JP3233403B2 - 光学活性な中間体および該製造法 - Google Patents

光学活性な中間体および該製造法

Info

Publication number
JP3233403B2
JP3233403B2 JP50928592A JP50928592A JP3233403B2 JP 3233403 B2 JP3233403 B2 JP 3233403B2 JP 50928592 A JP50928592 A JP 50928592A JP 50928592 A JP50928592 A JP 50928592A JP 3233403 B2 JP3233403 B2 JP 3233403B2
Authority
JP
Japan
Prior art keywords
substituent
compound
halogen
amino
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP50928592A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO1992022560A1 (ja
Inventor
敏郎 鴻池
美貴 荒木
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of JPWO1992022560A1 publication Critical patent/JPWO1992022560A1/ja
Application granted granted Critical
Publication of JP3233403B2 publication Critical patent/JP3233403B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/535—Organo-phosphoranes
    • C07F9/5352—Phosphoranes containing the structure P=C-
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
JP50928592A 1991-06-19 1992-05-14 光学活性な中間体および該製造法 Expired - Lifetime JP3233403B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP3-176209 1991-06-19
JP17620991 1991-06-19
PCT/JP1992/000611 WO1992022560A1 (fr) 1991-06-19 1992-05-14 Intermediaire optiquement actif et production de celui-ci

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2001218860A Division JP3635247B2 (ja) 1991-06-19 2001-07-18 光学活性な中間体および該製造法

Publications (2)

Publication Number Publication Date
JPWO1992022560A1 JPWO1992022560A1 (ja) 1993-08-05
JP3233403B2 true JP3233403B2 (ja) 2001-11-26

Family

ID=16009533

Family Applications (2)

Application Number Title Priority Date Filing Date
JP50928592A Expired - Lifetime JP3233403B2 (ja) 1991-06-19 1992-05-14 光学活性な中間体および該製造法
JP2001218860A Expired - Lifetime JP3635247B2 (ja) 1991-06-19 2001-07-18 光学活性な中間体および該製造法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2001218860A Expired - Lifetime JP3635247B2 (ja) 1991-06-19 2001-07-18 光学活性な中間体および該製造法

Country Status (11)

Country Link
US (1) US5354879A (2)
EP (1) EP0554455B1 (2)
JP (2) JP3233403B2 (2)
KR (1) KR100216011B1 (2)
AT (1) ATE161262T1 (2)
DE (1) DE69223603T2 (2)
DK (1) DK0554455T3 (2)
ES (1) ES2110499T3 (2)
GR (1) GR3026204T3 (2)
TW (1) TW201730B (2)
WO (1) WO1992022560A1 (2)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3091022B2 (ja) 1992-07-16 2000-09-25 塩野義製薬株式会社 グルタル酸誘導体の製造方法
US5717124A (en) * 1993-03-30 1998-02-10 Ube Industries, Ltd. Process for preparation of oxyglutaric acid ester derivatives
DE69424463T2 (de) * 1993-03-30 2000-09-14 Ube Industries, Ltd. Verfahren zur Herstellung von Ester-Derivaten der Oxyglutar-Säure
US6376476B1 (en) * 1996-12-13 2002-04-23 Zymogenetics Corporation Isoprenoid pathway inhibitors for stimulating bone growth
US6121475A (en) * 1999-09-17 2000-09-19 Ube Industries, Ltd. Preparation of optically active β-hydroxyester derivatives and platinum-containing catalyst
KR100511533B1 (ko) * 2002-04-09 2005-08-31 임광민 키랄 중간체, 그의 제조방법 및 그를 이용한 HMG-CoA환원저해제의 제조방법
GB0211751D0 (en) * 2002-05-22 2002-07-03 Avecia Ltd Compound and process
WO2005023778A2 (en) * 2003-08-28 2005-03-17 Teva Pharmaceutical Industries Ltd. Process for preparation of rosuvastatin calcium
EP1601658A1 (en) 2003-11-24 2005-12-07 Teva Pharmaceutical Industries Limited Crystalline ammonium salts of rosuvastatin
US7244844B2 (en) * 2003-12-02 2007-07-17 Teva Pharmaceutical Industries Ltd. Reference standard for characterization of rosuvastatin
US7851624B2 (en) * 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
WO2006017357A1 (en) * 2004-07-13 2006-02-16 Teva Pharmaceutical Industries Ltd. A process for the preparation of rosuvastatin involving a tempo-mediated oxidation step
US20070037979A1 (en) * 2005-02-22 2007-02-15 Valerie Niddam-Hildesheim Preparation of rosuvastatin
KR101020024B1 (ko) * 2005-02-22 2011-03-09 테바 파마슈티컬 인더스트리즈 리미티드 로수바스타틴 알킬에테르를 함유하지 않는 로수바스타틴 및이의 염 및 이의 제조 방법
US20070167625A1 (en) * 2005-02-22 2007-07-19 Anna Balanov Preparation of rosuvastatin
WO2007022488A2 (en) 2005-08-16 2007-02-22 Teva Pharmaceutical Industries Ltd. Crystalline rosuvastatin intermediate
CN1958593B (zh) * 2005-11-03 2010-05-05 上海医药工业研究院 一种用于合成瑞舒伐他汀钙的中间体的制备方法
US7687660B2 (en) * 2007-04-18 2010-03-30 Teva Pharmaceutical Industries Ltd. Process for preparing intermediates of HMG-CoA reductase inhibitors
US20090069563A1 (en) * 2007-07-12 2009-03-12 Valerie Niddam-Hildesheim Rosuvastatin intermediates and their preparation
EP2181089A2 (en) 2007-08-28 2010-05-05 Ratiopharm GmbH Process for preparing pentanoic diacid derivatives
CN101735272B (zh) * 2009-12-11 2012-10-31 重庆博腾制药科技股份有限公司 瑞舒伐他汀钙中间体的制备方法
EP2785851A2 (en) * 2011-11-28 2014-10-08 Mylan Laboratories, Limited Process for producing chiral statin side chain intermediates employing candida antarctica lipase b

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1421553A (en) * 1972-03-17 1976-01-21 Searle & Co Process for the production of prostaglandins
US3907852A (en) * 1972-06-23 1975-09-23 Exxon Research Engineering Co Silylhydrocarbyl phosphines and related compounds
DE3722807A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Neue 3,5-dihydroxycarbonsaeuren und deren derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
WO1989003212A1 (en) * 1987-10-13 1989-04-20 Pfizer Inc. 3,5-dihydroxy-6,8-nonadienoic acids and derivatives as hypocholesterolemic agents
US4804770A (en) * 1988-04-29 1989-02-14 E. R. Squibb & Sons, Inc. Process for preparing a keto-phosphonate intermediate useful in preparing HMG-CoA reductase inhibitors
DE3832570A1 (de) * 1988-09-24 1990-03-29 Hoechst Ag 7-substituierte derivate der 3,5-dihydroxyhept-6-insaeure, verfahren zur ihrer herstellung, ihre verwendung als arzneimittel, sowie zwischenprodukte
JP2719723B2 (ja) * 1988-12-14 1998-02-25 塩野義製薬株式会社 アリール酢酸モノエステル類およびその製造法
US5117039A (en) * 1988-12-14 1992-05-26 Shionogi & Co., Ltd. Monoesters of arylacetic acid and the process thereof
US5093363A (en) * 1989-08-22 1992-03-03 Shionogi & Co., Ltd. 2,4,6-substituted phenol derivatives

Also Published As

Publication number Publication date
US5354879A (en) 1994-10-11
EP0554455B1 (en) 1997-12-17
EP0554455A4 (2) 1994-03-23
KR100216011B1 (ko) 1999-08-16
TW201730B (2) 1993-03-11
JP2002088054A (ja) 2002-03-27
DE69223603T2 (de) 1998-04-09
DE69223603D1 (de) 1998-01-29
ATE161262T1 (de) 1998-01-15
KR930701460A (ko) 1993-06-11
WO1992022560A1 (fr) 1992-12-23
DK0554455T3 (da) 1998-01-19
ES2110499T3 (es) 1998-02-16
JP3635247B2 (ja) 2005-04-06
EP0554455A1 (en) 1993-08-11
GR3026204T3 (en) 1998-05-29

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