JP3822167B2 - アテローム性動脈硬化症を改善する経口投与ペプチド - Google Patents

アテローム性動脈硬化症を改善する経口投与ペプチド Download PDF

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JP3822167B2
JP3822167B2 JP2002520844A JP2002520844A JP3822167B2 JP 3822167 B2 JP3822167 B2 JP 3822167B2 JP 2002520844 A JP2002520844 A JP 2002520844A JP 2002520844 A JP2002520844 A JP 2002520844A JP 3822167 B2 JP3822167 B2 JP 3822167B2
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peptide
peptides
group
ldl
atherosclerosis
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JP2004506693A5 (enExample
JP2004506693A (ja
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フォーゲルマン、アラン、エム．
アナンサラマイア、ガッタダーリ、エム．
ナバブ、モハマド
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University of California
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University of California
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P31/14—Antivirals for RNA viruses
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
JP2002520844A 2000-08-24 2001-08-23 アテローム性動脈硬化症を改善する経口投与ペプチド Expired - Lifetime JP3822167B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/645,454 US6664230B1 (en) 2000-08-24 2000-08-24 Orally administered peptides to ameliorate atherosclerosis
PCT/US2001/026497 WO2002015923A1 (en) 2000-08-24 2001-08-23 Orally administered peptides to ameliorate atherosclerosis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2005304531A Division JP4205713B2 (ja) 2000-08-24 2005-10-19 アテローム性動脈硬化症を改善する経口投与ペプチド

Publications (3)

Publication Number Publication Date
JP2004506693A JP2004506693A (ja) 2004-03-04
JP2004506693A5 JP2004506693A5 (enExample) 2006-01-05
JP3822167B2 true JP3822167B2 (ja) 2006-09-13

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Application Number Title Priority Date Filing Date
JP2002520844A Expired - Lifetime JP3822167B2 (ja) 2000-08-24 2001-08-23 アテローム性動脈硬化症を改善する経口投与ペプチド
JP2005304531A Expired - Lifetime JP4205713B2 (ja) 2000-08-24 2005-10-19 アテローム性動脈硬化症を改善する経口投与ペプチド
JP2006220831A Expired - Lifetime JP4364222B2 (ja) 2000-08-24 2006-08-14 アテローム性動脈硬化症を改善する経口投与ペプチド
JP2007118451A Withdrawn JP2007277250A (ja) 2000-08-24 2007-04-27 アテローム性動脈硬化症を改善する経口投与ペプチド
JP2007250264A Pending JP2008150358A (ja) 2000-08-24 2007-09-26 アテローム性動脈硬化症を改善する経口投与ペプチド
JP2010203789A Expired - Lifetime JP5241790B2 (ja) 2000-08-24 2010-09-10 アテローム性動脈硬化症を改善する経口投与ペプチド

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2005304531A Expired - Lifetime JP4205713B2 (ja) 2000-08-24 2005-10-19 アテローム性動脈硬化症を改善する経口投与ペプチド
JP2006220831A Expired - Lifetime JP4364222B2 (ja) 2000-08-24 2006-08-14 アテローム性動脈硬化症を改善する経口投与ペプチド
JP2007118451A Withdrawn JP2007277250A (ja) 2000-08-24 2007-04-27 アテローム性動脈硬化症を改善する経口投与ペプチド
JP2007250264A Pending JP2008150358A (ja) 2000-08-24 2007-09-26 アテローム性動脈硬化症を改善する経口投与ペプチド
JP2010203789A Expired - Lifetime JP5241790B2 (ja) 2000-08-24 2010-09-10 アテローム性動脈硬化症を改善する経口投与ペプチド

Country Status (15)

Country Link
US (2) US6664230B1 (enExample)
EP (3) EP1318828B1 (enExample)
JP (6) JP3822167B2 (enExample)
CN (6) CN1943781B (enExample)
AT (2) ATE506958T1 (enExample)
AU (4) AU2001286732B2 (enExample)
CA (3) CA2639651C (enExample)
CY (1) CY1110204T1 (enExample)
DE (2) DE60141842D1 (enExample)
DK (1) DK1318828T3 (enExample)
EA (2) EA009528B1 (enExample)
ES (2) ES2342258T3 (enExample)
IL (3) IL154545A0 (enExample)
PT (1) PT1318828E (enExample)
WO (1) WO2002015923A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7531514B2 (en) 2000-08-24 2009-05-12 The Regents Of The University Of California Orally administered peptides synergize statin activity
US7579319B2 (en) 2004-12-06 2009-08-25 The Regents Of The University Of California Methods for improving the structure and function of arterioles
US8048851B2 (en) 2000-08-24 2011-11-01 The Regents Of The University Of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response

Families Citing this family (88)

* Cited by examiner, † Cited by third party
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US8568766B2 (en) 2000-08-24 2013-10-29 Gattadahalli M. Anantharamaiah Peptides and peptide mimetics to treat pathologies associated with eye disease
US7148197B2 (en) * 2000-08-24 2006-12-12 The Regents Of The University Of California Orally administered small peptides synergize statin activity
US7166578B2 (en) * 2000-08-24 2007-01-23 The Regents Of The University Of California Orally administered peptides synergize statin activity
US6664230B1 (en) * 2000-08-24 2003-12-16 The Regents Of The University Of California Orally administered peptides to ameliorate atherosclerosis
US7144862B2 (en) * 2000-08-24 2006-12-05 The Regents Of The University Of California Orally administered peptides to ameliorate atherosclerosis
US6930085B2 (en) * 2002-04-05 2005-08-16 The Regents Of The University Of California G-type peptides to ameliorate atherosclerosis
DE10222234A1 (de) * 2002-05-16 2003-11-27 Roche Diagnostics Gmbh Kontroll- und Kalibrationsmaterial für Blutgerinnungstests
WO2004041179A2 (en) * 2002-10-30 2004-05-21 The United States Of America As Represented By The Secretary Of Health And Human Services, Nih Scavenger receptor b1 (cla-1) targeting for the treatment of infection, sepsis and inflammation
EP1599173B1 (en) * 2002-11-13 2017-02-22 The Uab Research Foundation Synthetic single domain polypeptides mimicking apolipoprotein e and methods of use
US20050159362A1 (en) * 2003-04-22 2005-07-21 Sircar Jagadish C. Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia
MXJL05000046A (es) * 2003-04-22 2005-12-22 Avanir Pharmaceuticals Mediadores de transporte reverso de colesterol para el tratamiento de hipercolesterolemia.
GB0311081D0 (en) * 2003-05-14 2003-06-18 Btg Internat Limted Treatment of neurodegenerative conditions
FI20060154A7 (fi) * 2003-08-18 2006-05-11 Btg Int Ltd Neurogeneratiivisten tilojen hoito
US7781219B2 (en) 2003-12-05 2010-08-24 The Cleveland Clinic Foundation Risk markers for cardiovascular disease
GB0329958D0 (en) 2003-12-24 2004-01-28 Univ Manchester Treatment of viral infections
GB0404374D0 (en) 2004-02-27 2004-03-31 Univ Manchester Treatment of bacterial infections
CA2776927C (en) * 2004-04-15 2014-08-12 Athera Biotechnologies Ab Phosphorylcholine conjugates and corresponding antibodies
EP1750862B1 (en) * 2004-06-04 2011-01-05 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing irbesartan
MXJL06000068A (es) * 2004-06-09 2007-04-10 Avanir Pharmaceuticals Mediadores del transporte inverso de colesterol para el tratamiento de hipercolesterolemia.
EP1753733A1 (en) * 2004-06-09 2007-02-21 Avanir Pharmaceuticals Small molecules for treatment of hypercholesterolemia and related diseases
WO2005123686A1 (en) * 2004-06-09 2005-12-29 Avanir Pharmaceuticals Heterocyclic derivatives for treatment of hyperlipidemia and related diseases
BRPI0513402A (pt) * 2004-07-16 2008-05-06 Tufts College miméticos de apolipoproteìna a1 e usos dos mesmos
WO2006020498A2 (en) * 2004-08-11 2006-02-23 The Cleveland Clinic Foundation Therapeutic agents and methods for cardiovascular disease
CA2577026A1 (en) * 2004-08-11 2006-02-23 The Regents Of The University Of California Orally administered small peptides synergize statin activity
US20060205669A1 (en) * 2004-09-16 2006-09-14 The Regents Of The University Of California G-type peptides and other agents to ameliorate atherosclerosis and other pathologies
WO2006053754A1 (en) * 2004-11-19 2006-05-26 Novartis Ag COMBINATIONS OF ANTI-ATHEROSCLEROTIC PEPTIDES AND AN mTOR INHIBITING AGENT AND THEIR METHODS OF USE
GB0425932D0 (en) * 2004-11-25 2004-12-29 Btg Int Ltd Structured phospholipids
GB0504333D0 (en) * 2005-03-02 2005-04-06 Btg Int Ltd Treatment of cytokine dysregulation
GB0504362D0 (en) * 2005-03-02 2005-04-06 Btg Int Ltd Cytokine modulators
US8206750B2 (en) 2005-03-24 2012-06-26 Cerenis Therapeutics Holding S.A. Charged lipoprotein complexes and their uses
EA200900786A1 (ru) 2005-04-29 2009-10-30 Зе Риджентс Оф Зи Юнивесити Оф Кэлифонье Пептид в качестве лекарственного средства и способ лечения патологий, связанных с воспалительными процессами, посредством пептида
US20080293639A1 (en) * 2005-04-29 2008-11-27 The Regents Of The University Of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
GR1005428B (el) * 2005-05-27 2007-02-01 Χαραλαμπος Αλεξοπουλος Συνθετικα λιποπεπτιδια με αντιαθηρογονο δραση, που εμποδιζουν την οξειδωση της λιποπρωτεϊνης χαμηλης πυκνοτητας (ldl) και αναστελλουν την απενεργοποιηση του ενζυμου της paf ακετυλοϋδρολασης (paf-ah)
GB0513096D0 (en) * 2005-06-28 2005-08-03 Strathclyde Treatment of microbial infections
WO2007055873A2 (en) * 2005-11-04 2007-05-18 Avanir Pharmaceuticals Process for the manufacture of peptide facilitators of reverse cholesterol transport
WO2007059372A2 (en) * 2005-11-09 2007-05-24 St. Jude Children's Research Hospital Use of chloroquine to treat metabolic syndrome
US8163699B2 (en) * 2006-06-01 2012-04-24 Montreal Heart Institute Method for the treatment of valvular disease
US20080227686A1 (en) * 2006-06-16 2008-09-18 Lipid Sciences, Inc. Novel Peptides that Promote Lipid Efflux
EP2041174A2 (en) * 2006-06-16 2009-04-01 Lipid Sciences, Inc. Novel peptides that promote lipid efflux
US20080206142A1 (en) * 2006-06-16 2008-08-28 Lipid Sciences, Inc. Novel Peptides That Promote Lipid Efflux
EP2049137A4 (en) * 2006-08-08 2013-05-01 Univ California SALICYLANILIDES AS AMPLIFIERS OF THE ORAL RELEASE OF THERAPEUTIC PEPTIDES
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