JPH0466516A - Liquid cosmetic for hair - Google Patents

Abstract

PURPOSE:To obtain a liquid hair cosmetic containing an odd carbon-chain fatty acid, an ester of an even carbon-chain fatty acid and an alcohol. CONSTITUTION:The objective cosmetic contains 0.1-10wt.% of a fatty acid having a 3-25C carbon chain of odd carbon number or its derivative (e.g. pentadecanoic acid), 0.5-50wt.% of a mono- or diester of a fatty acid having a carbon chain of even carbon number (e.g. ethyl undecylenoate) and >=40wt.% of a lower alcohol. In addition to the above components, the cosmetic is further compounded properly with surfactants, oils, vitamins, hormones, keratolytic agent, disinfectant, etc. The weight ratio of the odd-carbon chain fatty acid to the even carbon number fatty acid ester is preferably 10/1 to 1/40.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a hair cosmetic with good transdermal absorption and a hair-nourishing effect.

[Conventional technology]

BACKGROUND ART Hair tonics containing various medicinal agents have been known. Examples of such medicinal agents include vitamins such as vitamin E, amino acids such as serine and methionine,
Vasodilators such as acetylcholine derivatives, anti-inflammatory agents such as purple root extract, female hormones such as estradiol,
Skin function brightening agents such as cephalanthine, melanin synthesis catalysts such as copper pantothenate, and keratolytic agents such as salicylic acid are used.

On the other hand, fatty acids with odd chain lengths or derivatives thereof have been discovered as new medicinal ingredients having a hair-nourishing effect, and a hair-nourishing agent containing these as active ingredients has been proposed (Japanese Patent Publication No. 63-41363).

However, with the hair growth agent composition disclosed herein, the percutaneous absorption of the active ingredients is insufficient, so the hair growth effect is not fully demonstrated. , it is expected that even more excellent hair-nourishing effects will be exhibited.

[Problem to be solved by the invention]

An object of the present invention is to provide a hair cosmetic that improves transdermal absorption of odd-number chain fatty acids or derivatives thereof that have a hair-nourishing effect.

[Means to solve the problem]

The present invention is based on the knowledge that when an odd-chain fatty acid or its derivative is dissolved in an alcoholic medium and a specific fatty acid ester is used in combination, the absorption from the scalp is improved and an excellent hair growth effect is exhibited. It has been done.

That is, the present invention contains (A) a fatty acid or a derivative thereof having an odd carbon chain length of 3 to 25 carbon atoms, and (B) a mono- or diester of a fatty acid having an even carbon chain length, and a lower To provide a liquid hair cosmetic characterized by having an alcohol content of 40% by weight or more.

The odd-numbered fatty acids used as the component (A) of this invention are:
Fatty acids with an odd number of carbon atoms constituting a carbon chain include saturated fatty acids and unsaturated fatty acids. Unsaturated fatty acids may contain multiple double bonds. It may also be lower fatty acids such as propionic acid (carbon chain length 3) and valeric acid (carbon chain length 5), or higher fatty acids such as pentadecanoic acid (carbon chain length 15) or heptadecanoic acid (carbon chain length 17). . Among these, those having 11 to 17 carbon atoms are preferred.

In this invention, any derivative of such odd chain length fatty acids can be used. However, it goes without saying that it is not possible to use substances that have an adverse effect on the human body. Examples of preferred derivatives include the following.

(a) Moglycerides indicated by General 2N] or [■] below.

(1) (n) CH2OCORCH2(011) C1l (OH) C) IOCORC
H2(01() CH2(OH) where R represents a linear organic group with an even carbon chain length.

(b) A diglyceride represented by the following general formula (II[) or (IV).

(III) (IV)C) lzO
cOR+ C)IzOCOR+C)l
OcOR2C)l (OH) CH2(OH) CH20CORZ where at least one of R and R2 represents a linear organic group having an even carbon chain length. R3 or R2
The effects of the present invention can be obtained if either one of them is a chain organic group having an even number of carbon chain lengths, and the other one may be a chain organic group having an odd number of carbon chain lengths. However, diglycerides of fatty acids of odd chain length are particularly preferred.

(c) Triglyceride represented by the following general formula (■).

(V) CH20COR.

Cll0COR2 CH2OCOR3 where at least one of R,, R2 and R3 does not represent a linear organic group having an even carbon chain length. R+, R
The effects of the present invention can be obtained if at least one of z and R3 is a chain organic group having an even carbon chain length, and the other is a chain organic group having an odd carbon chain length. I don't mind. However, triglycerides of odd-numbered fatty acids are particularly preferred.

(d) Fatty acid salt represented by the following general formula C■).

[■] (RCOO), where R is a linear organic group with an even carbon chain length, M
represents a metal atom, and n represents an integer corresponding to the valence of M. Representative ones are RCOONa, RCOOK, and RC
It is OOLi nato.

(e) Ester represented by the following general formula [■] [■] RCOOR' Here, R is a linear organic group having an even carbon chain length, R
' represents a monovalent or divalent aliphatic alcohol residue having an even number of carbon atoms, a polyoxyethylene residue, a sorbitan residue, or a sucrose residue.

Typical examples of monohydric alcohols are methanol and ethanol, and typical examples of amino residues are mono-, di-, and triethanolamine.

(f) The 17th compound represented by the following general formula [■] [■] RCONR'R'' Here, R represents a linear organic group having an even number of carbon chain lengths. R' and R'' are hydrogen or Represents an organic group that does not have any adverse effects on the human body.

(g) The second amide (I) represented by the following general formula [IX]
X) RICONCOR2 R' Here, at least one of R3 and R2 represents a linear organic group having an even number of carbon chain lengths. If at least one of R6 and R2 is an organic group with an even chain length, the effects of the present invention can be obtained;
may be any organic group as long as it does not have an adverse effect on the human body. However, it is particularly preferred that both groups are linear organic groups with even chain lengths. R' may be hydrogen.

(H) A tertiary amide represented by the following general formula (X).

(X) RrC0NC0Rz OR3 Here, at least one of R, , R, and R3 represents a linear organic group having an even carbon chain length. Rr, R
The effects of the present invention can be obtained if at least one of z and R3 is an organic group with an even chain length, and the other organic groups can be any organic group as long as they do not have an adverse effect on the human body. good.

However, it is particularly preferable that all three of these groups are straight-chain organic groups with even chain lengths.

(W) Dibasic acid and its salt represented by the following general formula (XI) [XI] HOOCRCOOH Here, R represents a linear organic group having an odd carbon chain length.

(J) Sterol ester represented by the following general formula [Xn] [XII] Here, R represents a linear organic group having an even number of carbon chain lengths.

(L) Phospholipids represented by the following general formula (XI[[)
Xl . X represents a choline residue, an ethanolamine residue, a serine residue, or an inositol residue. When X is a choline residue, it becomes phosphatidylcholine, when it is an ethanolamine residue, it becomes phosphatidylethanolamine, when it is a serine residue, it becomes phosphatidylserine, and when it is inositol, it becomes phosphatidylinositol.

(E) Phosphatidic acid represented by the following general formula (XTV) [×■] CH20COR CH2COR2 Here, R1 and R2 are chain organic groups, and at least one of them is a chain organic group, and particularly preferably both are Represents a straight-chain organic group with an even number of carbon chain lengths.

(W) Sphingolipid CXV represented by the following -C formula (XV)) C) 13(CII2)+zcH=cI(-C)l-CI
-(Jlz-0-XOll NH C-・O where R is a linear organic group with an even carbon chain length,
represents a sugar residue, a phosphate residue, or an amine base residue such as choline or ethanolamine.

The content of the above component (A) in the hair cosmetic can be set arbitrarily, but it is preferably 0.1 to 10% by weight (hereinafter abbreviated as %), more preferably 0.5 to 5% by weight. %.

The fatty acid mono- or diester having an even carbon chain length used as component (B) in the present invention acts as a transdermal absorption enhancer for component (A), and has 2 to 30 carbon atoms, preferably 8 to 22 carbon atoms. Examples include mono- or diesters of even-numbered fatty acids and monohydric alcohols or polyhydric alcohols having 1 to 20 carbon atoms, preferably 1 to 12 carbon atoms. Among these, esters of the above fatty acids and monohydric alcohols are preferred. In addition, the ingredients (
As the fatty acid B), both saturated fatty acids and unsaturated fatty acids can be used. Esters of saturated fatty acids include methyl laurate, ethyl laurate, propyl laurate, methyl myristate, ethyl myristate,
Propyl myristate, methyl balmitate, ethyl valmitate, propyl valmitate, methyl stearate, yucyl stearate, propyl stearate, etc.
- Seed or seed plate) x Iy')/\jS compound is exemplified. In addition, as esters of unsaturated fatty acids, methyl obsylate, ethyl undecylenate, propyl linderate,
Myris l-1, (methyl phosphate, ethyl myristoleate, propyl myristoleate, isopropyl myristoleate, methyl palmitoleate, methyl palmitoleate, propyl balmyleate, isopropyl palmitoleate, ethyl petroselate, propyl petroselate) , ethyl oleate, octyl oleate, decyl oleate, methyl elaidate, ethyl elaidate, propyl elaidate, methyl ricinoleate, ethyl linoleate, propyl ricinoleate, methyl gatoleate, ethyl gatoleate, propyl gadolate , methyl erucate, ethyl erucate, erucic acid] D, methyl sorbate, methyl sorbate, methyl sorbate,
ru, ethyl linoleate, υbutyl linoleate, methyl hyalate, utilyl hyalate, methyl lylunate, ethyl linoleate, propyl lylunate, T-methyl lylunate, T
Examples include ethyl linoleate and propyl T-linoleate, and one or a mixture of two or more of these can be used. In addition, as the fatty acid ester, unsaturated fatty acid Nisdel is more preferable.

The content of component (B) can be arbitrary, but it is 0.1 to 50%, preferably 0.5 to 20% in the hair cosmetic.
It is better to contain it. Furthermore, the weight ratio of component (A) and component (B) can be arbitrary, but A/B=100/1.
~11500, preferably 10/1~1/40.

In the present invention, the lower alcohol is further contained in an amount of 40% or more, preferably 40 to 99.5%, more preferably 75 to 99%.
Contains. Here, the lower alcohol includes alniol having 1 to G carbon atoms, such as methanol, ethanol, propatool, isopropanol, butanol, isobutanol, pentanol, ethylene glycol,
Examples include filobylene glycol and glycerin, and one or more of these can be used. Among these, ethanol is particularly preferred.

In the present invention, by using the above-mentioned lower alcohol, a uniform solution state can be obtained, and in this point, it is different from an emulsion type. Therefore, the hair cosmetic composition of the present invention can contain water as long as the system does not become emulsified.

The hair cosmetic of the present invention may further contain various commonly used auxiliary ingredients, such as surfactants and oils. In addition, the medicinal ingredients include vitamins, hormones,
Known hair nourishing agents such as amino acids, vasodilators, anti-inflammatory agents, and cell activators, keratolytic agents, bactericidal agents, known transdermal absorption enhancers, and the like may also be added at the same time.

According to the hair cosmetic of the present invention, the transdermal absorption of the active ingredient is improved, so that it is possible to exhibit a more excellent hair-nourishing effect. Furthermore, since transdermal absorption is improved, the same level of hair growth effect can be obtained by lowering the concentration of the active ingredient.

Next, the present invention will be explained with reference to examples.

〔Example〕

Example 1 The transdermal absorption of the liquid composition shown in Table 1 was measured as follows.

The dorsal skin of a guinea pig (Hartley strain, male) was cut out and fixed between the donor and receptor of a vertical diffusion cell with the epidermis facing upward.

The receptor side was then filled with physiological saline, kept warm at 32°C without stirring, and then applied onto the donor side skin.
The test sample is 50μ! Added. 24 hours later, the physiological saline was sampled, and the amount of permeated fatty acid or derivative thereof having an odd carbon chain length was measured.

Note that the results are expressed as relative values of the transmittance of each composition, with the transmittance of the component containing no fatty acid ester being 1.

Table 1 shows that the skin permeability of component (A,) is improved when a fatty acid ester and a lower alcohol are added, and the skin permeability is further improved when an unsaturated fatty acid ester is used.

Next, the hair growth effect was investigated using the following method.

A group of 12 to 15 male Eugie Landpoite rabbits weighing approximately 2.5 kg was prepared, the hair on the back was removed, and only those in the telogen phase were used for the experiment (U7). Apply the test sample for 0.2 d each to the hair-removed back of a telogen Q animal once a week.
The product was applied for 30 to 60 days, and the number of coats required for the telogen hair to convert into the anagen hair was determined. The "number of days of promotion" used as an index of the hair growth effect indicates how many days the conversion from telogen hair to anagen hair was promoted compared to the unapplied area.

The hair nourishing effect was evaluated based on the standard Q shown in Table 2 below.

Table of results table 3 and table 4.

From Tables 3 and 4, it can be seen that the hair growth effect of rabbits is further improved by adding the fatty acid nistyl and lower alcohol.

Example 2 Next, a formulation example of the hair cosmetic of the present invention will be shown. In all of the examples, it was confirmed that the plants exhibited excellent hair growth effects.

Formulation example 1 (hair tonic) Ingredients Weight (%) Glycery pentadecanoate F' 4.0A Ethyl oleate
4.0α-tocopherol 0
．． 5 Safflower oil 0.3 Isopropyl palmitate 3. OP Kano (20 mol) Glycerylmo 3.0 Neusostear l/-t! -Men 1--L 0.1 Fragrance
0.3 99.5% ethanol Remaining formulation example 2 (
Hair tonic) Ingredients n-) Lihendecanoin Ethyl linoleate Castor oil Olive oil Glyceryl monostearate Isopropyl myristate Benzyl nicotinate Fragrance Isopropatool Prescription Example 3 (Hair tonic) Ingredients n-) Ethyl lysocanoate Methyl myristoleate Cephalanthine POE (15) Glyceryl monostearate safflower oil! - Menthol fragrance weight (%) 5.0 10,0 1.0 1.0 0.5 3.0 0,003 0.3 Remaining weight (%) 5.0 3.0 1.0 0,5 0. 3 0.1 0.3 Propylene glycol Remainder Formulation Example 4 (Hair Tonic) Ingredients Weight (%) n-) Lihendecanoin 2.0 Propyl Elaidate
5.0 Isopropylmethylphenol 0.
05 Hinokitiol 0.1 Castor oil 10.0 Fragrance 0
．． 5 Ethanol Remainder Example 3 When Prescription Example 1 of Example 2 was applied to alopecia patients, it was found to be effective against a wide range of alopecias, and was particularly effective against androgenetic alopecia such as juvenile alopecia and middle age alopecia; It has been revealed that it has an excellent hair growth effect on alopecia areata.

Furthermore, no side effects were observed when using this hair growth agent. The hair growth agent of the above-mentioned example was administered to 25 healthy people.
When a skin irritation test using a closed punch test was conducted on the skin, all results were negative (positive rate 0%).

As described above, all of the active ingredients according to the present invention are highly safe.

Written amendment 3.5.13 May 1, 1998, Indication of the case 1990 Patent Application No. 1 66 2, Title of the invention Liquid hair cosmetics 3, Name related to the person making the amendment Application (676) U Human ion stock 5, date of amendment order 6, column for detailed explanation of the invention in the specification subject to amendment (1) page 3, line 12 of the specification [1. Scalp -: Correct.

(2) "Thousand Glycerides" in the 400th, 15th to 16th h of the same book. JT corrects Ko.

(3) General formula, page 11 of the same book, XV: "CH3(C
H,),,C11=[:old[:)l m11-[H,[
]
I+-[11,-0-Xtn+NH C=mouth II J to be corrected.

(4) In the same book, page 13, lines 4-5, ``Ethyl undecylenate'' is changed to ``Ethyl caproleate, .g7.

(J)) Dosen No. 1 [; True book 1111 "' test sample is 3F corrected to ゛'4 test sample 蓓-,・1゜ (6) Components (B) of Table 1 on page 11 of the same book Correct "ethyl undenoleate (2.0%)' to "ethyl caproleate (20%)j.

Claims (1)

[Scope of Claims] (A) a fatty acid or a derivative thereof having an odd carbon chain length of 3 to 25 carbon atoms, and (B) a mono- or diester of a fatty acid having an even carbon chain length, and containing a lower A liquid hair cosmetic having an alcohol content of 40% by weight or more.