JP3732408B2 - 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生 - Google Patents

抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生 Download PDF

Info

Publication number
JP3732408B2
JP3732408B2 JP2000569230A JP2000569230A JP3732408B2 JP 3732408 B2 JP3732408 B2 JP 3732408B2 JP 2000569230 A JP2000569230 A JP 2000569230A JP 2000569230 A JP2000569230 A JP 2000569230A JP 3732408 B2 JP3732408 B2 JP 3732408B2
Authority
JP
Japan
Prior art keywords
motif
antibody
protein
antibodies
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2000569230A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002524092A5 (enExample
JP2002524092A (ja
Inventor
タン，イー
コーム，マイケル・ジエイ
Original Assignee
セル・シグナリング・テクノロジー・インコーポレイテツド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by セル・シグナリング・テクノロジー・インコーポレイテツド filed Critical セル・シグナリング・テクノロジー・インコーポレイテツド
Publication of JP2002524092A publication Critical patent/JP2002524092A/ja
Publication of JP2002524092A5 publication Critical patent/JP2002524092A5/ja
Application granted granted Critical
Publication of JP3732408B2 publication Critical patent/JP3732408B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2000569230A 1998-09-04 1999-08-26 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生 Expired - Lifetime JP3732408B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/148,712 US6441140B1 (en) 1998-09-04 1998-09-04 Production of motif-specific and context-independent antibodies using peptide libraries as antigens
US09/148,712 1998-09-04
PCT/US1999/019597 WO2000014536A1 (en) 1998-09-04 1999-08-26 Production of motif-specific and context-independent antibodies using peptide libraries as antigens

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2005260207A Division JP5013693B2 (ja) 1998-09-04 2005-09-08 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生

Publications (3)

Publication Number Publication Date
JP2002524092A JP2002524092A (ja) 2002-08-06
JP2002524092A5 JP2002524092A5 (enExample) 2005-12-22
JP3732408B2 true JP3732408B2 (ja) 2006-01-05

Family

ID=22527002

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2000569230A Expired - Lifetime JP3732408B2 (ja) 1998-09-04 1999-08-26 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生
JP2005260207A Expired - Lifetime JP5013693B2 (ja) 1998-09-04 2005-09-08 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生
JP2012058996A Expired - Lifetime JP5648007B2 (ja) 1998-09-04 2012-03-15 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生
JP2014036821A Withdrawn JP2014132019A (ja) 1998-09-04 2014-02-27 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生
JP2016113229A Pending JP2016210783A (ja) 1998-09-04 2016-06-07 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2005260207A Expired - Lifetime JP5013693B2 (ja) 1998-09-04 2005-09-08 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生
JP2012058996A Expired - Lifetime JP5648007B2 (ja) 1998-09-04 2012-03-15 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生
JP2014036821A Withdrawn JP2014132019A (ja) 1998-09-04 2014-02-27 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生
JP2016113229A Pending JP2016210783A (ja) 1998-09-04 2016-06-07 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生

Country Status (6)

Country Link
US (5) US6441140B1 (enExample)
EP (3) EP1110086B1 (enExample)
JP (5) JP3732408B2 (enExample)
CA (1) CA2341143C (enExample)
DE (1) DE69936389T2 (enExample)
WO (1) WO2000014536A1 (enExample)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6884597B1 (en) * 1998-01-20 2005-04-26 Medical & Biological Laboratories, Co., Ltd. Method for detecting acetyltransferase and deacetylase activities and method for screening inhibitors or enhancers of these enzymes
US20120244594A9 (en) 1998-09-04 2012-09-27 Cell Signaling Technology, Inc. Immunoaffinity isolation of modified peptides from complex mixtures
US7300753B2 (en) * 1998-09-04 2007-11-27 John Rush Immunoaffinity isolation of modified peptides from complex mixtures
US7198896B2 (en) * 1998-09-04 2007-04-03 Cell Signaling Technology, Inc. Immunoaffinity isolation of modified peptides from complex mixtures
US6441140B1 (en) * 1998-09-04 2002-08-27 Cell Signaling Technology, Inc. Production of motif-specific and context-independent antibodies using peptide libraries as antigens
US9085609B2 (en) * 1998-09-04 2015-07-21 Cell Signaling Technology, Inc. Production of motif-specific and context-independent antibodies using peptide libraries as antigens
US7208581B1 (en) * 1999-11-05 2007-04-24 The Burnham Institute TRAF family proteins
WO2001049709A1 (en) * 2000-01-03 2001-07-12 Ramot University Authority For Applied Research & Industrial Development Ltd. Glycogen synthase kinase-3 inhibitors
EP1283879A2 (en) * 2000-05-04 2003-02-19 Mount Sinai Hospital Molecules that modulate ubiquitin-dependent proteolysis and methods for identifying same
US20020102248A1 (en) * 2000-09-06 2002-08-01 The Government Of The United States Of America Modulating response to genotoxic stress
CA2410460C (en) * 2001-03-23 2010-06-29 Japan Science And Technology Corporation Probes for imaging protein phosphorylation and dephosphorylation and method for detecting and determining protein phosphorylation and dephosphorylation using the same
US20110111424A1 (en) 2001-06-21 2011-05-12 Cell Signaling Technology, Inc. Analysis of ubiquitinated polypeptides
EP1434874A4 (en) 2001-06-21 2005-11-30 Cell Signaling Technology Inc IMMUNOAFFINITY ISOLATION OF MODIFIED PEPTIDES FROM COMPLEX MIXTURES
US7378432B2 (en) 2001-09-14 2008-05-27 Tel Aviv University Future Technology Development L.P. Glycogen synthase kinase-3 inhibitors
US7166441B2 (en) * 2002-03-12 2007-01-23 Perseptive Biosystems Inc. Method and apparatus for the identification and quantification of biomolecules
GB0208104D0 (en) 2002-04-09 2002-05-22 Univ Dundee Method
AU2003286411A1 (en) 2002-12-12 2004-06-30 Tel Aviv University Future Technology Development L.P. Glycogen synthase kinase-3 inhibitors
CA2530111A1 (en) * 2003-06-27 2005-01-06 Tel-Aviv University Future Technology Development L.P. Glycogen synthase kinase-3 inhibitors
AU2004267802B2 (en) * 2003-08-18 2011-03-17 Tethys Bioscience, Inc. Methods for reducing complexity of a sample using small epitope antibodies
US20070003977A1 (en) * 2003-08-20 2007-01-04 Amorfix Life Sciences Ltd Epitope protection assay and method for detecting protein conformations
US20050064507A1 (en) * 2003-09-11 2005-03-24 James Stephen Shaw Determining kinase specificity
US7282339B2 (en) * 2003-09-17 2007-10-16 Invitrogen Corporation Competitive immunoassay
US8852879B2 (en) 2004-04-29 2014-10-07 The Children's Hospital Of Philadelphia Materials and methods for the detection of nitrated fibrinogen
US20050244905A1 (en) * 2004-04-29 2005-11-03 Harry Ischiropoulos Nitrated fibrinogen as a marker for coronary artery disease and rapid blood clot formation
US7973134B2 (en) * 2004-07-07 2011-07-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways
US20070048797A1 (en) * 2004-08-11 2007-03-01 Xing Su Composite organic inorganic nanoclusters as carriers and identifiers of tester molecules
US7935790B2 (en) * 2004-10-04 2011-05-03 Cell Singaling Technology, Inc. Reagents for the detection of protein phosphorylation in T-cell receptor signaling pathways
US20070224662A1 (en) * 2004-12-17 2007-09-27 Jun Luo Post-translational modification of proteins in cell-free expression systems
US7807789B2 (en) * 2004-12-21 2010-10-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in EGFR-signaling pathways
WO2006106957A1 (ja) * 2005-04-01 2006-10-12 National University Corporation Hokkaido University ｐ５３翻訳後修飾部位を特異的に認識するモノクローナル抗体、及びその抗体を含む修飾部位測定キット
US20090099340A1 (en) * 2007-10-12 2009-04-16 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
WO2006117007A1 (en) * 2005-05-03 2006-11-09 The Antibody Project Aps Methods for obtaining antigen specific antibodies
US20060292642A1 (en) * 2005-06-24 2006-12-28 Javad Khosravi Immunoassay of phosphorylated proteins
US7906297B2 (en) 2005-07-20 2011-03-15 Cell Signaling Technology, Inc. Reagents for the detection of phosphorylated ATR kinase (Ser 428) and uses thereof
WO2007027906A2 (en) * 2005-08-31 2007-03-08 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in leukemia signaling pathways
US20100151495A9 (en) * 2005-08-31 2010-06-17 Cell Signaling Technolgy, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
WO2007079755A1 (en) * 2006-01-12 2007-07-19 Janus Beierholm Holding Aps Reimmunization and antibody design
US8097425B2 (en) * 2006-03-10 2012-01-17 Tethys Bioscience, Inc. Multiplex protein fractionation
US20090298093A1 (en) * 2006-04-27 2009-12-03 Roberto Polakiewicz Reagents for the Detection of Protein Phosphorylation in ATM & ATR Kinase Signaling Pathways
DK2027158T3 (da) 2006-05-02 2013-01-14 Carviar Aps Metode til immunisering af en fugleart
US20090325312A1 (en) * 2006-05-12 2009-12-31 Ailan Guo Reagens for the detection of protein acetylation signaling pathways
US20150232540A1 (en) 2006-07-11 2015-08-20 Cell Signaling Technology, Inc. Analysis of ubiquitnated polypeptides
US7939636B2 (en) * 2006-08-11 2011-05-10 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in c-Src signaling pathways
WO2008021542A2 (en) * 2006-08-17 2008-02-21 Cell Signaling Technology, Inc. Lysine acteylation sites
US20090258442A1 (en) * 2006-08-31 2009-10-15 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
EP1975184A3 (en) * 2007-03-26 2008-11-26 Cell Signaling Technology, Inc. Serine or threonine phosphorylation sites
US20080238709A1 (en) * 2007-03-28 2008-10-02 Faramarz Vaziri One-way communication apparatus with dynamic key generation
US7977462B2 (en) 2007-04-19 2011-07-12 Cell Signaling Technology, Inc. Tyrosine phosphorylation sites
JP5564431B2 (ja) 2007-10-29 2014-07-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 ゼアラレノンアナログ化合物ががんを処置する能力を予測する方法
US20090220991A1 (en) * 2008-02-29 2009-09-03 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in leukemia signaling pathways
EP2599793A1 (en) * 2008-05-29 2013-06-05 Nuclea Biotechnologies, Inc. Anti-phospho-akt antibodies
US9868781B2 (en) * 2008-06-02 2018-01-16 Cornell University Antibodies for ubiquitinated proteins
US7933146B2 (en) * 2008-10-08 2011-04-26 Seagate Technology Llc Electronic devices utilizing spin torque transfer to flip magnetic orientation
WO2010051215A1 (en) * 2008-10-31 2010-05-06 Proteonova, Inc. Methods for making hiv vaccines and related compositions
US8771693B2 (en) * 2009-10-27 2014-07-08 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the generation and use of conformation-specific antibodies
US9453845B2 (en) 2010-02-01 2016-09-27 Cell Signaling Technology, Inc. Mass spectroscopy analysis of mutant polypeptides in biological samples
CA2794851A1 (en) * 2010-04-02 2011-10-06 Kalobios Pharmaceuticals, Inc. Generation of antibodies to an epitope of interest
FI20105715A0 (fi) * 2010-06-18 2010-06-18 Helsingin Yliopisto Asetyloituun HMGB1:een sitoutuva polyklonaalinen vasta-aine
WO2012061732A1 (en) 2010-11-05 2012-05-10 Cell Signaling Technology, Inc. Motif-specific and context-independent antibodies to a cleaved caspase motif or a sumoylated lysine-containing motif
WO2012149334A2 (en) 2011-04-27 2012-11-01 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the generation and use of conformation-specific antibodies
CA2855781A1 (en) * 2011-09-17 2013-03-21 Suzhou Naao New Material Sciences Co., Ltd. Antibody recognizing arbitrarily designed epitope of three or more amino acid residues in a peptide and method of generating thereof
EP2573565A1 (en) 2011-09-23 2013-03-27 Gerhard Matthias Kresbach Immune detection method for common epitopes of two or more analytes in samples of complex compositions, device, and kit for enabling said immune detection method
WO2013125221A1 (ja) * 2012-02-21 2013-08-29 静岡県 抗体精製用アフィニティリガンド
JP6293409B2 (ja) * 2012-10-04 2018-03-14 国立大学法人富山大学 抗原特異的ウサギ抗体産生細胞の迅速な特定方法およびその利用
CN105283196B (zh) 2013-03-15 2018-10-12 贝丝以色列女执事医疗中心 用于产生和使用构象-特异性抗体的方法和组合物
US10857243B2 (en) * 2014-04-09 2020-12-08 Brandeis University Enzymatically responsive magnetic particles and their use
US20170165230A1 (en) 2014-04-09 2017-06-15 Christopher Rudd Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity
EP3137482A1 (en) 2014-05-02 2017-03-08 MorphoSys AG Peptide libraries
AU2016353453B2 (en) 2015-11-11 2022-08-11 Serimmune Inc. Methods and compositions for assessing antibody specificities
EP3661958A2 (en) * 2017-08-04 2020-06-10 Abcam Plc Methods and compositions for the development of antibodies specific to epitope post-translational modification status
US20230073946A1 (en) * 2020-01-20 2023-03-09 Arizona Board Of Regents On Behalf Of The University Of Arizona Affinity peptide conjugated with antioxidant for protection of proteins from oxidation
GB202012722D0 (en) * 2020-08-14 2020-09-30 Abcam Plc Validation method
EP4255498A4 (en) * 2020-12-07 2024-09-18 Nucmito Pharmaceuticals Co., Ltd. RXR-ALPHA BINDERS AND RXR-ALPHA/PLK1 MODULATORS
CN116444677A (zh) * 2023-06-09 2023-07-18 中国人民解放军军事科学院军事医学研究院 一种FoxM1蛋白Y575磷酸化的多克隆抗体及其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61227596A (ja) * 1985-04-01 1986-10-09 Fujisawa Pharmaceut Co Ltd 抗リン酸化チロシンモノクロ−ナル抗体およびそれを産生するハイブリド−マ
EP0544942A1 (en) * 1991-12-06 1993-06-09 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Novel tools for the diagnosis and treatment of Alzheimer disease
JPH05244987A (ja) * 1992-02-28 1993-09-24 Unitika Ltd 抗硫酸化チロシン抗体，その製造方法及び抗硫酸化チロシンモノクローナル抗体を産生するハイブリドーマ
US5532167A (en) * 1994-01-07 1996-07-02 Beth Israel Hospital Substrate specificity of protein kinases
US5679769A (en) * 1994-03-15 1997-10-21 Sloan-Kettering Institute For Cancer Research Synthesis of asparagine-linked glycopeptides on a polymeric solid support
CA2172771A1 (en) * 1995-03-28 1996-09-29 Akiyoshi Tani Method for assaying map kinase
US5759787A (en) * 1996-08-26 1998-06-02 Tularik Inc. Kinase assay
FR2757864B1 (fr) 1996-12-30 1999-03-19 Centre Nat Rech Scient Anticorps reconnaissant specifiquement une proteine nitrosylee, leur procede de preparation, leur utilisation therapeutique et diagnostique
US5965352A (en) * 1998-05-08 1999-10-12 Rosetta Inpharmatics, Inc. Methods for identifying pathways of drug action
US6441140B1 (en) * 1998-09-04 2002-08-27 Cell Signaling Technology, Inc. Production of motif-specific and context-independent antibodies using peptide libraries as antigens
US9919577B2 (en) 2014-11-14 2018-03-20 Hyundai Motor Company Air-conditioning device for vehicle

Also Published As

Publication number Publication date
JP5648007B2 (ja) 2015-01-07
EP1850131B1 (en) 2013-01-23
US6982318B1 (en) 2006-01-03
EP2325204A2 (en) 2011-05-25
WO2000014536A1 (en) 2000-03-16
JP2016210783A (ja) 2016-12-15
EP2325204A3 (en) 2011-10-26
CA2341143A1 (en) 2000-03-16
JP2006036784A (ja) 2006-02-09
US20020168684A1 (en) 2002-11-14
JP2014132019A (ja) 2014-07-17
US7259022B2 (en) 2007-08-21
US20020132988A1 (en) 2002-09-19
EP1850131A1 (en) 2007-10-31
US7344714B2 (en) 2008-03-18
US6441140B1 (en) 2002-08-27
CA2341143C (en) 2006-11-21
DE69936389D1 (de) 2007-08-09
JP2012162535A (ja) 2012-08-30
JP5013693B2 (ja) 2012-08-29
EP2325204B1 (en) 2014-08-13
JP2002524092A (ja) 2002-08-06
US20030068652A1 (en) 2003-04-10
EP1110086B1 (en) 2007-06-27
EP1110086A1 (en) 2001-06-27
DE69936389T2 (de) 2008-02-28
EP1110086A4 (en) 2003-08-27

Similar Documents

Publication Publication Date Title
JP3732408B2 (ja) 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生
US9738711B2 (en) Production of motif-specific and context-independent antibodies using peptide libraries as antigens
EP1718760A1 (en) Protein phosphorylation in c-src signaling pathways
US12577295B2 (en) Motif-specific and context-independent antibodies that specifically bind to a sumoylated lysine-containing residue
US20090298093A1 (en) Reagents for the Detection of Protein Phosphorylation in ATM & ATR Kinase Signaling Pathways
US20090061459A1 (en) Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
US20100173322A1 (en) Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways
US20090263832A1 (en) Reagents for the Detection of Protein Phosphorylation in Leukemia Signaling Pathways
WO2003107003A1 (en) Positive identification of phospho-proteins using motif-specific, context-independent antibodies coupled with database searching
AU2002318361B2 (en) Immunoaffinity isolation of modified peptides from complex mixtures
US7939636B2 (en) Reagents for the detection of protein phosphorylation in c-Src signaling pathways
EP1086134A2 (en) Methods to prepare antibodies which bind to posttranslationally modified amino acids within peptides

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20040610

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20040610

A975 Report on accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A971005

Effective date: 20040712

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20040803

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20041027

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20041110

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050202

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20050308

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20050601

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20050609

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050908

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20051004

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20051012

R150 Certificate of patent or registration of utility model

Ref document number: 3732408

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20081021

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20091021

Year of fee payment: 4

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20091021

Year of fee payment: 4

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20101021

Year of fee payment: 5

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20101021

Year of fee payment: 5

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20111021

Year of fee payment: 6

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20121021

Year of fee payment: 7

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20121021

Year of fee payment: 7

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20131021

Year of fee payment: 8

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20131021

Year of fee payment: 8

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term