JP6296259B1 - Hair restorer - Google Patents

Abstract

An excellent hair-growth effect can be exhibited as an external preparation. Moreover, it has the effect that it can be effectively utilized without discarding excess shochu oil contained in shochu raw sake. SOLUTION: In the production process of single distillation shochu, the shochu oil obtained by floating during the cooling of the raw liquor during normal pressure or reduced pressure shochu distillation is used as an active ingredient of the hair restorer. [Selection] Figure 1

Description

  The present invention relates to a hair restoring agent, and more particularly to a hair restoring agent containing shochu oil (fatty acid ester) obtained in the manufacturing process of shochu.

  Conventionally, various hair growth agents have been used for the prevention and treatment of various symptoms such as baldness, thinning hair, dandruff, and fat. In general, as a compounding agent for a hair growth agent, those mainly used for the purpose of promoting blood circulation of the scalp, activation of hair matrix cells, suppression of lipid secretion of the scalp, and nutritional supplementation to the hair are used.

  It is said that hair loss is caused by the loss of the balance of the hair growth cycle and the disruption of the hair growth cycle in the growth phase and the resting phase, but there are many unclear points regarding details. Among them, hair restorers that use various plant extracts as active ingredients among natural herbal medicines have been widely used due to their high safety, but sufficient scientific evidence has not been established for the actual hair restore effect. .

  For example, an oral hair restorer containing phytoestrogens contained in chili seeds as an active ingredient (see Patent Document 1). A hair nourishing and hair restorer that uses a solution of aloe and dokudami in ethanol or shochu (see Patent Document 2). A hair restorer containing a rice water extract or an organic solvent extract fermented with alcohol as it is or containing it (see Patent Document 3). In addition, a hair restorer containing black tea extract as an active ingredient (see Patent Document 4). A hair growth-promoting agent containing a component contained in the liquid part of the sweet potato shochu hydrolyzate (see Patent Document 5). Various proposals have been made on cosmetics having a hair-growth and hair-growth effect (see Patent Document 6) made of a fermentation product obtained from a sweet potato shochu (yeast extract) extract.

JP 2008-127382 A JP 2007-169206 A JP 05-163121 A JP 2011-148792 A JP 2009-234947 A JP 2009-185011 A

The present inventors, in view of the circumstances as described above, found that there is a hair growth promoting effect on shochu oil that will be produced in shochu production process, and have completed the present invention. That is, the present inventor believes that the reason why the conventional hair growth / hair growth agent cannot exhibit a satisfactory effect is due to the lack of components that promote activation of hair matrix cells in the hair root, As a result of diligent research to develop a hair growth agent, it was found that the shochu oil obtained in the manufacturing process of shochu has the effect of promoting the growth and division of hair matrix cells, making shochu oil an effective hair restorer. The present invention has been found and completed.
An object of the present invention is to provide a hair growth agent capable of improving hair papilla cells and promoting hair growth in a short period of time.

  Moreover, this invention intends to recycle the active ingredient contained in shochu oil by using the shochu oil normally discarded as a hair growth material.

  That is, the first feature of the present invention is that it is a hair restorer containing shochu oil as an active ingredient. The second feature is that the shochu oil used as the active ingredient is derived from a single distillation shochu. A third feature is that 5.0 g / 100 ml or more of palmitate is contained. The fourth feature is that 3.0 g / 100 ml or more of ethyl linoleate is contained. The fifth feature is that 1.9 g / 100 ml or more of α-linolenic acid ethyl is contained. Furthermore, the sixth feature is that other hair-growth ingredients are further added. Further, the seventh feature is that one or more components selected from vitamins, amino acids, animal and vegetable oils and sodium chloride are contained.

  The shochu oil, which is an active ingredient of the present invention, is obtained during the single distillation shochu manufacturing process, and was confirmed to have the ability to promote the production of VEGF, a hair growth growth factor, like minoxidil. However, it has been reported that minoxidil has side effects such as lowering blood pressure.

  In addition, although the hair growth agent which this invention provides contains shochu oil as an active ingredient, what is conventionally used as a hair nourishing agent compounding component can be suitably mix-added as another compounding component.

  According to the present invention, an excellent hair-growth effect as an external preparation can be exhibited. Moreover, it has the effect that it can be effectively utilized without discarding excess shochu oil contained in shochu raw sake. That is, the present invention aims to effectively reuse shochu oil by using the functionality of shochu oil as a cosmetic or chemical material.

It is a flowchart which shows one Example of a shochu manufacturing process. It is explanatory drawing shown about human hair formation. It is a graph which shows the toxicity test result of shochu oil. It is a graph which shows the VEGF production test result of shochu oil. It is a graph which shows the correlation of a test period and the area of regenerated hair (all active ingredients). It is a graph which shows the correlation of a test period and the area of regenerated hair (shochu oil). It is a graph which shows the correlation of a test period and the area of regenerated hair (ethyl palmitate). It is a graph which shows the correlation of a test period and the area of regenerated hair (ethyl linoleate). It is a graph which shows the correlation of a test period and the area of regenerated hair ((alpha)-ethyl linolenate). It is a mouse | mouth back photograph which shows a hair growth state (shochu oil). It is a mouse | mouth back photograph which shows a hair growth state (each active ingredient).

Hereinafter, the present invention will be described in more detail based on examples.

  EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated concretely, this invention is not limited by these Examples.

(Shochu oil production process)
As shown in FIG. 1, shochu oil used in the present invention is the one that floated during the cooling of the raw liquor after performing atmospheric pressure or reduced pressure shochu distillation in the manufacturing process of shochu using rice and sweet potato as raw materials. Table 1 shows the main components. All single distillation shochu oils contain the same main components.

  As a result of analysis, shochu oil is mainly composed of ethyl palmitate, ethyl linoleate, ethyl oleate, ethyl stearate, ethyl caprate, ethyl laurate, ethyl myristate, ethyl α-linolenate. It turns out that it is composed.

  Here, human hair formation will be described with reference to FIG. VEGF (Vascular Endothelial Cell Growth Factor) is secreted from the hair papilla cells of the hair bulb and has an action of promoting hair growth by promoting angiogenesis to the hair bulb.

(Toxicity test)
First, a hair growth test was performed by changing the concentration of shochu oil using human hair papilla cells. The number of live dermal papilla cells after 72 hours treatment of the test substance was counted. As can be seen from the graph of FIG. 3, no cytotoxicity was observed in all test sample (shochu oil) concentration groups.

Activation test of human hair papilla cells (VEGF production test)
As can be seen from the graph of FIG. 4, in the VEGF production test, production was significantly enhanced by minoxidil, which was an acceleration control substance. In addition, not only was shochu oil promoted to be produced in a concentration-dependent manner, but the promoting effect tended to exceed that of minoxidil.

The hair follicle is always growing change organ at a certain period, the hair cycle is anagen, catagen, and a rest period or, et al. In C3H mice, it is known that the hair cycle is synchronized with the rest period from 7 weeks of age to 50 days. In addition, it is known that the back hair of C3H mice is 45 to 95 days after birth, and the skin becomes pink when the back hair is shaved at this time. And the hair growth promotion effect | action can be evaluated by observing the part into which the hair follicle entered the growth period. Therefore, this C3H mouse was used in this test.

In the present invention, the back of 33 7-week-old male C3H mice whose hair cycle was in the resting phase was shaved and application was started. Incidentally, the solution used in the test, the white petrolatum and control, shochu oil so that the respective concentrations shown in Table 2, palmitic San'e Chi le, ethyl linoleate, was dissolved ethyl α- linolenic acid, it was shaved The mice were divided into 11 groups of 3 mice, one of which was the control group, and the test solution was applied to the remaining 10 groups each day on the back, and the hair appearance and skin quality of the back were observed.

That is, white petrolatum (0.0 g / 100 ml) was used as a control, and shochu oil was used in three concentrations of (75.0 g / 100 ml), (50.0 g / 100 ml) and (20.0 g / 100 ml). (49.0 g / 100 ml), (15.0 g / 100 ml), (10.0 g / 100 ml), (5.0 g / 100 ml) at four concentrations of ethyl linoleate (24.2 g / 100 ml) , (12.0 g / 100 ml), (6.0 g / 100 ml) and (3.0 g / 100 ml) at a concentration of 4 and α-ethyl ethyl linolenate (1.9 g / 100 ml) at a hair growth test Went. The results are shown in Table 2. The test period was completed by applying a cotton swab once a day to the back of a 7 week-shaved C3H mouse and confirming hair regeneration on the 21st and 29th days. The determination reference values are shown in Table 3.

(Mouse hair growth test results)
Evaluation was made on the effect of promoting hair growth for 4 weeks after the start of application. As a result, as can be seen from the graphs of FIGS. 5 to 9, shochu oil (20 g / 100 ml) or more, ethyl palmitate (5.0 g / 100 ml) or more, ethyl linoleate (3.0 g / 100 ml) or more, α -A hair growth effect (hair growth promoting effect) was observed in a sample containing ethyl linolenate (1.9 g / 100 ml) or more.

  FIG. 10 to FIG. 11 are photographs of mice. In the mice of the control group (untreated group, solvent white petrolatum group), slight hair growth was observed after 4 weeks of observation, but the hair cycle was still in the rest period. It can be seen that it belongs to. On the other hand, in the shochu oil group, the ethyl palmitate group, the ethyl linoleate group, and the ethyl α-linolenate, the hair growth effect was significantly observed in all mice. That is, since the hair cycle originally belongs to the rest period, the hair growth effect should not be seen, but in this example, it can be seen that the hair growth was promoted.

  That is, in the control group, only a slight hair-growth effect could be confirmed in all mice, whereas in the group to which the shochu oil was applied, the hair-growth effect was remarkably confirmed in almost all mice.

  In addition, Table 4 shows the results of observation of the skin quality of the mice after application of the test solution.

  As can be seen from the determination results in Table 2 and Table 4, the concentration of the shochu oil in the hair restorer according to the present invention is not particularly limited, but is preferably from the viewpoint of expression of the hair restoring effect and safety to the skin. Is 10 to 70 g / 100 ml, more preferably 25 to 50 g / 100 ml, and most preferably 30 to 45 g / 100 ml.

  The hair restorer of the present invention is prepared by mixing with a carrier for preparation and applied in the form of an external preparation. For example, in liquid, emulsion, cream, lotion, paste, mousse, gel, sheet (substrate support), aerosol, spray, oil, pack, gel, ointment, etc. It can be, but is not limited to these. Examples of the carrier for preparation include substances that are commonly used in the preparation field and do not react with the hair-growth component of the present invention.

  The hair restorer of the present invention may further contain various other active ingredients as necessary. Examples of such other active ingredients include cell activators, blood circulation promoters, anti-androgen hormone agents, sebum secretion inhibitors, immunosuppressants, antihistamines, bactericidal antiseptics, local stimulants, keratin softeners, anti-inflammatory agents. And anti-apoptotic agents and the like, but are not limited thereto. In addition, the content of other active ingredients can be appropriately changed depending on various factors such as a desired effect and the age, sex, and state of the subject to be applied.

  The hair restorer of the present invention is prepared by adding benzoic acid as a preservative, vitamin E as an antioxidant, or vitamin C as a pH adjuster to the shochu oil obtained as described above. Etc., and can be adjusted to withstand long-term storage. As other blending components, those used as conventional hair restorer blending components can be blended and added as appropriate. For example, vitamins, amino acids, animal and vegetable oils, sodium chloride and the like can be mentioned. Examples of vitamins in this case include vitamin A, vitamin B1, vitamin B2, niacin (nicotinic acid), vitamin C, vitamin E, sodium pantothenate, potassium pantothenate, biotin H (vitamin H) and the like. Examples of amino acids include dopa (β-3,4-dihydroxyfernylalanine). Further, as animal and vegetable oils, horse oil, egg oil, olive oil, camellia oil, rapeseed oil, sesame oil, germ oil and the like can be mentioned.

Claims (7)

A hair restorer containing shochu oil as an active ingredient. The hair restoring agent according to claim 1, wherein the shochu oil used as an active ingredient is derived from a single distillation shochu. 3. The hair restorer according to claim 1 or 2, comprising 5.0 g / 100 ml or more of ethyl palmitate as an active ingredient. The hair restoring agent according to any one of claims 1 to 3, comprising 3.0 g / 100 ml or more of ethyl linoleate as an active ingredient. A hair restorer comprising 1.9 g / 100 ml or more of ethyl α-linolenate as an active ingredient. The hair restoring agent according to any one of claims 1 to 5, further comprising other hair restoring components added thereto. The hair-restoring agent according to any one of claims 1 to 6, further comprising at least one component selected from vitamins, amino acids, animal and vegetable oils, and sodium chloride.