 | 2022-11-06 | Perfetti Van Melle Spa | Prodotto di confetteria |
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Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA76735B (en) * | 1975-02-20 | 1977-01-26 | Hoffmann La Roche | Therapeutic composition |
| CA1262442A (fr) * | 1984-03-09 | 1989-10-24 | Yasuo Kawai | Agent contre la carie et les periodontites |
| US4912089A (en) * | 1986-11-07 | 1990-03-27 | Yasutake Hiji | Cariostatic materials and foods, and method for preventing dental caries |
| JP2667422B2 (ja) * | 1988-01-26 | 1997-10-27 | 株式会社伊藤園 | うがい液 |
| JP2793271B2 (ja) * | 1989-07-21 | 1998-09-03 | 日本製紙株式会社 | 食味の改善された低カロリー低う蝕性キヤンデイ及びその製造方法 |
| JPH045222A (ja) * | 1990-04-20 | 1992-01-09 | Kao Corp | 口腔用生薬抽出物及びこれを有効成分とする口腔用組成物 |
| JPH06179780A (ja) * | 1992-12-15 | 1994-06-28 | Mitsubishi Petrochem Co Ltd | ポリオレフィン組成物 |
| FR2715582B1 (fr) * | 1994-02-02 | 1996-03-15 | Centre Nat Rech Scient | Microcapsules à paroi de flavonoïde réticulée et compositions en contenant. |
| JP3281716B2 (ja) * | 1994-03-24 | 2002-05-13 | 丸善製薬株式会社 | グルコシルトランスフェラーゼ阻害剤、口腔用剤および飲食物 |
| JPH08310931A (ja) * | 1995-05-19 | 1996-11-26 | Maruzen Pharmaceut Co Ltd | グルコシルトランスフェラーゼ阻害剤および口腔清浄化剤 |
| JP3499969B2 (ja) * | 1995-06-23 | 2004-02-23 | 明治製菓株式会社 | 結晶ケストース含有砂糖甘味料 |
| JP3590689B2 (ja) * | 1996-03-07 | 2004-11-17 | 東和化成工業株式会社 | う蝕誘発性の低い菓子用組成物及びそれを用いた菓子の製造方法 |
| JPH1081617A (ja) * | 1996-07-15 | 1998-03-31 | Lion Corp | う蝕予防用歯磨組成物 |
| GB2317339A (en) * | 1996-08-01 | 1998-03-25 | Procter & Gamble | Dentifrice composition containing a curcuminoid |
| JPH10139646A (ja) * | 1996-11-13 | 1998-05-26 | Maruzen Pharmaceut Co Ltd | グルコシルトランスフェラーゼ阻害剤、口腔用剤および飲食物 |
| KR100266752B1 (ko) * | 1997-08-07 | 2001-03-02 | 오종석 | 인체 구강내 치태형성을 억제하는 신규한 유산균 |
| JP3648587B2 (ja) * | 1998-03-04 | 2005-05-18 | サンスター株式会社 | 歯周病予防又は歯周病進行予防食品組成物 |
| JP3763075B2 (ja) * | 1998-04-24 | 2006-04-05 | サンスター株式会社 | 歯周病の予防又は治療用の食品組成物、口腔用組成物及び医薬組成物 |
| JP2000072790A (ja) * | 1998-09-01 | 2000-03-07 | Maruzen Pharmaceut Co Ltd | 植物抽出物中の残留農薬を除去する方法 |
| JP2000154127A (ja) * | 1998-11-18 | 2000-06-06 | Lion Corp | 口腔用組成物 |
| JP3650705B2 (ja) * | 1999-03-24 | 2005-05-25 | サンスター株式会社 | パラチニット含有食品 |
| JP2001081021A (ja) * | 1999-09-09 | 2001-03-27 | Ichimaru Pharcos Co Ltd | 化粧料組成物 |
-
2002
- 2002-04-02 AU AU2002243023A patent/AU2002243023A1/en not_active Abandoned
- 2002-04-02 JP JP2002578985A patent/JP3921175B2/ja not_active Expired - Lifetime
- 2002-04-02 WO PCT/JP2002/003293 patent/WO2002080946A1/fr active Application Filing
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| KR20110019420A (ko) * | 2008-06-11 | 2011-02-25 | 바스프 에스이 | 입냄새 예방 및/또는 치료를 위한 용도 및 방법 |
| KR101648992B1 (ko) | 2008-06-11 | 2016-08-17 | 바스프 에스이 | 입냄새 예방 및/또는 치료를 위한 용도 및 방법 |
| KR20200121173A (ko) * | 2019-04-15 | 2020-10-23 | 주식회사 오라팜 | 녹차 추출물 및 유산균, 그 배양물, 그 파쇄물 또는 그 추출물을 유효성분으로 포함하는 치주질환 예방 또는 개선용 조성물 |
| KR102208751B1 (ko) | 2019-04-15 | 2021-01-28 | 주식회사 오라팜 | 녹차 추출물 및 유산균, 그 배양물, 그 파쇄물 또는 그 추출물을 유효성분으로 포함하는 치주질환 예방 또는 개선용 조성물 |
| KR102488050B1 (ko) * | 2021-10-29 | 2023-01-13 | 주식회사 쎌바이오텍 | 락토바실러스계 균주 배양여액을 포함하는 항균 조성물 |
| WO2023075290A1 (fr) * | 2021-10-29 | 2023-05-04 | 주식회사 쎌바이오텍 | Composition antibactérienne contenant un filtrat de culture de souche de lactobacillus |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002080946A1 (fr) | 2002-10-17 |
| JPWO2002080946A1 (ja) | 2004-07-29 |
| AU2002243023A1 (en) | 2002-10-21 |
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