JP2902581B2 - 測定すべき物質の定性的または／および定量的検出法 - Google Patents
測定すべき物質の定性的または／および定量的検出法Info
- Publication number
- JP2902581B2 JP2902581B2 JP7246505A JP24650595A JP2902581B2 JP 2902581 B2 JP2902581 B2 JP 2902581B2 JP 7246505 A JP7246505 A JP 7246505A JP 24650595 A JP24650595 A JP 24650595A JP 2902581 B2 JP2902581 B2 JP 2902581B2
- Authority
- JP
- Japan
- Prior art keywords
- solid phase
- substance
- active
- measured
- reagent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000126 substance Substances 0.000 title claims description 74
- 238000001514 detection method Methods 0.000 title claims description 35
- 239000007790 solid phase Substances 0.000 claims description 136
- 239000003153 chemical reaction reagent Substances 0.000 claims description 101
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 54
- 238000009739 binding Methods 0.000 claims description 49
- 238000012360 testing method Methods 0.000 claims description 49
- 230000027455 binding Effects 0.000 claims description 48
- 238000000034 method Methods 0.000 claims description 46
- 238000003018 immunoassay Methods 0.000 claims description 36
- 108010090804 Streptavidin Proteins 0.000 claims description 27
- 238000003556 assay Methods 0.000 claims description 27
- 229960002685 biotin Drugs 0.000 claims description 27
- 235000020958 biotin Nutrition 0.000 claims description 27
- 239000011616 biotin Substances 0.000 claims description 27
- 108090001008 Avidin Proteins 0.000 claims description 25
- 238000007899 nucleic acid hybridization Methods 0.000 claims description 25
- 239000000427 antigen Substances 0.000 claims description 21
- 102000036639 antigens Human genes 0.000 claims description 21
- 108091007433 antigens Proteins 0.000 claims description 21
- 230000009870 specific binding Effects 0.000 claims description 21
- 230000008878 coupling Effects 0.000 claims description 15
- 238000010168 coupling process Methods 0.000 claims description 15
- 238000005859 coupling reaction Methods 0.000 claims description 15
- 230000009871 nonspecific binding Effects 0.000 claims description 11
- 239000004033 plastic Substances 0.000 claims description 9
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 239000012634 fragment Substances 0.000 claims description 6
- 238000012986 modification Methods 0.000 claims description 6
- 230000004048 modification Effects 0.000 claims description 6
- 239000011324 bead Substances 0.000 claims description 5
- 238000010353 genetic engineering Methods 0.000 claims description 5
- 239000011521 glass Substances 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 238000011895 specific detection Methods 0.000 claims description 5
- 150000001615 biotins Chemical class 0.000 claims description 4
- 239000004816 latex Substances 0.000 claims description 4
- 229920000126 latex Polymers 0.000 claims description 4
- 238000009738 saturating Methods 0.000 claims description 4
- 238000012217 deletion Methods 0.000 claims description 3
- 230000037430 deletion Effects 0.000 claims description 3
- 238000003780 insertion Methods 0.000 claims description 3
- 230000037431 insertion Effects 0.000 claims description 3
- 238000006467 substitution reaction Methods 0.000 claims description 3
- 239000006228 supernatant Substances 0.000 claims description 3
- 230000000415 inactivating effect Effects 0.000 claims description 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 230000002779 inactivation Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 description 24
- 108020004707 nucleic acids Proteins 0.000 description 17
- 150000007523 nucleic acids Chemical class 0.000 description 17
- 102000039446 nucleic acids Human genes 0.000 description 17
- 238000011534 incubation Methods 0.000 description 6
- 238000011533 pre-incubation Methods 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 108091022930 Glutamate decarboxylase Proteins 0.000 description 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000011549 displacement method Methods 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 238000010998 test method Methods 0.000 description 4
- 108091093037 Peptide nucleic acid Proteins 0.000 description 3
- 230000002452 interceptive effect Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 239000011882 ultra-fine particle Substances 0.000 description 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 108090000489 Carboxy-Lyases Proteins 0.000 description 1
- 102000004031 Carboxy-Lyases Human genes 0.000 description 1
- 102000008214 Glutamate decarboxylase Human genes 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 206010029719 Nonspecific reaction Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000036436 anti-hiv Effects 0.000 description 1
- 238000013096 assay test Methods 0.000 description 1
- 102000005936 beta-Galactosidase Human genes 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- -1 for example Chemical compound 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 102000013415 peroxidase activity proteins Human genes 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/969—Multiple layering of reactants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/823—Immunogenic carrier or carrier per se
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/825—Pretreatment for removal of interfering factors from sample
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4434093:1 | 1994-09-23 | ||
| DE4434093A DE4434093A1 (de) | 1994-09-23 | 1994-09-23 | Verfahren zum qualitativen oder/und quantitativen Nachweis einer zu bestimmenden Substanz |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH08114590A JPH08114590A (ja) | 1996-05-07 |
| JP2902581B2 true JP2902581B2 (ja) | 1999-06-07 |
Family
ID=6529055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7246505A Expired - Lifetime JP2902581B2 (ja) | 1994-09-23 | 1995-09-25 | 測定すべき物質の定性的または／および定量的検出法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5935780A (enExample) |
| EP (1) | EP0703452B1 (enExample) |
| JP (1) | JP2902581B2 (enExample) |
| DE (2) | DE4434093A1 (enExample) |
| ES (1) | ES2199233T3 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19637718A1 (de) | 1996-04-01 | 1997-10-02 | Boehringer Mannheim Gmbh | Rekombinante inaktive Core-Streptavidin Mutanten |
| US20030003464A1 (en) * | 2000-11-27 | 2003-01-02 | Phan Brigitte C. | Dual bead assays including optical biodiscs and methods relating thereto |
| US20040248093A1 (en) * | 2000-11-27 | 2004-12-09 | Coombs James Howard | Magneto-optical bio-discs and systems including related methods |
| US20020172980A1 (en) * | 2000-11-27 | 2002-11-21 | Phan Brigitte Chau | Methods for decreasing non-specific binding of beads in dual bead assays including related optical biodiscs and disc drive systems |
| US6905816B2 (en) * | 2000-11-27 | 2005-06-14 | Intelligent Medical Devices, Inc. | Clinically intelligent diagnostic devices and methods |
| WO2003075013A1 (fr) * | 2002-03-04 | 2003-09-12 | The New Industry Research Organization | Methode destinee a mesurer l'activite d'une proteine de liaison a l'adn |
| EP1493029B1 (en) * | 2002-04-10 | 2010-03-31 | Response Biomedical Corporation | Sensitive immunochromatographic assay |
| US7175992B2 (en) * | 2002-04-10 | 2007-02-13 | Response Biomedical Corporation | Sensitive immunochromatographic assay |
| US20030198967A1 (en) * | 2002-04-23 | 2003-10-23 | Matson Robert S. | Multi-functional microarrays and methods |
| US20050014249A1 (en) * | 2003-02-21 | 2005-01-20 | Norbert Staimer | Chromatographic analysis on optical bio-discs and methods relating thereto |
| US7875433B2 (en) * | 2007-02-26 | 2011-01-25 | Response Biomedical Corporation | Comparative multiple analyte assay |
| CA2753873A1 (en) | 2009-03-02 | 2010-09-10 | Japan Tobacco Inc. | Method for detecting substance in biological sample |
| EP2416158A4 (en) | 2009-03-31 | 2012-05-30 | Japan Tobacco Inc | METHOD FOR DETECTING A SUBSTANCE IN A BIOLOGICAL SAMPLE |
| US20130052669A1 (en) * | 2010-04-30 | 2013-02-28 | Amanda G. Paulovich | Compositions and methods for reliably detecting and/or measuring the amount of a modified target protein in a sample |
| JPWO2013018836A1 (ja) * | 2011-08-01 | 2015-03-05 | 日本たばこ産業株式会社 | 生物学的試料中の物質を検出する工程において、非特異的結合を抑制する方法、当該方法に使用するための剤 |
| JP6765232B2 (ja) * | 2016-06-30 | 2020-10-07 | シスメックス株式会社 | 免疫複合体転移法により被検物質を検出するための抗体試薬及びその製造方法、並びにその抗体試薬の利用 |
| CN114910635B (zh) * | 2017-10-26 | 2025-05-02 | 科美诊断技术股份有限公司 | 一种无基质效应的均相免疫检测试剂盒及其应用 |
| CN119881293A (zh) | 2018-03-21 | 2025-04-25 | 沃特世科技公司 | 基于非抗体高亲和力的样品制备、吸附剂、装置和方法 |
| EP3990921A4 (en) * | 2019-06-25 | 2023-08-02 | Veravas, Inc. | SAMPLE INTERFERENCE DETECTION AND DEPLETION COMPOSITIONS AND METHODS |
| CN116626285A (zh) * | 2019-07-19 | 2023-08-22 | 科美博阳诊断技术(上海)有限公司 | 一种均相化学发光分析的方法及其应用 |
| CN111812336A (zh) * | 2020-08-10 | 2020-10-23 | 苏州康和顺医疗技术有限公司 | 用于检测冠状病毒抗体的检测试剂盒及其制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL51667A (en) * | 1977-03-16 | 1979-10-31 | Miles Yeda Ltd | Immunoassay for the determination of a hapten |
| US4294817A (en) * | 1977-11-25 | 1981-10-13 | International Diagnostic Technology, Inc. | Method of fluoro immunoassay |
| JPS5510590A (en) * | 1978-05-04 | 1980-01-25 | Wellcome Found | Enzyme immunity quantity analysis |
| US4228237A (en) * | 1978-09-21 | 1980-10-14 | Calbiochem-Behring Corp. | Methods for the detection and determination of ligands |
| US4243655A (en) * | 1979-09-04 | 1981-01-06 | Gunther Roland E | Dental health-care aids |
| US4656252A (en) * | 1980-01-24 | 1987-04-07 | Giese Roger W | Amidobiotin compounds useful in a avidin-biotin multiple layering process |
| NL8102178A (nl) * | 1981-05-02 | 1982-12-01 | Stichting Centraal Lab | Werkwijze voor het aantonen van tegen bepaalde antigenen gerichte antistoffen, alsmede inrichting en reagentia voor het uitvoeren van deze werkwijze. |
| JPS59143960A (ja) * | 1983-02-08 | 1984-08-17 | Amano Pharmaceut Co Ltd | 酵素標識抗体に含まれる非特異的吸着成分の除去法 |
| US4490473A (en) * | 1983-03-28 | 1984-12-25 | Panab | Labeled antibodies and methods |
| JPS60242369A (ja) * | 1984-05-16 | 1985-12-02 | Fujirebio Inc | イムノアツセイにおける非特異反応吸収剤 |
| JPS61250559A (ja) * | 1985-04-30 | 1986-11-07 | Toshiba Corp | 免疫分析方法 |
| ZA877772B (en) * | 1986-10-23 | 1988-04-20 | Amoco Corporation | Target and background capture methods and apparatus for affinity assays |
| DE3705686C2 (de) * | 1987-02-23 | 1995-11-30 | Boehringer Mannheim Gmbh | Verfahren zur Bestimmung von Antikörpern |
| DE3720983A1 (de) * | 1987-06-25 | 1989-01-05 | Hoechst Ag | Immunometrisches bestimmungsverfahren |
| DE3806431A1 (de) * | 1988-02-29 | 1989-09-07 | Boehringer Mannheim Gmbh | Verfahren zur herstellung einer festphasenmatrix |
| US5268306A (en) * | 1988-02-29 | 1993-12-07 | Boehringer Mannheim Gmbh | Preparation of a solid phase matrix containing a bound specific binding pair |
| US5277589A (en) * | 1988-07-08 | 1994-01-11 | Boehringer Mannheim Gmbh | Process for the determination of antibodies |
| US5096837A (en) * | 1990-02-08 | 1992-03-17 | Pacific Biotech, Inc. | Immunochromatographic assay and method of using same |
| DE4024544A1 (de) * | 1990-08-02 | 1992-02-06 | Boehringer Mannheim Gmbh | Analyseelement und verfahren zu seiner herstellung |
| DE4134833A1 (de) * | 1991-09-25 | 1993-04-01 | Boehringer Mannheim Gmbh | Verfahren zur bestimmung von fibrin |
| US5656504A (en) * | 1992-10-26 | 1997-08-12 | Pharmacia Biosensor Ab | Method of preventing undesired binding in solid phase assays |
| JP3027770B2 (ja) * | 1994-03-05 | 2000-04-04 | ロシュ ダイアグノスティックス ゲーエムベーハー | イムノアッセイで使用するための干渉除去剤 |
-
1994
- 1994-09-23 DE DE4434093A patent/DE4434093A1/de not_active Withdrawn
-
1995
- 1995-09-21 US US08/531,838 patent/US5935780A/en not_active Expired - Lifetime
- 1995-09-22 EP EP95114973A patent/EP0703452B1/de not_active Expired - Lifetime
- 1995-09-22 DE DE59510661T patent/DE59510661D1/de not_active Expired - Lifetime
- 1995-09-22 ES ES95114973T patent/ES2199233T3/es not_active Expired - Lifetime
- 1995-09-25 JP JP7246505A patent/JP2902581B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE4434093A1 (de) | 1996-03-28 |
| US5935780A (en) | 1999-08-10 |
| EP0703452A2 (de) | 1996-03-27 |
| DE59510661D1 (de) | 2003-06-05 |
| EP0703452A3 (enExample) | 1996-05-01 |
| ES2199233T3 (es) | 2004-02-16 |
| EP0703452B1 (de) | 2003-05-02 |
| JPH08114590A (ja) | 1996-05-07 |
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