JP3836151B2 - Ｒｎａを添加された抗原提示細胞を用いる癌および病原体感染の治療方法 - Google Patents
Ｒｎａを添加された抗原提示細胞を用いる癌および病原体感染の治療方法 Download PDFInfo
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| DE841396T1 (de) | 1996-10-01 | 1998-09-24 | Geron Corp | Katalytische Untereinheit der menschlichen Telomerase |
| US6475789B1 (en) * | 1996-10-01 | 2002-11-05 | University Technology Corporation | Human telomerase catalytic subunit: diagnostic and therapeutic methods |
| US6251665B1 (en) | 1997-02-07 | 2001-06-26 | Cem Cezayirli | Directed maturation of stem cells and production of programmable antigen presenting dentritic cells therefrom |
| US6228640B1 (en) | 1997-02-07 | 2001-05-08 | Cem Cezayirli | Programmable antigen presenting cell of CD34 lineage |
| US6977073B1 (en) | 1997-02-07 | 2005-12-20 | Cem Cezayirli | Method for stimulating an immune response |
| US20050169898A1 (en) * | 1997-04-15 | 2005-08-04 | Jianlin Gong | Cell fusions and methods of making and using the same |
| US20020041868A1 (en) * | 1997-04-15 | 2002-04-11 | Charles Nicolette | Cell fusions and methods of making and using the same |
| US7413864B2 (en) * | 1997-04-18 | 2008-08-19 | Geron Corporation | Treating cancer using a telomerase vaccine |
| US7622549B2 (en) * | 1997-04-18 | 2009-11-24 | Geron Corporation | Human telomerase reverse transcriptase polypeptides |
| US6977074B2 (en) | 1997-07-10 | 2005-12-20 | Mannkind Corporation | Method of inducing a CTL response |
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| EP1068296B1 (en) | 1998-03-31 | 2011-08-10 | Geron Corporation | Compositions for eliciting an immune response to a telomerase antigen |
| US20030022854A1 (en) * | 1998-06-25 | 2003-01-30 | Dow Steven W. | Vaccines using nucleic acid-lipid complexes |
| US20040247662A1 (en) * | 1998-06-25 | 2004-12-09 | Dow Steven W. | Systemic immune activation method using nucleic acid-lipid complexes |
| FR2785542B1 (fr) * | 1998-11-06 | 2001-02-09 | Pf Medicament | UTILISATION D'UNE PROTEINE OmpA D'ENTEROBACTERIE, POUR LE CIBLAGE SPECIFIQUE D'UNE SUBSTANCE BIOLOGIQUEMENT ACTIVE QUI LUI EST ASSOCIEE VERS LES CELLULES PRESENTATRICES D'ANTIGENES TELLES QUE LES CELLULES DENDRITIQUES HUMAINES |
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| US7015204B1 (en) * | 1999-10-07 | 2006-03-21 | Cornell Research Foundation, Inc. | Protective immunity or immunological tolerance induced with RNA particularly total cellular RNA |
| US7541184B2 (en) | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US6783939B2 (en) * | 2000-07-07 | 2004-08-31 | Alphavax, Inc. | Alphavirus vectors and virosomes with modified HIV genes for use in vaccines |
| EP1436413A2 (en) * | 2000-10-24 | 2004-07-14 | Whitehead Institute For Biomedical Research | Response of dendritic cells to a diverse set of pathogens |
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| DE10112851C1 (de) | 2001-03-16 | 2002-10-10 | Gsf Forschungszentrum Umwelt | Semi-allogene Antitumor-Vakzine mit HLA-haplo-identischen Antigen-präsentierenden Zellen |
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| GB0111015D0 (en) * | 2001-05-04 | 2001-06-27 | Norsk Hydro As | Genetic material |
| ES2340499T3 (es) | 2001-06-05 | 2010-06-04 | Curevac Gmbh | Arnm de antigeno tumoral estabilizado con un contenido de g/c aumentado. |
| DE60233061D1 (de) * | 2001-09-06 | 2009-09-03 | Alphavax Inc | Alphavirus replikon-vektorsysteme |
| JP2005526001A (ja) * | 2001-10-04 | 2005-09-02 | アグイラルーコルドバ，カリオス，エスツアルド | 遺伝子療法用キメラ型ウイルスベクター |
| DE10162480A1 (de) | 2001-12-19 | 2003-08-07 | Ingmar Hoerr | Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen |
| WO2004004751A1 (en) * | 2002-07-05 | 2004-01-15 | Duke University | Angio-immunotherapy |
| AU2003278709A1 (en) * | 2002-08-14 | 2004-03-03 | Duke University | Method of enhancing cd4+ t cell responses |
| EP2261249B1 (en) | 2002-09-12 | 2015-02-11 | Oncotherapy Science, Inc. | KDR peptides and vaccines comprising the same |
| AU2003296439B2 (en) * | 2002-12-10 | 2009-05-07 | Argos Therapeutics, Inc. | In situ maturation of dendritic cells |
| WO2004055166A2 (en) | 2002-12-13 | 2004-07-01 | Alphavax, Inc. | Multi-antigenic alphavirus replicon particles and methods |
| EP1590451B1 (en) * | 2002-12-13 | 2015-09-16 | Alphavax, Inc. | Alphavirus particles and methods for preparation |
| US20040214333A1 (en) * | 2003-02-18 | 2004-10-28 | Maxcyte, Inc. | Loading of cells with antigens by electroporation |
| EP1641927B1 (en) | 2003-02-18 | 2015-07-08 | Baylor College of Medicine | Induced activation in dendritic cells |
| US20060134067A1 (en) * | 2003-02-18 | 2006-06-22 | Maxcyte, Inc. | Loading of cells with antigens by electroporation |
| US7442381B2 (en) * | 2003-03-20 | 2008-10-28 | Alphavax, Inc. | Alphavirus replicons and helper constructs |
| WO2005007689A1 (en) * | 2003-07-11 | 2005-01-27 | Alphavax, Inc. | Alphavirus-based cytomegalovirus vaccines |
| DE10335833A1 (de) * | 2003-08-05 | 2005-03-03 | Curevac Gmbh | Transfektion von Blutzellen mit mRNA zur Immunstimulation und Gentherapie |
| WO2005052128A2 (en) * | 2003-11-25 | 2005-06-09 | Argos Therapeutics, Inc. | Mrna transfected antigen presenting cells |
| US20050181035A1 (en) * | 2004-02-17 | 2005-08-18 | Dow Steven W. | Systemic immune activation method using non CpG nucleic acids |
| WO2005084387A2 (en) * | 2004-03-02 | 2005-09-15 | Tsuneya Ohno | Methods and compositions for hybrid cell vaccines for the treatment and prevention of cancer |
| CA2567254C (en) | 2004-05-18 | 2012-03-13 | Alphavax, Inc. | Tc-83-derived alphavirus vectors, particles and methods |
| WO2005116261A2 (en) * | 2004-05-24 | 2005-12-08 | Albert Einstein College Of Medecine Of Yeshiva University | Rna expression microarrays |
| CA2504451A1 (en) * | 2004-08-10 | 2006-02-10 | Geron Corporation | Dendritic cell vaccines for treating cancer made from embryonic stem cells |
| EP2742951B1 (en) | 2004-09-14 | 2016-02-03 | Argos Therapeutics, Inc. | Strain independent amplification of HIV polynucleotides |
| US8076132B2 (en) | 2004-09-17 | 2011-12-13 | Hasumi International Research Foundation | Dendritic cell tumor injection (DCTI) therapy |
| US20060216269A1 (en) * | 2004-09-17 | 2006-09-28 | Kenichiro Hasumi | Dendritic cell tumor injection (DCTI) therapy |
| GB0501129D0 (en) * | 2005-01-19 | 2005-02-23 | Ribostem Ltd | Method of treatment by administration of RNA |
| ES2459492T3 (es) | 2005-02-25 | 2014-05-09 | Oncotherapy Science, Inc. | Vacunas de péptidos para cánceres de pulmón que expresan polipéptidos TTK, URLC10 o KOC1 |
| EP2289533B1 (en) | 2005-02-28 | 2013-09-18 | Oncotherapy Science, Inc. | Epitope peptides derived from vascular endothelial growth factor receptor 1 and vaccines containing these peptides |
| EP1882031B1 (en) | 2005-04-08 | 2017-11-08 | Argos Therapeutics, Inc. | Dendritic cell compositions and methods |
| CA2616497C (en) | 2005-07-27 | 2016-06-07 | Oncotherapy Science, Inc. | Colon cancer related gene tom34 |
| WO2007047764A2 (en) | 2005-10-17 | 2007-04-26 | Sloan Kettering Institute For Cancer Research | Wt1 hla class ii-binding peptides and compositions and methods comprising same |
| ES2591029T3 (es) | 2006-04-10 | 2016-11-24 | Sloan Kettering Institute For Cancer Research | Péptidos WT-1 inmunogénicos y métodos para su uso |
| WO2007120863A2 (en) | 2006-04-14 | 2007-10-25 | Epicentre Technologies | Kits and methods for generating 5' capped rna |
| JP5570808B2 (ja) | 2006-08-18 | 2014-08-13 | アルゴス・セラピューティクス・インコーポレーテッド | 併用療法におけるｃｄ８３の使用 |
| SG175566A1 (en) | 2006-10-17 | 2011-11-28 | Oncotherapy Science Inc | Peptide vaccines for cancers expressing mphosph1 or depdc1 polypeptides |
| EP2076272B1 (en) * | 2006-10-19 | 2015-07-29 | Baylor College Of Medicine | Generating an immune response by inducing cd40 and pattern recognition receptors |
| WO2008055354A1 (en) * | 2006-11-10 | 2008-05-15 | Université de Montréal | Rna-loaded dendritic cell compositions for eliciting cd4+ t cell help and related methods |
| TWI596109B (zh) | 2007-02-21 | 2017-08-21 | 腫瘤療法 科學股份有限公司 | 表現腫瘤相關抗原之癌症的胜肽疫苗 |
| TW201425333A (zh) | 2007-04-11 | 2014-07-01 | Oncotherapy Science Inc | 腫瘤血管內皮標誌８胜肽及包含此胜肽之疫苗 |
| PL2947149T3 (pl) * | 2007-06-21 | 2018-09-28 | Alphavax, Inc. | Kasety bez promotora do ekspresji alfawirusowych białek strukturalnych |
| CN104774261B (zh) | 2007-08-20 | 2018-03-06 | 肿瘤疗法科学股份有限公司 | Foxm1 肽和包含foxm1 肽的药剂 |
| WO2009108341A1 (en) | 2008-02-28 | 2009-09-03 | Argos Therapeutics, Inc. | Transient expression of immunomodulatory polypeptides for the prevention and treatment of autoimmune disease, allergy and transplant rejection |
| EP3156069B8 (en) | 2008-06-20 | 2020-10-21 | Duke University | Compositions, methods, and kits for eliciting an immune response |
| EP3238739B1 (en) * | 2008-09-22 | 2020-10-21 | Baylor College of Medicine | Methods and compositions for generating an immune response by inducing cd40 and pattern recognition receptor adapters |
| DK2352756T3 (da) | 2008-11-24 | 2012-12-03 | Helmholtz Zentrum Muenchen | Højaffin T-cellereceptor og anvendelse af denne |
| TWI500932B (zh) | 2008-12-05 | 2015-09-21 | Oncotherapy Science Inc | Ｗｄｒｐｕｈ抗原決定位胜肽以及含此胜肽之疫苗 |
| WO2010065876A2 (en) | 2008-12-06 | 2010-06-10 | The Board Of Regents Of The University Of Texas System | Methods and compositions related to th-1 dendritic cells |
| TWI469791B (zh) | 2009-02-18 | 2015-01-21 | Oncotherapy Science Inc | Ｆｏｘｍ１胜肽以及含此胜肽之疫苗 |
| US9841426B2 (en) * | 2009-03-11 | 2017-12-12 | Marker Gene Technologies, Inc | Intracellular organelle peptide targeted enzyme substrates |
| ES2617434T3 (es) | 2009-03-18 | 2017-06-19 | Oncotherapy Science, Inc. | Péptidos NEIL3 y vacunas que incluyen los mismos |
| TWI507204B (zh) | 2009-05-26 | 2015-11-11 | Oncotherapy Science Inc | Ｃｄｃ４５ｌ胜肽與含此胜肽之疫苗 |
| TW201136604A (en) | 2009-12-14 | 2011-11-01 | Oncotherapy Science Inc | TMEM22 peptides and vaccines including the same |
| MX344579B (es) | 2010-03-11 | 2016-12-19 | Oncotherapy Science Inc * | Peptidos hjurp y vacunas que incluyen los mismos. |
| TWI538685B (zh) | 2010-04-02 | 2016-06-21 | 腫瘤療法 科學股份有限公司 | Ｅｃｔ２胜肽及含此胜肽之疫苗 |
| US9089520B2 (en) | 2010-05-21 | 2015-07-28 | Baylor College Of Medicine | Methods for inducing selective apoptosis |
| US8822663B2 (en) | 2010-08-06 | 2014-09-02 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| HUE058896T2 (hu) | 2010-10-01 | 2022-09-28 | Modernatx Inc | N1-metil-pszeudo-uracilt tartalmazó ribonukleinsavak és azok felhasználásai |
| DE12722942T1 (de) | 2011-03-31 | 2021-09-30 | Modernatx, Inc. | Freisetzung und formulierung von manipulierten nukleinsäuren |
| EP2557089A2 (en) | 2011-07-15 | 2013-02-13 | Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Compositions and methods for immunomodulation |
| ES2647900T3 (es) | 2011-08-12 | 2017-12-27 | Oncotherapy Science, Inc. | Péptidos MPHOSPH1 y vacunas que incluyen los mismos |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| LT3682905T (lt) | 2011-10-03 | 2022-02-25 | Modernatx, Inc. | Modifikuoti nukleozidai, nukleotidai ir nukleorūgštys bei jų naudojimas |
| CA3122778A1 (en) | 2011-10-28 | 2013-05-02 | Oncotherapy Science, Inc. | Topk peptides and vaccines including the same |
| PT2791160T (pt) | 2011-12-16 | 2022-07-04 | Modernatx Inc | Composições arnm modificado |
| AU2013207669C1 (en) | 2012-01-13 | 2018-05-31 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| WO2013151664A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| EP2872530A4 (en) | 2012-07-10 | 2016-04-06 | Oncotherapy Science Inc | KIF20A EPITOPE PEPTIDES FOR TH1 CELLS AND VACCINES CONTAINING SAME |
| US9597380B2 (en) | 2012-11-26 | 2017-03-21 | Modernatx, Inc. | Terminally modified RNA |
| HRP20201867T1 (hr) | 2013-01-15 | 2021-02-05 | Memorial Sloan Kettering Cancer Center | Imunogeni wt-1 peptidi i postupci za njihovu uporabu |
| US10815273B2 (en) | 2013-01-15 | 2020-10-27 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
| US9434935B2 (en) | 2013-03-10 | 2016-09-06 | Bellicum Pharmaceuticals, Inc. | Modified caspase polypeptides and uses thereof |
| TWI658049B (zh) | 2013-03-12 | 2019-05-01 | 腫瘤療法 科學股份有限公司 | Ｋｎｔｃ２胜肽及含此胜肽之疫苗 |
| US9944690B2 (en) | 2013-03-14 | 2018-04-17 | Bellicum Pharmaceuticals, Inc. | Methods for controlling T cell proliferation |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US9913882B2 (en) | 2013-06-05 | 2018-03-13 | Bellicum Pharmaceuticals, Inc. | Methods for inducing partial apoptosis using caspase polypeptides |
| HK1226299A1 (zh) | 2013-09-24 | 2017-09-29 | Duke University | 用於诱发免疫反应的组合物、方法及工具 |
| EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
| SG11201602503TA (en) | 2013-10-03 | 2016-04-28 | Moderna Therapeutics Inc | Polynucleotides encoding low density lipoprotein receptor |
| WO2015062738A1 (en) | 2013-11-01 | 2015-05-07 | Curevac Gmbh | Modified rna with decreased immunostimulatory properties |
| US10934346B2 (en) | 2014-02-14 | 2021-03-02 | Bellicum Pharmaceuticals, Inc. | Modified T cell comprising a polynucleotide encoding an inducible stimulating molecule comprising MyD88, CD40 and FKBP12 |
| US12214038B2 (en) * | 2014-07-22 | 2025-02-04 | The Trustees Of The University Of Pennsylvania | Compositions and methods for cancer immunotherapy |
| CA2956132A1 (en) | 2014-08-04 | 2016-02-11 | Oncotherapy Science, Inc. | Cdca1-derived peptide and vaccine containing same |
| AU2015300260B2 (en) | 2014-08-04 | 2020-01-02 | Oncotherapy Science, Inc. | URLC10-derived peptide and vaccine containing same |
| CN111925414B (zh) | 2014-08-04 | 2025-04-18 | 肿瘤疗法科学股份有限公司 | Koc1衍生的肽和包含它们的疫苗 |
| EP3189148A4 (en) | 2014-09-02 | 2018-05-02 | Bellicum Pharmaceuticals, Inc. | Costimulation of chimeric antigen receptors by myd88 and cd40 polypeptides |
| CN113791208B (zh) * | 2014-09-17 | 2024-09-24 | 约翰·霍普金斯大学 | 用于识别、富集和/或扩增抗原特异性t细胞的试剂和方法 |
| ES2897731T3 (es) | 2014-10-27 | 2022-03-02 | Hutchinson Fred Cancer Res | Composiciones y métodos para reforzar la eficacia de la inmunoterapia celular adoptiva |
| ES2904301T3 (es) | 2014-11-03 | 2022-04-04 | Academisch Ziekenhuis Leiden H O D N Leids Univ Medisch Centrum | Receptores de células T dirigidos contra Bob1 y usos de los mismos |
| JP2018090491A (ja) * | 2015-04-01 | 2018-06-14 | 株式会社細胞治療技術研究所 | 癌ワクチンの製造方法、及び癌ワクチン |
| US11090332B2 (en) * | 2015-05-21 | 2021-08-17 | Regen BioPharma, Inc. | Antigen specific mRNA cellular cancer vaccines |
| JP6666094B2 (ja) * | 2015-09-15 | 2020-03-13 | 株式会社東芝 | 吸着支持装置、および物品把持装置 |
| WO2017061523A1 (ja) | 2015-10-08 | 2017-04-13 | オンコセラピー・サイエンス株式会社 | Ｆｏｘｍ１由来ペプチドおよびそれを含むワクチン |
| US11780934B2 (en) | 2016-02-05 | 2023-10-10 | Institut Pasteur | Use of inhibitors of ADAM12 as adjuvants in tumor therapies |
| JP7033549B2 (ja) | 2016-05-04 | 2022-03-10 | フレッド ハッチンソン キャンサー リサーチ センター | 細胞に基づくネオ抗原ワクチンおよびその使用 |
| CN109414023A (zh) * | 2016-06-29 | 2019-03-01 | 杜克大学 | 用嵌合脊髓灰质炎病毒激活抗原呈递细胞的组合物和方法 |
| CN111818940A (zh) * | 2018-01-05 | 2020-10-23 | 安德烈亚斯·罗尔夫-乔纳斯·尼尔森 | 用作疫苗的内源性肿瘤衍生的环状rna及其蛋白质 |
| TW202023581A (zh) | 2018-08-02 | 2020-07-01 | 日商腫瘤療法 科學股份有限公司 | 來自cdca1的胜肽及含有此的疫苗 |
| US20250144143A1 (en) * | 2023-11-06 | 2025-05-08 | Immunitybio, Inc. | Virally Educated T cells |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4918164A (en) * | 1987-09-10 | 1990-04-17 | Oncogen | Tumor immunotherapy using anti-idiotypic antibodies |
| US5256536A (en) | 1990-11-09 | 1993-10-26 | Syntex (U.S.A.) Inc. | Nucleotide probe for Neisseria gonrrhoeae |
| US5662907A (en) * | 1992-08-07 | 1997-09-02 | Cytel Corporation | Induction of anti-tumor cytotoxic T lymphocytes in humans using synthetic peptide epitopes |
| JPH08502244A (ja) | 1992-08-11 | 1996-03-12 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 免疫調節ペプチド |
| US6696061B1 (en) * | 1992-08-11 | 2004-02-24 | President And Fellows Of Harvard College | Immunomodulatory peptides |
| DE4233430A1 (de) * | 1992-10-05 | 1994-04-07 | Basf Ag | Verfahren zur Herstellung von 4-Hydroxymethyltetrahydropyran |
| US5830877A (en) | 1993-08-26 | 1998-11-03 | The Regents Of The University Of California | Method, compositions and devices for administration of naked polynucleotides which encode antigens and immunostimulatory |
| PT765386E (pt) * | 1994-06-14 | 2015-02-06 | Univ Leland Stanford Junior | Processos para a activação in vivo de células t, através de células dendríticas pulsadas com antigénio |
| US5827642A (en) * | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| US5831068A (en) | 1995-08-21 | 1998-11-03 | Duke University | Method to increase the density of antigen on antigen presenting cells |
| US5853719A (en) * | 1996-04-30 | 1998-12-29 | Duke University | Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA |
| US6130087A (en) * | 1996-10-07 | 2000-10-10 | Fordham University | Methods for generating cytotoxic T cells in vitro |
| US6228640B1 (en) * | 1997-02-07 | 2001-05-08 | Cem Cezayirli | Programmable antigen presenting cell of CD34 lineage |
| US6831068B2 (en) * | 2002-02-13 | 2004-12-14 | Abbott Laboratories | Macrolide antibacterial compounds |
| DE102004055330A1 (de) | 2004-11-16 | 2006-05-24 | Bosch Rexroth Aktiengesellschaft | Verfahren und Vorrichtung zum Betreiben eines Netzwerkes |
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