JP3761898B2 - 生体特異性二光子励起蛍光検出方法およびそのための装置 - Google Patents

生体特異性二光子励起蛍光検出方法およびそのための装置 Download PDF

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JP3761898B2
JP3761898B2 JP52523798A JP52523798A JP3761898B2 JP 3761898 B2 JP3761898 B2 JP 3761898B2 JP 52523798 A JP52523798 A JP 52523798A JP 52523798 A JP52523798 A JP 52523798A JP 3761898 B2 JP3761898 B2 JP 3761898B2
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reaction
concentration
analyte
laser beam
time
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JP2001506750A5 (enExample
JP2001506750A (ja
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ソイニ，エルッキ
ハンニネン，ペッカ
ソイニ，ユハニ
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Priority claimed from FI971626A external-priority patent/FI104585B/fi
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/557—Immunoassay; Biospecific binding assay; Materials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
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  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP52523798A 1996-12-03 1997-11-18 生体特異性二光子励起蛍光検出方法およびそのための装置 Expired - Lifetime JP3761898B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FI964826A FI104586B (fi) 1996-12-03 1996-12-03 Menetelmä bioaffiniteettireaktion reaaliaikaista seuraamista varten
FI964826 1996-12-03
FI971626A FI104585B (fi) 1997-04-17 1997-04-17 Menetelmä bioaffiniteettimäärityksen dynamiikan laajentamiseksi
FI971626 1997-04-17
PCT/FI1997/000704 WO1998025143A1 (en) 1996-12-03 1997-11-18 Biospecific, two photon excitation, fluorescence detection and device

Publications (3)

Publication Number Publication Date
JP2001506750A JP2001506750A (ja) 2001-05-22
JP2001506750A5 JP2001506750A5 (enExample) 2004-10-28
JP3761898B2 true JP3761898B2 (ja) 2006-03-29

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JP52523798A Expired - Lifetime JP3761898B2 (ja) 1996-12-03 1997-11-18 生体特異性二光子励起蛍光検出方法およびそのための装置

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US (1) US6361956B1 (enExample)
EP (1) EP0968425B1 (enExample)
JP (1) JP3761898B2 (enExample)
AU (1) AU5054198A (enExample)
DE (1) DE69723111T2 (enExample)
WO (1) WO1998025143A1 (enExample)

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US6376843B1 (en) * 1999-06-23 2002-04-23 Evotec Oai Ag Method of characterizing fluorescent molecules or other particles using generating functions
DE19935766A1 (de) * 1999-07-29 2001-02-01 Friedrich Schiller Uni Jena Bu Verfahren zur optischen Anregung von Fluorophor-markierter DNA und RNA
US7008559B2 (en) * 2001-06-06 2006-03-07 Nomadics, Inc. Manganese doped upconversion luminescence nanoparticles
US7501092B2 (en) * 2001-06-06 2009-03-10 Nomadics, Inc. Manganese doped upconversion luminescence nanoparticles
JP4340149B2 (ja) 2001-07-02 2009-10-07 アークティク ダイアグノスティックス オサケユイチア 二光子吸収ジピロメテンボロンジフルオリド色素およびそれらの適用
US7067072B2 (en) * 2001-08-17 2006-06-27 Nomadics, Inc. Nanophase luminescence particulate material
US7054759B2 (en) * 2001-12-27 2006-05-30 Arkray, Inc Concentration measuring method
US20070189359A1 (en) * 2002-06-12 2007-08-16 Wei Chen Nanoparticle thermometry and pressure sensors
GB2402475A (en) * 2003-06-04 2004-12-08 Inverness Medical Switzerland Analyte assay reading providing prompt result declaration
US7239394B2 (en) 2003-06-04 2007-07-03 Inverness Medical Switzerland Gmbh Early determination of assay results
US7315378B2 (en) 2003-06-04 2008-01-01 Inverness Medical Switzerland Gmbh Optical arrangement for assay reading device
US7317532B2 (en) 2003-06-04 2008-01-08 Inverness Medical Switzerland Gmbh Flow sensing for determination of assay results
GB2450351B (en) 2007-06-20 2012-01-18 Cozart Bioscience Ltd Monitoring an Immunoassay
ITUD20080162A1 (it) * 2008-07-08 2010-01-09 Alifax Spa Procedimento e relativa apparecchiatura per l'esecuzione di analisi diagnostiche
GB2474224A (en) * 2009-07-07 2011-04-13 Toximet Ltd Devices and methods using fluorescent polymers in solid phase extraction
WO2011149525A1 (en) 2010-05-25 2011-12-01 Arryx, Inc. Holographic fluctuation microscopy apparatus and method for determining mobility of particle and/or cell dispersions
US8828329B2 (en) 2010-10-01 2014-09-09 Church & Dwight, Co., Inc. Electronic analyte assaying device
FI20115285A0 (fi) * 2011-03-24 2011-03-24 Reagena Ltd Oy Menetelmä pikatestin suorittamiseksi
US9588113B2 (en) 2012-02-22 2017-03-07 Church & Dwight Co., Inc. Methods for electronic analyte assaying
EP3237906B8 (en) 2014-12-23 2020-10-28 Bluelight Therapeutics, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection
FI20165148A7 (fi) * 2016-02-25 2017-08-26 Arcdia Int Oy Ltd Kaksoisfotoniviritteistä fluoresenssia hyödyntävä bioaffiniteettimääritysmenetelmä
EP3546937A4 (en) * 2016-11-22 2020-07-01 Chemclin Diagnostics Co., Ltd. METHOD, SYSTEM, REAGENT KIT AND SYSTEM FOR CHECKING A HIGH DOSE HOOK SAMPLE AND FOR IMMUNOASSAY
CN109470865B (zh) * 2016-11-22 2022-04-15 科美博阳诊断技术(上海)有限公司 免疫测定方法、用于鉴定免疫测定的系统和试剂盒
JP2020519866A (ja) * 2017-05-03 2020-07-02 バイオデシー， インコーポレイテッド ２光子蛍光測定を用いてタンパク質構造を決定する方法
TWI614502B (zh) * 2017-07-26 2018-02-11 國立成功大學 分析物濃度的檢測方法
CN110514651A (zh) * 2018-05-21 2019-11-29 博阳生物科技（上海）有限公司 一种化学发光免疫分析测定方法及使用该方法的系统、试剂盒
CN111795956B (zh) * 2020-06-29 2021-11-02 中国科学院苏州生物医学工程技术研究所 一种判断均相时间分辨荧光免疫分析钩状效应的方法

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US4760548A (en) * 1986-06-13 1988-07-26 International Business Machines Corporation Method and apparatus for producing a curve image
US5171688A (en) * 1988-08-30 1992-12-15 Cholestech Corporation Self-corrected assay device
US5100627A (en) * 1989-11-30 1992-03-31 The Regents Of The University Of California Chamber for the optical manipulation of microscopic particles
US5198369A (en) * 1990-04-25 1993-03-30 Canon Kabushiki Kaisha Sample measuring method using agglomeration reaction of microcarriers
JP3420765B2 (ja) * 1992-09-14 2003-06-30 エス・アール・アイ・インターナシヨナル レーザー励起技術を用いる生物学的および他の分析のためのアップコンバート性レポータ
DK0679251T3 (da) * 1993-01-18 1999-01-25 Evotec Biosystems Aktiengesell Fremgangsmåde og apparat til vurdering af biopolymerers fitness
CA2114371C (en) * 1993-01-28 2007-10-09 Kenji Kamada Method of spectrometry and apparatus therefor
CA2155186A1 (en) 1993-02-01 1994-08-18 Kevin M. Ulmer Methods and apparatus for dna sequencing
FI96452C (fi) 1994-01-26 1996-06-25 Pekka Haenninen Menetelmä väriaineiden virittämiseksi
US5512745A (en) * 1994-03-09 1996-04-30 Board Of Trustees Of The Leland Stanford Jr. University Optical trap system and method
FI98765C (fi) 1995-01-16 1997-08-11 Erkki Soini Virtaussytometrinen menetelmä ja laite
FI101829B1 (fi) * 1995-03-07 1998-08-31 Erkki Juhani Soini Biospesifinen määritysmenetelmä
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US5631141A (en) * 1995-05-05 1997-05-20 The Regents Of The University Of California High resolution biosensor for in-situ microthermometry
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EP0968425B1 (en) * 1996-12-03 2003-06-25 SOINI, Erkki Biospecific, two photon excitation, fluorescence detection and device

Also Published As

Publication number Publication date
EP0968425B1 (en) 2003-06-25
US6361956B1 (en) 2002-03-26
EP0968425A1 (en) 2000-01-05
DE69723111D1 (de) 2003-07-31
DE69723111T2 (de) 2004-02-19
WO1998025143A1 (en) 1998-06-11
AU5054198A (en) 1998-06-29
JP2001506750A (ja) 2001-05-22

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