JP3144903B2 - 縮合ピリミジン誘導体 - Google Patents

縮合ピリミジン誘導体

Info

Publication number
JP3144903B2
JP3144903B2 JP21767092A JP21767092A JP3144903B2 JP 3144903 B2 JP3144903 B2 JP 3144903B2 JP 21767092 A JP21767092 A JP 21767092A JP 21767092 A JP21767092 A JP 21767092A JP 3144903 B2 JP3144903 B2 JP 3144903B2
Authority
JP
Japan
Prior art keywords
group
formula
compound
pyrimidine derivative
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP21767092A
Other languages
English (en)
Japanese (ja)
Other versions
JPH05186437A (ja
Inventor
容朗 野村
融 羽田
良彦 小竹
教博 上田
恭輔 紀藤
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Priority to JP21767092A priority Critical patent/JP3144903B2/ja
Priority to FI923697A priority patent/FI923697A7/fi
Priority to TW081106523A priority patent/TW202451B/zh
Priority to CA002076431A priority patent/CA2076431A1/en
Priority to HU9202699A priority patent/HUT70180A/hu
Priority to NO92923249A priority patent/NO923249L/no
Priority to AU21157/92A priority patent/AU655051B2/en
Priority to CN92109669A priority patent/CN1070402A/zh
Priority to KR1019920015043A priority patent/KR950011740B1/ko
Publication of JPH05186437A publication Critical patent/JPH05186437A/ja
Application granted granted Critical
Publication of JP3144903B2 publication Critical patent/JP3144903B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP21767092A 1991-08-21 1992-08-17 縮合ピリミジン誘導体 Expired - Fee Related JP3144903B2 (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP21767092A JP3144903B2 (ja) 1991-08-21 1992-08-17 縮合ピリミジン誘導体
TW081106523A TW202451B (enExample) 1991-08-21 1992-08-18
FI923697A FI923697A7 (fi) 1991-08-21 1992-08-18 Kondenserat pyrimidinderivat
HU9202699A HUT70180A (en) 1991-08-21 1992-08-19 Process for producing condensed pyrimidine derivatives and pharmaceutical compositions containing them
CA002076431A CA2076431A1 (en) 1991-08-21 1992-08-19 Condensed pyrimidine derivative
NO92923249A NO923249L (no) 1991-08-21 1992-08-19 Terapeutisk aktive pyrimidinderivater og fremgangsmaate for deres fremstilling
AU21157/92A AU655051B2 (en) 1991-08-21 1992-08-20 Condensed pyrimidine derivative
CN92109669A CN1070402A (zh) 1991-08-21 1992-08-21 缩合的嘧啶衍生物
KR1019920015043A KR950011740B1 (ko) 1991-08-21 1992-08-21 축합된 피리미딘 유도체

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP3-209252 1991-08-21
JP20925291 1991-08-21
JP3-251548 1991-09-30
JP25154891 1991-09-30
JP21767092A JP3144903B2 (ja) 1991-08-21 1992-08-17 縮合ピリミジン誘導体

Publications (2)

Publication Number Publication Date
JPH05186437A JPH05186437A (ja) 1993-07-27
JP3144903B2 true JP3144903B2 (ja) 2001-03-12

Family

ID=27328976

Family Applications (1)

Application Number Title Priority Date Filing Date
JP21767092A Expired - Fee Related JP3144903B2 (ja) 1991-08-21 1992-08-17 縮合ピリミジン誘導体

Country Status (9)

Country Link
JP (1) JP3144903B2 (enExample)
KR (1) KR950011740B1 (enExample)
CN (1) CN1070402A (enExample)
AU (1) AU655051B2 (enExample)
CA (1) CA2076431A1 (enExample)
FI (1) FI923697A7 (enExample)
HU (1) HUT70180A (enExample)
NO (1) NO923249L (enExample)
TW (1) TW202451B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107041A (en) * 1992-09-25 2000-02-17 Lilly Co Eli Process for preparing omega(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo-6-¬2,3-d¾pyrimidin-5-YL)alkarylcarboxylic acids and N-(omega-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo¬2,3-d¾pyrimidin-5-YL)alk-aroyl-4-glutamic acids
US8252804B2 (en) 2008-10-01 2012-08-28 Duquesne University Of The Holy Spirit Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same
US20110082158A1 (en) * 2008-10-01 2011-04-07 Aleem Gangjee Selective proton coupled folate transporter and folate receptor, and garftase and/or other folate metabolizing enzymes inhibitor compounds and methods of using the same
CN106188060A (zh) * 2015-04-29 2016-12-07 厦门大学 嘧啶并吡咯类化合物、其制备方法、药用组合物及其应用
CN113788834B (zh) * 2021-09-18 2022-11-29 河南奥思恩医药科技有限公司 2,4-二氯-6,7-二氢-5H-吡咯并[3,4-d]嘧啶盐酸盐的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0438261A3 (en) * 1990-01-16 1992-02-26 Takeda Chemical Industries, Ltd. Condensed heterocyclic glutamic acid derivatives, their production and use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ；ｖｏｌ．３４，ｐ５５５−５６０（１９９１）

Also Published As

Publication number Publication date
AU2115792A (en) 1993-02-25
FI923697A0 (fi) 1992-08-18
CN1070402A (zh) 1993-03-31
KR930004307A (ko) 1993-03-22
AU655051B2 (en) 1994-12-01
JPH05186437A (ja) 1993-07-27
KR950011740B1 (ko) 1995-10-09
TW202451B (enExample) 1993-03-21
CA2076431A1 (en) 1993-02-22
FI923697A7 (fi) 1993-02-22
NO923249D0 (no) 1992-08-19
NO923249L (no) 1993-02-22
HUT70180A (en) 1995-09-28

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