JP5780886B2 - Hair composition - Google Patents
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- JP5780886B2 JP5780886B2 JP2011185370A JP2011185370A JP5780886B2 JP 5780886 B2 JP5780886 B2 JP 5780886B2 JP 2011185370 A JP2011185370 A JP 2011185370A JP 2011185370 A JP2011185370 A JP 2011185370A JP 5780886 B2 JP5780886 B2 JP 5780886B2
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本発明は毛周期における成長期への早期誘導を促す毛髪用組成物に関する。 The present invention relates to a hair composition that promotes early induction of the hair cycle to the growth phase.
毛髪を作り出す毛包は成長期（毛髪形成）、退行期、休止期、成長期を毛周期と呼ばれる独自の周期で繰り返すことが知られている。成長期においては毛包中の上皮系細胞である毛母細胞が激しく分裂する結果、毛髪の伸長が起こる。この毛母細胞の増殖や分化をコントロールしているのが間葉系細胞である毛乳頭細胞であり、毛乳頭細胞が産生する細胞増殖因子としてＩＧＦ−１やＨＧＦ、ＶＥＧＦ、ＦＧＦ−７等が挙げられている。一方、毛乳頭細胞がＦＧＦ−５やＴＧＦ−βを産生すると毛母細胞の増殖が抑制され、退行期が誘導されると報告されている。しかしながら毛髪形成の基となる毛母細胞の活性には毛乳頭細胞との相互作用による影響が大きく、その制御には上記以外にも多種多様な因子が関与していることが推測される。 It is known that hair follicles that produce hair repeat the growth period (hair formation), the regression period, the rest period, and the growth period in a unique cycle called a hair cycle. During growth, hair matrix cells, which are epithelial cells in the hair follicle, divide vigorously, resulting in hair elongation. The hair papilla cells that are mesenchymal cells control the growth and differentiation of the hair matrix cells, and IGF-1, HGF, VEGF, FGF-7, etc. are cell growth factors produced by the hair papilla cells. Are listed. On the other hand, it has been reported that when dermal papilla cells produce FGF-5 or TGF-β, the growth of hair matrix cells is suppressed and the regression phase is induced. However, the activity of hair matrix cells that form the basis of hair formation is greatly influenced by the interaction with hair papilla cells, and it is speculated that various factors other than the above are involved in the control.
毛髪は成人の象徴とされ、男女を問わず脱毛に関する悩みは大きいとされる。実際に養毛や育毛という効果をうたった製品が多数販売されており、そのような効果をもたらす物質に対する社会的要請は非常に大きい。 Hair is regarded as a symbol of adulthood, and it is said that there are great concerns about hair loss regardless of gender. There are many products on the market that are effective for hair restoration and hair growth, and there is a great social demand for substances that bring about such effects.
これまでに発明された育毛剤（医薬品）としては「ミノキシジル」を有効成分とするものが挙げられる（特許文献１）。「ミノキシジル」の作用機序は以下のように推測されている。つまり、ミノシキジルは毛包でミノキシジルサルフェートに変換され、毛乳頭細胞のスルフォニアウレア受容体（ＳＵＲ）に反応し、ＡＴＰを細胞外へ放出する。放出されたＡＴＰはＡＴＰアーゼによりアデノシンに分解され、このアデノシンが毛乳頭細胞膜上のアデノシン受容体に作用して血管内皮細胞増殖因子(ＶＥＧＦ)を放出して毛の成長に働くとされる。また毛乳頭細胞でのＦＧＦ−７の発現による毛成長の促進にも関与しているといわれている。 Examples of the hair restorer (medicine) invented so far include those containing “minoxidil” as an active ingredient (Patent Document 1). The mechanism of action of “minoxidil” is presumed as follows. That is, minoshixil is converted into minoxidil sulfate in the hair follicle, reacts with the sulphonia urea receptor (SUR) of the hair papilla cell, and releases ATP to the outside of the cell. The released ATP is decomposed into adenosine by ATPase, and this adenosine acts on the adenosine receptor on the hair papillary cell membrane to release vascular endothelial growth factor (VEGF), which acts on hair growth. It is also said to be involved in the promotion of hair growth by the expression of FGF-7 in hair papilla cells.
その他、薬用育毛剤（医薬部外品）に配合されている成分としてはビタミンE、塩化カルプロニウム、センブリエキスなどの末梢血管を拡張して血行を促進するもの、塩酸ジフェンドラミン、グリチルリチン誘導体、ヒノキチオールなどの抗炎症・抗菌効果により頭皮を清浄にして頭皮の状態を改善するもの、ビタミン類やアミノ酸、ジアルキルモノアミン誘導体、ペンタデカン酸グリセリド、にんじんエキス、プラセンタエキスなどの栄養補給や細胞賦活化作用を有するものなどが挙げられる。 In addition, ingredients blended in medicinal hair restorers (quasi-drugs) include those that promote blood circulation by expanding peripheral blood vessels such as vitamin E, carpronium chloride, and assembly extract, difendramine hydrochloride, glycyrrhizin derivatives, hinokitiol It improves the condition of the scalp by cleaning the scalp with anti-inflammatory and antibacterial effects such as vitamins, amino acids, dialkyl monoamine derivatives, pentadecanoic acid glycerides, carrot extract, placenta extract, etc. Things.
本発明は、毛周期のうち、成長期への早期誘導を促し、脱毛症に対する予防効果や改善効果を有する毛髪用組成物を提供することを目的とする。 An object of the present invention is to provide a hair composition that promotes early induction into the growth phase of the hair cycle and has a preventive effect and an improvement effect on alopecia.
上記課題を解決するために、本発明者らは、微生物の代謝産物に注目し、鋭意研究を進めてきたところ、本発明を完成させるに至った。すなわち、本発明は以下の態様を含むものである。
（１）微生物の代謝産物を有効成分とする毛髪用組成物。
（２）前記微生物が、リゾプス属、モナスカス属のいずれかに属することを特徴とする請求項１記載の毛髪用組成物。
（３）極性脂質を含む培地を使用し、微生物を培養することを特徴とする、毛髪用組成物の製造方法。
（４）前記極性脂質が、 ホスファシジルコリン、ホスファシジルエタノールアミン、スフィンゴミエリン、ホスファシジルイノシトール、ホスファシジルセリンから選択されるいずれか一種以上が少なくとも含まれることを特徴とする（３）に記載の毛髪用組成物の製造方法。
（５）前記代謝産物が、微生物を培養した培養液の有機溶媒抽出物であることを特徴とする（１）の毛髪用組成物。
（６）前記微生物を培養した培養液が、極性脂質を含むことを特徴とする（５）記載の毛髪用組成物。
（７）極性脂質を含む培地を用いて微生物を培養し、得られた培養液を有機溶媒抽出することを特徴とする、毛髪用組成物の製造方法。
（８）前記極性脂質が、 ホスファシジルコリン、ホスファシジルエタノールアミン、スフィンゴミエリン、ホスファシジルイノシトール、ホスファシジルセリンから選択されるいずれか一種以上が少なくとも含まれることを特徴とする（７）に記載の毛髪用組成物の製造方法。
In order to solve the above-mentioned problems, the present inventors have paid attention to the metabolites of microorganisms and have conducted extensive research, and have completed the present invention. That is, the present invention includes the following aspects.
(1) A composition for hair comprising a microbial metabolite as an active ingredient.
(2) The hair composition according to claim 1, wherein the microorganism belongs to either Rhizopus genus or Monascus genus.
(3) A method for producing a composition for hair, comprising culturing microorganisms using a medium containing polar lipids.
(4) The polar lipid includes at least one selected from phosphatidylcholine, phosphatidylethanolamine, sphingomyelin, phosphacidylinositol, and phosphatidylserine (3 The manufacturing method of the composition for hair as described in).
(5) The hair composition according to (1), wherein the metabolite is an organic solvent extract of a culture solution in which microorganisms are cultured.
(6) The composition for hair according to (5), wherein the culture medium in which the microorganism is cultured contains polar lipids.
(7) A method for producing a hair composition, comprising culturing microorganisms using a medium containing polar lipids and extracting the obtained culture solution with an organic solvent.
(8) The polar lipid includes at least one selected from phosphatidylcholine, phosphatidylethanolamine, sphingomyelin, phosphacidylinositol, and phosphatidylserine (7 The manufacturing method of the composition for hair as described in).
本発明の毛髪用組成物は、毛髪の成長期を早期に誘導する。従って本発明によれば、脱毛症の予防もしくは改善に有効である。また本発明により毛周期の成長期が早期誘導される毛髪用組成物が提供される。 The composition for hair of the present invention induces early hair growth. Therefore, according to the present invention, it is effective in preventing or improving alopecia. Moreover, the composition for hair by which the growth period of a hair cycle is induced early by this invention is provided.
本発明の毛髪用組成物は、微生物の代謝産物を有効成分としている。微生物としては、リゾプス属、モナスカス属のいずれかに属する微生物が挙げられる。より具体的には、リゾプス属として、Rhizopus oryzae、モナスカス属として、Monascus anka(purpureus)が挙げられる。微生物の培養方法については特に制限はなく、通常用いられる液体培地中でこれらの微生物を培養し、得られた培養液からメタノール・クロロホルムを用いて抽出し、濃縮・乾固した後、エタノール可溶画分を得る。本発明の有効成分である代謝産物は、このエタノール可溶画分を用いる。 The hair composition of the present invention contains a microbial metabolite as an active ingredient. Examples of the microorganism include microorganisms belonging to either Rhizopus or Monascus. More specifically, Rhizopus oryzae is exemplified as Rhizopus , and Monascus anka ( purpureus ) is exemplified as Monascus . There are no particular restrictions on the method of culturing the microorganisms. These microorganisms are cultured in a commonly used liquid medium, extracted from the obtained culture solution using methanol / chloroform, concentrated and dried, and then soluble in ethanol. Get the fraction. The ethanol soluble fraction is used as a metabolite which is an active ingredient of the present invention.
また、本発明では、微生物の培地として極性脂質を添加した極性脂質培地を使用する。添加する極性脂質としては、ホスファシジルコリン、ホスファシジルエタノールアミン、スフィンゴミエリン、ホスファシジルイノシトール、ホスファシジルセリンから選択されるいずれか１種以上が好ましい。 Moreover, in this invention, the polar lipid culture medium which added polar lipid as a culture medium of microorganisms is used. The polar lipid to be added is preferably at least one selected from phosphatidylcholine, phosphatidylethanolamine, sphingomyelin, phosphacidylinositol, and phosphatidylserine.
本発明の毛髪用組成物は、非経口的に直接頭皮に投与可能な製剤が好ましく、剤形としては外用剤を挙げることができる。具体的には、ローション剤、エアゾール剤等のほか、シャンプーやリンス、コンディショナー、ヘアトニック、ヘアクリームなどに配合して用いることもできる。製剤化は公知の方法によって行えばよく、一般的に使用される賦形剤や香料などの添加物を使用しても良い。 The hair composition of the present invention is preferably a preparation that can be parenterally administered directly to the scalp. Examples of the dosage form include an external preparation. Specifically, in addition to lotions, aerosols, etc., they can also be used in shampoos, rinses, conditioners, hair tonics, hair creams and the like. Formulation may be performed by a known method, and commonly used additives such as excipients and fragrances may be used.
本発明の毛髪用組成物は、使用者の年齢、症状などに応じて、毛髪が減少している部位や、あるいは毛髪の発生部位に塗布または噴霧等行うことによって、脱毛の症状を緩和できるものである。製剤中の毛髪用組成物の配合量としては、使用目的等を考慮し、適宜決定すればよいが、１〜５％配合することが好ましい。また、配合にあたっては、すでに育毛や発毛の効果を有することが知られている成分を配合しても良い。これらの成分としては、例えば、呉茱萸、五味子、牡丹皮、木瓜、白蘚皮、五加皮、半夏、大黄、牛膝、枸杞子、茯苓、干姜、陳皮、甘草、百部、地骨皮、柴胡、天麻、白芍、荊芥、桂枝、楊梅皮、側柏葉および当薬等の生薬並びにこれら生薬の抽出物（チンキ、エキスなど）、さらには塩化カルプロニウム、パントテニールエチルエーテル、ミノキシジル、セファランチン、ニコチン酸ベンジル、ニコチン酸アミド、ビオチン、D−パントテニルアルコール、イソプロピルメチルフィノール、ヒノキチオール、L−メントール、溶性シスチン、オクトピロックス、塩化ベンザルコニウム、ピリドキシンおよびその誘導体、サリチル酸、塩酸ジフェンヒドラミン、グリチルリチン酸、グリチルレチン酸、ペンタデカン酸グリセリドなどを挙げることができる。これらの成分は、本発明の毛髪用組成物に単独で加えてもよく、また２種以上を組み合わせて加えてもよい。 The hair composition of the present invention can alleviate the symptoms of hair loss by applying or spraying on the hair-decreasing part or the hair generating part according to the age and symptoms of the user. It is. The amount of the hair composition in the preparation may be appropriately determined in consideration of the purpose of use and the like, but it is preferably 1 to 5%. In blending, ingredients already known to have effects of hair growth and hair growth may be blended. These ingredients include, for example, Kureo, Gomi, Peony, Kiso, Birch, Goka, Semi-Summer, Daihuang, Beef Knee, Zushi, Mochi, Dashi, Chen, Licorice, Hundred Parts, Ground Herbal medicines such as bone skin, saiko, hempen, birch, cocoon, katsushi branch, ume plum skin, foliage and this medicine and extracts of these herbal medicines (tincture, extract, etc.), carpronium chloride, pantotenyl ethyl ether, Minoxidil, cephalanthin, benzyl nicotinate, nicotinamide, biotin, D-pantothenyl alcohol, isopropylmethylfinol, hinokitiol, L-menthol, soluble cystine, octopirox, benzalkonium chloride, pyridoxine and its derivatives, salicylic acid, List diphenhydramine hydrochloride, glycyrrhizic acid, glycyrrhetinic acid, pentadecanoic acid glyceride, etc. Door can be. These components may be added to the hair composition of the present invention alone or in combination of two or more.
本発明の毛髪用組成物は、具体的には育毛、発毛、発毛促進および／または養毛用に用いるものである。したがって、本発明の毛髪用組成物の効能・効果としては、育毛、発毛、薄毛、毛生促進、発毛促進、脱毛（抜け毛）の予防、病後・産後の脱毛、養毛、円形脱毛症、発毛不全、粃糠性脱毛症、脂漏性脱毛症、びまん性脱毛症、若禿（壮年性脱毛症）および老人禿等を挙げることができる。 The hair composition of the present invention is specifically used for hair growth, hair growth, hair growth promotion and / or hair nourishment. Therefore, the effects and effects of the hair composition of the present invention include hair growth, hair growth, thin hair, hair growth promotion, hair growth promotion, hair loss (hair loss) prevention, post-morbidity / postpartum hair removal, hair growth, alopecia areata. , Hair loss, dwarf alopecia, seborrheic alopecia, diffuse alopecia, juvenile (aged alopecia), and elderly man.
以下に実施例を記載し、本発明を詳細に説明するが、実施例は本発明の態様の１つであり、本発明は実施例に限定されるものではない。 Hereinafter, the present invention will be described in detail with reference to examples. However, the examples are one aspect of the present invention, and the present invention is not limited to the examples.
リゾプス属として、Rhizopus oryzae ＮＢＲＣ４７８０株（独立行政法人製品評価技術基盤機構生物遺伝資源部門）モナスカス属として、Monascus anka ＡＨＵ９０８５株（国立大学法人北海道大学農学部）を表１に示す培地を用い、３０℃で２週間培養した。なお、極性脂質としては、ミルクセラミドＭＣ−５（雪印乳業株式会社製）からクロロホルム、メタノール及びアセトンを用いて抽出したものを使用した。得られた培養液をクロロホルム、メタノールで各３回抽出を行い、濃縮・乾固させ、エタノール可溶画分を取り出した。得られたエタノール可溶画分を１．０％となるように希釈し、本発明の毛髪用組成物を得た。なお、Rhizopus oryzae ＮＢＲＣ４７８０株から得られたものを実施例品１、Monascus anka ＡＨＵ９０８５株から得られたものを実施例品２とした。 As a Rhizopus genus, Rhizopus oryzae NBRC 4780 (National Institute of Technology and Evaluation, Biological Genetic Resources Division), Monascus genus, Monascus anka AHU9085 (National University of Hokkaido, Faculty of Agriculture) was used at 30 ° C. Cultured for 2 weeks. In addition, as polar lipid, what was extracted from milk ceramide MC-5 (made by Snow Brand Milk Products Co., Ltd.) using chloroform, methanol and acetone was used. The obtained culture broth was extracted three times with chloroform and methanol, concentrated and dried, and an ethanol-soluble fraction was taken out. The obtained ethanol-soluble fraction was diluted to 1.0% to obtain the hair composition of the present invention. The product obtained from Rhizopus oryzae NBRC4780 strain was designated as Example product 1, and the product obtained from Monascus anka AHU9085 strain was designated as Example product 2.
［比較例１］
実施例で培養にもちいた極性脂質（ミルクセラミドＭＣ−５（雪印乳業株式会社製）からクロロホルム、メタノール及びアセトンを用いて抽出したもの）を１．０％となるようにエタノールに溶解し、比較例品１を得た。
[Comparative Example 1]
Polar lipids (milk ceramide MC-5 (manufactured by Snow Brand Milk Products Co., Ltd.) extracted with chloroform, methanol, and acetone) dissolved in ethanol so as to be 1.0% were compared for comparison. Example product 1 was obtained.
[比較例２]
Rhizopus oryzae ＮＢＲＣ４７８０株（独立行政法人製品評価技術基盤機構生物遺伝資源部門）、Monascus anka ＡＨＵ９０８５株（国立大学法人北海道大学農学部）を、極性資質を含まない表２に示す培地を用いて、３０℃で２週間培養した。得られた培養物をそれぞれクロロホルム、メタノールで各３回抽出を行い、濃縮・乾固させ、エタノール可溶画分を取り出した。得られたエタノール可溶画分を１．０％となるように希釈し、Rhizopus oryzae代謝産物（比較例品２）及びMonascus anka代謝産物（比較例品３）を得た。
[Comparative Example 2]
Rhizopus oryzae NBRC 4780 strain (National Institute of Technology and Evaluation Biological Genetic Resources Division), Monascus anka AHU9085 strain (National Hokkaido University Faculty of Agriculture) at 30 ° C using the medium shown in Table 2 without polar qualities. Cultured for 2 weeks. The obtained culture was extracted three times with chloroform and methanol, respectively, concentrated and dried, and an ethanol-soluble fraction was taken out. The ethanol-soluble fraction obtained was diluted to 1.0% to obtain a Rhizopus oryzae metabolite (Comparative Example product 2) and a Monascus anka metabolite (Comparative Example product 3).
［試験例１］
実施例１で得られた毛髪用組成物（実施例品１、実施例品２）についてマウスへの塗布実験を行った。マウスは、C57BL/6NcrlCrlj系統を用いた。このマウスの背部を剃毛後、１週間の予備飼育を行った。その後、エタノールのみのコントロール、ミノキシジル(１.０％・ポジティブコントロール)、微生物代謝産物由来エタノール可溶各分(１.０％)２種類を週に６回ずつ１００μlを塗布した。マウスの発毛状況を図１に示すようにA（局所・青）、A’(局所・発毛)、B(全体・青)、B’(全体・発毛)に分類した。C57BL/6NcrlCrlj系統のマウスは成長期が誘導されると発毛前に皮膚が青く変色することが知られている。この状態をAとし、この青色部分から発毛した状態をA’とした。また、皮膚全体に青色に変色した状態をB、青色部分から発毛した状態をB’とした。結果を図２に示す。
[Test Example 1]
The hair composition obtained in Example 1 (Example Product 1 and Example Product 2) was subjected to a mouse application experiment. The mouse used the C57BL / 6NcrlCrlj strain. After shaving the back of this mouse, preliminary breeding was carried out for 1 week. Thereafter, 100 μl of ethanol-only control, minoxidil (1.0%, positive control), and microbial metabolite-derived ethanol-soluble fraction (1.0%) were applied 6 times a week. As shown in FIG. 1, the hair growth state of the mice was classified into A (local / blue), A ′ (local / hair growth), B (overall / blue), and B ′ (overall / hair growth). It is known that the mouse of C57BL / 6NcrlCrlj strain turns blue before hair growth when the growth phase is induced. This state was designated as A, and the state of hair growth from this blue part was designated as A ′. In addition, the state in which the entire skin turned blue was designated as B, and the state of hair growth from the blue portion was designated as B ′. The results are shown in FIG.
図２では、各エタノール溶液を5匹ずつの57BL/6NcrlCrlj系統のマウスに63日齢から塗布を開始して毛包の成長期が誘導された時期を示した。エタノールはコントロール、ミノキシジルはポジティブコントロール、ミルクセラミドはMC-5由来極性脂質、Monascus anka及びRhizopus oryzaeはそれぞれの食用微生物代謝産物を塗布したマウスの結果を示している。オスの場合、コントロールのエタノールと比較して、ミルクセラミド及びRhizopus oryzaeはポジティブコントロールのミノキシジルと同様に５匹とも毛包の成長期が早期誘導されており、その効果が確認された。また、メスの場合は、Monascus ankaに成長期を早期誘導する効果が高いことが確認された。すなわち、本発明の毛髪用組成物は、毛法の成長期を誘導させることにより、脱毛症等の治療に有効であることが確認された。 FIG. 2 shows the time when the hair follicle growth phase was induced by applying each ethanol solution to 57 mice of the 57BL / 6NcrlCrlj strain starting at 63 days of age. Ethanol is the control, minoxidil is the positive control, milk ceramide is the MC-5-derived polar lipid, Monascus anka and Rhizopus oryzae are the results of mice coated with each edible microbial metabolite. In the case of males, as compared with control ethanol, milk ceramide and Rhizopus oryzae were induced early in the hair follicle growth period in the same manner as the positive control minoxidil, and the effects were confirmed. In the case of females, it was confirmed that Monascus anka is highly effective in inducing the early growth phase. That is, it was confirmed that the hair composition of the present invention is effective in treating alopecia and the like by inducing the growth period of the hair method.
［試験例２］
実施例品１、２の毛髪用組成物及び比較例品１、２の代謝産物について、マウスへの塗布実験により毛髪への影響を確認した。マウスは、C57BL/6NcrlCrlj系統(オス)を用いた。このマウスの背部を剃毛後、１週間の予備飼育を行った。その後、エタノールのみのネガティブコントロール（ＮＣ）、ミノキシジル（１.０％)のポジティブコントロール（ＰＣ）、実施例品１、実施例品２、比較例品１、比較例品２、比較例３をそれぞれ週に６回ずつ、１００μlを各サンプル６匹ずつのマウスに６３日齢から塗布を開始し、毛包の成長期の誘導を確認した。マウスの発毛状況を図３に示すように以下のとおりとした。
第１段階：塗布開始前と変わらず背部全体が休止期で、淡紅色を呈したままの状態。
第２段階：局部的に成長期に入り、一部が青い状態。
第３段階：背部全体が成長期になり、青色を呈する状態。
第４段階：成長期が進行し、発毛している状態。
結果として、各段階の個体数を表３に示す。
[Test Example 2]
About the hair composition of Example goods 1 and 2 and the metabolite of Comparative products 1 and 2, the effect on hair was confirmed by an application experiment to mice. The mouse used was a C57BL / 6NcrlCrlj strain (male). After shaving the back of this mouse, preliminary breeding was carried out for 1 week. Then, ethanol-only negative control (NC), minoxidil (1.0%) positive control (PC), Example product 1, Example product 2, Comparative product 1, Comparative product 2, and Comparative product 3, respectively. Six times a week, application of 100 μl to 6 mice of each sample was started from the age of 63 days to confirm the induction of hair follicle growth phase. The hair growth of the mice was as follows as shown in FIG.
First stage: The state where the entire back portion is in a rest period and remains light red as before the start of application.
Second stage: Entering the growth stage locally, partly blue.
Third stage: The whole back is in a growth period and is blue.
Fourth stage: A state in which the growth period has progressed and hair is growing.
As a result, the number of individuals at each stage is shown in Table 3.
C57BL/6NcrlCrlj系統のマウスは成長期が誘導されると発毛前に皮膚が青く変色することが知られている。極性脂質エタノール溶解物は比較例品１、Rhizopus oryzae及びMonascus ankaはそれぞれの培地を用いた培養抽出物(実施例品１、実施例品２、比較例品２、比較例品３)を塗布したマウスの結果を示している。極性脂質のエタノール溶解物である比較例品１では、６匹のうち４匹で毛包の成長期が促進されている。一方、Monascus ankaの極性脂質培地培養抽出物（実施例品２）では、ポジティブコントロールのミノキシジルと同様にすべてのマウスの毛包の成長期が早期誘導されていた。また、Rhizopus oryzaeの極性脂質培地培養抽出物（実施例品１）は６匹のうち５匹の毛包の成長期が早期誘導されており、比較例品１と比べても効果が高いことが確認された。すなわち、本発明の毛髪用組成物は、毛包の成長期を誘導させることにより、脱毛症等の治療に有効であることが確認された。 It is known that the mouse of C57BL / 6NcrlCrlj strain turns blue before hair growth when the growth phase is induced. Polar lipid ethanol lysate was applied to Comparative Example 1 and Rhizopus oryzae and Monascus anka were applied with culture extracts using the respective media (Example Product 1, Example Product 2, Comparative Product 2 and Comparative Product 3). Mouse results are shown. In Comparative Example Product 1, which is a polar lipid ethanolic solution, hair follicle growth phase is promoted in 4 out of 6 animals. On the other hand, in the polar lipid medium culture extract of Monascus anka (Example product 2), the hair follicle growth period of all mice was induced early as in the case of the positive control minoxidil. Moreover, the polar lipid medium culture extract of Rhizopus oryzae (Example product 1) has an early induction of the growth phase of 5 out of 6 hair follicles, and is more effective than Comparative product 1. confirmed. That is, it was confirmed that the hair composition of the present invention is effective in treating alopecia and the like by inducing the growth period of hair follicles.
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