JP3541007B2 - 両親媒性ポリサッカリド誘導体 - Google Patents
両親媒性ポリサッカリド誘導体 Download PDFInfo
- Publication number
- JP3541007B2 JP3541007B2 JP2000550884A JP2000550884A JP3541007B2 JP 3541007 B2 JP3541007 B2 JP 3541007B2 JP 2000550884 A JP2000550884 A JP 2000550884A JP 2000550884 A JP2000550884 A JP 2000550884A JP 3541007 B2 JP3541007 B2 JP 3541007B2
- Authority
- JP
- Japan
- Prior art keywords
- heparin
- acid
- doca
- pharmaceutical composition
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Botany (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR19980019469 | 1998-05-28 | ||
KR1019990014003A KR100314496B1 (ko) | 1998-05-28 | 1999-04-20 | 항혈전성이 있는 헤파린 유도체, 그의 제조방법 및 용도 |
US1999/14003 | 1999-04-27 | ||
US09/300,173 | 1999-04-27 | ||
US1998/19469 | 1999-04-27 | ||
US09/300,173 US6245753B1 (en) | 1998-05-28 | 1999-04-27 | Amphiphilic polysaccharide derivatives |
PCT/KR1999/000242 WO1999061481A1 (en) | 1998-05-28 | 1999-05-14 | Amphiphilic polysaccharide derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2002516355A JP2002516355A (ja) | 2002-06-04 |
JP3541007B2 true JP3541007B2 (ja) | 2004-07-07 |
Family
ID=27349744
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000550884A Expired - Fee Related JP3541007B2 (ja) | 1998-05-28 | 1999-05-14 | 両親媒性ポリサッカリド誘導体 |
Country Status (5)
Country | Link |
---|---|
JP (1) | JP3541007B2 (de) |
AU (1) | AU3735899A (de) |
DE (1) | DE19981169B4 (de) |
GB (1) | GB2342357B (de) |
WO (1) | WO1999061481A1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6656922B2 (en) * | 1998-05-28 | 2003-12-02 | Mediplex Corporation, Korea | Oral delivery of macromolecules |
US7772220B2 (en) | 2004-10-15 | 2010-08-10 | Seo Hong Yoo | Methods and compositions for reducing toxicity of a pharmaceutical compound |
US7303768B2 (en) | 1998-07-24 | 2007-12-04 | Seo Hong Yoo | Preparation of aqueous clear solution dosage forms with bile acids |
KR100378109B1 (ko) * | 2000-10-24 | 2003-03-29 | 주식회사 메디프렉스 | 소수성 다중복합 헤파린 결합체, 그의 제조방법 및 용도 |
CN1531436A (zh) * | 2001-05-09 | 2004-09-22 | (株)美大富历寿 | 用于增强粘膜吸收的两亲肝素衍生物制剂 |
US7145125B2 (en) | 2003-06-23 | 2006-12-05 | Advanced Optical Technologies, Llc | Integrating chamber cone light using LED sources |
FR2864091B1 (fr) * | 2003-12-19 | 2006-04-07 | Ethypharm Sa | Derive amphiphile d'heparine forme par couplage de l'heparine avec un acide biliaire |
JP2008511651A (ja) | 2004-08-30 | 2008-04-17 | セオ ホン ユー | 局所虚血モデルでの可溶化udcaの神経保護効果 |
KR20070084211A (ko) | 2004-10-15 | 2007-08-24 | 유서홍 | 약제학적 화합물의 독성을 감소시키기 위한 방법 및 조성물 |
MX340993B (es) | 2007-02-08 | 2016-08-02 | Emisphere Tech Inc * | Agentes de suministro de acido fenilalquilcarboxilico. |
WO2009092151A1 (en) * | 2007-12-05 | 2009-07-30 | Xiao-Xia Zhu | Amphiphilic polymers having a cholane core |
JP5542687B2 (ja) * | 2008-11-05 | 2014-07-09 | 国立大学法人 東京医科歯科大学 | ヒアルロン酸誘導体、およびその医薬組成物 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB891554A (en) * | 1959-10-19 | 1962-03-14 | Applic Chimiques D Etudes Et D | Galenic suppository containing salts of heparin |
US3482014A (en) * | 1966-06-29 | 1969-12-02 | Canada Packers Ltd | Orally active heparin and method for making and using same |
WO1995012620A1 (en) * | 1993-11-01 | 1995-05-11 | Alpha-Beta Technology, Inc. | Derivatized polysaccharide bile acid sequestrant for reducing cholesterol |
JPH07206903A (ja) * | 1994-01-24 | 1995-08-08 | Takeda Chem Ind Ltd | 超分子構造型集合体 |
-
1999
- 1999-05-14 WO PCT/KR1999/000242 patent/WO1999061481A1/en active Application Filing
- 1999-05-14 JP JP2000550884A patent/JP3541007B2/ja not_active Expired - Fee Related
- 1999-05-14 DE DE19981169T patent/DE19981169B4/de not_active Expired - Fee Related
- 1999-05-14 GB GB0001794A patent/GB2342357B/en not_active Expired - Fee Related
- 1999-05-14 AU AU37358/99A patent/AU3735899A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
GB0001794D0 (en) | 2000-03-22 |
WO1999061481A1 (en) | 1999-12-02 |
JP2002516355A (ja) | 2002-06-04 |
GB2342357A (en) | 2000-04-12 |
GB2342357B (en) | 2002-03-27 |
DE19981169B4 (de) | 2007-09-13 |
DE19981169T1 (de) | 2000-11-16 |
AU3735899A (en) | 1999-12-13 |
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