JP2640349B2 - Hair restoration - Google Patents

Hair restoration

Info

Publication number
JP2640349B2
JP2640349B2 JP62261274A JP26127487A JP2640349B2 JP 2640349 B2 JP2640349 B2 JP 2640349B2 JP 62261274 A JP62261274 A JP 62261274A JP 26127487 A JP26127487 A JP 26127487A JP 2640349 B2 JP2640349 B2 JP 2640349B2
Authority
JP
Japan
Prior art keywords
hair
fermentation product
rhizopus
fermentation
hair restorer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP62261274A
Other languages
Japanese (ja)
Other versions
JPH01102015A (en
Inventor
俊雄 堀内
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SANKO SEIBUTSU KAGAKU KENKYUSHO KK
Original Assignee
SANKO SEIBUTSU KAGAKU KENKYUSHO KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SANKO SEIBUTSU KAGAKU KENKYUSHO KK filed Critical SANKO SEIBUTSU KAGAKU KENKYUSHO KK
Priority to JP62261274A priority Critical patent/JP2640349B2/en
Publication of JPH01102015A publication Critical patent/JPH01102015A/en
Application granted granted Critical
Publication of JP2640349B2 publication Critical patent/JP2640349B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Description

【発明の詳細な説明】 （産業上の利用分野） この発明は、人の頭皮及び頭髪の正常化に有効な新し
い養毛料（医薬部外品たる薬用養毛料及び医薬品たる外
用皮膚用剤を含む。以下同じ）、即ち、頭皮及び頭髪の
フケ、カユミ又は脱毛の予防又は治療に有効な衛生物製
剤に係わる。DETAILED DESCRIPTION OF THE INVENTION (Industrial Application Field) The present invention relates to a new hair restoration (effective as a quasi-drug, a medicated hair restoration and a medicine as an external skin preparation) which is effective for normalizing human scalp and hair. The same shall apply hereinafter), that is, a hygiene preparation effective for preventing or treating dandruff, scabies or hair loss on the scalp and hair.

更に詳しくは、脱脂大豆又は脱脂大豆成分を含有する
培地に、リゾープス属に属する菌を作用せしめて得られ
る醗酵生成物を有効成分として含有する養毛料に関す
る。More specifically, the present invention relates to a hair restorer containing, as an active ingredient, a fermentation product obtained by allowing a bacterium belonging to the genus Rhizopus to act on a medium containing defatted soybeans or defatted soybean components.

（従来技術及びその問題点） 従来から、頭皮及び頭髪のフケ、カユミ又は脱毛等の
予防又は治療に、種々の薬剤を配合することが提案され
ているが、有効性、安全性あるいは安定性の面から、十
分満足できるものは少ない。(Prior art and its problems) Conventionally, it has been proposed to mix various drugs for the prevention or treatment of dandruff, kayumi, or hair loss on the scalp and hair, but the efficacy, safety or stability of the drug has been suggested. From the aspect, there are few things that can be sufficiently satisfied.

従来から、女性ホルモン剤、センブリエキス、ヒノキ
チオール、トウガラシチンキ、カンタリスチンキ、セフ
ァランチン、塩化カルプロニウム等がこの目的に用いら
れているがまた満足できるものではなく、それらの効果
は学問的に疑問視されているものも多い。Conventionally, female hormone agents, assembly extracts, hinokitiol, pepper tincture, tincture tincture, cepharanthin, cepharanthin, carpronium chloride, etc. have been used for this purpose, but they are not satisfactory, and their effects are academically questioned. There are many things.

（発明の経過） この発明者は、真に有効な養毛料を開発するべく鋭意
研究を行った結果、脱脂大豆又は脱脂大豆成分を含有す
る培地に、リゾープス属に属する菌を作用せしめて得ら
れる醗酵生成物が、シミ、ソバカス、ハダアレ等に対し
て極めて効果的な作用を有する事実を発見し、優れた皮
膚化粧料を完成するに至った。(Progress of the Invention) As a result of intensive studies to develop a truly effective hair nourishing agent, this inventor obtained a defatted soybean or a medium containing a defatted soybean component by applying a bacterium belonging to the genus Rhizopus. It has been discovered that fermentation products have an extremely effective action on spots, freckles, spots, and the like, leading to the completion of an excellent skin cosmetic.

この研究過程で、この醗酵生成物は、同時にフケ、カ
ユミ等に対して極めて効果的な作用を有し、ひいては脱
毛の予防又は治療に有効である事実を発見し、この知見
を基に、この発明を完成するに至った。In the course of this research, we discovered that this fermentation product has an extremely effective effect on dandruff, Kayumi, etc. at the same time and is thus effective in preventing or treating hair loss, and based on this finding, The invention has been completed.

尚、大豆に、リゾープス属に属する菌を作用せしめて
得られる醗酵生成物として、インドネシアの伝統的な醗
酵食品であるテンペー（Tempeh）があり、我が国に存在
する納豆と同様に優れた醗酵食品である。In addition, as a fermentation product obtained by reacting a soybean with a bacterium belonging to the genus Rhizopus, there is a traditional fermented food in Indonesia, Tempeh, which is an excellent fermented food similar to natto that exists in Japan. is there.

しかし、これらは専ら食用として使用されるのみで、
養毛料として使用された例は見当たらない。However, they are used exclusively for food,
There are no examples used as hair restorer.

この醗酵生成物を、養毛料に含有せしめることによっ
て、フケ、カユミ、脱毛等に有効で安全な新規の素材を
提供することを目的とするものである。It is an object of the present invention to provide a new material that is effective and safe for dandruff, Kayumi, hair loss, etc. by incorporating this fermentation product into a hair nourishing agent.

（目的を達成するための手段） この発明では脱脂大豆又は脱脂大豆成分を含有する培
地に、リゾープス属に属する菌を作用せしめて得られる
醗酵生成物を含有することを特徴とする養毛料を提供す
ることにより、上記目的を達成する。(Means for Achieving the Object) The present invention provides a hair restorer characterized by containing a fermentation product obtained by allowing a microorganism belonging to the genus Rhizopus to act on a medium containing defatted soybeans or defatted soybean components. By doing so, the above object is achieved.

（発明の構成） この発明でリゾープス属に属する菌を作用せしめる際
に使用される培地は、特に限定されないが、発明の実施
に使用する菌が良好に繁殖するもので、脱脂大豆又は脱
脂大豆組成分を含有するものであれば、いかなる培地で
もかまわず、大豆の加工品、調理品又は大豆から分離し
た組成物が好適に用いられる。(Constitution of the Invention) The medium used for causing a bacterium belonging to the genus Rhizopus to act in the present invention is not particularly limited, but the bacterium used for the practice of the present invention satisfactorily propagates, and defatted soybean or defatted soybean composition is used. Any medium may be used as long as it contains a soybean component, and a processed product of soybean, a cooked product, or a composition separated from soybean is suitably used.

また脱脂大豆には、酵母エキス、カゼイン、ホエープ
ロテイン、スキムミルク、蛋白分解物、各種アミノ酸、
無機窒素塩類等の窒素源とか、グルコース、フルクトー
ス、各種澱粉等の炭素源とか、無機塩類、ビタミン類と
かを添加して使用することができる。In addition, defatted soybeans include yeast extract, casein, whey protein, skim milk, proteolysates, various amino acids,
Nitrogen sources such as inorganic nitrogen salts, carbon sources such as glucose, fructose and various starches, and inorganic salts and vitamins can be added and used.

リゾープス属に属する菌を、脱脂大豆又は脱脂大豆成
分を含有する培地に作用せしめて醗酵させる方法は、使
用する菌の種類とか培地の種類により異なり、好適な養
毛料を製造できる方法であればいかなる方法でも採用で
きる。The method of fermenting a bacterium belonging to the genus Rhizopus by acting on a defatted soybean or a medium containing a defatted soybean component varies depending on the type of the bacterium used or the type of the medium, and any method can be used as long as it can produce a suitable hair restorer. The method can also be adopted.

この発明の醗酵に使用されるリゾープス属に属する菌
はいずれも使用してもよく、脱脂大豆又は脱脂大豆成分
を含有する培地に作用せしめて得られる醗酵生成物が、
フケ、カユミ、脱毛等に対して、予防又は治療効果を有
するものであれば、その菌種は特に限定されない。Any bacteria belonging to the genus Rhizopus used in the fermentation of the present invention may be used, and a fermentation product obtained by acting on a medium containing defatted soybeans or defatted soybean components is:
The bacterial species is not particularly limited as long as it has a preventive or therapeutic effect on dandruff, kayumi, hair loss, and the like.

より好ましくは、テンペー醗酵菌より分離同定されて
いるリゾープス・オリゴスポーラス、リゾープス・オリ
ーザ、リゾープス・アリザスまたはリゾープス・ストロ
ニィファのいずれか、もしくはそれらの組合せを混合し
て使用することができる。More preferably, any one of Rhizopus oligosporus, Rhizopus oryza, Rhizopus alizas, or Rhizopus stronifera, which has been separated and identified from the fermentation bacteria of Tempeh, or a combination thereof can be used.

これらの菌種は全て公知の微生物であるが、菌株は特
に限定されず、自然界から分離したもの、その人工的ま
たは自然的変異株を使用することができる。These bacterial species are all known microorganisms, but the strain is not particularly limited, and those isolated from the natural world and artificial or natural mutants thereof can be used.

更にリゾープス属に属する菌は、バナナをはじめチー
ク、ローレル等の広葉樹の葉に寄生しているので、テン
ペーを製造するのと同様に、これらの植物の葉を日陰干
しにして粉末とし、種菌として使用することもできる。Furthermore, fungi belonging to the genus Rhizopus are parasitic on broadleaf leaves such as bananas, teak, and laurel, so in the same manner as in the production of tempeh, the leaves of these plants are dried in the shade to form a powder, which is used as a seed fungus. Can also be used.

これらの醗酵生成物を実際に使用するに当たっては、
醗酵物をそのまま使用することも可能であるが、脱脂大
豆等の不溶固形物が多量に含有されているので、醗酵物
を搾汁した醗酵液または溶媒抽出液もしくはそれらの濃
縮物がより有効に使用され得る。In actually using these fermentation products,
It is possible to use the fermented product as it is, but since it contains a large amount of insoluble solids such as defatted soybeans, it is more effective to use a fermented solution or a solvent extract obtained by squeezing the fermented product or a concentrate thereof. Can be used.

搾汁した醗酵液の場合には、有効成分が残渣中に多量
に残存することがあるので、より好ましくは適当な溶媒
で抽出して使用する。In the case of a squeezed fermentation solution, a large amount of the active ingredient may remain in the residue, so that it is more preferably used by extracting with a suitable solvent.

使用する溶媒は、醗酵物からフケ、カユミ、脱毛等に
対して予防又は治療効果を有する成分が効果的に抽出さ
れ得る溶媒であれば、特に限定されない。The solvent to be used is not particularly limited as long as it is a solvent that can effectively extract a component having a preventive or therapeutic effect on fermented products against dandruff, kayumi, hair loss, and the like.

より好ましくは、水又はエタノールもしくはそれらの
混液が使用され得る。More preferably, water or ethanol or a mixture thereof can be used.

こうして得られた脱脂大豆又は脱脂大豆成分を含有す
る培地に、リゾープス属に属する菌を作用せしめて得ら
れる醗酵液もしくは醗酵抽出液は、そのままの形で養毛
料として単独で使用することができるが、養毛料の配合
原料として通常のローション、ヘアーオイル、ヘアーリ
キッド、ヘアークリーム、シャンプー、リンス等に配合
して使用することができる。A fermentation solution or fermentation extract obtained by allowing a bacterium belonging to the genus Rhizopus to act on the medium containing the defatted soybean or the defatted soybean component thus obtained can be used alone as a hair restorer in its original form. It can be used by blending it into a usual lotion, hair oil, hair liquid, hair cream, shampoo, rinse and the like as a compounding material for hair restorer.

この場合濃縮物もしくは乾燥物を使用することがより
好ましい。In this case, it is more preferable to use a concentrate or a dried product.

又、女性ホルモン、センブリエキス、カンタリスチン
キ、セファランチン、塩化カルプロニウム等の他の毛生
薬剤を同時に配合して養毛剤を製することもできる。Also, a hair restorer can be prepared by simultaneously mixing other hair biopharmaceuticals such as female hormone, assembly extract, cantaris tincture, cepharanthin, carpronium chloride and the like.

こうして得られた醗酵生成物は、フケ、カユミ、脱毛
等の予防又は治療に対して極めて有効に作用するが、こ
の醗酵生成物中の有効成分及びその作用機序については
まだ明らかではなく、現在鋭意研究中であるが、次のよ
うな事実も理由の一つと考えられる。The fermentation product thus obtained acts extremely effectively for the prevention or treatment of dandruff, kayumi, hair loss, etc., but the active ingredient in this fermentation product and its mechanism of action are not yet clear. We are studying hard, but the following facts may be one of the reasons.

即ち、脱脂大豆のリゾープス属に属する菌を作用せし
めて得られる醗酵生成物中には、脱脂大豆中には未検出
である４′,6,7−トリヒドロキシイソフラボンが検出さ
れることが知られている。That is, it is known that 4 ′, 6,7-trihydroxyisoflavone, which is not detected in defatted soybeans, is detected in a fermentation product obtained by allowing bacteria belonging to the genus Rhizopus of defatted soybeans to act. ing.

この物質は、分子式C15H10O5、融点319（decomp）、U
V λmax:260,327（ｍμ）の既知化合物で、このものは
極めて強力な抗酸化性、殺菌性を有することから、フ
ケ、カユミ等に対する効果性の重要な因子の一つである
ことは疑いない。This substance has the molecular formula C 15 H 10 O 5 , melting point 319 (decomp), U
V λmax: 260,327 (mμ), a known compound having extremely strong antioxidant and bactericidal properties, it is undoubtedly one of the important factors for its effectiveness against dandruff, Kayumi and the like.

然るに、脱脂大豆又は脱脂大豆成分を有する培地にリ
ゾープス属に属する菌を作用せしめて得られる醗酵生成
物の有する優れた効果性は、この物質の存在のみに帰属
させることは困難である。However, it is difficult to attribute the superior effectiveness of the fermentation product obtained by allowing a bacterium belonging to the genus Rhizopus to act on a medium containing defatted soybeans or defatted soybean components only to the presence of this substance.

当該醗酵生成物には、その他に多数の未知化合物が含
有されており、それらが相加的または相乗的に作用して
効果を発揮するものと考えられる。The fermentation product contains a large number of other unknown compounds, which are considered to exert an effect by acting additively or synergistically.

加えて、当該醗酵生成物中には各種のアミノ酸、ペプ
タイド、各種の糖類、クエン酸とかピログルタミン酸等
各種の有機酸、ビタミンB6とかニコチン酸等各種のビタ
ミン類及び各種の微量無機塩類等が含有されており、フ
ケ、カユミ、脱毛の防止等に加えて、発毛促進等養毛料
としてより好ましい性質を付与する。In addition, various amino acids in the fermentation product, peptide, various sugars, citric acid Toka pyroglutamic acid and various organic acids, vitamins and various vitamins B 6 Toka nicotinic acid and various trace inorganic salts and the like of It is contained and, in addition to the prevention of dandruff, kayumi and hair loss, etc., imparts more favorable properties as a hair nourishing agent such as promotion of hair growth.

従って、皮膚化粧料への使用に当たっては、必ずしも
有効成分を同定単離して使用する必要はない。Therefore, it is not always necessary to identify and isolate the active ingredient before use in skin cosmetics.

尚、４′,6,7−トリヒドロキシイソフラボンを他の手
段により得て、養毛料に含有させてもよい。Incidentally, 4 ', 6,7-trihydroxyisoflavone may be obtained by other means and contained in the hair tonic.

（発明の効果） この発明は脱脂大豆又は脱脂大豆成分を含有する培地
に、リゾープス属に属する菌を作用せしめて得られる醗
酵生成物を含有することを特徴とする養毛料であるか
ら、頭皮、頭髪のフケ、カユミ又は脱毛の予防又は治療
に対して極めて有効に作用する。(Effect of the Invention) The present invention is a hair restorer characterized by containing a fermentation product obtained by allowing a bacterium belonging to the genus Rhizopus to act on a medium containing defatted soybeans or defatted soybean components. It works very effectively for the prevention or treatment of dandruff, kayumi or hair loss on the hair.

Claims (5)

(57)【特許請求の範囲】(57) [Claims] 【請求項１】脱脂大豆又は脱脂大豆成分を含有する培地
に、リゾープス属に属する菌を作用せしめて得られる醗
酵生成物を含有することを特徴とする養毛料。A hair restorer comprising a fermentation product obtained by reacting a bacterium belonging to the genus Rhizopus with a medium containing defatted soybeans or defatted soybean components. 【請求項２】前記リゾープス属に属する菌が、リゾープ
ス・オリゴスポーラス（Rhizopus oligosporus）、リゾ
ープス・オリーザ（Rhizopus oryzae）、リゾープス・
アリザス（Rhizopus arrhizus）又はリゾープス・スト
ロニィファ（Rhizopus stolonifer）のいずれか、もし
くはそれらの組み合わせであることを特徴とする特許請
求の範囲第１項記載の養毛料。2. The microorganism belonging to the genus Rhizopus is Rhizopus oligosporus, Rhizopus oryzae, Rhizopus oryzae.
2. The hair restorer according to claim 1, wherein the hair restorer is any one of Rhizopus arrhizus and Rhizopus stolonifer, or a combination thereof. 【請求項３】前記醗酵生成物が、テンペー（Tempeh）で
あることを特徴とする特許請求の範囲第１項乃至第２項
記載の養毛料。3. The hair restorer according to claim 1, wherein said fermentation product is Tempeh. 【請求項４】前記醗酵生成物が、醗酵物、醗酵液又はそ
れらの抽出物であることを特徴とする特許請求の範囲第
１項乃至第３項記載の養毛料。4. The hair restorer according to claim 1, wherein said fermentation product is a fermentation product, a fermentation solution or an extract thereof. 【請求項５】前記醗酵生成物が、醗酵物を４′,6,7−ト
リヒドロキシイソフラボンを含有するように調整または
加工されたものである特許請求の範囲第１項乃至第４項
記載の養毛料。5. The fermentation product according to claim 1, wherein the fermentation product is prepared by adjusting or processing a fermentation product so as to contain 4 ′, 6,7-trihydroxyisoflavone. Hair restoration.
JP62261274A 1987-10-15 1987-10-15 Hair restoration Expired - Lifetime JP2640349B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62261274A JP2640349B2 (en) 1987-10-15 1987-10-15 Hair restoration

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62261274A JP2640349B2 (en) 1987-10-15 1987-10-15 Hair restoration

Publications (2)

Publication Number Publication Date
JPH01102015A JPH01102015A (en) 1989-04-19
JP2640349B2 true JP2640349B2 (en) 1997-08-13

Family

ID=17359543

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62261274A Expired - Lifetime JP2640349B2 (en) 1987-10-15 1987-10-15 Hair restoration

Country Status (1)

Country Link
JP (1) JP2640349B2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01128912A (en) * 1987-11-13 1989-05-22 Shogo Ogura Production of hair dressing and growing agent
DK292D0 (en) * 1991-11-29 1992-01-02 Tanisake Kk MEDITERRANEAN
JP2000327538A (en) * 1999-05-24 2000-11-28 Toyo Hakko:Kk Agent composition for hair treatment
JP5147805B2 (en) * 2004-03-15 2013-02-20 共栄化学工業株式会社 Cosmetics
JP4563225B2 (en) * 2004-03-15 2010-10-13 共栄化学工業株式会社 Cosmetics
GB0513193D0 (en) * 2005-06-29 2005-08-03 Quest Int Serv Bv Improvements in skin and hair care
JP2008007476A (en) * 2006-06-30 2008-01-17 Lion Corp Hair-growing and restoring agent composition
KR101111094B1 (en) * 2009-06-23 2012-02-15 (주)시너지코리아 Method for manufacturing hair-restorer and fallen hair prevention
JP5780886B2 (en) * 2010-09-02 2015-09-16 雪印メグミルク株式会社 Hair composition
CN112022792B (en) * 2020-09-27 2022-12-09 黑龙江省中医药科学院 Preparation method of edible traditional Chinese medicine hair dye with homology of medicine and food

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59141515A (en) * 1983-02-02 1984-08-14 Suntory Ltd Fermented hair tonic cosmetic

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59141515A (en) * 1983-02-02 1984-08-14 Suntory Ltd Fermented hair tonic cosmetic

Also Published As

Publication number Publication date
JPH01102015A (en) 1989-04-19

Similar Documents

Publication Publication Date Title
JP3966924B2 (en) Fibroblast growth promoter containing plant extract
JP2002241299A (en) Maillard reaction recovering agent
JP3810836B2 (en) Cosmetic composition for beauty
JPH1036283A (en) Fibroblast proliferation promoting agent
JP2002138045A (en) Inhibitor for inhibiting differentiation induction of pre- adipocyte
JPH11106336A (en) Maillard reaction inhibitor
JP2002241293A (en) Maillard reaction inhibitor
KR101196523B1 (en) Composition for promoting hair growth comprising fermented oriental medicine extract
JP4100911B2 (en) Glutamate decarboxylase activator
JP2001333731A (en) Food having immunostimulation activity
JPH09110710A (en) Dermal preparation for external use and bathing agent
JP2640349B2 (en) Hair restoration
JPH0987189A (en) Antiallergic agent containing isodon japonicus hara, paeonia suffruticosa andrews, perilla frutescens britton var. acuta kudo, and/or arunica montana linne
KR101336804B1 (en) Fermented ear shell using mushroom, manufacturing method thereof and cosmetic composition comprising the same
JP2004346045A (en) Cosmetic additive, bathing agent and health food containing sake lees extract obtained in brewing of sake using deep seawater
JPH11139986A (en) Physiologically active composition derived from hydrolyzate of silk protein
JP2004107286A (en) Cosmetic composition and food composition for beauty and health
JP2002020300A (en) Cosmetic composition
JPH10203994A (en) Physiologically active composition
JP2618658B2 (en) Skin cosmetics
JP2000143524A (en) Antiinflammatory agent containing extract of amaranthus
JP2002316937A (en) Plant extract-containing anti-allergic agent
JPH104953A (en) Composition for beauty and health utilizing melatonin yeast
JP2003113026A (en) Lipase activity promoter
JP2003128698A (en) Acylated attelo collagen from fish skin, its manufacturing method, and fine cosmetic compounded with its compound

Legal Events

Date Code Title Description
R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term
FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20080502

Year of fee payment: 11