JP3852712B2 - バイオセンサー用の親水性の膨潤性コーティング - Google Patents

バイオセンサー用の親水性の膨潤性コーティング Download PDF

Info

Publication number
JP3852712B2
JP3852712B2 JP51972098A JP51972098A JP3852712B2 JP 3852712 B2 JP3852712 B2 JP 3852712B2 JP 51972098 A JP51972098 A JP 51972098A JP 51972098 A JP51972098 A JP 51972098A JP 3852712 B2 JP3852712 B2 JP 3852712B2
Authority
JP
Japan
Prior art keywords
diisocyanate
glycol
group
ethylene
hydrophilic polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP51972098A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000502280A (ja
JP2000502280A5 (enExample
Inventor
ウィリアム ピーター バン，アントワープ
シー． デッカー，クリスチャン
ジョセフ マストロトトロ，ジョン
Original Assignee
メドトロニック ミニメッド、 インコーポレイティド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by メドトロニック ミニメッド、 インコーポレイティド filed Critical メドトロニック ミニメッド、 インコーポレイティド
Publication of JP2000502280A publication Critical patent/JP2000502280A/ja
Publication of JP2000502280A5 publication Critical patent/JP2000502280A5/ja
Application granted granted Critical
Publication of JP3852712B2 publication Critical patent/JP3852712B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/411—Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/4833—Polyethers containing oxyethylene units
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/61—Polysiloxanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/65—Low-molecular-weight compounds having active hydrogen with high-molecular-weight compounds having active hydrogen
    • C08G18/66—Compounds of groups C08G18/42, C08G18/48, or C08G18/52
    • C08G18/6666—Compounds of group C08G18/48 or C08G18/52
    • C08G18/667—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38
    • C08G18/6674—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/3203
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/42—Block-or graft-polymers containing polysiloxane sequences
    • C08G77/452—Block-or graft-polymers containing polysiloxane sequences containing nitrogen-containing sequences
    • C08G77/458—Block-or graft-polymers containing polysiloxane sequences containing nitrogen-containing sequences containing polyurethane sequences
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/20—Manufacture of shaped structures of ion-exchange resins
    • C08J5/22—Films, membranes or diaphragms
    • C08J5/2287—After-treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
    • C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
    • C08J2323/04—Homopolymers or copolymers of ethene
    • C08J2323/06—Polyethene
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31551—Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Manufacturing & Machinery (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Optics & Photonics (AREA)
  • Vascular Medicine (AREA)
  • Materials Engineering (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Materials For Medical Uses (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
JP51972098A 1996-10-24 1997-10-24 バイオセンサー用の親水性の膨潤性コーティング Expired - Fee Related JP3852712B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/749,754 US5786439A (en) 1996-10-24 1996-10-24 Hydrophilic, swellable coatings for biosensors
US08/749,754 1996-10-24
PCT/US1997/019513 WO1998017995A1 (en) 1996-10-24 1997-10-24 Hydrophilic, swellable coatings for biosensors

Publications (3)

Publication Number Publication Date
JP2000502280A JP2000502280A (ja) 2000-02-29
JP2000502280A5 JP2000502280A5 (enExample) 2005-06-16
JP3852712B2 true JP3852712B2 (ja) 2006-12-06

Family

ID=25015047

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51972098A Expired - Fee Related JP3852712B2 (ja) 1996-10-24 1997-10-24 バイオセンサー用の親水性の膨潤性コーティング

Country Status (9)

Country Link
US (3) US5786439A (enExample)
EP (1) EP0876604B1 (enExample)
JP (1) JP3852712B2 (enExample)
AT (1) ATE327504T1 (enExample)
AU (1) AU5092198A (enExample)
CA (1) CA2238648C (enExample)
DE (1) DE69735932T2 (enExample)
DK (1) DK0876604T3 (enExample)
WO (1) WO1998017995A1 (enExample)

Families Citing this family (307)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786439A (en) 1996-10-24 1998-07-28 Minimed Inc. Hydrophilic, swellable coatings for biosensors
WO1998022820A1 (en) * 1996-11-21 1998-05-28 Lawrence Livermore National Laboratory Detection of biological molecules using boronate-based chemical amplification and optical sensors
US6001067A (en) 1997-03-04 1999-12-14 Shults; Mark C. Device and method for determining analyte levels
US8527026B2 (en) 1997-03-04 2013-09-03 Dexcom, Inc. Device and method for determining analyte levels
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6331163B1 (en) 1998-01-08 2001-12-18 Microsense Cardiovascular Systems (1196) Ltd. Protective coating for bodily sensor
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US6060023A (en) * 1998-03-31 2000-05-09 Motorola, Inc. Molecular sensing apparatus
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6485703B1 (en) * 1998-07-31 2002-11-26 The Texas A&M University System Compositions and methods for analyte detection
US6605294B2 (en) * 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US6602678B2 (en) * 1998-09-04 2003-08-05 Powderject Research Limited Non- or minimally invasive monitoring methods
CA2666429A1 (en) * 1998-10-08 2000-04-13 Medtronic Minimed, Inc. Telemetered characteristic monitor system
US20060202859A1 (en) * 1998-10-08 2006-09-14 Mastrototaro John J Telemetered characteristic monitor system and method of using the same
US6424847B1 (en) 1999-02-25 2002-07-23 Medtronic Minimed, Inc. Glucose monitor calibration methods
WO2000066265A2 (en) 1999-04-27 2000-11-09 Ciphergen Biosystems, Inc. Probes for a gas phase ion spectrometer
US6342071B1 (en) 1999-07-08 2002-01-29 Benjamin David Pless Ambulatory blood pump
WO2001012746A1 (en) * 1999-08-17 2001-02-22 Porex Technologies Corporation Self-sealing materials and devices comprising same
US7045054B1 (en) 1999-09-20 2006-05-16 Roche Diagnostics Corporation Small volume biosensor for continuous analyte monitoring
US6589778B1 (en) * 1999-12-15 2003-07-08 Amersham Biosciences Ab Method and apparatus for performing biological reactions on a substrate surface
US7003336B2 (en) 2000-02-10 2006-02-21 Medtronic Minimed, Inc. Analyte sensor method of making the same
US6484045B1 (en) 2000-02-10 2002-11-19 Medtronic Minimed, Inc. Analyte sensor and method of making the same
US7890295B2 (en) 2000-02-23 2011-02-15 Medtronic Minimed, Inc. Real time self-adjusting calibration algorithm
US6405066B1 (en) 2000-03-17 2002-06-11 The Regents Of The University Of California Implantable analyte sensor
EP1304952A2 (en) 2000-03-17 2003-05-02 Roche Diagnostics GmbH Implantable analyte sensor
US7527821B2 (en) * 2000-05-02 2009-05-05 Smiths Detection Inc. Sensor fabricating method
US6340421B1 (en) * 2000-05-16 2002-01-22 Minimed Inc. Microelectrogravimetric method for plating a biosensor
AUPQ952800A0 (en) 2000-08-21 2000-09-14 Cochlear Limited Power efficient electrical stimulation
US8285382B2 (en) * 2000-08-21 2012-10-09 Cochlear Limited Determining stimulation signals for neural stimulation
US9008786B2 (en) * 2000-08-21 2015-04-14 Cochlear Limited Determining stimulation signals for neural stimulation
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US7470420B2 (en) * 2000-12-05 2008-12-30 The Regents Of The University Of California Optical determination of glucose utilizing boronic acid adducts
US6627177B2 (en) * 2000-12-05 2003-09-30 The Regents Of The University Of California Polyhydroxyl-substituted organic molecule sensing optical in vivo method utilizing a boronic acid adduct and the device thereof
US6653141B2 (en) 2000-12-05 2003-11-25 The Regents Of The University Of California Polyhydroxyl-substituted organic molecule sensing method and device
US6642015B2 (en) 2000-12-29 2003-11-04 Minimed Inc. Hydrophilic polymeric material for coating biosensors
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
AU2002309528A1 (en) 2001-04-02 2002-10-15 Therasense, Inc. Blood glucose tracking apparatus and methods
US6932894B2 (en) 2001-05-15 2005-08-23 Therasense, Inc. Biosensor membranes composed of polymers containing heterocyclic nitrogens
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
ES2336081T3 (es) 2001-06-12 2010-04-08 Pelikan Technologies Inc. Dispositivo de puncion de auto-optimizacion con medios de adaptacion a variaciones temporales en las propiedades cutaneas.
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
CA2448681C (en) 2001-06-12 2014-09-09 Pelikan Technologies, Inc. Integrated blood sampling analysis system with multi-use sampling module
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
ATE497731T1 (de) 2001-06-12 2011-02-15 Pelikan Technologies Inc Gerät zur erhöhung der erfolgsrate im hinblick auf die durch einen fingerstich erhaltene blutausbeute
ATE485766T1 (de) 2001-06-12 2010-11-15 Pelikan Technologies Inc Elektrisches betätigungselement für eine lanzette
AU2002312521A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Blood sampling apparatus and method
AU2002348683A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
AUPR604801A0 (en) * 2001-06-29 2001-07-26 Cochlear Limited Multi-electrode cochlear implant system with distributed electronics
US20030032874A1 (en) 2001-07-27 2003-02-13 Dexcom, Inc. Sensor head for use with implantable devices
US7344894B2 (en) 2001-10-16 2008-03-18 Agilent Technologies, Inc. Thermal regulation of fluidic samples within a diagnostic cartridge
US20050239155A1 (en) * 2002-01-04 2005-10-27 Javier Alarcon Entrapped binding protein as biosensors
US20030153026A1 (en) * 2002-01-04 2003-08-14 Javier Alarcon Entrapped binding protein as biosensors
US7247162B1 (en) * 2002-01-14 2007-07-24 Edwards Lifesciences Corporation Direct access atherectomy devices
US8364229B2 (en) 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US7828728B2 (en) 2003-07-25 2010-11-09 Dexcom, Inc. Analyte sensor
US7613491B2 (en) 2002-05-22 2009-11-03 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7582099B2 (en) 2002-04-19 2009-09-01 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7244265B2 (en) 2002-04-19 2007-07-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7563232B2 (en) 2002-04-19 2009-07-21 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7524293B2 (en) 2002-04-19 2009-04-28 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US7374544B2 (en) 2002-04-19 2008-05-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7141058B2 (en) 2002-04-19 2006-11-28 Pelikan Technologies, Inc. Method and apparatus for a body fluid sampling device using illumination
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7410468B2 (en) 2002-04-19 2008-08-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7485128B2 (en) 2002-04-19 2009-02-03 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
EP1501402A4 (en) 2002-04-19 2008-07-02 Pelikan Technologies Inc DEVICE AND METHOD FOR A LANZETTE AT VARIABLE SPEED
US9492111B2 (en) * 2002-04-22 2016-11-15 Medtronic Minimed, Inc. Methods and materials for stabilizing analyte sensors
US20070227907A1 (en) * 2006-04-04 2007-10-04 Rajiv Shah Methods and materials for controlling the electrochemistry of analyte sensors
US7153265B2 (en) * 2002-04-22 2006-12-26 Medtronic Minimed, Inc. Anti-inflammatory biosensor for reduced biofouling and enhanced sensor performance
US7813780B2 (en) * 2005-12-13 2010-10-12 Medtronic Minimed, Inc. Biosensors and methods for making and using them
DE10221047A1 (de) * 2002-05-10 2003-11-27 Degussa Verfahren zur lösemittelfreien,kontinuierlichen Herstellung von Polyharnstoffen
US7226978B2 (en) 2002-05-22 2007-06-05 Dexcom, Inc. Techniques to improve polyurethane membranes for implantable glucose sensors
US20040068230A1 (en) 2002-07-24 2004-04-08 Medtronic Minimed, Inc. System for providing blood glucose measurements to an infusion device
US7278983B2 (en) 2002-07-24 2007-10-09 Medtronic Minimed, Inc. Physiological monitoring device for controlling a medication infusion device
US20050008828A1 (en) * 2002-07-25 2005-01-13 Trustees Of Stevens Institute Of Technology Patterned polymer microgel and method of forming same
US20040061232A1 (en) * 2002-09-27 2004-04-01 Medtronic Minimed, Inc. Multilayer substrate
US8003513B2 (en) * 2002-09-27 2011-08-23 Medtronic Minimed, Inc. Multilayer circuit devices and manufacturing methods using electroplated sacrificial structures
US6770729B2 (en) * 2002-09-30 2004-08-03 Medtronic Minimed, Inc. Polymer compositions containing bioactive agents and methods for their use
CA2501825C (en) 2002-10-09 2009-12-01 Therasense, Inc. Fluid delivery device, system and method
US7993108B2 (en) 2002-10-09 2011-08-09 Abbott Diabetes Care Inc. Variable volume, shape memory actuated insulin dispensing pump
US7727181B2 (en) 2002-10-09 2010-06-01 Abbott Diabetes Care Inc. Fluid delivery device with autocalibration
US9237865B2 (en) * 2002-10-18 2016-01-19 Medtronic Minimed, Inc. Analyte sensors and methods for making and using them
US20040074785A1 (en) * 2002-10-18 2004-04-22 Holker James D. Analyte sensors and methods for making them
US20050272989A1 (en) * 2004-06-04 2005-12-08 Medtronic Minimed, Inc. Analyte sensors and methods for making and using them
US20040106163A1 (en) * 2002-11-12 2004-06-03 Workman Jerome James Non-invasive measurement of analytes
WO2004044557A2 (en) * 2002-11-12 2004-05-27 Argose, Inc. Non-invasive measurement of analytes
US20030134410A1 (en) * 2002-11-14 2003-07-17 Silva Robin M. Compositions and methods for performing biological reactions
US20040122353A1 (en) * 2002-12-19 2004-06-24 Medtronic Minimed, Inc. Relay device for transferring information between a sensor system and a fluid delivery system
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US8771183B2 (en) 2004-02-17 2014-07-08 Abbott Diabetes Care Inc. Method and system for providing data communication in continuous glucose monitoring and management system
US20040126831A1 (en) * 2002-12-31 2004-07-01 Medtronic Minimed, Inc. Functionalization of immobilized proteins
AU2003297503A1 (en) * 2002-12-31 2004-07-29 Medtronic Minimed, Inc. Hydrophilic cross-linking agents for use in enzymatic sensors
AU2003303597A1 (en) 2002-12-31 2004-07-29 Therasense, Inc. Continuous glucose monitoring system and methods of use
EP1617888B1 (en) 2003-04-23 2019-06-12 Valeritas, Inc. Hydraulically actuated pump for long duration medicament administration
US7679407B2 (en) 2003-04-28 2010-03-16 Abbott Diabetes Care Inc. Method and apparatus for providing peak detection circuitry for data communication systems
EP1628567B1 (en) 2003-05-30 2010-08-04 Pelikan Technologies Inc. Method and apparatus for fluid injection
EP1633235B1 (en) 2003-06-06 2014-05-21 Sanofi-Aventis Deutschland GmbH Apparatus for body fluid sampling and analyte sensing
US8066639B2 (en) 2003-06-10 2011-11-29 Abbott Diabetes Care Inc. Glucose measuring device for use in personal area network
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US7604592B2 (en) 2003-06-13 2009-10-20 Pelikan Technologies, Inc. Method and apparatus for a point of care device
US20060014003A1 (en) * 2003-07-24 2006-01-19 Libera Matthew R Functional nano-scale gels
US9763609B2 (en) 2003-07-25 2017-09-19 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
EP1649260A4 (en) 2003-07-25 2010-07-07 Dexcom Inc ELECTRODE SYSTEMS FOR ELECTROCHEMICAL DETECTORS
US7761130B2 (en) 2003-07-25 2010-07-20 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
EP1648298A4 (en) 2003-07-25 2010-01-13 Dexcom Inc OXYGEN-IMPROVED MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
US9135402B2 (en) 2007-12-17 2015-09-15 Dexcom, Inc. Systems and methods for processing sensor data
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
EP1671096A4 (en) 2003-09-29 2009-09-16 Pelikan Technologies Inc METHOD AND APPARATUS FOR PROVIDING IMPROVED SAMPLE CAPTURING DEVICE
US20050163714A1 (en) * 2003-10-02 2005-07-28 Sukhishvili Svetlana A. Capsules of multilayered neutral polymer films associated by hydrogen bonding
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
US8095197B2 (en) 2003-11-03 2012-01-10 Microchips, Inc. Medical device for sensing glucose
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8532730B2 (en) 2006-10-04 2013-09-10 Dexcom, Inc. Analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
WO2005057168A2 (en) * 2003-12-05 2005-06-23 Dexcom, Inc. Calibration techniques for a continuous analyte sensor
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
EP1706026B1 (en) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Method and apparatus for improving fluidic flow and sample capture
US20070184222A1 (en) * 2004-04-20 2007-08-09 University Of Rochester Hydrogel-supported porous semiconductor devices
US8277713B2 (en) 2004-05-03 2012-10-02 Dexcom, Inc. Implantable analyte sensor
US8792955B2 (en) 2004-05-03 2014-07-29 Dexcom, Inc. Transcutaneous analyte sensor
GB0411162D0 (en) 2004-05-19 2004-06-23 Precisense As Optical sensor for in vivo detection of analyte
WO2006011062A2 (en) 2004-05-20 2006-02-02 Albatros Technologies Gmbh & Co. Kg Printable hydrogel for biosensors
WO2005120365A1 (en) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
DE602005022704D1 (de) * 2004-06-09 2010-09-16 Dickinson And Co Sensor für mehrere analyte
CN100409909C (zh) * 2004-06-11 2008-08-13 文贵华 生物亲和的电极刺激装置
US7519435B2 (en) * 2004-06-23 2009-04-14 Cochlear Limited Methods for maintaining low impedance of electrodes
WO2006014425A1 (en) 2004-07-02 2006-02-09 Biovalve Technologies, Inc. Methods and devices for delivering glp-1 and uses thereof
US8989833B2 (en) 2004-07-13 2015-03-24 Dexcom, Inc. Transcutaneous analyte sensor
US20070045902A1 (en) 2004-07-13 2007-03-01 Brauker James H Analyte sensor
US8886272B2 (en) 2004-07-13 2014-11-11 Dexcom, Inc. Analyte sensor
BRPI0517066A (pt) * 2004-11-05 2008-09-30 Basf Ag dispersão de microcápsulas, processo para a preparação de uma dispersão de microcápsula, e, microcápsulas
US9788771B2 (en) 2006-10-23 2017-10-17 Abbott Diabetes Care Inc. Variable speed sensor insertion devices and methods of use
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
CN101180093B (zh) 2005-03-21 2012-07-18 雅培糖尿病护理公司 用于提供结合的药剂输液以及分析物监测系统的方法和系统
US8744546B2 (en) 2005-05-05 2014-06-03 Dexcom, Inc. Cellulosic-based resistance domain for an analyte sensor
US8112240B2 (en) 2005-04-29 2012-02-07 Abbott Diabetes Care Inc. Method and apparatus for providing leak detection in data monitoring and management systems
US7768408B2 (en) 2005-05-17 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing data management in data monitoring system
US7620437B2 (en) 2005-06-03 2009-11-17 Abbott Diabetes Care Inc. Method and apparatus for providing rechargeable power in data monitoring and management systems
WO2007024649A2 (en) * 2005-08-19 2007-03-01 X-Cell Medical Incorporated Methods of treating and preventing acute myocardial infarction
CA2620586A1 (en) 2005-08-31 2007-03-08 Boris P. Kovatchev Improving the accuracy of continuous glucose sensors
US7756561B2 (en) 2005-09-30 2010-07-13 Abbott Diabetes Care Inc. Method and apparatus for providing rechargeable power in data monitoring and management systems
US7583190B2 (en) 2005-10-31 2009-09-01 Abbott Diabetes Care Inc. Method and apparatus for providing data communication in data monitoring and management systems
US7766829B2 (en) 2005-11-04 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
US20070127745A1 (en) * 2005-12-07 2007-06-07 Cochlear Limited Prevention of static bonding between medical device components
US8344966B2 (en) 2006-01-31 2013-01-01 Abbott Diabetes Care Inc. Method and system for providing a fault tolerant display unit in an electronic device
KR101361376B1 (ko) 2006-03-30 2014-02-10 발레리타스 인코포레이티드 복합-카트리지 유체 전달 장치
US8478557B2 (en) 2009-07-31 2013-07-02 Abbott Diabetes Care Inc. Method and apparatus for providing analyte monitoring system calibration accuracy
US8224415B2 (en) 2009-01-29 2012-07-17 Abbott Diabetes Care Inc. Method and device for providing offset model based calibration for analyte sensor
US9675290B2 (en) 2012-10-30 2017-06-13 Abbott Diabetes Care Inc. Sensitivity calibration of in vivo sensors used to measure analyte concentration
US8219173B2 (en) 2008-09-30 2012-07-10 Abbott Diabetes Care Inc. Optimizing analyte sensor calibration
US8226891B2 (en) 2006-03-31 2012-07-24 Abbott Diabetes Care Inc. Analyte monitoring devices and methods therefor
US7620438B2 (en) 2006-03-31 2009-11-17 Abbott Diabetes Care Inc. Method and system for powering an electronic device
WO2007143225A2 (en) 2006-06-07 2007-12-13 Abbott Diabetes Care, Inc. Analyte monitoring system and method
US8141717B2 (en) * 2006-08-18 2012-03-27 Porex Corporation Sintered polymeric materials and applications thereof
ATE416526T1 (de) * 2006-08-25 2008-12-15 Alcatel Lucent Digitalsignalempfänger mit q-faktorüberwachung
US8579853B2 (en) 2006-10-31 2013-11-12 Abbott Diabetes Care Inc. Infusion devices and methods
US8732188B2 (en) 2007-02-18 2014-05-20 Abbott Diabetes Care Inc. Method and system for providing contextual based medication dosage determination
US8930203B2 (en) 2007-02-18 2015-01-06 Abbott Diabetes Care Inc. Multi-function analyte test device and methods therefor
US8123686B2 (en) 2007-03-01 2012-02-28 Abbott Diabetes Care Inc. Method and apparatus for providing rolling data in communication systems
US8093039B2 (en) * 2007-04-10 2012-01-10 The Trustees Of The Stevens Institute Of Technology Surfaces differentially adhesive to eukaryotic cells and non-eukaryotic cells
US8665091B2 (en) 2007-05-08 2014-03-04 Abbott Diabetes Care Inc. Method and device for determining elapsed sensor life
US8456301B2 (en) 2007-05-08 2013-06-04 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8461985B2 (en) 2007-05-08 2013-06-11 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US7928850B2 (en) 2007-05-08 2011-04-19 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8239166B2 (en) 2007-05-14 2012-08-07 Abbott Diabetes Care Inc. Method and apparatus for providing data processing and control in a medical communication system
US20200037875A1 (en) 2007-05-18 2020-02-06 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
DK2540225T3 (en) 2007-05-30 2015-10-12 Bayer Healthcare Llc A process for producing a multilayer coating
US20090030145A1 (en) * 2007-07-26 2009-01-29 Bayer Materialscience Llc Hydrophilic sealants
US20120046533A1 (en) 2007-08-29 2012-02-23 Medtronic Minimed, Inc. Combined sensor and infusion sets
US9968742B2 (en) 2007-08-29 2018-05-15 Medtronic Minimed, Inc. Combined sensor and infusion set using separated sites
CN101796403B (zh) * 2007-09-07 2014-08-20 东丽株式会社 液体展开用板
US20090088723A1 (en) * 2007-09-28 2009-04-02 Accessclosure, Inc. Apparatus and methods for treating pseudoaneurysms
US8000918B2 (en) * 2007-10-23 2011-08-16 Edwards Lifesciences Corporation Monitoring and compensating for temperature-related error in an electrochemical sensor
US20090247984A1 (en) * 2007-10-24 2009-10-01 Masimo Laboratories, Inc. Use of microneedles for small molecule metabolite reporter delivery
US8417312B2 (en) 2007-10-25 2013-04-09 Dexcom, Inc. Systems and methods for processing sensor data
US7783442B2 (en) * 2007-10-31 2010-08-24 Medtronic Minimed, Inc. System and methods for calibrating physiological characteristic sensors
CA2703840A1 (en) * 2007-11-02 2009-05-07 Edwards Lifesciences Corporation Analyte monitoring system having back-up power source for use in either transport of the system or primary power loss
US8512731B2 (en) * 2007-11-13 2013-08-20 Medtronic Minimed, Inc. Antimicrobial coatings for medical devices and methods for making and using them
US20090188811A1 (en) * 2007-11-28 2009-07-30 Edwards Lifesciences Corporation Preparation and maintenance of sensors
US8290559B2 (en) 2007-12-17 2012-10-16 Dexcom, Inc. Systems and methods for processing sensor data
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
CN102047101A (zh) * 2008-03-28 2011-05-04 德克斯康公司 用于连续的分析物传感器的聚合物膜
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
US20090294302A1 (en) * 2008-05-28 2009-12-03 John Pasqua Use of Alginate to Reduce Hematocrit Bias in Biosensors
EP2154167A1 (de) * 2008-07-30 2010-02-17 Bayer MaterialScience AG Elektromechanischer Wandler mit einem Polymerelement auf Polyisocyanat-Basis
WO2010027771A1 (en) 2008-08-27 2010-03-11 Edwards Lifesciences Corporation Analyte sensor
EP4549933A3 (en) 2008-09-19 2025-05-21 DexCom, Inc. Particle-containing membrane and particulate electrode for analyte sensors
US20100160756A1 (en) * 2008-12-24 2010-06-24 Edwards Lifesciences Corporation Membrane Layer for Electrochemical Biosensor and Method of Accommodating Electromagnetic and Radiofrequency Fields
US8103456B2 (en) 2009-01-29 2012-01-24 Abbott Diabetes Care Inc. Method and device for early signal attenuation detection using blood glucose measurements
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US8560082B2 (en) 2009-01-30 2013-10-15 Abbott Diabetes Care Inc. Computerized determination of insulin pump therapy parameters using real time and retrospective data processing
US9402544B2 (en) 2009-02-03 2016-08-02 Abbott Diabetes Care Inc. Analyte sensor and apparatus for insertion of the sensor
US8467972B2 (en) 2009-04-28 2013-06-18 Abbott Diabetes Care Inc. Closed loop blood glucose control algorithm analysis
WO2010127050A1 (en) 2009-04-28 2010-11-04 Abbott Diabetes Care Inc. Error detection in critical repeating data in a wireless sensor system
US20100278738A1 (en) * 2009-05-04 2010-11-04 Sitzman Thomas J Method to detect and monitor ischemia in transplanted organs and tissues
WO2010138856A1 (en) 2009-05-29 2010-12-02 Abbott Diabetes Care Inc. Medical device antenna systems having external antenna configurations
EP3689237B1 (en) 2009-07-23 2021-05-19 Abbott Diabetes Care, Inc. Method of manufacturing and system for continuous analyte measurement
DK3173014T4 (da) 2009-07-23 2026-03-30 Abbott Diabetes Care Inc Realtidsstyring af data vedrørende fysiologisk kontrol af glucoseniveauer
EP2280034A1 (de) 2009-07-31 2011-02-02 Bayer MaterialScience AG Elektromechanischer Wandler mit einem Polymerelement auf Basis einer Mischung aus Polyisocyanat und Isocyanat-funktionellem Prepolymer und einer Verbindung mit mindestens zwei isocyanatreaktiven Hydroxygruppen
JP5795584B2 (ja) 2009-08-31 2015-10-14 アボット ダイアベティス ケア インコーポレイテッドＡｂｂｏｔｔ Ｄｉａｂｅｔｅｓ Ｃａｒｅ Ｉｎｃ． 医療用装置
WO2011026147A1 (en) 2009-08-31 2011-03-03 Abbott Diabetes Care Inc. Analyte signal processing device and methods
EP2473099A4 (en) 2009-08-31 2015-01-14 Abbott Diabetes Care Inc ANALYTICAL MONITORING SYSTEM AND METHOD FOR POWERFUL AND NOISE MANAGEMENT
US9320461B2 (en) 2009-09-29 2016-04-26 Abbott Diabetes Care Inc. Method and apparatus for providing notification function in analyte monitoring systems
US20110082356A1 (en) 2009-10-01 2011-04-07 Medtronic Minimed, Inc. Analyte sensor apparatuses having interference rejection membranes and methods for making and using them
WO2011051690A2 (en) 2009-11-02 2011-05-05 Ocutec Limited Polymers for contact lenses
GB0919459D0 (en) * 2009-11-06 2009-12-23 Ocutec Ltd Polymer for contact lenses
GB0919411D0 (en) * 2009-11-05 2009-12-23 Ocutec Ltd Polymer for contact lenses
US20110288388A1 (en) 2009-11-20 2011-11-24 Medtronic Minimed, Inc. Multi-conductor lead configurations useful with medical device systems and methods for making and using them
US8660628B2 (en) * 2009-12-21 2014-02-25 Medtronic Minimed, Inc. Analyte sensors comprising blended membrane compositions and methods for making and using them
US10448872B2 (en) 2010-03-16 2019-10-22 Medtronic Minimed, Inc. Analyte sensor apparatuses having improved electrode configurations and methods for making and using them
ES2881798T3 (es) 2010-03-24 2021-11-30 Abbott Diabetes Care Inc Insertadores de dispositivos médicos y procedimientos de inserción y uso de dispositivos médicos
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9215995B2 (en) 2010-06-23 2015-12-22 Medtronic Minimed, Inc. Sensor systems having multiple probes and electrode arrays
US8515540B2 (en) 2011-02-24 2013-08-20 Cochlear Limited Feedthrough having a non-linear conductor
EP3575796B1 (en) 2011-04-15 2020-11-11 DexCom, Inc. Advanced analyte sensor calibration and error detection
US9008744B2 (en) 2011-05-06 2015-04-14 Medtronic Minimed, Inc. Method and apparatus for continuous analyte monitoring
EP2721103A1 (en) 2011-06-15 2014-04-23 Porex Corporation Sintered porous plastic liquid barrier media and applications thereof
CA2840640C (en) 2011-11-07 2020-03-24 Abbott Diabetes Care Inc. Analyte monitoring device and methods
AU2012352560B2 (en) 2011-12-11 2017-01-19 Abbott Diabetes Care Inc. Analyte sensor devices, connections, and methods
WO2013103514A1 (en) 2012-01-04 2013-07-11 The Trustees Of The Stevens Institute Of Technology Clay-containing thin films as carriers of absorbed molecules
US9462970B2 (en) 2012-04-24 2016-10-11 Abbott Diabetes Care Inc. Methods of lag-compensation for analyte measurements, and devices related thereto
EP2863990B1 (en) 2012-06-21 2017-08-09 Neuronano AB Medical microelectrode
US20140012115A1 (en) 2012-07-03 2014-01-09 Medtronic Minimed, Inc. Plasma deposited adhesion promoter layers for use with analyte sensors
US9968306B2 (en) 2012-09-17 2018-05-15 Abbott Diabetes Care Inc. Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems
EP2901153A4 (en) 2012-09-26 2016-04-27 Abbott Diabetes Care Inc METHOD AND DEVICE FOR IMPROVING DELAY CORRECTION FUNCTION DURING IN VIVO MEASUREMENT OF ANALYZ CONCENTRATION WITH ANALYZ CONCENTRATION VARIABILITY AND RANGE DATA
CA2907036A1 (en) 2013-03-15 2014-11-06 Microtech Medical Technologies Ltd. Implantable device with bridge
EP3041568B1 (en) 2013-09-06 2023-04-26 MED-EL Elektromedizinische Geräte GmbH Cochlear implant electrode with liquid metal alloy
EP3041444B1 (en) * 2013-09-06 2023-07-19 Med-El Elektromedizinische Geraete GmbH Electrode contact with hydrogel covering
CN104761697B (zh) * 2014-01-02 2017-12-26 上海移宇科技股份有限公司 一种生物传感器的膜层及制备方法
EP3180082A1 (en) * 2014-08-11 2017-06-21 Cardiac Pacemakers, Inc. Implantable medical device coating for wetting and microbial resistance
US10073188B2 (en) 2014-10-02 2018-09-11 Halliburton Energy Services, Inc. Three-dimensional waveguide sensors for sample analysis
CA2984939A1 (en) 2015-05-14 2016-11-17 Abbott Diabetes Care Inc. Compact medical device inserters and related systems and methods
US10342899B2 (en) 2015-12-19 2019-07-09 Cardiac Pacemakers, Inc. Biologically inert coating for implantable medical devices
US10324058B2 (en) 2016-04-28 2019-06-18 Medtronic Minimed, Inc. In-situ chemistry stack for continuous glucose sensors
WO2017195035A1 (en) 2016-05-10 2017-11-16 Interface Biologics, Inc. Implantable glucose sensors having a biostable surface
US11179078B2 (en) 2016-06-06 2021-11-23 Medtronic Minimed, Inc. Polycarbonate urea/urethane polymers for use with analyte sensors
EP3471787B1 (en) 2016-06-16 2021-08-18 Cardiac Pacemakers, Inc. Hydrophilization and antifouling of enhanced metal surfaces
US10842912B2 (en) 2016-08-09 2020-11-24 Cardiac Pacemakers, Inc. Functionalized PEG for implantable medical devices
WO2018100195A1 (en) 2016-12-02 2018-06-07 Magnamedics Gmbh Method to analyze compounds in biological samples
US11071478B2 (en) 2017-01-23 2021-07-27 Abbott Diabetes Care Inc. Systems, devices and methods for analyte sensor insertion
EP3618712A1 (en) 2017-05-03 2020-03-11 Abbott Diabetes Care Inc. Systems, devices, and methods with duration-based adjustment of sensor data
US11116898B2 (en) 2017-06-26 2021-09-14 Abbott Diabetes Care Inc. Artificial pancreas integrated CGM architectures and designs
EP4218568A1 (en) 2017-08-18 2023-08-02 Abbott Diabetes Care Inc. Analyte monitoring system storing a measured electrical characteristic of the in vivo analyte sensor of the system as individualized calibration information
US11643551B2 (en) * 2017-08-28 2023-05-09 Dsm Ip Assets B.V. Synthetic membrane composition comprising a polyurethane and a polyoxazoline
EP3692086B1 (en) * 2017-10-04 2025-01-22 Hercules LLC Elastic and stretchable gel polymer electrolyte
WO2019112889A1 (en) 2017-12-05 2019-06-13 Abbott Diabetes Care Inc. Medical devices having a dynamic surface profile and methods for production and use thereof
CA3083649A1 (en) 2017-12-11 2019-06-20 Innovative Surface Technologies, Inc. Polyurea copolymer coating compositions and methods
EP3794135A1 (en) 2018-05-16 2021-03-24 Medtronic MiniMed, Inc. Thermally stable glucose limiting membrane for glucose sensors
EP4070730A1 (en) 2018-06-07 2022-10-12 Abbott Diabetes Care, Inc. Focused sterilization and sterilized sub-assemblies for analyte monitoring systems
WO2019236850A1 (en) 2018-06-07 2019-12-12 Abbott Diabetes Care Inc. Focused sterilization and sterilized sub-assemblies for analyte monitoring systems
MX2021007294A (es) 2018-12-21 2021-07-15 Abbott Diabetes Care Inc Sistemas, dispositivos y metodos para la insercion de sensores de analito.
US11619576B2 (en) * 2020-02-18 2023-04-04 International Business Machines Corporation Corrosive substance detection using hydrophilic gel for improved corrosion exposure detection in electronic devices
EP4203819B1 (en) 2020-08-31 2024-07-31 Abbott Diabetes Care Inc. Systems, devices, and methods for analyte sensor insertion
ES3000715T3 (en) 2020-09-15 2025-03-03 Abbott Diabetes Care Inc Device for analyte monitoring
US12576599B2 (en) 2020-09-15 2026-03-17 Abbott Diabetes Care Inc. Systems, devices, and methods for an analyte sensor
US12533080B2 (en) 2020-12-30 2026-01-27 Abbott Diabetes Care Inc. Systems, devices, and methods for analyte monitoring
CA3196957A1 (en) 2020-12-31 2022-07-07 Xuandong Hua Embedded systems in medical monitoring systems
US11998330B2 (en) 2021-01-29 2024-06-04 Medtronic Minimed, Inc. Interference rejection membranes useful with analyte sensors
US20220338768A1 (en) 2021-04-09 2022-10-27 Medtronic Minimed, Inc. Hexamethyldisiloxane membranes for analyte sensors
JP2024527596A (ja) 2021-07-16 2024-07-25 アボット ダイアベティス ケア インコーポレイテッド 検体監視のためのシステム、装置、及び方法
US12201421B2 (en) 2021-10-08 2025-01-21 Medtronic Minimed, Inc. Immunosuppressant releasing coatings
US20240023849A1 (en) 2022-07-20 2024-01-25 Medtronic Minimed, Inc. Acrylate hydrogel membrane for dual function of diffusion limiting membrane as well as attenuation to the foreign body response
CN115141385B (zh) * 2022-07-27 2025-08-26 南京林业大学 一种高强度抗溶胀聚脲超分子水凝胶及其制备方法
US12522853B2 (en) 2022-10-28 2026-01-13 Medtronic Minimed, Inc. Enzyme mediator functionalized polymers for use with analyte sensors
US20240335147A1 (en) 2023-04-05 2024-10-10 Medtronic Minimed, Inc. Analyte transporting membranes for use with analyte sensors
US20250281074A1 (en) 2024-03-07 2025-09-11 Medtronic Minimed, Inc. Sensor membranes for dexamethosone rejection

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4484987A (en) 1983-05-19 1984-11-27 The Regents Of The University Of California Method and membrane applicable to implantable sensor
CA1283872C (en) 1985-02-19 1991-05-07 Steven D. Aust Process for the degradation of environmentally persistent organic compounds
US4890620A (en) 1985-09-20 1990-01-02 The Regents Of The University Of California Two-dimensional diffusion glucose substrate sensing electrode
US4909908A (en) 1986-04-24 1990-03-20 Pepi Ross Electrochemical cncentration detector method
US5214119A (en) 1986-06-20 1993-05-25 Minnesota Mining And Manufacturing Company Block copolymer, method of making the same, dimaine precursors of the same, method of making such diamines and end products comprising the block copolymer
GB2194843A (en) * 1986-09-08 1988-03-16 Cambridge Life Sciences Enzyme electrode membrane and method of making same
US4759828A (en) 1987-04-09 1988-07-26 Nova Biomedical Corporation Glucose electrode and method of determining glucose
US4816130A (en) * 1987-07-02 1989-03-28 Becton, Dickinson And Company Blood electrolyte sensors including crosslinked polyetherurethane membranes
US5128408A (en) 1987-11-16 1992-07-07 Toyo Boseki Kabushiki Kaisha Gas-permeable material with excellent compatibility with blood
US5000955A (en) * 1988-07-29 1991-03-19 Tyndale Plains-Hunter Ltd. Thermally reversible polyurethane hydrogels and cosmetic, biological and medical uses
JPH02298855A (ja) 1989-03-20 1990-12-11 Assoc Univ Inc 固定化酵素とレドックス重合体を用いた電気化学的バイオセンサー
US5320725A (en) * 1989-08-02 1994-06-14 E. Heller & Company Electrode and method for the detection of hydrogen peroxide
GB8918589D0 (en) * 1989-08-15 1989-09-27 Graham Neil B Polymeric compositions
US5108819A (en) 1990-02-14 1992-04-28 Eli Lilly And Company Thin film electrical component
US5165407A (en) 1990-04-19 1992-11-24 The University Of Kansas Implantable glucose sensor
US5334691A (en) * 1990-07-24 1994-08-02 Tyndale Plains-Hunter Ltd. Hydrophilic polyurethanes of improved strength
US5160790A (en) * 1990-11-01 1992-11-03 C. R. Bard, Inc. Lubricious hydrogel coatings
WO1992021976A1 (en) * 1991-06-04 1992-12-10 Fisons Plc Analytical device
US5322063A (en) 1991-10-04 1994-06-21 Eli Lilly And Company Hydrophilic polyurethane membranes for electrochemical glucose sensors
US5238732A (en) 1992-07-16 1993-08-24 Surface Coatings, Inc. Waterproof breathable polyurethane membranes and porous substrates protected therewith
US5208313A (en) 1992-07-16 1993-05-04 Surface Coatings, Inc. Waterproof breathable polyurethane membranes and porous substrates protected therewith
US5239037A (en) 1992-07-16 1993-08-24 Surface Coatings, Inc. Waterproof breathable polyurethane membranes and porous substrates protected therewith
CA2121660A1 (en) * 1993-05-10 1994-11-11 Gregory J. Mann Biostable polyurethane and medical article therefrom
US5484818A (en) * 1993-07-22 1996-01-16 Imperial Chemical Industries Plc Organic aerogels
PT705298E (pt) * 1993-12-01 2002-07-31 Bioartificial Gel Technologies Inc Hidrogel a base de albumina
US5674275A (en) * 1994-04-06 1997-10-07 Graphic Controls Corporation Polyacrylate and polymethacrylate ester based hydrogel adhesives
US5614586A (en) * 1994-04-06 1997-03-25 Graphic Controls Corporation Polyacrylate and Polymethacrylate ester based hydrogel adhesives
ES2173979T3 (es) 1994-11-14 2002-11-01 Bayer Ag Poliuretanos termoplasticos segmentados aleatoriamente como matriz para el analisis electroquimico de iones ca++.
US5882494A (en) * 1995-03-27 1999-03-16 Minimed, Inc. Polyurethane/polyurea compositions containing silicone for biosensor membranes
US5786439A (en) * 1996-10-24 1998-07-28 Minimed Inc. Hydrophilic, swellable coatings for biosensors
US5665222A (en) * 1995-10-11 1997-09-09 E. Heller & Company Soybean peroxidase electrochemical sensor

Also Published As

Publication number Publication date
JP2000502280A (ja) 2000-02-29
CA2238648C (en) 2007-03-13
EP0876604A1 (en) 1998-11-11
CA2238648A1 (en) 1998-04-30
ATE327504T1 (de) 2006-06-15
US20010008931A1 (en) 2001-07-19
WO1998017995A1 (en) 1998-04-30
EP0876604B1 (en) 2006-05-24
DE69735932T2 (de) 2007-01-04
US6462162B2 (en) 2002-10-08
US20030069383A1 (en) 2003-04-10
US6784274B2 (en) 2004-08-31
DK0876604T3 (da) 2006-09-11
US5786439A (en) 1998-07-28
DE69735932D1 (de) 2006-06-29
AU5092198A (en) 1998-05-15

Similar Documents

Publication Publication Date Title
JP3852712B2 (ja) バイオセンサー用の親水性の膨潤性コーティング
US5777060A (en) Silicon-containing biocompatible membranes
US6642015B2 (en) Hydrophilic polymeric material for coating biosensors
US12023155B2 (en) Polycarbonate urea/urethane polymers for use with analyte sensors
JP5781088B2 (ja) ブレンド膜組成物を含む検体センサならびにそれらを製造および使用するための方法
US7687586B2 (en) Biosensor membrane material
CA2860059C (en) Stabilized polymers for use with analyte sensors and methods for making and using them
US12109023B2 (en) Thermally stable glucose limiting membrane for glucose sensors
CA3100384A1 (en) Thermally stable glucose limiting membrane for glucose sensors
WO1998013685A1 (en) Silicon-containing biocompatible membranes
JP4098364B2 (ja) 珪素含有生体適合性膜
CA2238005C (en) Silicon-containing biocompatible membranes
JP2000500691A (ja) 珪素含有生体適合性膜

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20040916

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20040916

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20060801

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20060831

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20090915

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20100915

Year of fee payment: 4

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110915

Year of fee payment: 5

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110915

Year of fee payment: 5

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120915

Year of fee payment: 6

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130915

Year of fee payment: 7

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees